Lista de obras - Asfar S Azmi - Dominio Público Uruguay

A multi-targeted approach to suppress tumor-promoting inflammation

artículo científico publicado en 2015

A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo

artículo científico publicado en 2013

A(3) adenosine receptor: a plausible therapeutic target for cardio-protection in diabetes

artículo científico publicado en 2012

Aberrant epigenetic grooming of miRNAs in pancreatic cancer: a systems biology perspective

artículo científico publicado en 2011

Activated K-Ras and INK4a/Arf deficiency promote aggressiveness of pancreatic cancer by induction of EMT consistent with cancer stem cell phenotype

artículo científico publicado en 2013

Adopting network pharmacology for cancer drug discovery

artículo científico

Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction

artículo científico publicado en 2017

An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals

artículo científico publicado en 2009

An efficient method for significant motifs discovery from multiple DNA sequences.

artículo científico publicado en 2017

Anti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasone

artículo científico publicado en 2016

Ascorbic acid mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for anticancer properties.

artículo científico publicado en 2006

Author Correction: The nuclear export protein XPO1 - from biology to targeted therapy

artículo científico publicado en 2020

Broad targeting of resistance to apoptosis in cancer.

artículo científico publicado en 2015

Calcium Release-Activated Calcium (CRAC) Channel Inhibition Suppresses Pancreatic Ductal Adenocarcinoma Cell Proliferation and Patient-Derived Tumor Growth

artículo científico publicado en 2020

Can network pharmacology rescue neutraceutical cancer research?

artículo científico publicado en 2012

Catalytic therapy of cancer by ascorbic acid involves redox cycling of exogenous/endogenous copper ions and generation of reactive oxygen species

artículo científico publicado en 2010

Cellular DNA breakage by soy isoflavone genistein and its methylated structural analogue biochanin A.

artículo científico publicado en 2009

Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancer

artículo científico publicado en 2012

Curcumin Analogue CDF Inhibits Pancreatic Tumor Growth by Switching on Suppressor microRNAs and Attenuating EZH2 Expression ⬇️

artículo científico publicado el 22 de noviembre de 2011

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

artículo científico publicado en 2015

Development of Precision Small-Molecule Proneurotrophic Therapies for Neurodegenerative Diseases.

artículo científico publicado en 2016

Differentially expressed miRNAs in cancer-stem-like cells: markers for tumor cell aggressiveness of pancreatic cancer

artículo científico publicado en 2014

Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells

artículo científico publicado en 2011

Emerging Bcl-2 inhibitors for the treatment of cancer ⬇️

artículo científico publicado el 3 de septiembre de 2010

Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review

artículo científico

Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration.

artículo científico publicado en 2017

Gastric cancer: a comprehensive review of current and future treatment strategies

artículo científico publicado en 2020

Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment

artículo científico publicado en 2012

MDM2 inhibitors for pancreatic cancer therapy

artículo científico publicado en 2010

MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy ⬇️

artículo científico publicado el 6 de septiembre de 2010

Metformin inhibits cell proliferation, migration and invasion by attenuating CSC function mediated by deregulating miRNAs in pancreatic cancer cells.

artículo científico publicado en 2011

Nab-paclitaxel: potential for the treatment of advanced pancreatic cancer

artículo científico publicado en 2014

Network Modeling of MDM2 Inhibitor-Oxaliplatin Combination Reveals Biological Synergy in wt-p53 solid tumors ⬇️

artículo científico publicado el 1 de mayo de 2011

Network modeling of CDF treated pancreatic cancer cells reveals a novel c-myc-p73 dependent apoptotic mechanism ⬇️

artículo científico publicado el 26 de julio de 2011

Network perspectives on HDM2 inhibitor chemotherapy combinations

artículo científico publicado en 2011

Network pharmacology for cancer drug discovery: are we there yet?

artículo científico publicado en 2012

Network pharmacology: an emerging field in cancer drug discovery)

artículo científico publicado en 2013

Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy.

artículo científico publicado en 2009

Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells

artículo científico publicado en 2011

Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma

artículo científico publicado en 2016

Nuclear Export Inhibition for Pancreatic Cancer Therapy.

artículo científico publicado en 2018

Old wine in a new bottle: the Warburg effect and anticancer mechanisms of resveratrol

artículo científico

Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells

artículo científico publicado en 2011

Overview of cancer stem cells (CSCs) and mechanisms of their regulation: implications for cancer therapy.

scientific article published on June 2013

Oxidative breakage of cellular DNA by plant polyphenols: a putative mechanism for anticancer properties.

artículo científico publicado en 2007

PAK4-NAMPT Dual Inhibition Sensitizes Pancreatic Neuroendocrine Tumors to Everolimus

artículo científico publicado en 2021

PAK4-NAMPT Dual Inhibition as a Novel Strategy for Therapy Resistant Pancreatic Neuroendocrine Tumors

artículo científico publicado en 2019

PAR-4 as a possible new target for pancreatic cancer therapy

artículo científico publicado en 2010

Paclitaxel and di-fluorinated curcumin loaded in albumin nanoparticles for targeted synergistic combination therapy of ovarian and cervical cancers.

artículo científico publicado en 2018

Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells

artículo científico publicado en 2012

Pancreatic cancer stem-like cells display aggressive behavior mediated via activation of FoxQ1.

artículo científico publicado en 2014

Pancreatic cancer: understanding and overcoming chemoresistance

artículo científico publicado en 2010

Pharmaceutical reactivation of p53 pathways in cancer

artículo científico publicado en 2011

Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for anticancer properties

artículo científico publicado en 2005

Plant polyphenols mobilize nuclear copper in human peripheral lymphocytes leading to oxidatively generated DNA breakage: implications for an anticancer mechanism

artículo científico publicado en 2008

Plumbagin induces cell death through a copper-redox cycle mechanism in human cancer cells

artículo científico publicado en 2009

Preclinical Assessment with Clinical Validation of Selinexor with Gemcitabine and Nab-Paclitaxel for the Treatment of Pancreatic Ductal Adenocarcinoma

scientific article published on 12 December 2019

Prior exposure to restraint stress enhances 7,12-dimethylbenz(a)anthracene (DMBA) induced DNA damage in rats

scientific article published on 21 June 2006

Pro-oxidant activity of dietary chemopreventive agents: an under-appreciated anti-cancer property

artículo científico publicado en 2013

Progress in nanotechnology based approaches to enhance the potential of chemopreventive agents

artículo científico

Proof of Concept: Network and Systems Biology Approaches Aid in the Discovery of Potent Anticancer Drug Combinations ⬇️

artículo científico publicado el 1 de noviembre de 2010

Prooxidant DNA breakage induced by caffeic acid in human peripheral lymphocytes: involvement of endogenous copper and a putative mechanism for anticancer properties.

artículo científico publicado en 2006

Prostate cancer stem cells: molecular characterization for targeted therapy

artículo científico publicado en 2012

Prostate cancer: evidence-based indications for postoperative radiotherapy

artículo científico publicado en 2010

Providing activation-induced cytidine deaminase (AID) to nuclear export inhibitors. Response to: "Complex downstream effects of nuclear export inhibition in B-cell lymphomas: a possible role for activation-induced cytidine deaminase".

artículo científico publicado en 2013

Rectifying cancer drug discovery through network pharmacology

artículo científico publicado en 2014

Regulation of KRAS-PAK4 axis by microRNAs in cancer

artículo científico publicado en 2014

Restoring sensitivity to oxaliplatin by a novel approach in gemcitabine-resistant pancreatic cancer cells in vitro and in vivo

artículo científico publicado en 2010

Resveratrol mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for chemoprevention of cancer

artículo científico publicado en 2010

Resveratrol-Cu(II) induced DNA breakage in human peripheral lymphocytes: implications for anticancer properties

artículo científico publicado en 2005

Resveratrol‐induced apoptosis is enhanced in low pH environments associated with cancer ⬇️

artículo científico publicado el 1 de abril de 2012

Retracted: Activated K-ras and INK4a/Arf Deficiency Cooperate During the Development of Pancreatic Cancer by Activation of Notch and NF-κB Signaling Pathways

artículo científico publicado en 2011

Rho GTPase effectors and NAD metabolism in cancer immune suppression.

artículo científico publicado en 2017

SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status.

artículo científico publicado en 2009

Selective inhibitors of nuclear export for the treatment of non-Hodgkin's lymphomas

artículo científico publicado en 2013

Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death

artículo científico publicado en 2016

Small Molecule Inhibitors of Bcl-2 Family Proteins for Pancreatic Cancer Therapy ⬇️

artículo científico publicado el 1 de junio de 2011

Structure-activity studies on therapeutic potential of Thymoquinone analogs in pancreatic cancer

artículo científico publicado en 2010

Systems analysis reveals a transcriptional reversal of the mesenchymal phenotype induced by SNAIL-inhibitor GN-25.

artículo científico publicado en 2013

Systems and Network Pharmacology Approaches to Cancer Stem Cells Research and Therapy

scientific article published on December 2012

Systems and network biology in pharmaceutical drug discovery

artículo científico publicado en 2014

Systems biology approaches to pancreatic cancer detection, prevention and treatment

artículo científico publicado en 2014

Targeting CSCs within the tumor microenvironment for cancer therapy: a potential role of mesenchymal stem cells

artículo científico

Targeting Cancer at the Nuclear Pore

artículo científico publicado en 2016

Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer

artículo científico publicado en 2017

Targeting Notch signaling pathway to overcome drug resistance for cancer therapy

artículo científico publicado en 2010

Targeting Nuclear Exporter Protein XPO1/CRM1 in Gastric Cancer

artículo científico publicado en 2019

Targeting Rho GTPase effector p21 activated kinase 4 (PAK4) suppresses p-Bad-microRNA drug resistance axis leading to inhibition of pancreatic ductal adenocarcinoma proliferation.

artículo científico publicado en 2017

Targeting XPO1 and PAK4 in 8505C Anaplastic Thyroid Cancer Cells: Putative Implications for Overcoming Lenvatinib Therapy Resistance

artículo científico publicado en 2019

Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance.

artículo científico publicado en 2010

Targeting notch to eradicate pancreatic cancer stem cells for cancer therapy.

artículo científico publicado en 2011

The Role of microRNAs in the Diagnosis and Treatment of Pancreatic Adenocarcinoma

artículo científico publicado en 2016

The anthocyanidin delphinidin mobilizes endogenous copper ions from human lymphocytes leading to oxidative degradation of cellular DNA.

artículo científico publicado en 2008

The biflavonoid, amentoflavone degrades DNA in the presence of copper ions

artículo científico publicado en 2004

The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness.

artículo científico publicado en 2012

The evolution into personalized therapies in pancreatic ductal adenocarcinoma: challenges and opportunities.

artículo científico publicado en 2017

The evolving role of nuclear transporters in cancer

artículo científico publicado en 2014

The immunological contribution of NF-κB within the tumor microenvironment: a potential protective role of zinc as an anti-tumor agent.

artículo científico publicado en 2011

The nuclear export protein XPO1 - from biology to targeted therapy

scientific article published on 10 November 2020

Understanding XPO1 target networks using systems biology and mathematical modeling

artículo científico

Unveiling the role of nuclear transport in epithelial-to-mesenchymal transition

artículo científico publicado en 2013

Lista de obras de Asfar S Azmi

A multi-targeted approach to suppress tumor-promoting inflammation

A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo

A(3) adenosine receptor: a plausible therapeutic target for cardio-protection in diabetes

Aberrant epigenetic grooming of miRNAs in pancreatic cancer: a systems biology perspective

Activated K-Ras and INK4a/Arf deficiency promote aggressiveness of pancreatic cancer by induction of EMT consistent with cancer stem cell phenotype

Adopting network pharmacology for cancer drug discovery

Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction

An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals

An efficient method for significant motifs discovery from multiple DNA sequences.

Anti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasone

Ascorbic acid mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for anticancer properties.

Author Correction: The nuclear export protein XPO1 - from biology to targeted therapy

Broad targeting of resistance to apoptosis in cancer.

Calcium Release-Activated Calcium (CRAC) Channel Inhibition Suppresses Pancreatic Ductal Adenocarcinoma Cell Proliferation and Patient-Derived Tumor Growth

Can network pharmacology rescue neutraceutical cancer research?

Catalytic therapy of cancer by ascorbic acid involves redox cycling of exogenous/endogenous copper ions and generation of reactive oxygen species

Cellular DNA breakage by soy isoflavone genistein and its methylated structural analogue biochanin A.

Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancer

Curcumin Analogue CDF Inhibits Pancreatic Tumor Growth by Switching on Suppressor microRNAs and Attenuating EZH2 Expression ⬇️

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Development of Precision Small-Molecule Proneurotrophic Therapies for Neurodegenerative Diseases.

Differentially expressed miRNAs in cancer-stem-like cells: markers for tumor cell aggressiveness of pancreatic cancer

Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells

Emerging Bcl-2 inhibitors for the treatment of cancer ⬇️

Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review

Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration.

Gastric cancer: a comprehensive review of current and future treatment strategies

Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment

MDM2 inhibitors for pancreatic cancer therapy

MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy ⬇️

Metformin inhibits cell proliferation, migration and invasion by attenuating CSC function mediated by deregulating miRNAs in pancreatic cancer cells.

Nab-paclitaxel: potential for the treatment of advanced pancreatic cancer

Network Modeling of MDM2 Inhibitor-Oxaliplatin Combination Reveals Biological Synergy in wt-p53 solid tumors ⬇️

Network modeling of CDF treated pancreatic cancer cells reveals a novel c-myc-p73 dependent apoptotic mechanism ⬇️

Network perspectives on HDM2 inhibitor chemotherapy combinations

Network pharmacology for cancer drug discovery: are we there yet?

Network pharmacology: an emerging field in cancer drug discovery)

Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy.

Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells

Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma

Nuclear Export Inhibition for Pancreatic Cancer Therapy.

Old wine in a new bottle: the Warburg effect and anticancer mechanisms of resveratrol

Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells

Overview of cancer stem cells (CSCs) and mechanisms of their regulation: implications for cancer therapy.

Oxidative breakage of cellular DNA by plant polyphenols: a putative mechanism for anticancer properties.

PAK4-NAMPT Dual Inhibition Sensitizes Pancreatic Neuroendocrine Tumors to Everolimus

PAK4-NAMPT Dual Inhibition as a Novel Strategy for Therapy Resistant Pancreatic Neuroendocrine Tumors

PAR-4 as a possible new target for pancreatic cancer therapy

Paclitaxel and di-fluorinated curcumin loaded in albumin nanoparticles for targeted synergistic combination therapy of ovarian and cervical cancers.

Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells

Pancreatic cancer stem-like cells display aggressive behavior mediated via activation of FoxQ1.

Pancreatic cancer: understanding and overcoming chemoresistance

Pharmaceutical reactivation of p53 pathways in cancer

Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for anticancer properties

Plant polyphenols mobilize nuclear copper in human peripheral lymphocytes leading to oxidatively generated DNA breakage: implications for an anticancer mechanism

Plumbagin induces cell death through a copper-redox cycle mechanism in human cancer cells

Preclinical Assessment with Clinical Validation of Selinexor with Gemcitabine and Nab-Paclitaxel for the Treatment of Pancreatic Ductal Adenocarcinoma

Prior exposure to restraint stress enhances 7,12-dimethylbenz(a)anthracene (DMBA) induced DNA damage in rats

Pro-oxidant activity of dietary chemopreventive agents: an under-appreciated anti-cancer property

Progress in nanotechnology based approaches to enhance the potential of chemopreventive agents

Proof of Concept: Network and Systems Biology Approaches Aid in the Discovery of Potent Anticancer Drug Combinations ⬇️

Prooxidant DNA breakage induced by caffeic acid in human peripheral lymphocytes: involvement of endogenous copper and a putative mechanism for anticancer properties.

Prostate cancer stem cells: molecular characterization for targeted therapy

Prostate cancer: evidence-based indications for postoperative radiotherapy

Providing activation-induced cytidine deaminase (AID) to nuclear export inhibitors. Response to: "Complex downstream effects of nuclear export inhibition in B-cell lymphomas: a possible role for activation-induced cytidine deaminase".

Rectifying cancer drug discovery through network pharmacology

Regulation of KRAS-PAK4 axis by microRNAs in cancer

Restoring sensitivity to oxaliplatin by a novel approach in gemcitabine-resistant pancreatic cancer cells in vitro and in vivo

Resveratrol mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for chemoprevention of cancer

Resveratrol-Cu(II) induced DNA breakage in human peripheral lymphocytes: implications for anticancer properties

Resveratrol‐induced apoptosis is enhanced in low pH environments associated with cancer ⬇️

Retracted: Activated K-ras and INK4a/Arf Deficiency Cooperate During the Development of Pancreatic Cancer by Activation of Notch and NF-κB Signaling Pathways

Rho GTPase effectors and NAD metabolism in cancer immune suppression.

SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status.

Selective inhibitors of nuclear export for the treatment of non-Hodgkin's lymphomas

Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death

Small Molecule Inhibitors of Bcl-2 Family Proteins for Pancreatic Cancer Therapy ⬇️

Structure-activity studies on therapeutic potential of Thymoquinone analogs in pancreatic cancer

Systems analysis reveals a transcriptional reversal of the mesenchymal phenotype induced by SNAIL-inhibitor GN-25.