Lista de obras - Sergio Abrignani - Dominio Público Uruguay

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin

scientific article published on 12 December 2019

A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans

artículo científico publicado en 2013

A novel polyclonal antibody library for expression profiling of poorly characterized, membrane and secreted human proteins.

artículo científico publicado en 2011

Activation of the alternative complement pathway by Newcastle disease virus. II) Effects mediated by infected lymphoid cells in vitro

artículo científico publicado el 31 de agosto de 1984

Analysis RNA-seq and Noncoding RNA.

artículo científico publicado en 2016

Anti-spike antibodies and neutralising antibody activity in people living with HIV vaccinated with COVID-19 mRNA-1273 vaccine: a prospective single-centre cohort study

artículo científico publicado en 2021

Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets.

artículo científico publicado en 1988

Antigen-independent activation of naive and memory resting T cells by a cytokine combination

artículo científico publicado en 1994

Antigen-independent activation of resting T-cells in the liver of patients with chronic hepatitis.

artículo científico publicado en 1998

Association of hepatitis C virus envelope proteins with exosomes

artículo científico publicado en 2004

Binding of hepatitis C virus envelope protein E2 to CD81 up-regulates matrix metalloproteinase-2 in human hepatic stellate cells.

artículo científico publicado en 2004

Bystander Activation by Cytokines of Intrahepatic T Cells in Chronic Viral Hepatitis ⬇️

artículo científico publicado el 1 de enero de 1997

CD1d-restricted help to B cells by human invariant natural killer T lymphocytes

artículo científico publicado en 2003

CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs.

artículo científico publicado en 2001

Cellular immune reactions against hepatitis C core in chronic hepatitis C.

artículo científico publicado en 1995

Characterization of antibodies induced by vaccination with hepatitis C virus envelope glycoproteins.

artículo científico publicado en 2010

Characterization of human monoclonal antibodies specific to the hepatitis C virus glycoprotein E2 with in vitro binding neutralization properties

artículo científico publicado en 1998

Chlamydia pneumoniae genome sequence analysis and identification of HLA-A2-restricted CD8+ T cell epitopes recognized by infection-primed T cells.

scientific article published on October 2005

Circulating hepatitis B surface antigen particles carry hepatocellular microRNAs

artículo científico publicado en 2012

Coligation of the hepatitis C virus receptor CD81 with CD28 primes naive T lymphocytes to acquire type 2 effector function

artículo científico publicado en 2008

CombiROC: an interactive web tool for selecting accurate marker combinations of omics data.

artículo científico publicado en 2017

Comparable functions of plasmacytoid and monocyte-derived dendritic cells in chronic hepatitis C patients and healthy donors

Compartmentalization of T lymphocytes to the site of disease: intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C

artículo científico publicado en 1993

Complement activation by cell-associated immune complexes in contact sensitivity

artículo científico

Cytoskeleton rearrangement induced by tetraspanin engagement modulates the activation of T and NK cells

scholarly article by Stefania Crotta et al published April 2006 in European Journal of Immunology

De novo transcriptome profiling of highly purified human lymphocytes primary cells

artículo científico publicado en 2015

Differences in serum and synovial CD4+ T cells and cytokine profiles to stratify patients with inflammatory osteoarthritis and rheumatoid arthritis

artículo científico publicado en 2017

Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b.

artículo científico publicado en 2011

Dual role of anti-TNF therapy: Enhancement of TCR-mediated T cell activation in peripheral blood and inhibition of inflammation in target tissues

article

Dynamics of intra-hepatic lymphocytes in chronic hepatitis C: enrichment for Valpha24+ T cells and rapid elimination of effector cells by apoptosis.

artículo científico publicado en 1998

Eomesodermin controls a unique differentiation program in human IL-10 and IFN-γ coproducing regulatory T cells

scientific article published on 29 November 2018

Evidence for a pathogenic role of extrafollicular, IL-10-producing CCR6+B helper T cells in systemic lupus erythematosus

artículo científico publicado en 2020

Evidence of blood-brain barrier alteration and activation in HIV-1 gp120 transgenic mice

article

Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response

artículo científico publicado en 2022

Exploring the links between cancer and placenta development

article

Expression of human CD81 in transgenic mice does not confer susceptibility to hepatitis C virus infection

artículo científico publicado en 2002

Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity

artículo científico publicado en 2017

Folding and dimerization of hepatitis C virus E1 and E2 glycoproteins in stably transfected CHO cells

artículo científico publicado en 2005

Folding of hepatitis C virus E1 glycoprotein in a cell-free system.

artículo científico publicado en 2001

Follicular Helper NKT Cells Induce Limited B Cell Responses and Germinal Center Formation in the Absence of CD4+ T Cell Help ⬇️

artículo científico publicado el 29 de febrero de 2012

Gaps in knowledge and prospects for research of adjuvanted vaccines

artículo científico publicado en 2015

Genetic variation in the interleukin -28B gene is not associated with fibrosis progression in patients with chronic hepatitis C and known date of infection

article

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

scholarly article

HCV E1E2-MF59 vaccine in chronic hepatitis C patients treated with PEG-IFNα2a and Ribavirin: a randomized controlled trial

artículo científico publicado en 2013

Hepatic expansion of a virus-specific regulatory CD8(+) T cell population in chronic hepatitis C virus infection

artículo científico publicado en 2004

Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity.

artículo científico publicado en 2015

Hepatitis C virus envelope glycoprotein immunization of rodents elicits cross-reactive neutralizing antibodies

artículo científico publicado en 2007

Hepatitis C virus polyprotein vaccine formulations capable of inducing broad antibody and cellular immune responses

artículo científico publicado en 2006

Hepatitis C virus-specific directly acting antiviral drugs

artículo científico

High titers of antibodies inhibiting the binding of envelope to human cells correlate with natural resolution of chronic hepatitis C.

artículo científico publicado en 1998

High-dose vitamin C enhances cancer immunotherapy

artículo científico publicado en 2020

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses

artículo científico publicado en 2013

Human monoclonal antibodies that inhibit binding of hepatitis C virus E2 protein to CD81 and recognize conserved conformational epitopes

artículo científico publicado en 2000

Human naive T cells activated by cytokines differentiate into a split phenotype with functional features intermediate between naive and memory T cells

scientific article published on 01 September 1995

IL-10 promotes homeostatic proliferation of human CD8(+) memory T cells and, when produced by CD1c(+) DCs, shapes naive CD8(+) T-cell priming

artículo científico publicado en 2016

IL-10-producing forkhead box protein 3-negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus.

artículo científico publicado en 2015

IL-21 is a central memory T cell-associated cytokine that inhibits the generation of pathogenic Th1/17 effector cells

artículo científico publicado en 2014

IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen-negative patients with chronic hepatitis B.

artículo científico publicado en 2012

Identification of New Hematopoietic Cell Subsets with a Polyclonal Antibody Library Specific for Neglected Proteins ⬇️

artículo científico publicado el 4 de abril de 2012

Identification of new autoantigens by protein array indicates a role for IL4 neutralization in autoimmune hepatitis

artículo científico publicado en 2012

Immune responses throughout hepatitis C virus (HCV) infection: HCV from the immune system point of view ⬇️

artículo científico publicado el 1 de enero de 1997

Immunity to Pathogens Taught by Specialized Human Dendritic Cell Subsets

artículo científico publicado en 2015

Immunization of human volunteers with hepatitis C virus envelope glycoproteins elicits antibodies that cross-neutralize heterologous virus strains

artículo científico publicado en 2011

Induction of CD4+ T cell depletion in mice doubly transgenic for HIV gp120 and human CD4

article

Infection of mice with Newcastle disease virus inhibits the T suppressor afferent cell circuit which regulates contact sensitivity to picryl chloride

artículo científico publicado en 1985

Inhibition of Natural Killer Cells through Engagement of CD81 by the Major Hepatitis C Virus Envelope Protein

artículo científico publicado en 2002

Inhibition of lymphocyte mitogenesis in mice infected with Newcastle disease virus: viral interference with the interleukin system.

artículo científico publicado en 1986

Intestinal IFN-γ-producing Tr1-cells co-express CCR5 and PD-1, and down-regulate IL-10 in the inflamed gut of IBD patients.

artículo científico publicado en 2018

Intracellular accumulation of hepatitis C virus proteins in a human hepatoma cell line

artículo científico publicado en 2006

Intracellular modulation, extracellular disposal and serum increase of MiR-150 mark lymphocyte activation

artículo científico publicado en 2013

Invariant NKT cells sustain specific B cell responses and memory

artículo científico publicado en 2007

Lack of evidence for post-vaccine onset of autoimmune/lymphoproliferative disorders, during a nine-month follow-up in multiply vaccinated Italian military personnel

artículo científico publicado en 2017

Long Intergenic Non-Coding RNAs: Novel Drivers of Human Lymphocyte Differentiation

artículo científico publicado en 2015

Maturation signatures of conventional dendritic cell subtypes in COVID-19 suggest direct viral sensing

artículo científico publicado en 2021

Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity

artículo científico publicado en 2012

Molecular analysis of VHI+ B lymphocytes in hepatitis C patients

article

Multi-plasmid DNA vaccination avoids antigenic competition and enhances immunogenicity of a poorly immunogenic plasmid

article

NKT-cell help to B lymphocytes can occur independently of cognate interaction.

artículo científico publicado en 2008

NS5A inhibitors impair NS5A-phosphatidylinositol 4-kinase IIIα complex formation and cause a decrease of phosphatidylinositol 4-phosphate and cholesterol levels in hepatitis C virus-associated membranes

artículo científico publicado en 2014

Neonatal invariant Valpha24+ NKT lymphocytes are activated memory cells.

artículo científico publicado en 2000

Next-Generation Sequencing Analysis of Long Noncoding RNAs in CD4+ T Cell Differentiation

artículo científico publicado en 2017

Nonneutralizing human antibody fragments against hepatitis C virus E2 glycoprotein modulate neutralization of binding activity of human recombinant Fabs.

artículo científico publicado en 2001

Normalization of circulating microRNA expression data obtained by quantitative real-time RT-PCR

artículo científico publicado en 2015

Novel biomarkers for primary biliary cholangitis to improve diagnosis and understand underlying regulatory mechanisms

scientific article published on 15 May 2019

Perspectives for a hepatitis C virus vaccine

artículo científico publicado en 1998

Phylogeny of the SARS coronavirus

artículo científico publicado en 2003

Plasticity of human CD4 T cell subsets

artículo científico

Prophylaxis of Hepatitis C with Intramuscular Immunoglobulin

artículo científico publicado en 1999

Prospects for a vaccine against the hepatitis C virus

artículo científico publicado en 2005

Rationally designed strings of promiscuous CD4+ T cell epitopes provide help toHaemophilus influenzae type b oligosaccharide: a model for new conjugate vaccines

artículo científico publicado en 2001

Recognition of viral and self-antigens by TH1 and TH1/TH17 central memory cells in patients with multiple sclerosis reveals distinct roles in immune surveillance and relapses

artículo científico publicado en 2017

Reduction of CD68+ macrophages and decreased IL-17 expression in intestinal mucosa of patients with inflammatory bowel disease strongly correlate with endoscopic response and mucosal healing following infliximab therapy

artículo científico publicado en 2013

Repression of miR-31 by BCL6 stabilizes the helper function of human follicular helper T cells

artículo científico publicado en 2017

Reverse plasticity: TGF-β and IL-6 induce Th1-to-Th17-cell transdifferentiation in the gut.

artículo científico publicado en 2016

Role of macrophages in bypassing the inhibitory activity of Newcastle disease virus on the T-suppressor-cell circuit which regulates contact sensitivity to picryl chloride

artículo científico publicado en 1988

Role of microRNAs and long-non-coding RNAs in CD4(+) T-cell differentiation.

artículo científico

SARS--beginning to understand a new virus

artículo científico publicado en 2003

Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults.

artículo científico publicado en 2010

Safety and immunogenicity of a genetically engineered human immunodeficiency virus vaccine.

artículo científico publicado en 1991

Serum microRNAs as Biomarkers of Human Lymphocyte Activation in Health and Disease

artículo científico

Signal Strength and Metabolic Requirements Control Cytokine-Induced Th17 Differentiation of Uncommitted Human T Cells

artículo científico publicado en 2015

Small Interfering RNA-Mediated Inhibition of Hepatitis C Virus Replication in the Human Hepatoma Cell Line Huh-7

artículo científico publicado en 2003

Synthesis and characterization of a native, oligomeric form of recombinant severe acute respiratory syndrome coronavirus spike glycoprotein

artículo científico publicado en 2004

T cell costimulation by the hepatitis C virus envelope protein E2 binding to CD81 is mediated by Lck.

artículo científico publicado en 2003

T cells can present antigens such as HIV gp120 targeted to their own surface molecules

artículo científico publicado en 1988

T suppressor afferent cells which regulate contact sensitivity to picryl chloride act across genetic barrier

artículo científico publicado en 1986

TCTN2: a novel tumor marker with oncogenic properties

artículo científico publicado en 2017

The CD4-centered universe of human T cell subsets.

artículo científico publicado en 2013

The Enigmatic Role of Viruses in Multiple Sclerosis: Molecular Mimicry or Disturbed Immune Surveillance?

artículo científico publicado en 2017

The circulating microRNome demonstrates distinct lymphocyte subset-dependent signatures.

artículo científico publicado en 2015

The light and the dark sides of Interleukin-10 in immune-mediated diseases and cancer.

artículo científico publicado en 2016

The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4.

artículo científico publicado en 2015

The small extracellular loop of CD81 is necessary for optimal surface expression of the large loop, a putative HCV receptor

artículo científico publicado en 2001

Third trimester NG2-positive amniotic fluid cells are effective in improving repair in spinal cord injury

artículo científico publicado en 2014

Third trimester amniotic fluid cells with the capacity to develop neural phenotypes and with heterogeneity among sub-populations.

artículo científico publicado en 2012

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells.

artículo científico publicado en 2016

Two of Them Do It Better: Novel Serum Biomarkers Improve Autoimmune Hepatitis Diagnosis

artículo científico publicado en 2015

Uncontrolled IL-17 Production by Intraepithelial Lymphocytes in a Case of non-IPEX Autoimmune Enteropathy

artículo científico publicado en 2016

Why is it so difficult to develop a hepatitis C virus preventive vaccine?

artículo científico publicado en 2013

iNKT-cell help to B cells: a cooperative job between innate and adaptive immune responses

artículo científico publicado en 2014

miR-17∼92 family clusters control iNKT cell ontogenesis via modulation of TGF-β signaling

scientific article published on 05 December 2016

miRiadne: a web tool for consistent integration of miRNA nomenclature.

artículo científico publicado en 2015

Lista de obras de Sergio Abrignani

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin

A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans

A novel polyclonal antibody library for expression profiling of poorly characterized, membrane and secreted human proteins.

Activation of the alternative complement pathway by Newcastle disease virus. II) Effects mediated by infected lymphoid cells in vitro

Analysis RNA-seq and Noncoding RNA.

Anti-spike antibodies and neutralising antibody activity in people living with HIV vaccinated with COVID-19 mRNA-1273 vaccine: a prospective single-centre cohort study

Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets.

Antigen-independent activation of naive and memory resting T cells by a cytokine combination

Antigen-independent activation of resting T-cells in the liver of patients with chronic hepatitis.

Association of hepatitis C virus envelope proteins with exosomes

Binding of hepatitis C virus envelope protein E2 to CD81 up-regulates matrix metalloproteinase-2 in human hepatic stellate cells.

Bystander Activation by Cytokines of Intrahepatic T Cells in Chronic Viral Hepatitis ⬇️

CD1d-restricted help to B cells by human invariant natural killer T lymphocytes

CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs.

Cellular immune reactions against hepatitis C core in chronic hepatitis C.

Characterization of antibodies induced by vaccination with hepatitis C virus envelope glycoproteins.

Characterization of human monoclonal antibodies specific to the hepatitis C virus glycoprotein E2 with in vitro binding neutralization properties

Chlamydia pneumoniae genome sequence analysis and identification of HLA-A2-restricted CD8+ T cell epitopes recognized by infection-primed T cells.

Circulating hepatitis B surface antigen particles carry hepatocellular microRNAs

Coligation of the hepatitis C virus receptor CD81 with CD28 primes naive T lymphocytes to acquire type 2 effector function

CombiROC: an interactive web tool for selecting accurate marker combinations of omics data.

Comparable functions of plasmacytoid and monocyte-derived dendritic cells in chronic hepatitis C patients and healthy donors

Compartmentalization of T lymphocytes to the site of disease: intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C

Complement activation by cell-associated immune complexes in contact sensitivity

Cytoskeleton rearrangement induced by tetraspanin engagement modulates the activation of T and NK cells

De novo transcriptome profiling of highly purified human lymphocytes primary cells

Differences in serum and synovial CD4+ T cells and cytokine profiles to stratify patients with inflammatory osteoarthritis and rheumatoid arthritis

Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b.

Dual role of anti-TNF therapy: Enhancement of TCR-mediated T cell activation in peripheral blood and inhibition of inflammation in target tissues

Dynamics of intra-hepatic lymphocytes in chronic hepatitis C: enrichment for Valpha24+ T cells and rapid elimination of effector cells by apoptosis.

Eomesodermin controls a unique differentiation program in human IL-10 and IFN-γ coproducing regulatory T cells

Evidence for a pathogenic role of extrafollicular, IL-10-producing CCR6+B helper T cells in systemic lupus erythematosus

Evidence of blood-brain barrier alteration and activation in HIV-1 gp120 transgenic mice

Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response

Exploring the links between cancer and placenta development

Expression of human CD81 in transgenic mice does not confer susceptibility to hepatitis C virus infection

Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity

Folding and dimerization of hepatitis C virus E1 and E2 glycoproteins in stably transfected CHO cells

Folding of hepatitis C virus E1 glycoprotein in a cell-free system.

Follicular Helper NKT Cells Induce Limited B Cell Responses and Germinal Center Formation in the Absence of CD4+ T Cell Help ⬇️

Gaps in knowledge and prospects for research of adjuvanted vaccines

Genetic variation in the interleukin -28B gene is not associated with fibrosis progression in patients with chronic hepatitis C and known date of infection

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

HCV E1E2-MF59 vaccine in chronic hepatitis C patients treated with PEG-IFNα2a and Ribavirin: a randomized controlled trial

Hepatic expansion of a virus-specific regulatory CD8(+) T cell population in chronic hepatitis C virus infection

Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity.

Hepatitis C virus envelope glycoprotein immunization of rodents elicits cross-reactive neutralizing antibodies

Hepatitis C virus polyprotein vaccine formulations capable of inducing broad antibody and cellular immune responses

Hepatitis C virus-specific directly acting antiviral drugs

High titers of antibodies inhibiting the binding of envelope to human cells correlate with natural resolution of chronic hepatitis C.

High-dose vitamin C enhances cancer immunotherapy

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses

Human monoclonal antibodies that inhibit binding of hepatitis C virus E2 protein to CD81 and recognize conserved conformational epitopes

Human naive T cells activated by cytokines differentiate into a split phenotype with functional features intermediate between naive and memory T cells

IL-10 promotes homeostatic proliferation of human CD8(+) memory T cells and, when produced by CD1c(+) DCs, shapes naive CD8(+) T-cell priming

IL-10-producing forkhead box protein 3-negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus.

IL-21 is a central memory T cell-associated cytokine that inhibits the generation of pathogenic Th1/17 effector cells

IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen-negative patients with chronic hepatitis B.

Identification of New Hematopoietic Cell Subsets with a Polyclonal Antibody Library Specific for Neglected Proteins ⬇️

Identification of new autoantigens by protein array indicates a role for IL4 neutralization in autoimmune hepatitis

Immune responses throughout hepatitis C virus (HCV) infection: HCV from the immune system point of view ⬇️

Immunity to Pathogens Taught by Specialized Human Dendritic Cell Subsets

Immunization of human volunteers with hepatitis C virus envelope glycoproteins elicits antibodies that cross-neutralize heterologous virus strains

Induction of CD4+ T cell depletion in mice doubly transgenic for HIV gp120 and human CD4

Infection of mice with Newcastle disease virus inhibits the T suppressor afferent cell circuit which regulates contact sensitivity to picryl chloride

Inhibition of Natural Killer Cells through Engagement of CD81 by the Major Hepatitis C Virus Envelope Protein

Inhibition of lymphocyte mitogenesis in mice infected with Newcastle disease virus: viral interference with the interleukin system.

Intestinal IFN-γ-producing Tr1-cells co-express CCR5 and PD-1, and down-regulate IL-10 in the inflamed gut of IBD patients.

Intracellular accumulation of hepatitis C virus proteins in a human hepatoma cell line

Intracellular modulation, extracellular disposal and serum increase of MiR-150 mark lymphocyte activation

Invariant NKT cells sustain specific B cell responses and memory

Lack of evidence for post-vaccine onset of autoimmune/lymphoproliferative disorders, during a nine-month follow-up in multiply vaccinated Italian military personnel

Long Intergenic Non-Coding RNAs: Novel Drivers of Human Lymphocyte Differentiation

Maturation signatures of conventional dendritic cell subtypes in COVID-19 suggest direct viral sensing

Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity

Molecular analysis of VHI+ B lymphocytes in hepatitis C patients

Multi-plasmid DNA vaccination avoids antigenic competition and enhances immunogenicity of a poorly immunogenic plasmid

NKT-cell help to B lymphocytes can occur independently of cognate interaction.

NS5A inhibitors impair NS5A-phosphatidylinositol 4-kinase IIIα complex formation and cause a decrease of phosphatidylinositol 4-phosphate and cholesterol levels in hepatitis C virus-associated membranes