Lista de obras - Kristian Strømgaard - Dominio Público Uruguay

A Heteromeric Snake Toxin and the Molecular Details of Pain Perception

scholarly article by Kristian Strømgaard & Anders S Kristensen published 15 March 2012 in Angewandte Chemie International Edition

A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain.

artículo científico publicado en 2011

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

artículo científico publicado en 2012

A parallel semisynthetic approach for structure-activity relationship studies of peptide YY.

artículo científico publicado en 2013

A sequential binding mechanism in a PDZ domain.

artículo científico publicado en 2009

AMPA receptor ligands: synthetic and pharmacological studies of polyamines and polyamine toxins

artículo científico publicado en 2004

Analogues of neuroactive polyamine wasp toxins that lack inner basic sites exhibit enhanced antagonism toward a muscle-type mammalian nicotinic acetylcholine receptor.

artículo científico publicado en 1999

Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: discovery of nanomolar, nonselective, and use-dependent antagonists

artículo científico publicado en 2010

Binding of ArgTX-636 in the NMDA receptor ion channel

artículo científico publicado en 2014

Binding of the multimodal antidepressant drug vortioxetine to the human serotonin transporter.

artículo científico publicado en 2015

Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter

artículo científico publicado en 2015

Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97.

artículo científico publicado en 2010

Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction.

artículo científico publicado en 2011

Characterization of intracellular regions in the human serotonin transporter for phosphorylation sites.

artículo científico publicado en 2014

Chemistry meets Biology: Chemical Approaches to the Study of Biology

artículo científico publicado en 2004

Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors

artículo científico publicado en 2003

Controlling Ca2+ Permeable α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Photochromic Ion Channel Blockers

scholarly article by Niels G. Nørager et al published 20 August 2018 in Journal of Medicinal Chemistry

Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example.

artículo científico publicado en 2010

Design and Synthesis of Peptide YY Analogues with C-terminal Backbone Amide-to-Ester Modifications

artículo científico publicado en 2013

Design and synthesis of high-affinity dimeric inhibitors targeting the interactions between gephyrin and inhibitory neurotransmitter receptors

artículo científico publicado en 2015

Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction

artículo científico publicado en 2009

Design and synthesis of labeled analogs of PhTX-56, a potent and selective AMPA receptor antagonist.

artículo científico publicado en 2005

Design, synthesis, and characterization of fatty acid derivatives of a dimeric peptide-based postsynaptic density-95 (PSD-95) inhibitor

artículo científico publicado en 2015

Design, synthesis, and pharmacological characterization of polyamine toxin derivatives: potent ligands for the pore-forming region of AMPA receptors

artículo científico publicado en 2006

Designing Poly-agonists for Treatment of Metabolic Diseases: Challenges and Opportunities

scientific article published on 01 July 2019

Detecting protein-protein interactions in living cells: development of a bioluminescence resonance energy transfer assay to evaluate the PSD-95/NMDA receptor interaction

artículo científico publicado en 2009

Development of potent fluorescent polyamine toxins and application in labeling of ionotropic glutamate receptors in hippocampal neurons.

artículo científico publicado en 2013

Effects of Dimeric PSD-95 Inhibition on Excitotoxic Cell Death and Outcome After Controlled Cortical Impact in Rats.

artículo científico

Effects of the dimeric PSD-95 inhibitor UCCB01-144 in mouse models of pain, cognition and motor function

artículo científico publicado en 2016

Effects of the dimeric PSD-95 inhibitor UCCB01-144 on functional recovery after fimbria-fornix transection in rats

artículo científico publicado en 2017

Energetic pathway sampling in a protein interaction domain.

artículo científico publicado en 2013

Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors.

artículo científico publicado en 2013

From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: synthesis and structure-activity relationship studies.

artículo científico publicado en 2008

General Synthesis of β-Alanine-Containing Spider Polyamine Toxins and Discovery of Nephila Polyamine Toxins 1 and 8 as Highly Potent Inhibitors of Ionotropic Glutamate Receptors

artículo científico publicado en 2012

Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter

artículo científico publicado en 2016

Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission.

artículo científico publicado en 2016

Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation

artículo científico publicado en 2002

Ginkgolides and glycine receptors: a structure-activity relationship study

artículo científico publicado en 2004

Ginkgolides: selective acetylations, translactonization, and biological evaluation

artículo científico publicado en 2002

Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery

artículo científico publicado en 2019

Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1.

artículo científico publicado en 2014

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.

artículo científico publicado en 2009

Importance of a Conserved Lys/Arg Residue for Ligand/PDZ Domain Interactions as Examined by Protein Semisynthesis.

artículo científico publicado en 2016

Importance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation

artículo científico publicado en 2015

In vitro and in vivo effects of a novel dimeric inhibitor of PSD-95 on excitotoxicity and functional recovery after experimental traumatic brain injury

artículo científico publicado en 2016

Inhibition of AMPA receptors by polyamine toxins is regulated by agonist efficacy and stargazin

artículo científico publicado en 2014

Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket

artículo científico publicado en 2012

Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy

artículo científico publicado en 2013

Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands

artículo científico publicado en 2016

Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors

artículo científico publicado en 2017

Ligand binding by PDZ domains.

artículo científico

Ligand binding to the PDZ domains of postsynaptic density protein 95.

artículo científico publicado en 2016

Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.

artículo científico publicado en 2009

Mapping the Binding Site for Escitalopram and Paroxetine in the Human Serotonin Transporter Using Genetically Encoded Photo-Cross-Linkers.

artículo científico publicado en 2017

Mechanism and site of action of big dynorphin on ASIC1a

artículo científico publicado en 2020

Mechanistic insight into benzenethiol catalyzed amide bond formations from thioesters and primary amines.

artículo científico publicado en 2014

Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction

artículo científico publicado en 2008

Molecular Details of a Coupled Binding and Folding Reaction between the Amyloid Precursor Protein and a Folded Domain

artículo científico publicado en 2021

Molecular basis for selective serotonin reuptake inhibition by the antidepressant agent fluoxetine (Prozac).

artículo científico publicado en 2014

Molecular basis of the alternative recruitment of GABA(A) versus glycine receptors through gephyrin

artículo científico publicado en 2014

Multisite NHERF1 phosphorylation controls GRK6A regulation of hormone-sensitive phosphate transport

artículo científico publicado en 2021

Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.

artículo científico publicado en 2009

PDZ Domains as Drug Targets

artículo científico publicado en 2019

PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions

artículo científico publicado en 2013

PSD-95 uncoupling from NMDA receptors by Tat- N-dimer ameliorates neuronal depolarization in cortical spreading depression

artículo científico publicado en 2016

Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in Pseudomonas Strains by Directing Monomers to Off-Pathway Oligomers

artículo científico publicado en 2019

Polyamine toxins: development of selective ligands for ionotropic receptors.

artículo científico publicado en 2005

Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling.

artículo científico publicado en 2016

Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists

artículo científico publicado en 2003

Preparation of a tritiated ginkgolide

artículo científico publicado en 2004

Probing Backbone Hydrogen Bonds in Proteins by Amide-to-Ester Mutations

artículo científico publicado en 2018

Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations.

artículo científico publicado en 2014

Probing the Mint2 protein-protein interaction network with relevance for the pathophysiology of Alzheimer's disease.

artículo científico publicado en 2018

Probing the role of backbone hydrogen bonds in protein-peptide interactions by amide-to-ester mutations

artículo científico publicado en 2013

Protein Engineering Reveals Mechanisms of Functional Amyloid Formation in Pseudomonas aeruginosa Biofilms

scholarly article by Alissa Bleem published in October 2018

Protolytic properties of polyamine wasp toxin analogues studied by 13C NMR spectroscopy.

artículo científico publicado en 2006

Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity

artículo científico publicado en 2019

Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives

artículo científico publicado en 2009

Recent achievements in developing selective Gq inhibitors

Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters.

artículo científico publicado en 2009

Recombinant production of peptide C-terminal α-amides using an engineered intein

artículo científico publicado en 2013

Rigidified clicked dimeric ligands for studying the dynamics of the PDZ1-2 supramodule of PSD-95.

artículo científico publicado en 2014

Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor

scientific article published on 02 March 2019

Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains.

artículo científico publicado en 2011

Site-Specific Phosphorylation of PSD-95 PDZ Domains Reveals Fine-Tuned Regulation of Protein-Protein Interactions

artículo científico publicado en 2017

Site-specific phosphorylation of PSD-95 dynamically regulates the postsynaptic density as observed by phase separation

artículo científico publicado en 2021

Small molecules from spiders used as chemical probes.

artículo científico publicado en 2011

Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12.

artículo científico publicado en 2000

Solid-phase synthesis and biological evaluation of Joro spider toxin-4 from Nephila clavata.

artículo científico publicado en 2010

Solid-phase synthesis and pharmacological evaluation of analogues of PhTX-12-A potent and selective nicotinic acetylcholine receptor antagonist.

artículo científico publicado en 2002

Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors

artículo científico publicado en 2002

Structure-Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the Gq Protein

artículo científico publicado en 2017

Structure-Activity Relationship Studies of the Natural Product Gq/11 Protein Inhibitor YM-254890

artículo científico publicado en 2019

Structure-activity relationship studies of N-methylated and N-hydroxylated spider polyamine toxins as inhibitors of ionotropic glutamate receptors

artículo científico publicado en 2014

Structure-activity relationship studies of argiotoxins: selective and potent inhibitors of ionotropic glutamate receptors

artículo científico publicado en 2013

Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5-HT transporter

artículo científico

Structure-activity relationship study of spider polyamine toxins as inhibitors of ionotropic glutamate receptors.

artículo científico publicado en 2014

Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1

artículo científico publicado en 2010

Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359

artículo científico publicado en 2018

Synthesis and biological activity of argiotoxin 636 and analogues: selective antagonists for ionotropic glutamate receptors

artículo científico publicado en 2009

Synthesis and biological activity of novel alpha-conotoxin analogues incorporating substituted proline derivatives.

artículo científico publicado en 2009

Synthesis of peptides using tert-butyloxycarbonyl (Boc) as the α-amino protection group

artículo científico publicado en 2013

Synthetic and mechanistic insight into nosylation of glycine residues.

artículo científico publicado en 2013

Targeting protein-protein interactions with trimeric ligands: high affinity inhibitors of the MAGUK protein family

artículo científico publicado en 2015

Targeting receptor complexes: a new dimension in drug discovery

artículo científico publicado en 2020

Targeting the APP-Mint2 Protein-Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation

scientific article published on 05 January 2021

Targeting the γ-Aminobutyric Acid Type B (GABAB) Receptor Complex: Development of Inhibitors Targeting the K+ Channel Tetramerization Domain (KCTD) Containing Proteins/GABAB Receptor Protein-Protein Interaction

artículo científico publicado en 2019

Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors

artículo científico publicado en 2003

The role of backbone hydrogen bonds in the transition state for protein folding of a PDZ domain.

artículo científico publicado en 2014

Total synthesis and structure-activity relationship studies of a series of selective G protein inhibitors

artículo científico publicado en 2016

UCCB01-125, a dimeric inhibitor of PSD-95, reduces inflammatory pain without disrupting cognitive or motor performance: comparison with the NMDA receptor antagonist MK-801.

artículo científico publicado en 2012

Uncompetitive antagonism of AMPA receptors: Mechanistic insights from studies of polyamine toxin derivatives

artículo científico publicado en 2006

Lista de obras de Kristian Strømgaard

A Heteromeric Snake Toxin and the Molecular Details of Pain Perception

A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain.

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

A parallel semisynthetic approach for structure-activity relationship studies of peptide YY.

A sequential binding mechanism in a PDZ domain.

AMPA receptor ligands: synthetic and pharmacological studies of polyamines and polyamine toxins

Analogues of neuroactive polyamine wasp toxins that lack inner basic sites exhibit enhanced antagonism toward a muscle-type mammalian nicotinic acetylcholine receptor.

Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: discovery of nanomolar, nonselective, and use-dependent antagonists

Binding of ArgTX-636 in the NMDA receptor ion channel

Binding of the multimodal antidepressant drug vortioxetine to the human serotonin transporter.

Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter

Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97.

Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction.

Characterization of intracellular regions in the human serotonin transporter for phosphorylation sites.

Chemistry meets Biology: Chemical Approaches to the Study of Biology

Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors

Controlling Ca2+ Permeable α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Photochromic Ion Channel Blockers

Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example.

Design and Synthesis of Peptide YY Analogues with C-terminal Backbone Amide-to-Ester Modifications

Design and synthesis of high-affinity dimeric inhibitors targeting the interactions between gephyrin and inhibitory neurotransmitter receptors

Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction

Design and synthesis of labeled analogs of PhTX-56, a potent and selective AMPA receptor antagonist.

Design, synthesis, and characterization of fatty acid derivatives of a dimeric peptide-based postsynaptic density-95 (PSD-95) inhibitor

Design, synthesis, and pharmacological characterization of polyamine toxin derivatives: potent ligands for the pore-forming region of AMPA receptors

Designing Poly-agonists for Treatment of Metabolic Diseases: Challenges and Opportunities

Detecting protein-protein interactions in living cells: development of a bioluminescence resonance energy transfer assay to evaluate the PSD-95/NMDA receptor interaction

Development of potent fluorescent polyamine toxins and application in labeling of ionotropic glutamate receptors in hippocampal neurons.

Effects of Dimeric PSD-95 Inhibition on Excitotoxic Cell Death and Outcome After Controlled Cortical Impact in Rats.

Effects of the dimeric PSD-95 inhibitor UCCB01-144 in mouse models of pain, cognition and motor function

Effects of the dimeric PSD-95 inhibitor UCCB01-144 on functional recovery after fimbria-fornix transection in rats

Energetic pathway sampling in a protein interaction domain.

Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors.

From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: synthesis and structure-activity relationship studies.

General Synthesis of β-Alanine-Containing Spider Polyamine Toxins and Discovery of Nephila Polyamine Toxins 1 and 8 as Highly Potent Inhibitors of Ionotropic Glutamate Receptors

Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter

Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission.

Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation

Ginkgolides and glycine receptors: a structure-activity relationship study

Ginkgolides: selective acetylations, translactonization, and biological evaluation

Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery

Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1.

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.

Importance of a Conserved Lys/Arg Residue for Ligand/PDZ Domain Interactions as Examined by Protein Semisynthesis.

Importance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation

In vitro and in vivo effects of a novel dimeric inhibitor of PSD-95 on excitotoxicity and functional recovery after experimental traumatic brain injury

Inhibition of AMPA receptors by polyamine toxins is regulated by agonist efficacy and stargazin

Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket

Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy

Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands

Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors

Ligand binding by PDZ domains.

Ligand binding to the PDZ domains of postsynaptic density protein 95.

Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.

Mapping the Binding Site for Escitalopram and Paroxetine in the Human Serotonin Transporter Using Genetically Encoded Photo-Cross-Linkers.

Mechanism and site of action of big dynorphin on ASIC1a

Mechanistic insight into benzenethiol catalyzed amide bond formations from thioesters and primary amines.

Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction

Molecular Details of a Coupled Binding and Folding Reaction between the Amyloid Precursor Protein and a Folded Domain

Molecular basis for selective serotonin reuptake inhibition by the antidepressant agent fluoxetine (Prozac).

Molecular basis of the alternative recruitment of GABA(A) versus glycine receptors through gephyrin

Multisite NHERF1 phosphorylation controls GRK6A regulation of hormone-sensitive phosphate transport

Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.

PDZ Domains as Drug Targets

PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions

PSD-95 uncoupling from NMDA receptors by Tat- N-dimer ameliorates neuronal depolarization in cortical spreading depression

Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in Pseudomonas Strains by Directing Monomers to Off-Pathway Oligomers

Polyamine toxins: development of selective ligands for ionotropic receptors.

Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling.

Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists

Preparation of a tritiated ginkgolide

Probing Backbone Hydrogen Bonds in Proteins by Amide-to-Ester Mutations

Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations.

Probing the Mint2 protein-protein interaction network with relevance for the pathophysiology of Alzheimer's disease.

Probing the role of backbone hydrogen bonds in protein-peptide interactions by amide-to-ester mutations

Protein Engineering Reveals Mechanisms of Functional Amyloid Formation in Pseudomonas aeruginosa Biofilms

Protolytic properties of polyamine wasp toxin analogues studied by 13C NMR spectroscopy.

Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity

Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives

Recent achievements in developing selective Gq inhibitors