Filtros de búsqueda

Lista de obras de Jacques Pouysségur

"Carrier activation" and glucose transport in Chinese hamster fibroblasts

artículo científico publicado el 29 de diciembre de 1978

2-Keto-3-deoxy-gluconate transport system in E. coli K 12: map location of a structural gene and of its operator ⬇️

artículo científico publicado el 1 de marzo de 1973

99mTc-A1 as a Novel Imaging Agent Targeting Mesothelin-Expressing Pancreatic Ductal Adenocarcinoma

artículo científico publicado en 2019

A dialogue between the hypoxia-inducible factor and the tumor microenvironment

artículo científico publicado en 2008

A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis

artículo científico publicado en 2010

A genetic approach to the role of energy metabolism in the growth of tumor cells: Tumorigenicity of fibroblast mutants deficient either in glycolysis or in respiration ⬇️

artículo científico publicado el 15 de junio de 1981

A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae

artículo científico publicado en 2007

A peptide ligand of the human thrombin receptor antagonizes alpha-thrombin and partially activates platelets

scientific article published on 01 July 1993

A point mutation of the Na+/H+ exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis

artículo científico publicado en 1993

A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor

artículo científico publicado en 2004

A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH ⬇️

artículo científico publicado el 1 de agosto de 1984

A temporal and biochemical link between growth factor-activated MAP kinases, cyclin D1 induction and cell cycle entry

artículo científico publicado en 1996

AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity

artículo científico publicado en 2018

AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts

artículo científico publicado en 2015

ARDent about acetylation and deacetylation in hypoxia signalling

artículo científico publicado en 2006

ATP dependence of NHE-1, the ubiquitous isoform of the Na+/H+ antiporter. Analysis of phosphorylation and subcellular localization.

artículo científico publicado en 1994

Abrogation of p27Kip1 by cDNA antisense suppresses quiescence (G0 state) in fibroblasts

artículo científico publicado en 1996

Accumulation of D glucuronate by the transport system of 2-keto-3-deoxy-D-gluconate in Escherichia coli K 12

artículo científico publicado el 16 de octubre de 1972

Activation of HIF-1alpha in exponentially growing cells via hypoxic stimulation is independent of the Akt/mTOR pathway

artículo científico publicado en 2009

Activation of Src family kinase activity by the G protein-coupled thrombin receptor in growth-responsive fibroblasts.

artículo científico publicado en 1994

Activation of the Na+/H+ antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism ⬇️

artículo científico publicado el 25 de noviembre de 1992

Adenylate cyclase in a fibroblast mutant defective in glycolipid and glycoprotein synthesis

artículo científico publicado en 1978

Affinity labeling of high-affinity alpha-thrombin binding sites on the surface of hamster fibroblasts

scientific article published on 01 December 1985

Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene

artículo científico publicado en 1990

Alpha-thrombin receptor and MAP kinases in the control of cell growth

scientific article published on 01 June 1993

Alpha-thrombin receptors and growth signaling

artículo científico publicado en 1993

Alpha-thrombin, epidermal growth factor, and okadaic acid activate the Na+/H+ exchanger, NHE-1, by phosphorylating a set of common sites

scientific article published on 01 October 1991

Alpha-thrombin-induced inositol phosphate formation in G0-arrested and cycling hamster lung fibroblasts: evidence for a protein kinase C-mediated desensitization response

artículo científico publicado en 1986

Alpha-thrombin-induced tyrosine phosphorylation of 43,000- and 41,000-Mr proteins is independent of cytoplasmic alkalinization in quiescent fibroblasts

artículo científico publicado en 1986

Amino Acid Transporters Are a Vital Focal Point in the Control of mTORC1 Signaling and Cancer

artículo científico publicado en 2020

An anchorage-dependent signal distinct from p42/44 MAP kinase activation is required for cell cycle progression

scientific article published on 01 September 1998

Analysis of growth factor "relaxation" in Chinese hamster lung fibroblasts required for tumoral expression

scientific article published on 01 May 1983

Angiogenesis and G-protein-coupled receptors: signals that bridge the gap.

artículo científico publicado en 2001

Angiogenesis: how a tumor adapts to hypoxia

artículo científico publicado en 1999

Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF

artículo científico publicado en 2005

Atypical BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia

artículo científico publicado en 2009

B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222

scientific journal article

Biochemical characterization of the amiloride-sensitive Na+/H+ antiport in Chinese hamster lung fibroblasts

artículo científico publicado en 1983

Biochemical studies of the structure, mechanism and differentiation of the voltage-sensitive sodium channel

artículo científico publicado en 1980

Biochemical titration of glycogen in vitro

artículo científico publicado en 2013

Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity ⬇️

artículo científico publicado el 1 de mayo de 1992

Blockade of the Na+/H+ antiport abolishes growth factor-induced DNA synthesis in fibroblasts. Structure-activity relationships in the amiloride series

artículo científico publicado en 1984

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

artículo científico publicado en 2011

Calmodulin-Binding Autoinhibitory Domain Controls “pH-Sensing” in the Na+/H+ Exchanger NHE1 through Sequence-Specific Interaction ⬇️

artículo científico publicado el 21 de octubre de 1997

Cannabinoid receptor CB1 activates the Na+/H+ exchanger NHE-1 isoform via Gi-mediated mitogen activated protein kinase signaling transduction pathways

artículo científico publicado en 1999

Carbonic anhydrase XII expression is linked to suppression of Sonic hedgehog ligand expression in triple negative breast cancer cells

scientific article published on 18 June 2019

Cell mutants as a tool to study malignant transformation of fibroblasts

artículo científico publicado en 1980

Cell surface glycoproteins and malignant transformation

artículo científico publicado en 1978

Cell surface glycoproteins and malignant transformation

scientific article published in 1979

Characterization of the neuropilin-1 promoter; gene expression is mediated by the transcription factor Sp1.

artículo científico publicado en 2003

Chinese hamster serotonin (5-HT) type 2 receptor cDNA sequence

artículo científico publicado en 1990

Cloning and expression of a cAMP-activated Na+/H+ exchanger: evidence that the cytoplasmic domain mediates hormonal regulation ⬇️

artículo científico publicado el 1 de agosto de 1992

Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2) ⬇️

artículo científico publicado el 5 de junio de 1993

Cloning and sequencing of a rabbit cDNA encoding an intestinal and kidney-specific Na+/H+ exchanger isoform (NHE-3) ⬇️

artículo científico publicado el 5 de mayo de 1992

Cloning of the human genomic amiloride-sensitive Na+/H+ antiporter gene, identification of genetic polymorphisms, and localization on the genetic map of chromosome 1p

scientific article published on 01 May 1990

Cloning, functional expression and role in cell growth regulation of a hamster 5-HT2 receptor subtype

artículo científico publicado en 1991

Cloning, sequence, and tissue distribution of a rabbit renal Na+/H+ exchanger transcript

artículo científico publicado en 1991

Co-culture of human fibroblasts, smooth muscle and endothelial cells promotes osteopontin induction in hypoxia

artículo científico publicado en 2020

Complete structure of an increasing capillary permeability protein (ICPP) purified from Vipera lebetina venom. ICPP is angiogenic via vascular endothelial growth factor receptor signalling

artículo científico publicado en 2002

Confluence of vascular endothelial cells induces cell cycle exit by inhibiting p42/p44 mitogen-activated protein kinase activity

artículo científico publicado en 1999

Constitutive MAP kinase phosphatase (MKP-1) expression blocks G1 specific gene transcription and S-phase entry in fibroblasts

scientific article published on 01 May 1995

Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1).

scientific article published on July 1994

Constitutively active mutants of MAP kinase kinase (MEK1) induce growth factor-relaxation and oncogenicity when expressed in fibroblasts

artículo científico publicado en 1994

Conventional techniques to monitor mitochondrial oxygen consumption

artículo científico

Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition ⬇️

artículo científico publicado el 5 de julio de 1992

Coupling between phosphoinositide breakdown and early mitogenic events in fibroblasts. Studies with fluoroaluminate, vanadate, and pertussis toxin.

artículo científico publicado en 1987

Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells

artículo científico publicado en 2009

Cyclin D1 expression is a major target of the cAMP-induced inhibition of cell cycle entry in fibroblasts

artículo científico publicado en 1997

Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.

artículo científico publicado en 1996

Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death

artículo científico publicado en 2020

Cytoplasmic Domain of the Ubiquitous Na+/H+ Exchanger NHE1 Can Confer Ca2+ Responsiveness to the Apical Isoform NHE3 ⬇️

artículo científico publicado el 3 de noviembre de 1995

Cytoplasmic pH, a key determinant of growth factor-induced DNA synthesis in quiescent fibroblasts

article by Jacques Pouysségur et al published 1 October 1985 in FEBS Letters

Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter

artículo científico publicado en 1990

Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

artículo científico publicado en 1999

Deletion of ERK1 and ERK2 in the CNS causes cortical abnormalities and neonatal lethality: Erk1 deficiency enhances the impairment of neurogenesis in Erk2-deficient mice

scientific article published on 01 January 2011

Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositide-specific phospholipase C.

artículo científico publicado en 1988

Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b

artículo científico publicado en 2004

Differential activation of p44mapk (ERK1) by alpha-thrombin and thrombin-receptor peptide agonist

artículo científico publicado en 1993

Differential localization of Na+/H+ exchanger isoforms (NHE1 and NHE3) in polarized epithelial cell lines.

artículo científico publicado en 1996

Differential regulation of Na+/H+ antiporter gene expression in vascular smooth muscle cells by hypertrophic and hyperplastic stimuli.

artículo científico publicado en 1990

Disrupting glucose-6-phosphate isomerase fully suppresses the "Warburg effect" and activates OXPHOS with minimal impact on tumor growth except in hypoxia

artículo científico publicado en 2017

Disrupting proton dynamics and energy metabolism for cancer therapy

artículo científico publicado en 2013

Disrupting the 'Warburg effect' re-routes cancer cells to OXPHOS offering a vulnerability point via 'ferroptosis'-induced cell death

artículo científico publicado en 2017

Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status

artículo científico publicado en 2015

Dissecting the Process of Activation of Cancer-promoting Zinc-requiring Ectoenzymes by Zinc Metalation Mediated by ZNT Transporters

artículo científico publicado en 2016

Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis

artículo científico publicado en 2002

Distinct deregulation of the hypoxia inducible factor by PHD2 mutants identified in germline DNA of patients with polycythemia

artículo científico publicado en 2011

Distinct mechanisms regulate 5-HT2 and thrombin receptor desensitization.

artículo científico publicado en 1995

Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism

scientific article published on 29 August 2018

Down-regulation of the hexose transport system: metabolic basis studied with a fibroblast mutant lacking phosphoglucose isomerase

artículo científico publicado en 1982

Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin

artículo científico publicado en 2017

ERK implication in cell cycle regulation

artículo científico publicado en 2006

ERK nuclear translocation is dimerization-independent but controlled by the rate of phosphorylation

artículo científico publicado en 2009

ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy?

artículo científico publicado en 2016

ERK1 and ERK2 are required for radial glial maintenance and cortical lamination ⬇️

artículo científico publicado el 5 de septiembre de 2010

ERK1 and ERK2 present functional redundancy in tetrapods despite higher evolution rate of ERK1.

artículo científico publicado en 2015

ERK1 is dispensable for mouse pancreatic beta cell function but is necessary for glucose-induced full activation of MSK1 and CREB.

artículo científico publicado en 2017

ERK1 is important for Th2 differentiation and development of experimental asthma

artículo científico publicado en 2012

ERK1 plays a critical protective role against N-methyl-D-aspartate-induced retinal injury

scientific article published on 01 January 2008

ERK1 regulates the hematopoietic stem cell niches

artículo científico publicado en 2012

ERK2 but not ERK1 plays a key role in hepatocyte replication: an RNAi-mediated ERK2 knockdown approach in wild-type and ERK1 null hepatocytes.

artículo científico publicado en 2007

Early and late mitogenic events induced by FGF on bovine epithelial lens cells are not triggered by hydrolysis of polyphosphoinositides

artículo científico publicado en 1987

Effects of 5-HT1c-receptor expression on cell proliferation control in hamster fibroblasts: Serotonin fails to induce a transformed phenotype ⬇️

artículo científico publicado el 1 de junio de 1992

Effects of cytotoxic necrotizing factor 1 and lethal toxin on actin cytoskeleton and VE-cadherin localization in human endothelial cell monolayers.

artículo científico publicado en 1999

Emergence of hamster fibroblast tumors in nude mice--evidence for in vivo selection leading to loss of growth factor requirement

artículo científico publicado en 1981

Endothelial cells genetically selected from differentiating mouse embryonic stem cells incorporate at sites of neovascularization in vivo.

artículo científico publicado en 2002

Endothelin rapidly stimulates mitogen-activated protein kinase activity in rat mesangial cells ⬇️

artículo científico publicado el 15 de octubre de 1992

Endothelin stimulates mitogen-activated protein kinase activity in mesangial cells through ETA.

artículo científico publicado en 1994

Endothelin stimulates mitogen-activated protein kinase p42 activity through the phosphorylation of the kinase in rat mesangial cells

scientific article published on 01 January 1993

Enhanced phosphorylation of the C-terminal domain of RNA polymerase II upon serum stimulation of quiescent cells: possible involvement of MAP kinases

artículo científico publicado en 1994

Enzymatic synthesis of 2-keto-3-deoxy-D-gluconate

artículo científico

Enzyme-linked immunosorbent assay for pharmacological studies targeting hypoxia-inducible factor 1alpha

artículo científico publicado en 2005

EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway

scientific journal article

Epithelial localization of a reptilian Na+/H+ exchanger homologous to NHE-1 ⬇️

artículo científico publicado el 1 de junio de 1997

Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion.

artículo científico publicado en 2008

Evidence for a GTP-binding protein coupling thrombin receptor to PIP2-phospholipase C in membranes of hamster fibroblasts

artículo científico publicado en 1987

Evidence that Na+/H+ exchanger isoforms NHE1 and NHE3 exist as stable dimers in membranes with a high degree of specificity for homodimers.

artículo científico publicado en 1994

Evidence that hamster fibroblasts tumors emerge in nude mice through the process of two in vivo selections leading to growth factor "relaxation" and to immune resistance.

artículo científico publicado en 1982

Exclusion of the Na(+)-H+ antiporter as a candidate gene in human essential hypertension

artículo científico publicado en 1991

Expression of a truncated active form of VDAC1 in lung cancer associates with hypoxic cell survival and correlates with progression to chemotherapy resistance

artículo científico publicado en 2012

Expression of rat renal Na/H antiporter mRNA levels in response to respiratory and metabolic acidosis

artículo científico publicado en 1991

Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome.

artículo científico publicado en 2014

Extracellular Signal-Regulated Kinase Signaling in CD4-Expressing Cells Inhibits Osteochondromas

artículo científico publicado en 2017

Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation

artículo científico publicado en 2005

Fibroblast growth factor potentiates receptor- and nonreceptor-mediated stimulation of adenylate cyclase in hamster fibroblasts

artículo científico publicado en 1989

Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling

artículo científico publicado en 2002

Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling

scientific article published on 01 August 2003

Focal localization of the NHE-1 isoform of the Na+/H+ antiport: assessment of effects on intracellular pH.

artículo científico publicado en 1993

From Malignant Progression to Therapeutic Targeting: Current Insights of Mesothelin in Pancreatic Ductal Adenocarcinoma

artículo científico publicado en 2020

Functional characteristics of a cloned epithelial Na+/H+ exchanger (NHE3): resistance to amiloride and inhibition by protein kinase C

artículo científico publicado en 1993

Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk ⬇️

artículo científico publicado el 1 de enero de 1992

Functional expression of Ca2(+)-mobilizing alpha-thrombin receptors in mRNA-injected Xenopus oocytes

artículo científico publicado en 1990

Functional expression of a human Na+/H+ antiporter gene transfected into antiporter-deficient mouse L cells

artículo científico publicado en 1986

Functional expression of the human growth factor-activatable sodium/hydrogen ion antiporter in baculovirus-infected cells ⬇️

artículo científico publicado el 1 de octubre de 1991

Functional expression of the human receptor for colony-stimulating factor 1 (CSF-1) in hamster fibroblasts: CSF-1 stimulates Na+/H+ exchange and DNA-synthesis in the absence of phosphoinositide breakdown

artículo científico publicado en 1990

Further evidence for a phospholipase C-coupled G protein in hamster fibroblasts. Induction of inositol phosphate formation by fluoroaluminate and vanadate and inhibition by pertussis toxin

artículo científico publicado en 1987

G protein-controlled signal transduction pathways and the regulation of cell proliferation

artículo científico publicado el 1 de enero de 1992

Gene Transfer in Vascular Cells Using an Engineered Na-H Exchanger (NHE1) as a Selectable Marker

artículo científico publicado el 1 de enero de 1999

Gene disruption using zinc finger nuclease technology

artículo científico publicado en 2014

Gene regulation in response to graded hypoxia: the non-redundant roles of the oxygen sensors PHD and FIH in the HIF pathway

artículo científico publicado en 2009

Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses

artículo científico publicado en 2019

Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth

artículo científico publicado en 2016

Genetic approach to structure, function, and regulation of the Na+/H+ antiporter

artículo científico publicado en 1987

Genetic control of the 2-keto-3-deoxy-d-gluconate metabolism in Escherichia coli K-12: kdg regulon

artículo científico publicado en 1974

Genetic disruption of lactate/H+ symporters (MCTs) and their subunit CD147/BASIGIN sensitizes glycolytic tumor cells to phenformin

artículo científico publicado en 2014

Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells

artículo científico publicado en 2016

Glucocorticoid stimulation of ileal Na+ absorptive cell brush border Na+/H+ exchange and association with an increase in message for NHE-3, an epithelial Na+/H+ exchanger isoform.

artículo científico publicado en 1993

Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts ⬇️

artículo científico publicado el 1 de septiembre de 1977

Glucose-induced O₂ consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cells

artículo científico publicado en 2012

Glycogen Synthesis is Induced in Hypoxia by the Hypoxia-Inducible Factor and Promotes Cancer Cell Survival

artículo científico publicado en 2012

Growth factor action and intracellular pH regulation in fibroblasts. Evidence for a major role of the Na+/H+ antiport ⬇️

artículo científico publicado el 10 de mayo de 1984

Growth factor activation and "H(+)-sensing" of the Na+/H+ exchanger isoform 1 (NHE1). Evidence for an additional mechanism not requiring direct phosphorylation

scientific article published on 01 February 1994

Growth factor activation of an amiloride-sensitive Na+/H+ exchange system in quiescent fibroblasts: coupling to ribosomal protein S6 phosphorylation

artículo científico publicado en 1982

Growth factor requirements of Chinese hamster lung fibroblasts in serum free media: high mitogenic action of thrombin

artículo científico publicado en 1981

Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteins

artículo científico publicado en 1998

Growth factor-stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1)

scientific journal article

Growth factor-stimulated protein phosphorylation in G0/G1-arrested fibroblasts. Two distinct classes of growth factors with potentiating effects.

artículo científico publicado en 1983

Growth factor-stimulated protein synthesis is inhibited by sodium orthovanadate

artículo científico publicado en 2001

Growth factors activate the Na+/H+ antiporter in quiescent fibroblasts by increasing its affinity for intracellular H+ ⬇️

artículo científico publicado el 10 de septiembre de 1984

Growth factors activate the bumetanide-sensitive Na+/K+/Cl-cotransport in hamster fibroblasts

scientific article published on 01 May 1986

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

artículo científico publicado en 1993

Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kD

artículo científico publicado en 1990

Guanosine 5'-O-(3-thiotriphosphate) and guanosine 5'-O-(2-thiodiphosphate) activate G proteins and potentiate fibroblast growth factor-induced DNA synthesis in hamster fibroblasts

artículo científico publicado en 1990

HIF at a glance

scientific article published on April 2009

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

artículo científico publicado en 2003

HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation

artículo científico publicado en 2001

HIF-1: master and commander of the hypoxic world. A pharmacological approach to its regulation by siRNAs

artículo científico publicado en 2004

HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome

artículo científico publicado en 2007

HIF-1alpha mediates the induction of IL-8 and VEGF expression on infection with Afa/Dr diffusely adhering E. coli and promotes EMT-like behaviour

artículo científico publicado en 2009

HIF-Prolyl Hydroxylase 2 Inhibition Enhances the Efficiency of Mesenchymal Stem Cell-Based Therapies for the Treatment of Critical Limb Ischemia

HIF1 transcription factor regulates laminin-332 expression and keratinocyte migration.

artículo científico publicado en 2008

Harnessing the hypoxia-inducible factor in cancer and ischemic disease

artículo científico publicado en 2006

Hif-2alpha mediates UV-induced apoptosis through a novel ATF3-dependent death pathway

scientific article published on 30 May 2008

High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancer

artículo científico publicado en 2010

Highlights of the European Association of Cancer Research (EACR 2008).

artículo científico publicado en 2009

Hirudin, a probe to analyze the growth-promoting activity of thrombin in fibroblasts; reevaluation of the temporal action of competence factors

scientific article published on 01 May 1982

Homologous desensitization of thrombin-induced phosphoinositide breakdown in hamster lung fibroblasts

scientific article published on 01 August 1988

Hormonal regulation, pharmacology, and membrane sorting of vertebrate Na+/H+ exchanger isoforms

artículo científico publicado en 1995

Hypoxia and cancer

artículo científico publicado en 2007

Hypoxia and cellular metabolism in tumour pathophysiology

artículo científico publicado en 2017

Hypoxia and energetic tumour metabolism

artículo científico publicado en 2010

Hypoxia in cancer cell metabolism and pH regulation

artículo científico publicado en 2007

Hypoxia in health and disease

artículo científico publicado en 2016

Hypoxia optimises tumour growth by controlling nutrient import and acidic metabolite export

artículo científico

Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels

artículo científico publicado en 2013

Hypoxia protects against the cell death triggered by oxovanadium-galactomannan complexes in HepG2 cells

artículo científico publicado en 2019

Hypoxia signalling controls metabolic demand

artículo científico publicado en 2007

Hypoxia signalling in cancer and approaches to enforce tumour regression

artículo científico publicado en 2006

Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters

artículo científico publicado en 2016

Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains

scientific journal article

Hypoxia-induced autophagy: cell death or cell survival?

artículo científico publicado en 2009

Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH.

artículo científico publicado en 2009

Hypoxia-inducible factor 1 transactivates the human leptin gene promoter

artículo científico publicado en 2002

Hypoxia-inducible factor 1{alpha} is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells

artículo científico publicado en 2005

Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm

artículo científico publicado en 2001

Hypoxia: the tumor's gateway to progression along the angiogenic pathway

artículo científico publicado en 2001

Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli

artículo científico publicado en 2010

Hypoxic mitochondria: accomplices in resistance ⬇️

artículo científico publicado el 1 de mayo de 2011

Identification of MAP kinase domains by redirecting stress signals into growth factor responses

artículo científico publicado en 1996

Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients

artículo científico publicado en 2020

Identification of a tetrodotoxin-sensitive Na+ channel in a variety in fibroblast lines

artículo científico publicado en 1980

Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha

artículo científico publicado en 2000

Identification of cytoplasmic subdomains that control pH-sensing of the Na+/H+ exchanger (NHE1): pH-maintenance, ATP-sensitive, and flexible loop domains

artículo científico publicado en 1997

Identification of the protein and cDNA of the cardiac Na+/H+ exchanger

artículo científico publicado en 1991

Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription

artículo científico publicado en 2002

Immunolocalization of anion exchanger AE2 and cation exchanger NHE-1 in distinct adjacent cells of gastric mucosa

Implication of the ERK Pathway on the Post-transcriptional Regulation of VEGF mRNA Stability ⬇️

artículo científico publicado el 1 de enero de 2010

In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH.

artículo científico publicado en 2011

Independent activation of endogenous p21-activated protein kinase-3 (PAK3) and JNK by thrombin in CCL39 fibroblasts

artículo científico publicado en 2000

Inducible expression of a MAP kinase phosphatase-3-GFP chimera specifically blunts fibroblast growth and ras-dependent tumor formation in nude mice

artículo científico publicado en 2004

Induction of hypoxia-inducible factor-1alpha by transcriptional and translational mechanisms

artículo científico publicado en 2002

Induction of two transformation-sensitive membrane polypeptides in normal fibroblasts by a block in glycoprotein synthesis or glucose deprivation ⬇️

artículo científico publicado el 1 de agosto de 1977

Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization.

artículo científico publicado en 2009

Inhibition of the amino-acid transporter LAT1 demonstrates anti-neoplastic activity in medulloblastoma

Integration of a 'proton antenna' facilitates transport activity of the monocarboxylate transporter MCT4.

artículo científico publicado en 2016

Intracellular pH controls growth factor-induced ribosomal protein S6 phosphorylation and protein synthesis in the G0----G1 transition of fibroblasts

artículo científico publicado en 1986

Involvement of extracellular signal-regulated kinase module in HIV-mediated CD4 signals controlling activation of nuclear factor-kappa B and AP-1 transcription factors ⬇️

artículo científico publicado el 15 de febrero de 1998

Isolation and immunological characterization of a glucose-regulated fibroblast cell surface glycoprotein and its nonglycosylated precursor ⬇️

artículo científico publicado el 1 de enero de 1978

Isolation and properties of fibroblast mutants overexpressing an altered Na+/H+ antiporter.

artículo científico publicado en 1986

Isolation of a Chinese hamster fibroblast mutant defective in hexose transport and aerobic glycolysis: its use to dissect the malignant phenotype

artículo científico publicado en 1980

JunD reduces tumor angiogenesis by protecting cells from oxidative stress

artículo científico publicado en 2004

Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction

artículo científico publicado en 2015

Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis

artículo científico publicado en 2012

Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory

artículo científico publicado en 2002

Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation

artículo científico publicado en 2015

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

artículo científico publicado en 2016

Leu143 in the putative fourth membrane spanning domain is critical for amiloride inhibition of an epithelial Na+/H+ exchanger isoform (NHE-2).

artículo científico publicado en 1993

Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia

artículo científico publicado en 2015

Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6.

scientific article published on January 2010

Low cytoplasmic pH inhibits endocytosis and transport from the trans-Golgi network to the cell surface

artículo científico publicado en 1989

MAP kinase module: role in the control of cell proliferation

artículo científico publicado el 1 de enero de 1995

MAP kinases and hypoxia in the control of VEGF expression

artículo científico publicado en 2000

MAP kinases: activation, subcellular localization and role in the control of cell proliferation

artículo científico publicado en 1993

MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo

artículo científico publicado en 2004

MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma

artículo científico publicado en 2002

Major contribution of MEK1 to the activation of ERK1/ERK2 and to the growth of LS174T colon carcinoma cells

artículo científico publicado en 2008

Mammalian MAP kinase modules: how to transduce specific signals

artículo científico publicado el 1 de enero de 1997

Mechanical allodynia but not thermal hyperalgesia is impaired in mice deficient for ERK2 in the central nervous system

artículo científico publicado en 2012

Membrane-bound carbonic anhydrases are key pH regulators controlling tumor growth and cell migration

artículo científico publicado en 2009

Metabolic Plasiticy in Cancers-Distinct Role of Glycolytic Enzymes GPI, LDHs or Membrane Transporters MCTs

artículo científico publicado en 2017

Metabolism of hexuronides and hexuronates in Escherichia coli K12: physiologic and genetic aspects of its regulation

artículo científico publicado en 1974

MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines.

artículo científico publicado en 2013

Microfilament bundles and cell shape are related to adhesiveness to substratum and are dissociable from growth control in cultured fibroblasts ⬇️

artículo científico publicado el 1 de marzo de 1977

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation

artículo científico publicado en 1993

Mitogen-potentiating action and binding characteristics of insulin and insulin-like growth factors in Chinese hamster fibroblasts ⬇️

artículo científico publicado el 1 de septiembre de 1983

Mitogenic effects of fibroblast growth factors in cultured fibroblasts. Interaction with the G-protein-mediated signaling pathways

artículo científico publicado en 1991

Molecular aspects of the structure and mechanism of the voltage-dependent sodium channel ⬇️

artículo científico publicado el 1 de enero de 1980

Molecular biology and hormonal regulation of vertebrate Na+/H+ exchanger isoforms

artículo científico publicado en 1994

Molecular biology and hormonal regulation of vertebrate Na+/H+ exchanger isoforms.

artículo científico publicado en 1993

Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger ⬇️

artículo científico publicado el 1 de agosto de 1991

Molecular cloning of the growth-factor-activatable human Na+/H+ antiporter

scientific article published on 01 January 1988

Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter

artículo científico publicado en 1989

Molecular physiology of vertebrate Na+/H+ exchangers

artículo científico publicado en 1997

Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect

artículo científico publicado en 2015

Multiple division cycles and long-term survival of hepatocytes are distinctly regulated by extracellular signal-regulated kinases ERK1 and ERK2.

artículo científico publicado en 2009

Mutant α subunits of Gi2 inhibit cyclic AMP accumulation ⬇️

artículo científico publicado el 2 de mayo de 1991

Mutants of mouse fibroblasts altered in the synthesis of cell surface glycoproteins. Preliminary evidence for a defect in the acetylation of glucosamine 6-phosphate ⬇️

artículo científico publicado el 10 de marzo de 1977

Mutation of calmodulin-binding site renders the Na+/H+ exchanger (NHE1) highly H(+)-sensitive and Ca2+ regulation-defective

scientific article published on 01 May 1994

Mutations of the structural gene of 2-keto-3-desoxy-6-P-gluconate aldolase in E. coli K 12 ⬇️

artículo científico publicado el 1 de enero de 1972

Na(+)/H(+) antiporter (NHE1) and lactate/H(+) symporters (MCTs) in pH homeostasis and cancer metabolism

artículo científico publicado en 2016

Na+/H+ antiporter gene expression during monocytic differentiation of HL60 cells

artículo científico publicado en 1991

Na+/H+ antiporter gene expression increases during retinoic acid‐induced granulocytic differentiation of HL60 cells ⬇️

artículo científico publicado el 1 de mayo de 1992

Na/H exchange activities in NHE1-transfected OK-cells: cell polarity and regulation

artículo científico publicado en 1993

Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells

artículo científico

Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry

artículo científico publicado en 1999

Nucleotide sequence of the Chinese hamster Na+/H+ exchanger NHE1.

artículo científico publicado en 1993

Okadaic acid, a phosphatase inhibitor, induces activation and phosphorylation of the Na+/H+ antiport

artículo científico publicado en 1991

Oncogenic Raf-1 activates p70 S6 kinase via a mitogen-activated protein kinase-independent pathway

artículo científico publicado en 1996

Optimized Protocol for the In Situ Derivatization of Glutathione with N-Ethylmaleimide in Cultured Cells and the Simultaneous Determination of Glutathione/Glutathione Disulfide Ratio by HPLC-UV-QTOF-MS

scientific article published on 17 July 2020

Overexpression of carbonic anhydrase XII in tissues from resectable non-small cell lung cancers is a biomarker of good prognosis

artículo científico publicado en 2010

Oxygen tension regulates pancreatic beta-cell differentiation through hypoxia-inducible factor 1alpha

artículo científico publicado en 2009

Oxygen, a source of life and stress

artículo científico publicado en 2007

Oxygen, hypoxia, and stress.

artículo científico publicado en 2007

PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation

artículo científico publicado en 2003

PHD2 mutation and congenital erythrocytosis with paraganglioma.

artículo científico publicado en 2008

PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis

artículo científico publicado en 2008

Pertussis toxin inhibits thrombin-induced activation of phosphoinositide hydrolysis and Na+/H+ exchange in hamster fibroblasts

artículo científico publicado en 1986

Pharmacological characterization of stably transfected Na+/H+ antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties.

artículo científico publicado en 1993

Pharmacological inhibitors of the ERK signaling pathway: application as anticancer drugs

artículo científico publicado el 1 de enero de 2003

Phosphorylation of Na(+)-H+ antiporter is not stimulated by phorbol ester and acidification in granulocytic HL-60 cells

artículo científico publicado en 1993

Physical and genetic mapping of a human apical epithelial Na+/H+ exchanger (NHE3) isoform to chromosome 5p15.3.

artículo científico publicado en 1993

Physical interactions and functional coupling between Daxx and sodium hydrogen exchanger 1 in ischemic cell death

artículo científico publicado en 2007

Physiologic and genetic control of metabolism of 2-keto-3-deoxy-gluconate in E. coli K 12. Regulon kdg

artículo científico publicado el 10 de abril de 1972

Polar opposites: Erk direction of CD4 T cell subsets

artículo científico publicado en 2012

Positron emission tomography/computed tomography imaging of residual skull base chordoma before radiotherapy using fluoromisonidazole and fluorodeoxyglucose: potential consequences for dose painting

artículo científico publicado en 2012

Post-translational and activation-dependent modifications of the G protein-coupled thrombin receptor.

artículo científico

Production of 2-keto-3-deoxy-6-phosphogluconate by a mutant of Escherichia coli K 12

artículo científico publicado en 1970

Progressive relaxation of Go-arrest controls and altered responsiveness to insulin, EGF and thrombin in CCL39 lung fibroblasts over-expressing myc and ras oncogenes

artículo científico publicado en 1988

Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

artículo científico publicado en 2006

Protein kinases and the hypoxia-inducible factor-1, two switches in angiogenesis

artículo científico publicado en 2003

Proton dynamics in cancer

artículo científico publicado en 2010

Quantitative in vivo characterization of intracellular and extracellular pH profiles in heterogeneous tumors: a novel method enabling multiparametric pH analysis

artículo científico publicado en 2013

RT-PCR method to quantify vascular endothelial growth factor expression.

artículo científico publicado en 2001

Random mutagenesis reveals a novel site involved in inhibitor interaction within the fourth transmembrane segment of the Na+/H+ exchanger-1

scientific article published on 01 March 1997

Redox regulation of the hypoxia-inducible factor

artículo científico publicado en 2006

Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation

artículo científico publicado en 1999

Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function

artículo científico publicado en 1998

Regulation of tumor cell motility by ERK mitogen-activated protein kinases

artículo científico publicado en 2004

Regulatory mechanisms of fear extinction and depression-like behavior

artículo científico publicado en 2007

Relationship between increased aerobic glycolysis and DNA synthesis initiation studied using glycolytic mutant fibroblasts

artículo científico publicado en 1980

Reply to Beltinger: Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism

artículo científico publicado en 2019

Response of CAIX and CAXII to in vitro re-oxygenation and clinical significance of the combined expression in NSCLC patients

artículo científico publicado en 2013

Responsiveness of mutants of NHE1 isoform of Na+/H+ antiport to osmotic stress

artículo científico publicado en 1995

Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy

scientific article published on 01 October 2019

Role of a Na+-dependent Cl-/HCO3- exchange in regulation of intracellular pH in fibroblasts

artículo científico publicado en 1985

Role of cell surface carbohydrates and proteins in cell behavior: studies on the biochemical reversion of an N-acetylglucosamine-deficient fibroblast mutant ⬇️

artículo científico publicado el 1 de enero de 1977

Role of cytoplasmic domain of the Na+/H+ exchanger in hormonal activation.

artículo científico publicado en 1993

S

SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity

artículo científico publicado en 2007

Selective inhibition of MEK1/2 reveals a differential requirement for ERK1/2 signalling in the regulation of HIF-1 in response to hypoxia and IGF-1.

artículo científico publicado en 2007

Serotonin as a growth factor

artículo científico publicado en 1990

Serotonin stimulates DNA synthesis in fibroblasts acting through 5-HT1B receptors coupled to a Gi-protein

artículo científico publicado en 1988

Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor

artículo científico publicado en 1996

Signal transduction in hamster fibroblasts overexpressing the human EGF receptor

artículo científico publicado en 1989

Signal transduction. An arresting start for MAPK.

artículo científico publicado en 2000

Signaling angiogenesis via p42/p44 MAP kinase and hypoxia

artículo científico publicado en 2000

Signaling angiogenesis via p42/p44 MAP kinase cascade

artículo científico publicado en 2000

Signaling pathways of the thrombin receptor

artículo científico publicado en 1993

Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications

artículo científico publicado en 2005

Simultaneous positron emission tomography and ultrafast ultrasound for hybrid molecular, anatomical and functional imaging

artículo científico publicado en 2018

Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels

artículo científico publicado en 2007

Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility

artículo científico publicado en 2006

Spatiotemporal regulation of the p42/p44 MAPK pathway

artículo científico publicado en 2001

Spontaneous chondroma formation in CD2-Cre-driven Erk-deficient mice

artículo científico publicado en 2017

Stimulation of phosphatidylcholine breakdown by thrombin and carbachol but not by tyrosine kinase receptor ligands in cells transfected with M1 muscarinic receptors. Rapid desensitization of phosphocholine-specific (PC) phospholipase D but sustained

artículo científico publicado en 1992

Stress-activated protein kinases (JNK and p38/HOG) are essential for vascular endothelial growth factor mRNA stability.

artículo científico publicado en 2000

Strong and persistent activation of inositol lipid breakdown induces early mitogenic events but not Go to S phase progression in hamster fibroblasts. Comparison of thrombin and carbachol action in cells expressing M1 muscarinic acetylcholine recepto

artículo científico publicado en 1990

Structural and functional analysis of a chimeric protein COL1A1-PDGFB generated by the translocation t(17;22)(q22;q13.1) in Dermatofibrosarcoma protuberans (DP).

artículo científico publicado en 2001

Structure function of the growth factor-activatable Na+/H+ exchanger (NHE1) ⬇️

artículo científico publicado el 1 de enero de 1992

Structure of the 5'-flanking regulatory region and gene for the human growth factor-activatable Na/H exchanger NHE-1.

artículo científico publicado en 1991

Structure, function, and regulation of vertebrate Na+/H+ exchangers.

artículo científico publicado en 1993

Structure-activity analysis of synthetic α-thrombin-receptor-activating peptides ⬇️

artículo científico publicado el 15 de junio de 1993

Structure-function studies and molecular regulation of the growth factor activatable sodium-hydrogen exchanger (NHE-1).

artículo científico publicado en 1995

Structure/function studies of the epithelial isoforms of the mammalian Na+/H+ exchanger gene family

artículo científico publicado en 1993

Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity

artículo científico publicado en 1993

Study of MAPK signaling using knockout mice.

artículo científico publicado en 2004

Study of the common degradative pathway of hexuronates in Escherichia coli K 12. Purification, properties and individuality of 2-keto-3-deoxy-D-gluconnokinase

artículo científico publicado el 1 de enero de 1971

Substrate Recognition Domains within Extracellular Signal-regulated Kinase Mediate Binding and Catalytic Activation of Mitogen-activated Protein Kinase Phosphatase-3

artículo científico publicado en 2000

Sugar transport in chick embryo cardiac cells in culture: analysis by countertransport, relationship to phosphorylation and effect of glucose starvation

scientific article published on 01 November 1980

Synthetic alpha-thrombin receptor peptides activate G protein-coupled signaling pathways but are unable to induce mitogenesis ⬇️

artículo científico publicado el 1 de enero de 1992

TGF-beta 1 and cAMP attenuate cyclin A gene transcription via a cAMP responsive element through independent pathways.

artículo científico publicado en 1995

TGF-beta inhibits growth factor-induced DNA synthesis in hamster fibroblasts without affecting the early mitogenic events

artículo científico publicado en 1988

TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation

scientific journal article

Targeting amino acids transporters (SLCs) to starve cancer cells to death

scientific article published on 01 December 2019

Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors

artículo científico publicado en 2011

Targeting pH regulating proteins for cancer therapy-Progress and limitations

artículo científico publicado en 2017

Targeting the ERK signaling pathway in cancer therapy

artículo científico publicado en 2006

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

artículo científico publicado en 2014

The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code

artículo científico publicado en 2017

The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

artículo científico publicado en 2007

The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth

artículo científico publicado en 2011

The MAPK ERK1 is a negative regulator of the adult steady-state splenic erythropoiesis

artículo científico publicado en 2010

The Na(+)/HCO3(-) Co-Transporter SLC4A4 Plays a Role in Growth and Migration of Colon and Breast Cancer Cells

artículo científico publicado en 2015

The Na+/H+ antiporter cytoplasmic domain mediates growth factor signals and controls "H(+)-sensing" ⬇️

artículo científico publicado el 15 de marzo de 1992

The Na+/H+ exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain

artículo científico publicado en 1994

The Na+/H+ exchanger isoform 1 (NHE1) is a novel member of the calmodulin-binding proteins. Identification and characterization of calmodulin-binding sites

artículo científico publicado en 1994

The Na+/H+exchanger is phosphorylated in human platelets in response to activating agents ⬇️

artículo científico publicado el 24 de junio de 1991

The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1.

artículo científico publicado en 2008

The asparaginyl hydroxylase factor-inhibiting HIF is essential for tumor growth through suppression of the p53-p21 axis

artículo científico publicado en 2011

The cytoplasmic domain of the Na+/H+ exchangers (NHEs) dictates the nature of the hormonal response: behavior of a chimeric human NHE1/trout beta NHE antiporter

artículo científico publicado en 1994

The directionality of locomotion of mouse fibroblasts. Role of cell adhesiveness

artículo científico publicado el 1 de julio de 1979

The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascade

scientific article published on 01 January 1997

The expanding family of eucaryotic Na(+)/H(+) exchangers

artículo científico publicado en 2000

The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis

artículo científico publicado en 2005

The gene encoding human retinoic acid-receptor-related orphan receptor alpha is a target for hypoxia-inducible factor 1. ⬇️

artículo científico publicado en 2004

The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5).

artículo científico publicado en 2018

The great joy of a BBRC editor

scientific article published on 01 December 2019

The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization

artículo científico publicado en 1988

The hypoxia-inducible factor and tumor progression along the angiogenic pathway.

artículo científico publicado en 2005

The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling

artículo científico publicado en 2006

The mammalian Na+/H+ exchanger gene family--initial structure/function studies

artículo científico publicado en 1993

The mitogenic signaling pathway of fibroblast growth factor is not mediated through polyphosphoinositide hydrolysis and protein kinase C activation in hamster fibroblasts

scientific article published on 01 December 1986

The mouse p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1) gene. Genomic organization and structure of the 5'-flanking regulatory region

artículo científico publicado en 1995

The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP kinases.

artículo científico publicado en 2001

The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha

artículo científico publicado en 2006

The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal

artículo científico publicado en 2000

The p42/p44 mitogen-activated protein kinase cascade is determinant in mediating activation of the Na+/H+ exchanger (NHE1 isoform) in response to growth factors

artículo científico publicado en 1997

The phosphotyrosine phosphatase PTP1D, but not PTP1C, is an essential mediator of fibroblast proliferation induced by tyrosine kinase and G protein-coupled receptors

artículo científico publicado en 1995

The role of erk1 and erk2 in multiple stages of T cell development

artículo científico publicado en 2005

The role of intracellular pH in ligand internalization

scientific article published on 01 July 1986

The role of the hypoxia-inducible factor in tumor metabolism growth and invasion.

artículo científico publicado en 2006

The silencing approach of the hypoxia-signaling pathway

artículo científico publicado en 2007

The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma

artículo científico publicado en 2018

Thrombin and its receptor in growth control.

artículo científico publicado en 1995

Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production.

artículo científico

Thrombin exerts a dual effect on stimulated adenylate cyclase in hamster fibroblasts, an inhibition via a GTP-binding protein and a potentiation via activation of protein kinase C

artículo científico publicado en 1988

Thrombin-induced protein phosphorylation in resting platelets and fibroblasts: evidence for common post-receptor molecular events

artículo científico publicado en 1983

Tie1 deficiency induces endothelial-mesenchymal transition

artículo científico publicado en 2012

Together we stand, apart we fall: how cell-to-cell contact/interplay provides resistance to ferroptosis

scientific article published on 23 September 2020

Total ERK1/2 activity regulates cell proliferation

artículo científico publicado en 2009

Transcriptional regulation of VCAM-1 expression by tumor necrosis factor-alpha in human tracheal smooth muscle cells: involvement of MAPKs, NF-kappaB, p300, and histone acetylation

artículo científico publicado en 2006

Transcriptional regulation of the Vascular Endothelial Growth Factor gene--a concert of activating factors

artículo científico publicado en 2005

Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling

artículo científico publicado en 2001

Transient Blockade of ERK Phosphorylation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice

artículo científico publicado en 2015

Transmembrane Receptors and Intracellular Pathways that Control Cell Proliferation ⬇️

artículo científico publicado el 1 de enero de 1992

Transmembrane signalling pathways initiating cell growth in fibroblasts.

artículo científico publicado en 1988

Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response

artículo científico publicado en 2019

Tumor cell metabolism: cancer's Achilles' heel

artículo científico publicado en 2008

Tumor hypoxia and metabolism -- towards novel anticancer approaches

artículo científico

Tumor hypoxic and nutritional stress. New anticancer treatment ⬇️

artículo científico publicado el 1 de noviembre de 2010

Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages

artículo científico publicado en 2018

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

artículo científico publicado en 2010

Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin

artículo científico publicado en 1987

Tyrosine kinase-activating growth factors potentiate thrombin- and AIF4- -induced phosphoinositide breakdown in hamster fibroblasts. Evidence for positive cross-talk between the two mitogenic signaling pathways

scientific article published on 01 September 1988

Use of tritium-labeled precursors to select mutants

artículo científico publicado en 1987

Warburg and Beyond: The Power of Mitochondrial Metabolism to Collaborate or Replace Fermentative Glycolysis in Cancer

scientific article published on 30 April 2020

When hypoxia signalling meets the ubiquitin-proteasomal pathway, new targets for cancer therapy

artículo científico publicado en 2005

Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase

artículo científico publicado en 2020

[Hypoxia inducible factor 1a is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells]

artículo científico publicado en 2006

[Induced biosynthesis of the 2 last enzymes of hexuronate degradative sequence in Escherichia coli K 12]

article published in 1970

[Metamorphoses]

artículo científico publicado en 2010

[Regulation of the Hypoxia-Inducible Factor-1alpha (HIF-1alpha): a breath of fresh air in hypoxia research].

artículo científico publicado en 2004

alpha-Thrombin-induced early mitogenic signalling events and G0 to S-phase transition of fibroblasts require continual external stimulation.

artículo científico publicado en 1985

c-myc gene is transcribed at high rate in G0-arrested fibroblasts and is post-transcriptionally regulated in response to growth factors

artículo científico publicado en 1985

cAMP-mediated growth inhibition in fibroblasts is not mediated via mitogen-activated protein (MAP) kinase (ERK) inhibition. cAMP-dependent protein kinase induces a temporal shift in growth factor-stimulated MAP kinases

artículo científico publicado en 1996

cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization

artículo científico publicado en 1991

cDNA cloning and immunolocalization of a Na(+)-H+ exchanger in LLC-PK1 renal epithelial cells ⬇️

artículo científico publicado el 1 de diciembre de 1991

miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity

artículo científico publicado en 2011

p42/mitogen-activated protein kinase as a converging target for different growth factor signaling pathways: use of pertussis toxin as a discrimination factor ⬇️

artículo científico publicado el 1 de agosto de 1991

p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts

artículo científico publicado en 1998

p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol

artículo científico publicado en 2002

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

artículo científico publicado en 1999

p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis.

artículo científico publicado en 2006

p70 S6 kinase-mediated protein synthesis is a critical step for vascular endothelial cell proliferation

artículo científico publicado en 1999

pH control mechanisms of tumor survival and growth ⬇️

artículo científico publicado el 1 de febrero de 2011

pHi, aerobic glycolysis and vascular endothelial growth factor in tumour growth.

artículo científico publicado en 2001

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda