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Lista de obras de Timothy J Mitchell

A Serine-Threonine Kinase (StkP) Regulates Expression of the Pneumococcal Pilus and Modulates Bacterial Adherence to Human Epithelial and Endothelial Cells In Vitro

artículo científico publicado en 2015

A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.

artículo científico publicado en 2011

A conserved tryptophan in pneumolysin is a determinant of the characteristics of channels formed by pneumolysin in cells and planar lipid bilayers

artículo científico publicado en 1998

A dynamic relationship between mucosal T helper type 17 and regulatory T-cell populations in nasopharynx evolves with age and associates with the clearance of pneumococcal carriage in humans

artículo científico publicado en 2016

A neuraminidase from Streptococcus pneumoniae has the features of a surface protein

artículo científico publicado en 1994

A role for pneumolysin but not neuraminidase in the hearing loss and cochlear damage induced by experimental pneumococcal meningitis in guinea pigs ⬇️

artículo científico publicado el 1 de noviembre de 1997

A role in cell-binding for the C-terminus of pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae

artículo científico publicado en 1994

A two-component system that controls the expression of pneumococcal surface antigen A (PsaA) and regulates virulence and resistance to oxidative stress in Streptococcus pneumoniae.

artículo científico

Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue.

artículo científico publicado en 2011

Activation of brain endothelium by pneumococcal neuraminidase NanA promotes bacterial internalization.

artículo científico publicado en 2010

Active release of pneumolysin prepores and pores by mammalian cells undergoing a Streptococcus pneumoniae attack

artículo científico publicado en 2016

Amino acid changes affecting the activity of pneumolysin alter the behaviour of pneumococci in pneumonia

artículo científico publicado en 1998

Amino acids in pneumolysin important for hemolytic activity identified by random mutagenesis

artículo científico publicado en 1994

An operon in Streptococcus pneumoniae containing a putative alkylhydroperoxidase D homologue contributes to virulence and the response to oxidative stress.

artículo científico publicado en 2006

Antibiotic resistance in invasive Streptococcus pneumoniae isolates identified in Scotland between 1999 and 2007.

artículo científico publicado en 2010

Antipneumolysin antibody titers in HIV-seropositive injection drug users before and after pneumococcal bacteremia.

artículo científico

Astrocytic tissue remodeling by the meningitis neurotoxin pneumolysin facilitates pathogen tissue penetration and produces interstitial brain edema

artículo científico publicado en 2011

Bacterial cytolysin during meningitis disrupts the regulation of glutamate in the brain, leading to synaptic damage.

artículo científico publicado en 2013

Biological mode of action of Clostridium difficile toxin A: a novel enterotoxin

artículo científico publicado en 1987

Biological properties of pneumolysin

artículo científico publicado en 1997

Changes in astrocyte shape induced by sublytic concentrations of the cholesterol-dependent cytolysin pneumolysin still require pore-forming capacity

artículo científico publicado en 2011

Characterisation of an oxidative response inhibitor produced by Streptococcus pneumoniae

artículo científico publicado en 1994

Characterization of the interactions of the pneumolysoid, Δ6 PLY, with human neutrophils in vitro

scientific article published on 01 October 2011

Characterization of the solution properties and conformation of pneumolysin, the membrane-damaging toxin of Streptococcus pneumoniae

artículo científico publicado en 1993

Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae.

artículo científico publicado en 2007

Cloning, overexpression, purification, crystallization and preliminary diffraction analysis of the receiver domain of MicA.

artículo científico publicado en 2003

Clostridium difficile--a spectrum of virulence and analysis of putative virulence determinants in the hamster model of antibiotic-associated colitis

artículo científico publicado en 1987

Comparative genomic analysis of ten Streptococcus pneumoniae temperate bacteriophages

artículo científico publicado en 2009

Comparison of pneumolysin genes and proteins from Streptococcus pneumoniae types 1 and 2.

artículo científico publicado en 1990

Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitro

scientific article published on 10 September 2007

Complement activation and antibody binding by pneumolysin via a region of the toxin homologous to a human acute-phase protein

artículo científico publicado en 1991

Contribution of the ATP-dependent protease ClpCP to the autolysis and virulence of Streptococcus pneumoniae

artículo científico publicado en 2005

Control of virulence by the two-component system CiaR/H is mediated via HtrA, a major virulence factor of Streptococcus pneumoniae

scientific article published on August 2004

Crystal Structure of the C-terminal Region of Streptococcus mutans Antigen I/II and Characterization of Salivary Agglutinin Adherence Domains ⬇️

artículo científico publicado el 19 de abril de 2011

Crystal structure of the response regulator 02 receiver domain, the essential YycF two-component system of Streptococcus pneumoniae in both complexed and native states ⬇️

artículo científico publicado en 2004

Crystallization and preliminary crystallographic studies of the D59A mutant of MicA, a YycF response-regulator homologue from Streptococcus pneumoniae

artículo científico publicado en 2004

Cytotoxic effects on hair cells of guinea pig cochlea produced by pneumolysin, the thiol activated toxin of Streptococcus pneumoniae

artículo científico publicado en 1993

Death or survival from invasive pneumococcal disease in Scotland: associations with serogroups and multilocus sequence types.

artículo científico publicado en 2011

Delta 32 deletion of CCR5 gene and association with asthma or atopy

artículo científico publicado en 2000

Detection of large numbers of pneumococcal virulence genes in streptococci of the mitis group.

artículo científico publicado en 2010

Development of a prophage typing system and analysis of prophage carriage in Streptococcus pneumoniae

artículo científico publicado en 2009

Differences in genotype and virulence among four multidrug-resistant Streptococcus pneumoniae isolates belonging to the PMEN1 clone.

artículo científico publicado en 2011

Differential alveolar epithelial injury and protein expression in pneumococcal pneumonia

artículo científico publicado en 2012

Direct transmembrane interaction between actin and the pore-competent, cholesterol-dependent cytolysin pneumolysin

artículo científico publicado en 2012

Dissecting the components of the humoral immune response elicited by DNA vaccines

artículo científico publicado en 2005

Distinct roles for pneumolysin's cytotoxic and complement activities in the pathogenesis of pneumococcal pneumonia

artículo científico publicado en 1996

Distribution of epidemic antibiotic-resistant pneumococcal clones in Scottish pneumococcal isolates analysed by multilocus sequence typing

scientific article published on 01 February 2006

Dominant role of nucleotide substitution in the diversification of serotype 3 pneumococci over decades and during a single infection

artículo científico publicado en 2013

Dose-dependent activation of microglial cells by Toll-like receptor agonists alone and in combination

artículo científico publicado en 2004

Dynamics of pneumococcal colonization in healthy Dutch children

artículo científico publicado en 2006

Effect of defined point mutations in the pneumolysin gene on the virulence of Streptococcus pneumoniae

artículo científico publicado en 1995

Effect of immunization with Freund's adjuvant and pneumolysin on histologic features of pneumococcal infection in the rat lung in vivo

artículo científico publicado en 1992

Effect of pneumolysin on rat brain ciliary function: comparison of brain slices with cultured ependymal cells

scientific article published on 01 March 2000

Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon

artículo científico publicado en 1986

Effects of cigarette smoke condensate on pneumococcal biofilm formation and pneumolysin

scientific article published on 27 June 2012

Effects of deletion of the Streptococcus pneumoniae lipoprotein diacylglyceryl transferase gene lgt on ABC transporter function and on growth in vivo

artículo científico publicado en 2012

Exposure of a 23F serotype strain of Streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (TCS11).

artículo científico publicado en 2014

Expression and regulation of the Escherichia coli O157:H7 effector proteins NleH1 and NleH2

artículo científico publicado en 2012

Expression of a Cu,Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of neuroblastoma cells to infectious injury

artículo científico publicado en 2007

Expression of the pneumolysin gene in Escherichia coli: rapid purification and biological properties

artículo científico publicado en 1989

Expression, purification and X-ray characterization of residues 18-230 from the pneumococcal histidine triad protein A (PhtA) from Streptococcus pneumoniae

artículo científico publicado en 2004

Expression, purification, crystallization and preliminary X-ray crystallographic data from TktA, a transketolase from the lactic acid bacterium Lactobacillus salivarius

artículo científico publicado en 2010

Extracellular calcium reduction strongly increases the lytic capacity of pneumolysin from streptococcus pneumoniae in brain tissue

artículo científico publicado en 2011

Genetic analysis of diverse disease-causing pneumococci indicates high levels of diversity within serotypes and capsule switching

artículo científico publicado en 2004

Genetic conjugation of components in two pneumococcal fusion protein vaccines enhances paediatric mucosal immune responses

artículo científico publicado en 2015

Growth and virulence of a complement-activation-negative mutant of Streptococcus pneumoniae in the rabbit cornea

scientific article published on 01 April 1995

Growth of Clostridium difficile and production of toxins A and B in complex and defined media

artículo científico publicado en 1986

Host cellular immune response to pneumococcal lung infection in mice.

artículo científico publicado en 2000

Hyaluronidase augments pneumolysin-mediated injury to human ciliated epithelium.

artículo científico publicado en 2006

IL-17 can be protective or deleterious in murine pneumococcal pneumonia.

artículo científico publicado en 2018

Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts.

artículo científico publicado en 2005

Identification of a secreted cholesterol-dependent cytolysin (mitilysin) from Streptococcus mitis

artículo científico publicado en 2006

Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence-blocking compounds.

artículo científico

Identification of invasive serotype 1 pneumococcal isolates that express nonhemolytic pneumolysin.

artículo científico publicado en 2006

Identification of novel pneumolysin alleles from paediatric carriage isolates of Streptococcus pneumoniae.

artículo científico publicado en 2010

Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator CD59.

artículo científico publicado en 2009

IgG responses to Pneumococcal and Haemophilus influenzae protein antigens are not impaired in children with a history of recurrent acute otitis media.

artículo científico publicado en 2012

Immune ageing and susceptibility to Streptococcus pneumoniae

artículo científico

Immunisation with anthrolysin O or a genetic toxoid protects against challenge with the toxin but not against Bacillus anthracis

artículo científico publicado en 2007

Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae

artículo científico publicado en 1994

Induction of CC and CXC chemokines in human antigen-presenting dendritic cells by the pneumococcal proteins pneumolysin and CbpA, and the role played by toll-like receptor 4, NF-kappaB, and mitogen-activated protein kinases

artículo científico publicado en 2008

Influence of subinhibitory concentrations of protein-synthesis-inhibiting antibiotics on production and release of the pneumococcal virulence factor pneumolysin in vitro

artículo científico publicado en 2007

Innate immunity and the pneumococcus.

artículo científico publicado en 2006

Interaction of pneumolysin-sufficient and -deficient isogenic variants of Streptococcus pneumoniae with human respiratory mucosa.

artículo científico publicado en 1995

Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages

artículo científico publicado en 2011

Intracochlear perfusion of pneumolysin, a pneumococcal protein, rapidly abolishes auditory potentials in the Guinea pig cochlea.

artículo científico publicado en 2004

Investigating the role of pneumococcal neuraminidase A activity in isolates from pneumococcal haemolytic uraemic syndrome

artículo científico publicado en 2013

Isolation and characterization of a new plasmid pSpnP1 from a multidrug-resistant clone of Streptococcus pneumoniae

artículo científico publicado en 2007

Isolation and characterization of the promoter and partial enhancer region of the porcine inter-alpha-trypsin inhibitor heavy chain 4 gene

artículo científico publicado en 2005

Limited protection of TAT-Bcl-X(L) against pneumolysin-induced neuronal cell death

artículo científico publicado en 2005

Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children

artículo científico publicado en 2007

Magnesium therapy improves outcome in Streptococcus pneumoniae meningitis by altering pneumolysin pore formation

artículo científico publicado en 2017

Maturation of Streptococcus pneumoniae lipoproteins by a type II signal peptidase is required for ABC transporter function and full virulence.

artículo científico publicado en 2007

Microarray-based identification of a novel Streptococcus pneumoniae regulon controlled by an autoinduced peptide

artículo científico publicado en 2000

Molecular analysis of the pathogenicity of Streptococcus pneumoniae: the role of pneumococcal proteins

artículo científico publicado en 1993

Molecular analysis of virulence factors of Streptococcus pneumoniae

artículo científico publicado en 1997

Molecular basis of virulence Commentary ⬇️

artículo científico publicado el 1 de marzo de 1998

Molecular epidemiology of pneumococcal colonization in response to pneumococcal conjugate vaccination in children with recurrent acute otitis media

artículo científico publicado en 2005

NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence.

artículo científico publicado en 2016

Natural Antibodies against Several Pneumococcal Virulence Proteins in Children during the Pre-Pneumococcal-Vaccine Era: the Generation R Study ⬇️

artículo científico publicado el 31 de enero de 2011

Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase.

artículo científico publicado en 2002

Nitric oxide exerts distinct effects in local and systemic infections with Streptococcus pneumoniae

artículo científico publicado en 2004

Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection.

artículo científico publicado en 2004

Novel mucosal vaccines generated by genetic conjugation of heterologous proteins to pneumolysin (PLY) from Streptococcus pneumoniae.

artículo científico publicado en 2010

Overexpression, purification and crystallization of a choline-binding protein CbpI from Streptococcus pneumoniae

artículo científico publicado en 2006

Palladium attenuates the pro-inflammatory interactions of C5a, interleukin-8 and pneumolysin with human neutrophils.

artículo científico publicado en 2007

PclA, a pneumococcal collagen-like protein with selected strain distribution, contributes to adherence and invasion of host cells.

artículo científico publicado en 2008

Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin.

artículo científico publicado en 2003

Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis

scientific journal article

Pneumococcal pneumonia: mechanisms of infection and resolution.

artículo científico

Pneumococci causing invasive disease in children prior to the introduction of pneumococcal conjugate vaccine in Scotland

artículo científico publicado en 2006

Pneumococci induced TLR- and Rac1-dependent NF-kappaB-recruitment to the IL-8 promoter in lung epithelial cells

artículo científico publicado en 2005

Pneumolysin Mediates Platelet Activation In Vitro

artículo científico publicado en 2016

Pneumolysin activates macrophage lysosomal membrane permeabilization and executes apoptosis by distinct mechanisms without membrane pore formation

artículo científico publicado en 2014

Pneumolysin activates neutrophil extracellular trap formation

artículo científico publicado en 2016

Pneumolysin activates phospholipase A in pulmonary artery endothelial cells.

artículo científico publicado en 1994

Pneumolysin activates the synthesis and release of interleukin-8 by human neutrophils in vitro.

artículo científico publicado en 2002

Pneumolysin causes neuronal cell death through mitochondrial damage

artículo científico publicado en 2007

Pneumolysin induces release of matrix metalloproteinase-8 and -9 from human neutrophils.

artículo científico publicado en 2009

Pneumolysin induces the salient histologic features of pneumococcal infection in the rat lung in vivo

artículo científico publicado en 1991

Pneumolysin mediates heterotypic aggregation of neutrophils and platelets in vitro

artículo científico publicado en 2017

Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils

artículo científico publicado en 2001

Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes.

artículo científico publicado en 1994

Pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae, does not require a thiol group for in vitro activity

artículo científico

Pneumolysin-induced CXCL8 production by nasopharyngeal epithelial cells is dependent on calcium flux and MAPK activation via Toll-like receptor 4.

artículo científico publicado en 2010

Pneumolysin-mediated activation of NFkappaB in human neutrophils is antagonized by docosahexaenoic acid.

artículo científico publicado en 2005

Potential impact of conjugate vaccine on the incidence of invasive pneumococcal disease among children in Scotland

artículo científico publicado en 2006

Presence of nonhemolytic pneumolysin in serotypes of Streptococcus pneumoniae associated with disease outbreaks

artículo científico publicado en 2007

Production and release of toxins A and B by Clostridium difficile

artículo científico publicado en 1984

Proinflammatory interactions of pneumolysin with human neutrophils.

artículo científico publicado en 2001

Protection of infant mice from challenge with Streptococcus pneumoniae type 19F by immunization with a type 19F polysaccharide--pneumolysoid conjugate

scientific article published on 01 August 1994

Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability

artículo científico publicado en 2012

Purification and immunogenicity of genetically obtained pneumolysin toxoids and their conjugation to Streptococcus pneumoniae type 19F polysaccharide

artículo científico publicado en 1991

Purification, crystallization and preliminary X-ray analysis of the Enterococcus faecalis protein EF0377.

artículo científico publicado en 2003

Purification, crystallization and preliminary X-ray diffraction analysis of RafE, a sugar-binding lipoprotein from Streptococcus pneumoniae

artículo científico

Rapid Pneumococcal Evolution in Response to Clinical Interventions ⬇️

artículo científico publicado el 28 de enero de 2011

Rapid microtubule bundling and stabilization by the Streptococcus pneumoniae neurotoxin pneumolysin in a cholesterol-dependent, non-lytic and Src-kinase dependent manner inhibits intracellular trafficking.

artículo científico publicado en 2008

Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia

artículo científico publicado en 2008

Red Blood Cell Susceptibility to Pneumolysin: CORRELATION WITH MEMBRANE BIOCHEMICAL AND PHYSICAL PROPERTIES.

artículo científico publicado en 2016

Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone

artículo científico publicado en 2003

Regulation of gene expression in Streptococcus pneumoniae by response regulator 09 is strain dependent

artículo científico publicado en 2006

Regulation of production of mucosal antibody to pneumococcal protein antigens by T-cell-derived gamma interferon and interleukin-10 in children.

artículo científico publicado en 2006

Relationship of structure to function in pneumolysin

artículo científico publicado en 1997

Relative roles of pneumolysin and hydrogen peroxide from Streptococcus pneumoniae in inhibition of ependymal ciliary beat frequency.

artículo científico publicado en 2000

Role of HtrA in the virulence and competence of Streptococcus pneumoniae

artículo científico publicado en 2004

Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniaeSpain23F ST81

artículo científico publicado en 2008

Role of interleukin-18 in experimental infections with Streptococcus pneumoniae.

artículo científico publicado en 2005

Role of manganese-containing superoxide dismutase in oxidative stress and virulence of Streptococcus pneumoniae.

artículo científico publicado en 2000

Role of platelet-activating factor in pneumolysin-induced acute lung injury

artículo científico publicado en 2007

Role of pneumolysin for the development of acute lung injury in pneumococcal pneumonia.

artículo científico publicado en 2006

Self-interaction of pneumolysin, the pore-forming protein toxin of Streptococcus pneumoniae

article

Sensitivities of human monocytes and epithelial cells to pneumolysin are different.

artículo científico publicado en 2002

Serum and mucosal antibody responses to pneumococcal protein antigens in children: relationships with carriage status

artículo científico publicado en 2006

Serum immunoglobulin G response to candidate vaccine antigens during experimental human pneumococcal colonization

artículo científico publicado en 2003

Simultaneous nasopharyngeal carriage of two pneumococcal multilocus sequence types with a serotype 3 phenotype

artículo científico publicado en 2010

Sortase A contributes to pneumococcal nasopharyngeal colonization in the chinchilla model.

artículo científico publicado en 2005

Sporogenesis and toxin A production by Clostridium difficile

scientific article published on 01 August 1986

Streptococcus pneumoniae Cell-Wall-Localized Phosphoenolpyruvate Protein Phosphotransferase Can Function as an Adhesin: Identification of Its Host Target Molecules and Evaluation of Its Potential as a Vaccine

artículo científico publicado en 2016

Streptococcus pneumoniae induces exocytosis of Weibel-Palade bodies in pulmonary endothelial cells

artículo científico publicado en 2011

Streptococcus pneumoniae produces a second haemolysin that is distinct from pneumolysin

scientific article published on 01 March 1997

Streptococcus pneumoniae produces at least two distinct enzymes with neuraminidase activity: cloning and expression of a second neuraminidase gene in Escherichia coli.

artículo científico publicado en 1991

Streptococcus pneumoniae-associated human macrophage apoptosis after bacterial internalization via complement and Fcgamma receptors correlates with intracellular bacterial load.

artículo científico publicado en 2003

Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium

artículo científico publicado en 2004

Streptococcus pneumoniae-induced inhibition of rat ependymal cilia is attenuated by antipneumolysin antibody

artículo científico publicado en 2004

Streptococcus pneumoniae: infection, inflammation and disease

artículo científico publicado en 2006

Structural and functional characterisation of two proteolytic fragments of the bacterial protein toxin, pneumolysin

scientific article published on 01 August 1997

Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle

artículo científico publicado en 2020

Structure and function of pneumolysin, the multifunctional, thiol-activated toxin of Streptococcus pneumoniae ⬇️

artículo científico publicado el 1 de noviembre de 1991

Studies on the structure and mechanism of a bacterial protein toxin by analytical ultracentrifugation and small-angle neutron scattering

artículo científico publicado en 1999

Subunit organisation and symmetry of pore-forming, oligomeric pneumolysin

artículo científico publicado en 1995

T cell memory response to pneumococcal protein antigens in an area of high pneumococcal carriage and disease

artículo científico publicado en 2009

Temporal Analysis of Invasive Pneumococcal Clones from Scotland Illustrates Fluctuations in Diversity of Serotype and Genotype in the Absence of Pneumococcal Conjugate Vaccine. ⬇️

artículo científico publicado en 2010

Temporal analysis of invasive pneumococcal clones from Scotland illustrates fluctuations in diversity of serotype and genotype in the absence of pneumococcal conjugate vaccine. ⬇️

artículo científico publicado en 2009

The Ami-AliA/AliB permease of Streptococcus pneumoniae is involved in nasopharyngeal colonization but not in invasive disease.

artículo científico publicado en 2004

The NLRP3 Inflammasome Is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia

artículo científico publicado en 2011

The biology of Gram-positive sortase enzymes

artículo científico publicado en 2004

The biology of pneumolysin

artículo científico

The effect of Streptococcus pneumoniae pneumolysin on human respiratory epithelium in vitro

artículo científico publicado en 1990

The effect of the pneumococcal toxin, pneumolysin on brain ependymal cilia

scientific article published on 01 November 1999

The effects of Clostridium difficile crude toxins and purified toxin A on stripped rabbit ileal mucosa in Ussing chambers

scientific article published on 01 May 1987

The effects of Clostridium difficile crude toxins and toxin A on ileal and colonic loops in immune and non-immune rabbits

artículo científico publicado en 1987

The effects of Clostridium difficile toxins A and B on membrane integrity and protein synthesis in intestinal cells in vivo and in vitro and in McCoy cells in vitro

artículo científico publicado en 1987

The effects of PspC on complement-mediated immunity to Streptococcus pneumoniae vary with strain background and capsular serotype.

artículo científico publicado en 2009

The human-specific action of intermedilysin, a homolog of streptolysin O, is dictated by domain 4 of the protein

artículo científico publicado en 2004

The interaction of Streptococcus pneumoniae with intact human respiratory mucosa in vitro

artículo científico publicado en 1992

The mechanism of pneumolysin-induced cochlear hair cell death in the rat.

artículo científico publicado en 2005

The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae.

artículo científico publicado en 1998

The pathogenesis of streptococcal infections: from tooth decay to meningitis

artículo científico publicado en 2003

The role of Streptococcus pneumoniae sortase A in colonisation and pathogenesis.

artículo científico publicado en 2005

The role of cholesterol in the activity of pneumolysin, a bacterial protein toxin.

artículo científico publicado en 2004

The role of pneumolysin and autolysin in the pathology of pneumonia and septicemia in mice infected with a type 2 pneumococcus

scientific article published on 01 July 1995

The role of streptococcal toxins in disease ⬇️

artículo científico publicado el 1 de enero de 1998

The solution structure and oligomerization behavior of two bacterial toxins: pneumolysin and perfringolysin O.

artículo científico publicado en 2004

The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion

artículo científico publicado en 2009

The use of microarray technology for the analysis of Streptococcus pneumoniae.

artículo científico publicado en 2002

Transcriptional regulation, occurrence and putative role of the Pht family of Streptococcus pneumoniae

artículo científico publicado en 2010

Trends in serotypes and sequence types among cases of invasive pneumococcal disease in Scotland, 1999-2010.

artículo científico publicado en 2013

Upper and lower respiratory tract infection by Streptococcus pneumoniae is affected by pneumolysin deficiency and differences in capsule type.

artículo científico publicado en 2002

Use of green fluorescent protein in visualisation of pneumococcal invasion of broncho-epithelial cells in vivo

scientific article published on 01 January 2001

Virulence factors and the pathogenesis of disease caused by Streptococcus pneumoniae.

artículo científico publicado en 2000

What is different about serotype 1 pneumococci?

artículo científico

ZmpB, a novel virulence factor of Streptococcus pneumoniae that induces tumor necrosis factor alpha production in the respiratory tract

artículo científico publicado en 2003

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