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Lista de obras de William Vainchenker

A 93-kDa glycoprotein expressed on human cultured monocytes and dendritic reticulum cells defined by an anti-K562 monoclonal antibody

scientific article published on 01 December 1986

A CALR mutation preceding BCR-ABL1 in an atypical myeloproliferative neoplasm.

artículo científico publicado en 2015

A JAK2 mutation in myeloproliferative disorders: pathogenesis and therapeutic and scientific prospects.

artículo científico publicado en 2005

A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis.

artículo científico publicado en 2009

A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome

artículo científico publicado en 2003

A gamma and G gamma globin chain synthesis in BFU-E colonies from adult, newborn, and fetal subjects and from thalassemic patients

artículo científico publicado en 1980

A lentiviral vector encoding the human Wiskott-Aldrich syndrome protein corrects immune and cytoskeletal defects in WASP knockout mice.

artículo científico publicado en 2005

A major role of TGF-beta1 in the homing capacities of murine hematopoietic stem cell/progenitors

artículo científico publicado en 2010

A monoclonal antibody against an erythrocyte ontogenic antigen identifies fetal and adult erythroid progenitors

artículo científico publicado en 1986

A murine stromal cell line allows the proliferation of very primitive human CD34++/CD38- progenitor cells in long-term cultures and semisolid assays ⬇️

artículo científico publicado el 1 de junio de 1993

A new c-kit mutation in a case of aggressive mast cell disease

scientific article published on 01 February 1997

A new congenital dysmegakaryopoietic thrombocytopenia (Paris-Trousseau) associated with giant platelet alpha-granules and chromosome 11 deletion at 11q23.

artículo científico publicado en 1995

A new efficient tool for non-invasive diagnosis of fetomaternal platelet antigen incompatibility

artículo científico publicado en 2020

A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene

artículo científico publicado en 2014

A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia

artículo científico publicado en 2007

A p53-JAK-STAT connection involved in myeloproliferative neoplasm pathogenesis and progression to secondary acute myeloid leukemia

artículo científico publicado en 2020

A partial down-regulation of WASP is sufficient to inhibit podosome formation in dendritic cells

artículo científico publicado en 2005

A senescence-like cell-cycle arrest occurs during megakaryocytic maturation: implications for physiological and pathological megakaryocytic proliferation

artículo científico publicado en 2010

A unique activating mutation in JAK2 (V617F) is at the origin of polycythemia vera and allows a new classification of myeloproliferative diseases

artículo científico publicado en 2005

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

artículo científico publicado en 2005

ATG2B and GSKIP: 2 new genes predisposing to myeloid malignancies

artículo científico publicado en 2015

Absence of erythroblastic islands in plasma clot culture and their possible reconstitution after clot lysis

artículo científico publicado el 1 de agosto de 1979

Absence of mutations in the HoxA10, HoxA11 and HoxD11 nucleotide coding sequences in thrombocytopenia with absent radius syndrome

artículo científico publicado en 2002

Acceleration of the hemoglobin switch in cultures in neonate erythroid precursors by adult cells

scientific article published on 01 September 1980

Acquired TET2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development of pre-leukaemic clone resulting in T2-ALL and AML-M0

artículo científico publicado en 2016

Acquired initiating mutations in early hematopoietic cells of CLL patients

artículo científico publicado en 2014

Activating mutations in human acute megakaryoblastic leukemia.

artículo científico publicado en 2008

Activity of nonmuscle myosin II isoforms determines localization at the cleavage furrow of megakaryocytes.

artículo científico publicado en 2016

Adenoviral supply of active transforming growth factor-beta1 (TGF-beta1) did not prevent lethality in transforming growth factor-beta1-knockout embryos

scientific article published on 01 October 2001

Adenoviral-mediated TGF-beta1 inhibition in a mouse model of myelofibrosis inhibit bone marrow fibrosis development

article

Alterations of NFIA in chronic malignant myeloid diseases

artículo científico publicado en 2008

An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia

scientific article published on 20 July 2009

An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor. ⬇️

artículo científico publicado en 2005

An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L.

artículo científico publicado en 2016

Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms

scientific article published on 29 June 2009

Antiviral agent Cidofovir restores p53 function and enhances the radiosensitivity in HPV-associated cancers.

artículo científico publicado en 2002

Apoptosis regulation in tetraploid cancer cells

artículo científico publicado en 2006

Applying ecological and evolutionary theory to cancer: a long and winding road ⬇️

artículo científico publicado en 2012

Aurora B is dispensable for megakaryocyte polyploidization, but contributes to the endomitotic process.

artículo científico publicado en 2010

Autocrine stimulation by erythropoietin (Epo) requires Epo secretion.

artículo científico publicado en 1994

Autocrine stimulation by erythropoietin and autonomous growth of human erythroid leukemic cells in vitro

artículo científico publicado en 1991

Autonomous megakaryocyte growth in essential thrombocythemia and idiopathic myelofibrosis is not related to a c-mpl mutation or to an autocrine stimulation by Mpl-L.

artículo científico publicado en 1999

BCR-ABL Fails to Inhibit Apoptosis in U937 Myelomonocytic Cells Expressing a Carboxyl-Terminal Truncated Stat5 ⬇️

artículo científico publicado el 1 de julio de 2001

BCR-ABL activates STAT3 via JAK and MEK pathways in human cells

artículo científico publicado en 2006

Beta O-thalassemia/Hb E association. Hemoglobin synthesis in blood reticulocytes and bone marrow cells fractionated by density gradient and in blood erythroid colonies in culture

scientific article published on 01 January 1980

Beta-thalassemia and sickle cell disease in culture of early erythroid precursors: hemoglobin synthesis and ultrastructural study

scientific article published on 01 January 1981

Biological effects induced by variable levels of BCR-ABL protein in the pluripotent hematopoietic cell line UT-7.

artículo científico publicado en 2000

Biosynthesis of major platelet proteins in human blood platelets.

artículo científico publicado en 1987

CCND2 mutations are infrequent events in BCR-ABL1 negative myeloproliferative neoplasm patients

scientific article published on 15 May 2020

CK2: a key regulator of thrombopoiesis.

artículo científico publicado en 2017

CXCL12/CXCR4 pathway is activated by oncogenic JAK2 in a PI3K-dependent manner

artículo científico publicado en 2016

CXCR4 inhibitors selectively eliminate CXCR4-expressing human acute myeloid leukemia cells in NOG mouse model.

artículo científico publicado en 2012

CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress

artículo científico publicado en 2016

Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN

artículo científico publicado en 2020

Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants

scientific article published on 22 March 2019

Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis

artículo científico publicado en 2015

Carboxyl-terminal-dependent recruitment of nonmuscle myosin II to megakaryocyte contractile ring during polyploidization

artículo científico publicado en 2014

Caspase-activated ROCK-1 allows erythroblast terminal maturation independently of cytokine-induced Rho signaling.

artículo científico publicado en 2010

Cellular and molecular mechanisms of haemoglobin switching in man.

artículo científico publicado en 1982

Cellular regulation of i and I antigen expressions in human erythroblasts grown in vitro

artículo científico publicado en 1981

Change in i-antigen expression of erythrocytes during in vivo aging

artículo científico publicado en 1981

Characterization of hematopoietic progenitors from human yolk sacs and embryos.

artículo científico publicado en 1995

Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models

artículo científico publicado en 2012

Clonal architecture of chronic myelomonocytic leukemias

artículo científico publicado en 2013

Clonal expression of the Tn antigen in erythroid and granulocyte colonies and its application to determination of the clonality of the human megakaryocyte colony assay.

artículo científico publicado en 1982

Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily

artículo científico publicado en 2000

Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors

artículo científico publicado en 2013

Comparative patterns of i-antigen expression, F-cell frequency and Hb A2 level in acute myeloid leukemia and in acute lymphoid leukemia

scientific article published on 01 January 1981

Compared effects of Mpl ligand and other cytokines on human MK differentiation

artículo científico publicado en 1998

Concise Review: Induced Pluripotent Stem Cells as New Model Systems in Oncology

artículo científico publicado en 2015

Concomitant germ-line RUNX1 and acquired ASXL1 mutations in a T-cell acute lymphoblastic leukemia.

artículo científico publicado en 2013

Congenital dyserythropoietic anaemia type I: absence of clonal expression in the nuclear abnormalities of cultured erythroblasts

scientific article published on 01 September 1980

Congenital dyserythropoietic anemia type III. studies on erythroid differentiation of blood erythroid progenitor cells (BFUE) in vitro

artículo científico publicado en 1980

Constitutive JunB expression, associated with the JAK2 V617F mutation, stimulates proliferation of the erythroid lineage.

artículo científico publicado en 2008

Constitutive activation of STAT5 and Bcl-xL overexpression can induce endogenous erythroid colony formation in human primary cells

artículo científico publicado en 2006

Constitutive and specific activation of STAT3 by BCR-ABL in embryonic stem cells.

artículo científico publicado en 2003

Constitutive expression of GATA-1 interferes with the cell-cycle regulation.

artículo científico publicado en 1996

Constitutive expression of Mpl ligand transcripts during thrombocytopenia or thrombocytosis.

artículo científico publicado en 1996

Critical role of the HDAC6-cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect.

artículo científico publicado en 2017

Cytogenetic study of myeloid and erythroid colonies in chronic myeloid leukaemia with stable Ph1 mosaicism.

artículo científico publicado en 1987

Defective endomitosis during megakaryopoiesis leads to thrombocytopenia in Fanca-/- mice

artículo científico publicado en 2014

Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment

artículo científico publicado en 2006

Description of a knock-in mouse model of JAK2V617F MPN emerging from a minority of mutated hematopoietic stem cells

scientific article published on 01 December 2019

Detection of JAK2 V617F as a first intention diagnostic test for erythrocytosis.

artículo científico publicado en 2006

Developmental changes in human megakaryocyte ploidy.

artículo científico publicado en 1991

Developmental changes in human megakaryopoiesis.

artículo científico publicado en 2013

Developmentally regulated expression of a 78 kDa erythroblast membrane glycoprotein immunologically related to the platelet thrombospondin receptor

artículo científico publicado en 1989

Diagnosis of megakaryoblastic leukemias.

artículo científico publicado en 1983

Different impact of calreticulin mutations on human hematopoiesis in myeloproliferative neoplasms

artículo científico publicado en 2020

Differential association of calreticulin type 1 and type 2 mutations with myelofibrosis and essential thrombocytemia: relevance for disease evolution

scientific article published on 12 September 2014

Differential regulation of actin stress fiber assembly and proplatelet formation by alpha2beta1 integrin and GPVI in human megakaryocytes

scientific article published on 20 July 2004

Differential signalling of NH2-terminal flag-labelled thrombopoietin receptor activated by TPO or anti-FLAG antibodies.

artículo científico publicado en 2004

Differentiation of human megakaryocytes in culture starting from the primordial circulating cells in the newborn

artículo científico publicado el 17 de julio de 1978

Disappearance of Hb F and i antigen during the first year of life

scientific article published on 01 January 1980

Disrupted filamin A/αβ interaction induces macrothrombocytopenia by increasing RhoA activity

artículo científico publicado en 2019

Distinct effects of the soluble versus membrane-bound forms of the notch ligand delta-4 on human CD34+CD38low cell expansion and differentiation

artículo científico publicado en 2007

Distinct effects of thrombopoietin depending on a threshold level of activated Mpl in BaF-3 cells

scientific article published on 01 June 2002

Distinct localizations and roles of non-muscle myosin II during proplatelet formation and platelet release

artículo científico publicado en 2015

Does increasing the JAK2V617F assay sensitivity allow to identify more patients with MPN?

artículo científico publicado en 2012

Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia.

artículo científico publicado en 2011

Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis

artículo científico publicado en 2017

Dysmegakaryopoiesis of FPD/AML pedigrees with constitutional RUNX1 mutations is linked to myosin II deregulated expression

artículo científico publicado en 2012

EKLF restricts megakaryocytic differentiation at the benefit of erythrocytic differentiation

artículo científico publicado en 2008

ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.

artículo científico publicado en 2017

EZH2: a molecular switch of the MPN phenotype

artículo científico publicado en 2016

Early and Persistent Bone Marrow Hematopoiesis Defect in Simian/Human Immunodeficiency Virus-Infected Macaques despite Efficient Reduction of Viremia by Highly Active Antiretroviral Therapy during Primary Infection ⬇️

artículo científico publicado el 1 de diciembre de 2001

Early erythroid markers as probes for normal and leukaemic erythroid differentiation

artículo científico publicado en 1987

Ectopic expression of the erythropoietin receptor in a murine interleukin-6-dependent plasmacytoma cell line (TEPC-2027) confers proliferative responsiveness to erythropoietin.

artículo científico publicado en 1997

Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in mice.

artículo científico publicado en 2007

Effects of cytokines on platelet production from blood and marrow CD34+ cells

scientific article published on 01 February 1998

Effects of five recombinant hematopoietic growth factors on enriched human erythroid progenitors in serum-replaced cultures

artículo científico publicado en 1989

Effects of granulocyte-macrophage colony-stimulating factor and erythropoietin on leukemic erythroid colony formation in human early erythroblastic leukemias

scientific article published on 01 October 1987

Effects of the recombinant hematopoietic growth factors interleukin-3, interleukin-6, stem cell factor, and leukemia inhibitory factor on the megakaryocytic differentiation of CD34+ cells

scientific article published on 01 July 1993

Efficient ex vivo expansion of NOD/SCID-repopulating cells with lympho-myeloid potential in hematopoietic grafts of children with solid tumors

artículo científico publicado en 2001

Elevated Hb F associated with beta-thalassaemia trait: haemoglobin synthesis in reticulocytes and in blood BFU-E

scientific article published on 01 October 1980

Elevated HbF associated with an unstable hemoglobin, hemoglobin Saint Etienne: Hb synthesis in blood BFUe in culture ⬇️

artículo científico publicado el 1 de agosto de 1979

Eltrombopag, a potent stimulator of megakaryopoiesis.

artículo científico publicado en 2016

Embryonic and fetal hemoglobin synthesis in K562 cell line

artículo científico publicado en 1981

Emergence of a BCR-ABL translocation in a patient with the JAK2V617F mutation: evidence for secondary acquisition of BCR-ABL in the JAK2V617F clone.

artículo científico publicado en 2014

Endomitosis of human megakaryocytes are due to abortive mitosis.

artículo científico publicado en 1998

Erythroid progenitors in polycythemia vera: demonstration of their hypersensitivity to erythropoietin using serum free cultures

artículo científico publicado en 1982

Erythroid properties of K562 cells. Effect of hemin, butyrate and TPA induction

scientific article published on 01 July 1983

Erythropoietin induces the association of phosphatidylinositol 3'-kinase with a tyrosine-phosphorylated protein complex containing the erythropoietin receptor.

artículo científico publicado en 1993

Evaluation of hematopoietic potential generated by transplantation of muscle-derived stem cells in mice.

artículo científico publicado en 2004

Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis

scientific article published on 20 August 2007

Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis.

artículo científico publicado en 2006

Ex vivo expanded mobilized peripheral blood CD34+ cells accelerate haematological recovery in a baboon model of autologous transplantation

artículo científico publicado en 2000

Ex vivo expansion marginally amplifies repopulating cells from baboon peripheral blood mobilized CD34+ cells

artículo científico publicado en 2002

Expression and function of the collagen receptor GPVI during megakaryocyte maturation.

artículo científico publicado en 2001

Expression of CD34 and platelet glycoproteins during human megakaryocytic differentiation ⬇️

artículo científico publicado el 15 de diciembre de 1992

Expression of CD4 by human hematopoietic progenitors ⬇️

artículo científico publicado el 15 de noviembre de 1994

Expression of SSEA-I antigen (3-fucosyl-N-acetyl-lactosamine) on normal and leukaemic human haemopoietic cells: modulation by neuraminidase treatment ⬇️

artículo científico publicado el 1 de diciembre de 1984

Expression of a foreign protein in human megakaryocytes and platelets by retrovirally mediated gene transfer.

artículo científico publicado en 1999

Expression of blood group A antigen during erythroid differentiation in A1 and A2 subjects

artículo científico publicado en 1987

Expression of interleukin 6 and its specific receptor by untreated and PMA-stimulated human erythroid and megakaryocytic cell lines.

artículo científico publicado en 1991

Expression of osteoprotegerin mRNA and protein in murine megakaryocytes

scientific article published on 01 November 2003

Expression of platelet glycoproteins by erythroid blasts in four cases of trisomy 21

Expression of platelet membrane glycoproteins and alpha-granule proteins by a human erythroleukemia cell line (HEL).

artículo científico publicado en 1984

Expression of platelet proteins during maturation of human megakaryocytes and of the K 562/HEL cell lines

artículo científico publicado en 1986

Expression of tal-1 and GATA-binding proteins during human hematopoiesis

artículo científico publicado en 1993

Expression of the c-fos protooncogene by human and murine erythroblasts

scientific article published on 01 August 1989

Expression of vimentin intermediate filament cytoskeleton in acute nonlymphoblastic leukemias

scientific article published on 01 June 1985

F-cells are preferentially distributed among high density erythrocytes

artículo científico publicado en 1981

FLI1 monoallelic expression combined with its hemizygous loss underlies Paris-Trousseau/Jacobsen thrombopenia

artículo científico publicado en 2004

FLT3-mediated p38-MAPK activation participates in the control of megakaryopoiesis in primary myelofibrosis.

artículo científico publicado en 2011

Fetal hemoglobin synthesis in culture of early erythroid precursors (BFU-E) from the blood of normal adults

artículo científico publicado en 1980

From hematopoietic stem cells to platelets.

artículo científico publicado en 2007

From the v-mpl oncogene to thrombopoietin

scientific article published on 01 April 1995

Fucoidan promotes early step of cardiac differentiation from human embryonic stem cells and long-term maintenance of beating areas.

artículo científico publicado en 2014

Generation and characterisation of Rhd and Rhag null mice

scientific journal article

Genetic Alterations of the Thrombopoietin/MPL/JAK2 Axis Impacting Megakaryopoiesis

artículo científico publicado en 2017

Genetic and clinical implications of the Val617Phe JAK2 mutation in 72 families with myeloproliferative disorders

artículo científico publicado en 2006

Genetic basis and molecular pathophysiology of classical myeloproliferative neoplasms

artículo científico publicado en 2016

Germ-line JAK2 mutations in the kinase domain are responsible for hereditary thrombocytosis and are resistant to JAK2 and HSP90 inhibitors

scientific article published on 07 January 2014

Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies

artículo científico publicado en 2015

Germline genetic factors in the pathogenesis of myeloproliferative neoplasms

artículo científico publicado en 2020

Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells

artículo científico publicado en 2005

Globin-chain affinity chromatography on Sepharose-haptoglobin: a new method of study of hemoglobin synthesis in reticulocytes, in bone marrow and in colonies of erythroid precursors

artículo científico publicado en 1980

Glycoprotein I identification during normal and pathological megakaryocytic maturation

artículo científico publicado el 1 de enero de 1983

Gray platelet syndrome: immunoelectron microscopic localization of fibrinogen and von Willebrand factor in platelets and megakaryocytes

scientific article published on 01 December 1985

Growth and differentiation of the human megakaryoblastic cell line (ELF-153): a model for early stages of megakaryocytopoiesis.

artículo científico publicado en 1994

Growth of erythroid colonies in chronic myelogenous leukemia is independent of erythropoietin only in the presence of steel factor

artículo científico publicado en 1994

Growth of human megakaryocyte colonies in culture from fetal, neonatal, and adult peripheral blood cells: ultrastructural analysis

artículo científico publicado en 1979

HLA-DR restriction in suppression of hematopoiesis by T cells from allogeneic bone marrow transplants

artículo científico publicado en 1986

Hb Kokura alpha 2 47 (CE5) Asp----Gly beta 2 in a French Jewish family

artículo científico publicado en 1986

Hb switching in neonatal cultures. Increase of Hb A synthesis in presence of an erythroid potentiating activity (EPA)

scientific article published on 01 February 1982

Hematopoietic growth factors and human megakaryocyte differentiation

artículo científico publicado en 1992

Hematopoietic-promoting activity of the murine stromal cell line MS-5 is not related to the expression of the major hematopoietic cytokines.

artículo científico publicado en 1995

Hemin regulates the expression of transferrin receptors in human hematopoietic cell lines

artículo científico publicado en 1982

Hemoglobin expression in clones of K-562 cell line

scientific article published on 01 January 1982

Hemoglobin expression in clones of K562 cell line

scientific article published on 01 January 1982

Hemoglobin synthesis in 7-day and 14-day-old erythroid colonies from the bone marrow of normal individuals

scientific article published on 01 January 1980

Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm

artículo científico publicado en 2014

Heterozygous and homozygous JAK2(V617F) states modeled by induced pluripotent stem cells from myeloproliferative neoplasm patients

artículo científico publicado en 2013

High molecular response rate of polycythemia vera patients treated with pegylated interferon alpha-2a

artículo científico publicado en 2006

High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice

scientific article published on 01 December 1997

Human platelet alpha granules contain a nonspecific inhibitor of megakaryocyte colony formation: its relationship to type beta transforming growth factor (TGF-beta)

artículo científico publicado en 1988

Hydrocortisone differentially affects the ability of murine stromal cells and human marrow-derived adherent cells to promote the differentiation of CD34++/CD38- long-term culture-initiating cells.

artículo científico publicado en 1994

Identification of CXCR4 as a new nitric oxide-regulated gene in human CD34+ cells.

artículo científico publicado en 2006

Identification of MPL R102P Mutation in Hereditary Thrombocytosis.

artículo científico publicado en 2017

Identification of human T-lymphoid progenitor cells in CD34+CD38low and CD34+CD38+ subsets of human cord blood and bone marrow cells using NOD-SCID fetal thymus organ cultures

article

Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling

artículo científico publicado en 2013

Immunological characterization of the leukemic megakaryocytic line at light and electron microscopic levels.

artículo científico publicado en 1984

Immunological study of in vitro maturation of human megakaryocytes

scientific article published on 01 April 1984

Immunophenotype of leukemic blasts with small peroxidase-positive granules detected by electron microscopy

artículo científico publicado en 1988

Immunosuppression by Mutated Calreticulin Released from Malignant Cells

scientific article published on 27 November 2019

Impaired megakaryocytopoiesis in type 2B von Willebrand disease with severe thrombocytopenia

artículo científico publicado en 2006

In vitro effects of hematopoietic growth factors on the proliferation, endoreplication, and maturation of human megakaryocytes

artículo científico publicado en 1991

In vitro infection of bone marrow-adherent cells by human immunodeficiency virus type 1 (HIV-1) does not alter their ability to support hematopoiesis.

artículo científico publicado en 1995

In vitro inhibition of hematopoiesis by HNK1, DR-positive T cells and monocytes after allogeneic bone marrow transplantation

artículo científico publicado en 1987

In vitro inhibition of normal human hematopoiesis by marrow CD3+, CD8+, HLA-DR+, HNK1+ lymphocytes

scientific article published on 01 November 1988

Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemia achieving complete remission.

artículo científico publicado en 2010

Individual CD34+CD38lowCD19-CD10- progenitor cells from human cord blood generate B lymphocytes and granulocytes

artículo científico publicado en 1997

Induced Pluripotent Stem Cells Enable Disease Modeling and Drug Screening in Calreticulin del52 and ins5 Myeloproliferative Neoplasms

artículo científico publicado en 2021

Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor.

artículo científico publicado en 2009

Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors

artículo científico publicado en 2011

Inhibition of angiotensin I-converting enzyme induces radioprotection by preserving murine hematopoietic short-term reconstituting cells

artículo científico publicado en 2004

Inhibition of erythroid differentiation and induction of megakaryocytic differentiation by thrombopoietin are regulated by two different mechanisms in TPO-dependent UT-7/c-mpl and TF-1/c-mpl cell lines

artículo científico publicado en 1998

Inhibition of insulin receptor binding by phorbol esters.

artículo científico publicado en 1982

Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach

artículo científico publicado en 2006

Intracellular localization and constitutive endocytosis of CXCR4 in human CD34+ hematopoietic progenitor cells.

artículo científico publicado en 2004

Isolation and culture of megakaryocyte precursors.

artículo científico publicado en 2004

JAK inhibitors for the treatment of myeloproliferative neoplasms and other disorders.

artículo científico publicado en 2018

JAK/STAT signaling in hematological malignancies.

artículo científico publicado en 2012

JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.

artículo científico publicado en 2005

JAK2 and MPL protein levels determine TPO-induced megakaryocyte proliferation vs differentiation.

artículo científico publicado en 2014

JAK2 inhibition has different therapeutic effects according to myeloproliferative neoplasm development in mice

artículo científico publicado en 2015

JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders.

artículo científico publicado en 2008

JAK2, the JAK2 V617F mutant and cytokine receptors.

artículo científico publicado en 2006

JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα.

artículo científico publicado en 2013

JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis.

artículo científico publicado en 2006

JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML

artículo científico publicado en 2021

JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma.

artículo científico publicado en 2013

JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies.

artículo científico publicado en 2008

K562 cells induced to differentiate by phorbol ester tumor promotors resist NK lysis

artículo científico publicado en 1984

Kit-activating mutations cooperate with Spi-1/PU.1 overexpression to promote tumorigenic progression during erythroleukemia in mice.

artículo científico publicado en 2005

Knock-in of murine Calr del52 induces essential thrombocythemia with slow-rising dominance in mice and reveals key role of Calr exon 9 in cardiac development

artículo científico publicado en 2019

LYL-1 deficiency induces a stress erythropoiesis

artículo científico publicado en 2011

Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.

artículo científico publicado en 2014

Ligand-independent thrombopoietin mutant receptor requires cell surface localization for endogenous activity

artículo científico publicado en 2009

Limits of phenotypic markers for the diagnosis of megakaryoblastic leukemia

scientific article published on 01 January 1989

Localization of platelet osteonectin at the internal face of the alpha-granule membranes in platelets and megakaryocytes

artículo científico publicado en 1992

Loss of attachment to fibronectin with terminal human erythroid differentiation

artículo científico publicado en 1990

MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9.

artículo científico publicado en 2009

MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors

artículo científico publicado en 2019

MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations.

artículo científico publicado en 2012

Macrophage migration inhibitory factor is overproduced through EGR1 in TET2<sup>low</sup> resting monocytes

artículo científico publicado en 2022

Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation.

artículo científico publicado en 2005

Mechanisms of WASp-mediated hematologic and immunologic disease.

artículo científico publicado en 2004

Megakaryocyte and polyploidization

artículo científico publicado en 2017

Megakaryocyte colony formation from human bone marrow precursors ⬇️

artículo científico publicado el 1 de octubre de 1979

Megakaryocyte cultures in the chronic phase and in the blast crisis of chronic myeloid leukaemia: studies on the differentiation of the megakaryocyte progenitors and on the maturation of megakaryocytes in vitro

scientific article published on 01 May 1982

Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling

artículo científico publicado en 2008

Megakaryocyte polyploidization is associated with a functional gene amplification

article

Megakaryocyte polyploidization: role in platelet production

scientific article published on 22 September 2019

Megakaryocytes tame erythropoiesis with TGFβ1

scientific article published on 01 August 2020

Megakaryocytic and erythrocytic lineages share specific transcription factors

artículo científico publicado en 1990

Megakaryopoiesis: regulation of platelet production by thrombopoietin

artículo científico publicado en 2013

Microarray analysis of LIF/Stat3 transcriptional targets in embryonic stem cells

artículo científico publicado en 2005

Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy.

artículo científico publicado en 2004

Molecular and genetic bases of myeloproliferative disorders: questions and perspectives.

artículo científico publicado en 2009

Molecular pathophysiology of chronic myelogenous leukemia

artículo científico publicado en 1998

Monoclonal antibodies specific for human platelet membrane glycoproteins bind to monocytes by focal absorption of platelet membrane fragments: an ultrastructural immunogold study

scientific article published on 01 February 1987

Monocyte/macrophage dysfunctions do not impair the promotion of myelofibrosis by high levels of thrombopoietin

artículo científico publicado en 2006

Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions

artículo científico publicado en 2011

Morphological Abnormalities in Cultured Erythroid Colonies (BFU-E) from the Blood of Two Patients with HEMPAS

artículo científico publicado el 1 de julio de 1979

Mpl ligand (thrombopoietin) and platelet regulation

artículo científico publicado en 1996

Mpl ligand or thrombopoietin: biological activities.

artículo científico publicado en 1998

MplK, a natural variant of the thrombopoietin receptor with a truncated cytoplasmic domain, binds thrombopoietin but does not interfere with thrombopoietin-mediated cell growth.

artículo científico publicado en 2002

Multilayer intraclonal heterogeneity in chronic myelomonocytic leukemia

scientific article published on 02 May 2019

Multiple signaling pathways are involved in erythropoietin-independent differentiation of erythroid progenitors in polycythemia vera.

artículo científico publicado en 2004

Multivesicular bodies are an intermediate stage in the formation of platelet alpha-granules.

artículo científico publicado en 1998

Murine stromal cells counteract the loss of long-term culture-initiating cell potential induced by cytokines in CD34(+)CD38(low/neg) human bone marrow cells

artículo científico publicado en 1999

Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents

artículo científico publicado en 2016

Mutations du gèneTET2dans les hémopathies myéloïdes humaines

article

Mutations in JAK2V617F homologous domain of JAK genes are uncommon in solid tumors

article

Mutations in exon 12 of JAK2 are mainly found in JAK2 V617F-negative polycythaemia vera patients.

artículo científico publicado en 2008

Mutations in the SRP54 gene cause severe congenital neutropenia as well as Shwachman-Diamond-like syndrome

artículo científico publicado en 2018

Mutations of ASXL1 gene in myeloproliferative neoplasms.

artículo científico publicado en 2009

Myelofibrosis, JAK2 inhibitors and erythropoiesis.

artículo científico publicado en 2013

Myeloid and megakaryocytic properties of K-562 cell lines

artículo científico publicado en 1983

Myeloproliferative Neoplasms: Molecular Pathophysiology, Essential Clinical Understanding, and Treatment Strategies ⬇️

artículo científico publicado el 10 de enero de 2011

Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice.

artículo científico publicado en 2010

Myeloproliferative neoplasms: JAK2 signaling pathway as a central target for therapy.

artículo científico

NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs.

artículo científico publicado en 2004

NK cell sensitivity of the leukemic K 562 cells; effect of sodium butyrate and hemin induction.

artículo científico publicado en 1982

New hematopoietic differentiation antigens detected by anti-K562 monoclonal antibodies

artículo científico publicado en 1988

New insights into the pathogenesis of JAK2 V617F-positive myeloproliferative disorders and consequences for the management of patients.

artículo científico publicado en 2006

New mutations and pathogenesis of myeloproliferative neoplasms.

artículo científico publicado en 2011

New mutations of MPL in primitive myelofibrosis: only the MPL W515 mutations promote a G1/S-phase transition

scientific article published on 05 June 2008

New pathogenic mechanisms induced by germline erythropoietin receptor mutations in primary erythrocytosis.

artículo científico publicado en 2017

Non-apoptotic functions of caspases in myeloid cell differentiation.

artículo científico publicado en 2017

Normal human serum contains a factor(s) capable of inhibiting megakaryocyte colony formation

artículo científico publicado en 1982

Notch/Delta4 interaction in human embryonic liver CD34+ CD38- cells: positive influence on BFU-E production and LTC-IC potential maintenance.

artículo científico publicado en 2005

Notch/Delta4 signaling inhibits human megakaryocytic terminal differentiation.

artículo científico publicado en 2010

Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia.

artículo científico publicado en 2006

Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis.

artículo científico publicado en 1993

Oncogenic kinases of myeloproliferative disorders induce both protein synthesis and G1 activators

artículo científico publicado en 2006

Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia

scientific article published on 29 October 2019

Orientation-specific signalling by thrombopoietin receptor dimers.

artículo científico publicado en 2011

Osteopontin is upregulated by BCR-ABL

artículo científico publicado en 2005

Overexpression of FKBP51 in idiopathic myelofibrosis regulates the growth factor independence of megakaryocyte progenitors

artículo científico publicado en 2002

Overexpression of the partially activated alpha(IIb)beta3D723H integrin salt bridge mutant downregulates RhoA activity and induces microtubule-dependent proplatelet-like extensions in Chinese hamster ovary cells.

artículo científico publicado en 2009

P19INK4D links endomitotic arrest and megakaryocyte maturation and is regulated by AML-1.

artículo científico publicado en 2008

P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis.

artículo científico publicado en 2016

P53 deletion and NrasG12D cooperate for AML

artículo científico publicado en 2017

Pathogenesis of myelofibrosis with myeloid metaplasia: Insight from mouse models.

artículo científico publicado en 2006

Pathologic activation of thrombopoietin receptor and JAK2-STAT5 pathway by frameshift mutants of mouse calreticulin.

artículo científico publicado en 2016

Pattern of pyruvate kinase isozymes in erythroleukemia cell lines and in normal human erythroblasts

artículo científico publicado en 1984

Peroxidatic activity distinct from myeloperoxidase in human monocytes cultured in vitro and in alveolar macrophages.

artículo científico publicado en 1982

Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation

artículo científico publicado en 2014

Phenotype and function of human hematopoietic cells engrafting immune-deficient CB17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells

artículo científico publicado en 1996

Platelet formation is the consequence of caspase activation within megakaryocytes

artículo científico publicado en 2002

Posttransfusion purpura-like syndrome associated with CD36 (Naka) isoimmunization.

artículo científico publicado en 1995

Preferential liver irradiation enhances hematopoiesis through a thrombopoietin-independent mechanism

artículo científico publicado en 1999

Presence of a defect in karyokinesis during megakaryocyte endomitosis

artículo científico publicado en 2012

Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients

artículo científico publicado en 2015

Presence of cross-reactive antibody between human immunodeficiency virus (HIV) and platelet glycoproteins in HIV-related immune thrombocytopenic purpura ⬇️

artículo científico publicado el 1 de julio de 1992

Presence of the Tn antigen on hematopoietic progenitors from patients with the Tn syndrome

artículo científico publicado en 1985

Primary hematopoietic cells from DBA patients with mutations in RPL11 and RPS19 genes exhibit distinct erythroid phenotype in vitro.

artículo científico publicado en 2012

Prognostic score including gene mutations in chronic myelomonocytic leukemia.

artículo científico publicado en 2013

Prominent role of TGF-beta 1 in thrombopoietin-induced myelofibrosis in mice

artículo científico publicado en 2002

Properties and biological roles of TET proteins during embryogenesis and in hematopoiesis

artículo científico publicado en 2015

Proplatelet formation is regulated by the Rho/ROCK pathway

artículo científico publicado en 2007

Proteasome inhibitor bortezomib impairs both myelofibrosis and osteosclerosis induced by high thrombopoietin levels in mice.

artículo científico publicado en 2007

Protective effects of differentiation inducers on natural killer sensitivity of K 562 cells: Analysis at a single-cell level.

artículo científico publicado en 1983

Protein kinase C mediates the mitogenic action of thrombopoietin in c-Mpl-expressing UT-7 cells.

artículo científico publicado en 1998

Putative innate immunity of antiatherogenic paraoxanase-2 via STAT5 signal transduction in HIV-1 infection of hematopoietic TF-1 cells and in SCID-hu mice.

artículo científico publicado en 2010

Pyruvate kinase synthesis and degradation by normal and pathologic cells during erythroid maturation

artículo científico publicado en 1988

Quantitative and qualitative in vitro analysis of the stem cell potential of hematopoietic cells purified from murine skeletal muscle

artículo científico publicado en 2007

RGS16 is a negative regulator of SDF-1-CXCR4 signaling in megakaryocytes.

artículo científico publicado en 2005

RNA interference shows critical requirement for NF-kappa B p50 in the production of IL-12 by human dendritic cells

artículo científico publicado en 2003

RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization

artículo científico publicado en 2012

Radiation-induced expression of functional Fas ligand in EBV-positive human nasopharyngeal carcinoma cells.

artículo científico publicado en 2000

Rare type 1-like and type 2-like calreticulin mutants induce similar myeloproliferative neoplasms as prevalent type 1 and 2 mutants in mice

artículo científico publicado en 2018

Recent advances in understanding myelofibrosis and essential thrombocythemia

artículo científico publicado en 2016

Recurrent V75M mutation within the Wiskott-Aldrich syndrome protein: description of a homozygous female patient.

artículo científico publicado en 2005

Reduced retention of radioprotective hematopoietic cells within the bone marrow microenvironment in CXCR4-/- chimeric mice.

artículo científico publicado en 2005

Regulation of i- and I-antigen expression in the K562 cell line.

artículo científico publicado en 1982

Regulation of megakaryocyte maturation and platelet formation.

artículo científico publicado en 2009

Regulation of the expression of IL-6 in human monocytes

scientific article published on 01 June 1989

Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging

artículo científico publicado en 2019

Reticulocytosis, hypochromia, and microcytosis: an unusual presentation of the preleukemic syndrome

scientific article published on 01 February 1982

Retrovirus-Mediated Gene Transfer into Human CD34+38lowPrimitive Cells Capable of Reconstituting Long-Term CulturesIn Vitroand Nonobese Diabetic–Severe Combined Immunodeficiency MiceIn Vivo ⬇️

artículo científico publicado el 1 de julio de 1998

Retrovirus-mediated transfer of the erythropoietin gene in hematopoietic cells improves the erythrocyte phenotype in murine beta-thalassemia.

artículo científico publicado en 1994

Rifampicin-induced pure red cell aplasia.

artículo científico publicado en 1989

Role for the nuclear factor kappaB pathway in transforming growth factor-beta1 production in idiopathic myelofibrosis: possible relationship with FK506 binding protein 51 overexpression

artículo científico publicado en 2005

Role of granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5 in the eosinophilia associated with T cell lymphoma

scientific article published on 01 March 1993

Role of human immunodeficiency virus replication in defective in vitro growth of hematopoietic progenitors ⬇️

artículo científico publicado el 15 de diciembre de 1992

Role of p21Cip1/Waf1 in cell-cycle exit of endomitotic megakaryocytes ⬇️

artículo científico publicado el 1 de diciembre de 2001

Role of tyrosine kinases and phosphatases in polycythemia vera.

artículo científico publicado en 2005

SOCS3 inhibits TPO-stimulated, but not spontaneous, megakaryocytic growth in primary myelofibrosis.

artículo científico publicado en 2009

STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model.

artículo científico publicado en 2013

Selective reduction of JAK2V617F-dependent cell growth by siRNA/shRNA and its reversal by cytokines.

artículo científico publicado en 2009

Simultaneous detection of membrane markers with monoclonal antibodies and peroxidatic activities in leukaemia: ultrastructural analysis using a new method of fixation preserving the platelet peroxidase

scientific article published on 01 November 1984

Small-molecule inhibitors in myeloproliferative neoplasms: are we aiming for the right targets?

artículo científico publicado el 1 de enero de 2012

Specific involvement of caspases in the differentiation of monocytes into macrophages

artículo científico publicado en 2002

Spi-1 transgenic mice develop a clonal erythroleukemia which does not depend on p53 mutation ⬇️

artículo científico publicado el 11 de junio de 1998

Spontaneous STAT5 activation induces growth factor independence in idiopathic myelofibrosis: possible relationship with FKBP51 overexpression.

artículo científico publicado en 2003

Stimulation of osteoprotegerin production is responsible for osteosclerosis in mice overexpressing TPO.

artículo científico publicado en 2002

Stromal cells maintain the radioprotective capacity of CFU-S during retroviral infection.

artículo científico publicado en 1996

Study of hemoglobin synthesis by affinity chromatography on Sepharose haptoglobin

scientific article published on 01 January 1981

Susceptibility of human bone marrow stromal cells to human immunodeficiency virus (HIV).

artículo científico publicado en 1995

TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis

TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells.

artículo científico publicado en 2014

TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia

scientific article published on October 2009

TET2 haploinsufficiency alters reprogramming into induced pluripotent stem cells

scientific article published on 06 March 2020

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

scientific journal article

TET2 loss, a rescue of JAK2V617F HSCs.

artículo científico publicado en 2015

TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs).

artículo científico publicado en 2009

TET2, a tumor suppressor in hematological disorders.

artículo científico

TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis.

artículo científico publicado en 2016

Telomere dysfunction and telomerase reactivation in human leukemia cell lines after telomerase inhibition by the expression of a dominant-negative hTERT mutant

artículo científico publicado en 2002

The JAK2 617V>F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia vera

artículo científico publicado en 2007

The Mpl-ligand is involved in the growth-promoting activity of the murine stromal cell line MS-5 on ES cell-derived hematopoiesis.

artículo científico publicado en 1998

The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors

scientific article published on 01 October 1995

The NF-κB pathway is rarely spontaneously activated in mantle cell lymphoma (MCL) cell lines and patient's samples.

artículo científico publicado en 2013

The Notch Delta-4 ligand helps to maintain the quiescence and the short-term reconstitutive potential of haematopoietic progenitor cells through activation of a key gene network

artículo científico publicado en 2014

The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model

artículo científico publicado en 2009

The Pediatric Acute Leukemia Fusion Oncogene ETO2-GLIS2 Increases Self-Renewal and Alters Differentiation in a Human Induced Pluripotent Stem Cells-Derived Model

scientific article published on 22 January 2020

The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation

scientific journal article

The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases

artículo científico publicado en 2013

The Tie receptor tyrosine kinase is expressed by human hematopoietic progenitor cells and by a subset of megakaryocytic cells.

artículo científico publicado en 1996

The abnormal proplatelet formation in MYH9-related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition.

artículo científico publicado en 2013

The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation.

artículo científico publicado en 2016

The first international meeting on V617F JAK2 mutation and its relevance in Philadelphia-negative myeloproliferative disorders.

artículo científico publicado en 2006

The formin DIAPH1 (mDia1) regulates megakaryocyte proplatelet formation by remodeling the actin and microtubule cytoskeletons.

artículo científico publicado en 2014

The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneity

scientific article published on 08 July 2008

The interaction between Cdc42 and WASP is required for SDF-1-induced T-lymphocyte chemotaxis.

artículo científico publicado en 2001

The myeloproliferative disorder associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3

artículo científico publicado en 2007

The origin of human B and T cells from multipotent stem cells: a study of the Tn syndrome

artículo científico publicado en 1983

The role of phorbol esters in the control of the proliferation and differentiation of hematopoietic cells.

artículo científico publicado en 1983

The role of the thrombopoietin receptor MPL in myeloproliferative neoplasms: recent findings and potential therapeutic applications

scientific article published on 22 May 2019

The serum response factor (SRF)/megakaryocytic acute leukemia (MAL) network participates in megakaryocyte development

artículo científico publicado en 2010

The severe phenotype of Diamond-Blackfan anemia is modulated by heat shock protein 70

scientific article published on 10 October 2017

The syndrome of T8 hyperlymphocytosis: variation in phenotype and cytotoxic activities of granular cells and evaluation of their role in associated neutropenia

scientific article published on 01 April 1987

The transcription factor Srf regulates hematopoietic stem cell adhesion

scientific journal article

The value of flow cytometric analysis of platelet glycoprotein expression of CD34+ cells measured under conditions that prevent P-selectin-mediated binding of platelets

artículo científico publicado en 1995

Therapy-related leukemia associated with myelofibrosis. Blast cell characterization in six cases.

artículo científico publicado en 1984

Thrombocytopenia in HIV infection

artículo científico publicado el 1 de septiembre de 1994

Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms.

artículo científico publicado en 2013

Thrombocytopenia resulting from mutations in filamin A can be expressed as an isolated syndrome.

artículo científico publicado en 2011

Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation

artículo científico publicado en 2014

Thrombopoietin (Mpl ligand) and the regulation of platelet production.

artículo científico publicado en 1997

Thrombopoietin (Mpl-ligand) and the regulation of platelet production.

artículo científico publicado en 1997

Thrombopoietin (TPO) knockout phenotype induced by cross-reactive antibodies against TPO following injection of mice with recombinant adenovirus encoding human TPO.

artículo científico publicado en 1998

Thrombopoietin and its receptor

artículo científico publicado en 1998

Thrombopoietin and its receptor, the proto-oncogene c-mpl.

artículo científico publicado en 1995

Thrombopoietin and megakaryocyte differentiation

artículo científico publicado en 1998

Thrombopoietin does not induce lineage-restricted commitment of Mpl-R expressing pluripotent progenitors but permits their complete erythroid and megakaryocytic differentiation.

artículo científico publicado en 1997

Thrombopoietin from human embryonic kidney cells is the same factor as c-mpl-ligand

scientific article published on 01 January 1995

Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants.

artículo científico publicado en 2015

Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes

scientific article published on 29 February 2012

Thrombopoietin receptor is required for the oncogenic function of CALR mutants.

artículo científico publicado en 2016

Thrombopoietin responsiveness reflects the number of doublings undergone by megakaryocyte progenitors.

artículo científico publicado en 2004

Thrombospondin-1 is not the major activator of TGF-β1 in thrombopoietin-induced myelofibrosis

artículo científico publicado en 2010

Thromboxane synthase has the same pattern of expression as platelet specific glycoproteins during human megakaryocyte differentiation

artículo científico publicado en 2000

Transfer of differentiation signal by membrane microvesicles harboring hedgehog morphogens.

artículo científico publicado en 2006

Transferrin binding to K562 cell line. Effect of heme and sodium butyrate induction

artículo científico publicado en 1982

Treatment of pure red cell aplasia by high dose intravenous immunoglobulins

scientific article published on 01 October 1983

Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm.

artículo científico publicado en 2009

Ultrastructural and cytochemical changes induced by short and prolonged culture of human monocytes

artículo científico publicado en 1980

Ultrastructural and cytochemical characterization of blasts from early erythroblastic leukemias

artículo científico publicado en 1987

Ultrastructure of platelet formation by human megakaryocytes cultured with the Mpl ligand

scientific article published on 01 April 1997

Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint

artículo científico publicado en 2016

Unfractionated peripheral blood stem cell autografts and CD(34+)-enriched autografts have similar long-term culture initiating capacity in multiple myeloma

artículo científico publicado en 1999

Use of a monoclonal antibody (GA3) to demonstrate lineage restricted O-glycosylation on leukosialin during terminal erythroid differentiation

artículo científico publicado en 1988

Use of the 46/1 haplotype to model JAK2(V617F) clonal architecture in PV patients: clonal evolution and impact of IFNα treatment.

artículo científico publicado en 2013

Wiskott-Aldrich syndrome protein-deficient hematopoietic cells can be efficiently mobilized by granulocyte colony-stimulating factor

artículo científico publicado en 2013

[A case of erythoblastic leukemia with basophilic reaction]

artículo científico publicado en 1991

[A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera]

artículo científico publicado en 2005

[Cellular regulation of the expression of i and I antigens during the in vitro differentiation of BFU-E]

scientific article published on 01 September 1980

[Erythrocyte receptors of insulin]

scientific article published on 01 January 1982

[Erythropoiesis and its regulation]

scientific article published on 01 June 1993

[Ex-vivo expansion of hematopoietic stem cells: study in the primate model]

artículo científico publicado en 1999

[Fli1 haploinsufficiency underlies Paris-Trousseau thrombopenia]

artículo científico publicado en 2004

[From giant to micro: a platelet story]

scientific article published on 01 May 2008

[Hematopoiesis and its regulation. Comparison between erythropoiesis and megakaryocytopoiesis]

artículo científico publicado en 1994

[Hematopoietic stem cells]

artículo científico publicado en 2001

[Hope and limits in cell therapies]

scientific article published on 01 June 2005

[In cauda venenum or the importance of TET(2)]

scientific article published on 23 December 2011

[Physiopathologic and therapeutic importance of animal models of hemoglobinopathies]

scientific article published on 01 June 1993

[Regulation of erythropoiesis]

scientific article published on 01 June 1993

[Treatment of chronic autoimmune thrombopenic purpura with intravenous immunoglobulins. Study of 18 cases]

scientific article published on 01 January 1983

c-jun and c-fos are expressed by human megakaryocytes.

artículo científico publicado en 1992

c-mpl, the thrombopoietin receptor

scientific article published on 01 July 1995

miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets.

artículo científico publicado en 2010

p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging

artículo científico publicado en 2014

p210BCR-ABL inhibits SDF-1 chemotactic response via alteration of CXCR4 signaling and down-regulation of CXCR4 expression

artículo científico publicado en 2005

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