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Lista de obras de Michel Chrétien

'Acrylamide-induced' neuropathy and impairment of axonal transport of proteins. I. Multifocal retention of fast transported proteins at the periphery of axons as revealed by light microscope radioautography

artículo científico publicado en 1981

60 YEARS OF POMC: From the prohormone theory to pro-opiomelanocortin and to proprotein convertases (PCSK1 to PCSK9)

artículo científico publicado en 2016

7B2, a possible marker for nonfunctioning pancreatic islet cell tumor

artículo científico publicado en 1991

A betaLPH precursor model: recent developments concerning morphine-like substances

artículo científico publicado en 1977

A chimeric proinsulin-CD5 protein expressed in AtT-20 cells is directed to the cell surface via the constitutive pathway

scientific article published on 01 September 1995

A fluorogenic peptide containing the processing site of human SARS corona virus S-protein: kinetic evaluation and NMR structure elucidation.

artículo científico publicado en 2007

A novel serine protease (IRCM-serine protease 1) from porcine neurointermediate and anterior pituitary lobes. Isolation, polypeptide chain structure, inhibitor sensitivity, and substrate specificity with fluorogenic peptide substrates

artículo científico publicado en 1986

A rapid fluorometric assay for the proteolytic activity of SKI-1/S1P based on the surface glycoprotein of the hemorrhagic fever Lassa virus

artículo científico publicado en 2002

A specific homologous radioimmunoassay for human beta-endorphin: direct measurement in biological fluids

artículo científico publicado en 1980

A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat.

artículo científico publicado en 2007

AIDS in Canada

artículo científico publicado en 1990

ANF (Arg 101--Tyr 126) is the peptide secreted by rat atrial cardiocytes in culture

artículo científico publicado en 1985

ANF mRNA is detected by the polymerase chain reaction technique in the chorioidea and bodies but not in the retina of the rat eye

scientific article published on 01 July 1991

Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases

artículo científico publicado en 2005

Acromegaly and empty sella turcica

artículo científico publicado el 1 de febrero de 1975

Acrylamide neuropathy and changes in the axonal transport and muscular content of the molecular forms of acetylcholinesterase ⬇️

artículo científico publicado el 1 de abril de 1982

Action of Testosterone on the Differentiation and Secretory Activity of a Target Organ: The Submaxillary Gland of the Mouse

artículo científico publicado el 1 de enero de 1977

Aldosterone secretion inhibitory factor: a novel neuropeptide in bovine chromaffin cells

scientific article published on 01 March 1989

Allelic clustering and ancestry-dependent frequencies of rs6232, rs6234, and rs6235 PCSK1 SNPs in a Northern Ontario population sample

artículo científico publicado en 2012

Alpha1-antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway

artículo científico publicado en 1997

Amino acid sequence of rabbit kidney neutral endopeptidase 24.11 (enkephalinase) deduced from a complementary DNA.

artículo científico publicado en 1987

Amino acids of the Torpedo marmorata acetylcholine receptor alpha subunit labeled by a photoaffinity ligand for the acetylcholine binding site

artículo científico publicado en 1988

Aminoethyl benzenesulfonyl fluoride and its hexapeptide (Ac-VFRSLK) conjugate are both in vitro inhibitors of subtilisin kexin isozyme-1.

artículo científico publicado en 2004

An aldosterone stimulating agent: a novel human pituitary hormone from pro-opiomelanocortin

scientific article published on 01 January 1981

An infant with deletion of the distal long arm of chromosome 15 (q26.1----qter) and loss of insulin-like growth factor 1 receptor gene. ⬇️

artículo científico publicado en 1991

Analgesic action of chronic high levels of endogenous neuropeptides in rats bearing the MtT-F4 tumor

artículo científico publicado en 1980

Antiviral activity of quercetin-3-β-O-D-glucoside against Zika virus infection.

artículo científico publicado en 2017

Apolipoprotein A-I binds to a family of bovine seminal plasma proteins

artículo científico publicado en 1989

Application of the multiple antigenic peptides (MAP) strategy to the production of prophormone convertases antibodies: Synthesis, characterization and use of 8-branched immunogenic peptides

article

Association of the rs562556 PCSK9 Gene Polymorphism with Reduced Mortality in Severe Malaria among Malian Children

artículo científico publicado en 2020

Associations Between Soluble LDLR and Lipoproteins in a White Cohort and the Effect of PCSK9 Loss-of-Function

artículo científico publicado en 2018

Atrial natriuretic factor: isolation, identification, biological and pharmacological actions

artículo científico publicado en 1985

Atrial pronatriodilatin: a precursor for natriuretic factor and cardiodilatin

scientific article published on 01 June 1984

Axonal flow and toxic neuropathies

artículo científico publicado el 1 de enero de 1980

Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin

artículo científico publicado en 2005

Beta-endorphin and beta-lipotropin secretion by an ACTH-secreting mouse pituitary tumor

artículo científico publicado en 1978

Beta-endorphin induced akinesia in rats: a pharmacological study (author's transl)

artículo científico publicado el 1 de octubre de 1979

Beta-endorphin induced akinesia in rats: effect of apomorhine and alpha-methyl-p-tyrosine and related modifications of dopamine turnover in the basal ganglia

artículo científico publicado en 1977

Beta-lipotropin precursor of beta-MSH and beta-endorphin

artículo científico publicado el 1 de enero de 1979

Binding inhibition by monoclonal antibodies of ovine placental lactogen to growth hormone receptors in human liver

artículo científico publicado en 1986

Biochemical aspects of a new hormone: rat atrial natriuretic factor (rANF)

artículo científico publicado en 1985

Biosynthesis of beta-endorphin

artículo científico publicado el 1 de marzo de 1978

Biosynthesis of beta-endorphin by the neurointermediate lobes from rats treated with morphine or alcohol

artículo científico publicado en 1981

Biosynthesis of beta-endorphin from beta-lipotropin and a larger molecular weight precursor in rat pars intermedia ⬇️

artículo científico publicado el 1 de octubre de 1978

Biosynthesis of beta-endorphin, beta-lipotropin and the putative ACTH-LPH precursor in the frog pars intermedia

artículo científico publicado en 1978

Blood cortisol in neoplasm cases

artículo científico publicado en 1971

CNS connections with the median raphe nucleus: retrograde tracing with WGA-apoHRP-Gold complex in the rat

artículo científico publicado en 1989

Cataleptic effect of 61-91 beta-lipotropic hormone in rat.

artículo científico publicado en 1977

Cathepsin-B Fusion Proteins Misroute Secretory Protein Partners Such as the Proprotein Convertase PC2-7B2 Complex toward the Lysosomal Degradation Pathways

artículo científico publicado en 2000

Cell-free synthesis of porcine proopiomelanocortin: two distinct primary translation products ⬇️

artículo científico publicado el 1 de junio de 1983

Changes of Endocrine Properties of a Transplantable, Multihormonal, Pituitary Tumor (MtT-F4) After Hypophysectomy of Host Rats ⬇️

artículo científico publicado el 1 de marzo de 1975

Characterization of N-terminal fragment of proopiomelanocortin in cerebrospinal fluid

artículo científico publicado en 1987

Characterization of a repressor element in the promoter region of proprotein convertase 2 (PC2) gene

artículo científico publicado en 2002

Characterization of multiple forms of porcine anterior pituitary proopiomelanocortin amino-terminal glycopeptide

artículo científico publicado en 1982

Characterization of peptides derived from pro-opiomelanocortin in the biological fluids of a patient with Nelson's syndrome.

artículo científico publicado en 1985

Chemical Characterization of Adrenocorticotropin and a Novel Peptide Biosynthesized from a Pituitary Adenoma of a Patient with Cushing' Disease* ⬇️

artículo científico publicado el 1 de agosto de 1980

Chromogranin A can act as a reversible processing enzyme inhibitor

artículo científico publicado en 1987

Chromogranin B (secretogranin I), a putative precursor of two novel pituitary peptides through processing at paired basic residues

artículo científico publicado en 1987

Chronic ethanol treatment alters the biosynthesis of β -endorphin by the rat neurointermediate lobe ⬇️

artículo científico publicado el 1 de septiembre de 1983

Circular dichroism studies of sheep β-lipotropic hormone ⬇️

artículo científico publicado el 1 de noviembre de 1976

Comparing expression and activity of PCSK9 in SPRET/EiJ and C57BL/6J mouse strains shows lack of correlation with plasma cholesterol

scientific article published on 10 December 2016

Complete amino acid sequence of Shigella toxin B-chain. A novel polypeptide containing 69 amino acids and one disulfide bridge

scientific article published on 01 October 1986

Complete amino acid sequence of a VLDV-type neurophysin from ostrich differs markedly from known mammalian neurophysins

artículo científico publicado en 1987

Complete sequence of the glycosylated amino terminal segment of porcine pro-opiomelanocortin

artículo científico publicado en 1981

Complete structure of the porcine pro-opiomelanocortin mRNA derived from the nucleotide sequence of doned cDNA ⬇️

artículo científico publicado el 25 de noviembre de 1983

Concomitant synthesis of beta-endorphin and alpha-melanotropin from two forms of pro-opiomelanocortin in the rat pars intermedia ⬇️

artículo científico publicado el 1 de octubre de 1979

Content of beta-LPH and its fragments (including endorphins) in anterior and intermediate lobes of the bovine pituitary gland

artículo científico publicado en 1978

Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo.

artículo científico publicado en 2003

Corticotropin releasing factor (CRF): effects on the release of pro-opiomelanocortin (POMC)-related peptides by human anterior pituitary cells in vitro

artículo científico publicado en 1982

Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1.

artículo científico publicado en 2003

Cyclic nucleotides and platelet aggregation in hypertensive rats with ectopic pituitary tumor.

artículo científico publicado en 1980

Cyclical edema and hypokalemia due to occult episodic hypercorticism

scientific article published on 01 January 1987

Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse

artículo científico publicado en 2006

Demonstration of the vasopressin associated glycopeptide in the brain and peripheral tissues of the Brattleboro rat.

artículo científico publicado en 1986

Dependence of tonin activity in rat submaxillary gland on growth hormone and testosterone

artículo científico publicado en 1977

Depolarizing action of secretory granule protein 7B2 on rat supraoptic neurosecretory neurons

artículo científico publicado en 1993

Development of hyperlipidemia associated with increased lipolytic response of isolated adipose tissue cells following prolonged stimulation by an ectopic pituitary tumor

artículo científico publicado en 1978

Developmental changes in immunoreactive content of novel pituitary protein 7B2 in human pancreas and its identification in pancreatic tumors

artículo científico publicado en 1987

Differences of pancreatic expression of 7B2 between C57BL/6J and C3H/HeJ mice and genetic polymorphisms at its locus (Sgne1).

artículo científico publicado en 2006

Different processing of chromogranin B into GAWK-immunoreactive fragments in the bovine adrenal medulla and pituitary gland

artículo científico publicado en 1988

Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations

artículo científico publicado en 2013

Dynamics of 7B2 and galanin expression in solitary magnocellular hypothalamic vasopressin neurons of the homozygous Brattleboro rat.

artículo científico publicado en 1992

Effect of N-Terminal Portion of Pro-opiomelanocortin on Aldosterone Release by Human Adrenal Adenomain Vitro* ⬇️

artículo científico publicado el 1 de junio de 1981

Effect of beta-lipotropin on aldosterone production in the isolated rat adrenal cell preparation

artículo científico publicado en 1982

Effect of clofibrate treatment on chronic hyperlipidemia induced by an ACTH-producing tumor ⬇️

artículo científico publicado el 1 de abril de 1977

Effect of somatostatin on growth hormone release by MtT-F4 rat pituitary tumor in vitro ⬇️

artículo científico publicado el 1 de agosto de 1977

Effects of Pituitary β-LPH on Blood Platelets and Coagulation in Rabbits ⬇️

artículo científico publicado el 1 de septiembre de 1971

Effects of glacial acetic acid on the extraction, chemical stability, and biological activities of beta-LPH.

artículo científico publicado en 1970

Effects of pro-opiomelanocortin fragments on release of catecholamines from adrenal chromaffin cells

artículo científico publicado en 1982

Effects of proopiomelanocortin-derived peptides, methionine-enkephalin and forskolin on the maturation of ovine fetal adrenal cells in culture

artículo científico publicado en 1984

Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity

scientific article published on 24 September 2011

Endoproteolysis in health and diseases--implications of proprotein convertases (PCs)

scientific article published on 08 September 2005

Endoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling

scientific journal article

Endorphins: structure, roles and biogenesis ⬇️

artículo científico publicado el 1 de mayo de 1981

Enzymatic cleavage of pro-opiomelanocortin by anterior pituitary granules. Evidence for a chymotryptic-like enzyme

artículo científico publicado en 1983

Ethnic differences in the frequency of the cardioprotective C679X PCSK9 mutation in a West African population

artículo científico publicado en 2008

Eukaryotic protein processing: endoproteolysis of precursor proteins

artículo científico publicado en 1997

Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi.

artículo científico publicado en 2005

Evidence for the release of a novel pituitary polypeptide (7B2) from the growth hormone-producing pituitary adenoma of patients with acromegaly

artículo científico publicado en 1988

Experimental hyperlipidemia in rats

artículo científico publicado el 1 de enero de 1979

Expression and Sorting of Rat Plasma Kallikrein in POMC-Producing AtT-20 Cells

scholarly article by N. SAWYER published in May 1991

Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.

artículo científico publicado en 2005

Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine.

artículo científico publicado en 2008

Expression of neuroendocrine secretory protein 7B2 mRNA in the mouse and rat pituitary gland.

artículo científico publicado en 1993

Expression of the neuroendocrine cell marker 7B2 in human ACTH secreting tumours

artículo científico publicado el 1 de junio de 1992

Expression of the prohormone convertase PC2 correlates with the presence of corticotropin-like intermediate lobe peptide in human adrenocorticotropin-secreting tumors

artículo científico publicado en 1994

Formation of secretion granules in the Golgi apparatus of plasma cells in the rat

artículo científico publicado en 1989

Formation of secretory granules in the Golgi apparatus of prolactin cells in the rat pituitary gland: a stereoscopic study

artículo científico publicado en 1992

From β-lipotropin to β-endorphin and 'pro-opio-melanocortin' ⬇️

artículo científico publicado el 1 de septiembre de 1979

Functional aspects of multitransmitter neurons. Studies of interactions among pro-opiomelanocortin products.

artículo científico publicado en 1987

Functional diversity of bioactive peptides in the nervous system itself: "how the brain may understand".

artículo científico publicado en 1989

Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis

artículo científico publicado en 2005

GAWK, a novel human pituitary polypeptide: isolation, immunocytochemical localization and complete amino acid sequence

artículo científico publicado en 1985

Gene expression of peptides: the pro-opiomelanocortin model

artículo científico publicado el 1 de enero de 1982

Genetic mapping of the gene for SKI-1/S1P protease (locus symbol Mbtps1) to mouse chromosome 8.

artículo científico publicado en 2002

Henry Friesen Lecture. Clinical relevance of convertases: atherosclerosis, Alzheimer's disease, obesity, diabetes and HIV.

artículo científico publicado en 1999

Homologous IRCM-serine protease 1 from pituitary, heart atrium and ventricle: a common pro-hormone maturation enzyme?

artículo científico publicado en 1986

How the prohormone theory solved two important controversies in hormonal and neural Peptide biosynthesis

artículo científico

Human NH2 terminal of pro-opiomelanocortin as a potential marker for pulmonary carcinoma

artículo científico publicado en 1983

Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates.

artículo científico publicado en 1987

Hyperlipoproteinemia induced by a transplantable pituitary tumor in the rat ⬇️

artículo científico publicado el 1 de enero de 1979

Identification and localization of 7B2 protein in human, porcine, and rat thyroid gland and in human medullary carcinoma

artículo científico publicado en 1988

Identification of a biologically active circulating form of rat atrial natriuretic factor

artículo científico publicado en 1985

Identification of the released form of atrial natriuretic factor by the perfused rat heart

artículo científico publicado en 1986

Immunocytochemistry of the C-terminal peptide of propressophysin (CPP): relationship to vasopressin, oxytocin and neurophysin

artículo científico publicado en 1983

Immunohistochemical localization of beta-lipotropic hormone in the pituitary gland

artículo científico publicado en 1977

Immunohistochemical localization of human pituitary glycopeptide (HPGP)-like immunoreactivity in the hypothalamus and pituitary of normal and homozygous diabetes insipidus (Brattleboro) rats

artículo científico publicado en 1982

Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis.

artículo científico publicado en 2005

Immunological characterization of beta-lipotropin fragments (endorphin, beta-MSH, and N-fragment) from fish pituitaries

artículo científico publicado en 1978

Immunological identification and sequence characterization of a peptide derived from the processing of neuroendocrine protein 7B2.

artículo científico publicado en 1991

Immunoreactive beta-endorphin in the rat mammotropic transplantable tumor (MtT-F4) ⬇️

artículo científico publicado el 1 de junio de 1978

Impairment of rapid axonal transport and concomitant anomaly of smooth endoplasmic reticulum in acrylamide induced neuropathy

artículo científico publicado el 19 de febrero de 1979

Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus

artículo científico publicado en 2005

Implications of proprotein Convertase 5 (PC5) in the arterial restenotic process in a porcine model.

artículo científico publicado en 2004

In vitro biosynthesis and chemical characterization of beta-lipotropin, gamma-lipotropin, and beta-endorphin in rat pars intermedia ⬇️

artículo científico publicado el 1 de julio de 1978

In vitro biosynthesis of beta-endorphin in pituitary glands ⬇️

artículo científico publicado el 1 de abril de 1977

In vitro biosynthesis of beta-endorphin, gamma-lipoprotein, and beta-lipotropin by the pars intermedia of beef pituitary glands ⬇️

artículo científico publicado el 1 de octubre de 1977

In vitro biosynthesis of beta-lipotropin in brain tissue

artículo científico publicado el 5 de febrero de 1979

In vitro biosynthesis of γ-lipotropic hormone ⬇️

artículo científico publicado el 1 de junio de 1976

In vitro elucidation of substrate specificity and bioassay of proprotein convertase 4 using intramolecularly quenched fluorogenic peptides.

artículo científico publicado en 2004

In vivo bioassay of ACTH: new developments.

artículo científico publicado en 1970

Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2.

artículo científico publicado en 2006

Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein

artículo científico publicado en 2008

Inhibition of binding of ovine placental lactogen to growth hormone and prolactin receptors by monoclonal antibodies

artículo científico publicado en 1986

Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions

artículo científico publicado en 2001

Inhibition of release of a novel pituitary polypeptide, 7B2, follicle-stimulating hormone, and luteinizing hormone from rat anterior pituitary cells in vitro by human beta-inhibin

artículo científico publicado en 1986

Inhibitory specificity and potency of proSAAS-derived peptides toward proprotein convertase 1.

artículo científico publicado en 2001

Intranuclear rodlets in the substantia nigra: interactions with marinesco bodies, ubiquitin, and promyelocytic leukemia protein

artículo científico publicado en 2004

Involvement of matrix metalloproteinases in the adipose conversion of 3T3-L1 preadipocytes.

artículo científico publicado en 2002

Isolation and NH2-terminal sequence of a novel porcine anterior pituitary polypeptide. Homology to proinsulin, secretin and Rous sarcoma virus transforming protein TVFV60.

artículo científico publicado en 1982

Isolation and characterization of four proteases from porcine pituitary neurointermediate lobes: relationship to the maturation enzyme of prohormones

artículo científico publicado en 1985

Isolation and characterization of β-lipolytic hormone from porcine pituitary gland ⬇️

artículo científico publicado el 1 de septiembre de 1970

Isolation and partial characterization of a biosynthetic N-terminal methionyl peptide of bovine pars intermedia: relationship to ubiquitin

artículo científico publicado en 1978

Isolation of peptides with opiate activity from sheep and human pituitaries: relationship to beta-lipotropin

artículo científico publicado en 1976

Lipogenic Activity of a Potent Lipolytic Hormone: Sheep β Lipotropin (β-LPH) - II. Further Effects of Sheep β-LPH on Specifically Labeled Glucose and the Localization of Lipogenic Active Center of the Molecule ⬇️

artículo científico publicado el 1 de enero de 1972

Lipogenic activity of a potent lipolytic hormone: sheep beta lipotropin (beta-LPH). A comparative study of the effects of beta-LPH and insulin on in vitro glucose metabolism of adipose tissue

artículo científico publicado en 1970

Lipolytic activity of rat pituitaries in vitro

artículo científico publicado en 1973

Lipolytic response, cyclic AMP and cyclic GMP accumulation in rat adipocytes stimulated with ACTH: Effect of MtT-F4 tumor and clofibrate treatment ⬇️

artículo científico publicado el 1 de julio de 1979

Lipotropic and adrenocorticotropic hormones. Biological activities of the carboxyl-modified hormones

artículo científico publicado en 1974

Localization of the human prostatic secretory protein PSP94 and its mRNA in the epithelial cells of the prostate

artículo científico publicado en 1988

Loss- and gain-of-function PCSK9 variants: cleavage specificity, dominant negative effects, and low density lipoprotein receptor (LDLR) degradation

artículo científico publicado en 2012

Lower plasma PCSK9 in normocholesterolemic subjects is associated with upregulated adipose tissue surface-expression of LDLR and CD36 and NLRP3 inflammasome

artículo científico publicado en 2021

Malaria severity: Possible influence of the E670G PCSK9 polymorphism: A preliminary case-control study in Malian children

artículo científico publicado en 2018

Malignant hypertension with hypokalemia in a patient with renin-producing pulmonary carcinoma

artículo científico publicado el 1 de enero de 1975

Measurement of N-Terminal (1–76) of Human Proopiomelanocortin in Human Plasma: Correlation with Adrenocorticotropin* ⬇️

artículo científico publicado el 1 de abril de 1983

Mechanisms required to ensure research integrity ⬇️

artículo científico publicado el 18 de octubre de 2011

Medical research: an absolute necessity and not a tollerated luxury

artículo científico publicado en 1974

Metabolic clearance rate and half-time disappearance rate of human N-terminal and adrenocorticotropin of pro-opiomelanocortin in the rat: a comparative study.

artículo científico publicado en 1983

Mice Fed a High-Cholesterol Diet Supplemented with Quercetin-3-Glucoside Show Attenuated Hyperlipidemia and Hyperinsulinemia Associated with Differential Regulation of PCSK9 and LDLR in their Liver and Pancreas.

artículo científico publicado en 2018

Modification of Cunningham's method for the detection of proteases in tissue sections

artículo científico publicado en 1975

Modification of Cunningham's method for the detection of proteases in tissue sections

artículo científico publicado en 1977

Modulation of the Golgi apparatus in stimulated and nonstimulated prolactin cells of female rats.

artículo científico publicado en 1993

Molecular heterogeneity of pro-atrial natriuretic factor

scientific article published in 1989

Morphine-like substances and the pituitary gland ⬇️

artículo científico publicado el 18 de septiembre de 1976

Morphological aspects of protein synthesis

artículo científico publicado en 1973

Mouse plasma kallikrein: cDNA structure, enzyme characterization, and comparison of protein and mRNA levels among species.

artículo científico publicado en 1990

Multipotent lipotropic hormones. In search of a pituitary cell producing multipotent LPH

artículo científico publicado el 1 de noviembre de 1975

My road to Damascus: how I converted to the prohormone theory and the proprotein convertases ⬇️

artículo científico publicado el 8 de noviembre de 2012

N-Terminal amino acid sequence of rat tonin: homology with serine proteases ⬇️

artículo científico publicado el 1 de septiembre de 1978

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

artículo científico publicado en 2004

NH2-terminal specificity and axonal localization of adrenocorticotropin binding sites in rat median eminence

artículo científico publicado en 1985

Neuroanatomical and functional studies of peptide precursor-processing enzymes

artículo científico publicado en 1991

Neuropeptides in human cerebrospinal fluid

artículo científico publicado en 1985

New perspectives in neuropeptides. Biosynthesis from large precursors. The pro-opio-melanocortin model in the pars intermedia

scientific article published on 01 September 1980

Novel approach to rapid and sensitive localization of protein disulfide bridges by high-performance liquid chromatography and electrochemical detection

Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture

artículo científico publicado en 2011

Obesity and pituitary lipolytic hormones.

artículo científico publicado en 1974

Of PCSK9, cholesterol homeostasis and parasitic infections: possible survival benefits of loss-of-function PCSK9 genetic polymorphisms

artículo científico publicado en 2007

On the circulating form of atrial natriuretic factor

artículo científico publicado en 1985

On the isolation of human pituitary hormones

artículo científico publicado en 1978

Ontogeny of a novel pituitary protein (7B2) in the human fetal intestine

artículo científico publicado en 1985

Ostrich MSEL-neurophysin belongs to the class of two-domain "big" neurophysin as indicated by complete amino acid sequence of the neurophysin/copeptin

artículo científico publicado en 1989

PCSK2-null mice exhibit delayed intestinal motility, reduced refeeding response and altered plasma levels of several regulatory peptides.

artículo científico publicado en 2010

PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans

artículo científico publicado en 2008

PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities.

artículo científico publicado en 2009

PCSK9: a key modulator of cardiovascular health

artículo científico publicado en 2014

Partial Sequence of Trypsin Inhibitor From Ovomucoid ⬇️

artículo científico publicado el 1 de noviembre de 1973

Partial amino acid sequence of a human seminal plasma peptide with inhibin-like activity

artículo científico publicado en 1984

Peptides of the neurointermediary lobe of rat pituitary stimulate GH secretion in vitro

artículo científico publicado en 1983

Peptides related to the N-terminus of pro-opiomelanocortin in the human adrenal medulla

artículo científico publicado en 1989

Pilocarpine-induced seizures are accompanied by a transient elevation in the messenger RNA expression of the prohormone convertase PC1 in rat hippocampus: comparison with nerve growth factor and brain-derived neurotrophic factor expression

artículo científico publicado en 1997

Pituitary lipotropins (LPH)

artículo científico publicado el 1 de abril de 1973

Plasma PCSK9 levels are significantly modified by statins and fibrates in humans

artículo científico publicado en 2008

Plasma PCSK9 levels correlate with cholesterol in men but not in women

artículo científico publicado en 2007

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

artículo científico publicado en 2001

Precursor convertases: an evolutionary ancient, cell-specific, combinatorial mechanism yielding diverse bioactive peptides and proteins

artículo científico publicado en 1998

Presence of a pre-sequence (signal sequence) in the common precursor to ACTH and endorphin and the role of glycosylation in processing of the precursor and secretion of ACTH and endorphin

artículo científico publicado en 1980

Presence of the novel pituitary protein "7B2" in bovine chromaffin granules: possible co-release of 7B2 and catecholamine as induced by nicotine

artículo científico publicado en 1987

Presence of vasopressin, oxytocin and neurophysin in the retina of mammals, effect of light and darkness, comparison with the neuropeptide content of the neurohypophysis and the pineal gland

artículo científico publicado en 1983

Primary hyperaldosteronism: a pituitary--adrenal dysfunction related to a new pituitary glycopeptide?

artículo científico publicado en 1982

Primary structure and morphine-like activity of human β-endorphin ⬇️

artículo científico publicado el 1 de junio de 1977

Primary structure determination of Escherichia coli heat-stable enterotoxin of porcine origin ⬇️

artículo científico publicado el 1 de mayo de 1983

Primary structure of a high M r form of rat atrial natriuretic factor

artículo científico publicado en 1984

Primary structure of mouse chromogranin B deduced from cDNA sequence

artículo científico publicado en 1990

Primary structure of the major human pituitary pro-opiomelanocortin NH2-terminal glycopeptide. Evidence for an aldosterone-stimulating activity

scientific article published on 01 August 1981

Primary structure of the ovine pituitary follitropin beta-subunit

artículo científico publicado en 1981

Processed forms of neuroendocrine proteins 7B2 and secretogranin II are found in porcine pituitary extracts ⬇️

artículo científico publicado el 1 de octubre de 1991

Prophylactic Efficacy of Quercetin 3-β-O-d-Glucoside against Ebola Virus Infection

artículo científico publicado en 2016

Propressophysin is present in neurones at multiple sites in Wistar and homozygous Brattleboro rat brain

artículo científico publicado en 1986

Proprotein and prohormone convertases of the subtilisin family Recent developments and future perspectives

artículo científico publicado en 1992

Proprotein conversion is determined by a multiplicity of factors including convertase processing, substrate specificity, and intracellular environment. Cell type-specific processing of human prorenin by the convertase PC1.

artículo científico publicado en 1992

Proprotein convertase PC5 regulation by PDGF-BB involves PI3-kinase/p70(s6)-kinase activation in vascular smooth muscle cells

scientific journal article

Proprotein convertases and the pathophysiology of human diseases: prospective considerations

artículo científico publicado en 1995

Proprotein convertases are important mediators of the adipocyte differentiation of mouse 3T3-L1 cells.

artículo científico publicado en 2002

Proprotein convertases as therapeutic targets

artículo científico publicado en 2008

Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy

artículo científico publicado en 2002

Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor

artículo científico publicado en 2004

Proprotein convertases subtilisin/kexin type 9, an enzyme turned escort protein: hepatic and extra hepatic functions

artículo científico

Proprotein convertases: lessons from knockouts

artículo científico publicado en 2006

Proteases and posttranslational processing of prohormones: a review ⬇️

artículo científico publicado el 1 de julio de 1983

Proteomic analysis of neuroendocrine peptidergic system disruption using the AtT20 pituitary cell line as a model

artículo científico publicado en 2008

Pulmonary neoplasms and adrenal gland insufficiency: study of a case and hypothesis on an ACTH-inhibiting factor (ACTH-IF) or an abnormal ACTH secreted by the tumor

artículo científico publicado en 1973

Purification and partial chemical characterization of human pituitary lipolytic hormone ⬇️

artículo científico publicado el 1 de septiembre de 1976

Purification and primary structure of pro-aldosterone secretion inhibitory factor from bovine adrenal chromaffin cells

article published in 1989

Purification of ovine placental lactogen (oPL) using high-performance liquid chromatography

artículo científico publicado en 1986

Purification of three rat atrial natriuretic factors and their amino acid composition

article

Quantitative proteomic analysis of PCSK9 gain of function in human hepatic HuH7 cells

artículo científico publicado en 2011

Quercetin-3-glucoside increases low-density lipoprotein receptor (LDLR) expression, attenuates proprotein convertase subtilisin/kexin 9 (PCSK9) secretion, and stimulates LDL uptake by Huh7 human hepatocytes in culture

artículo científico publicado en 2014

Radioimmunoassay of ovine beta-lipotropic hormone

artículo científico publicado en 1972

Radiolabeled biotinyl peptides as useful reagents for the study of proteolytic enzymes

scientific article published on 01 March 1993

Recent progress in endocrinology. Polypeptide hormones

artículo científico publicado el 1 de agosto de 1972

Regional distribution of a novel pituitary protein (7B2) in the rat brain

artículo científico publicado en 1985

Regional distribution of a novel pituitary protein (7B2) in the rat spinal cord: effect of neonatal capsaicin treatment and thoracic cord transection

artículo científico publicado en 1985

Regional heterogeneity in the processing of pro-opiomelanocortin in rat brain

artículo científico publicado en 1983

Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes

artículo científico publicado en 1992

Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase

scientific journal article

Reinvestigation of the N-terminal amino acid sequence of beta-lipotropin from human pituitary glands

artículo científico publicado en 1981

Relationship between testosterone, estradiol and circulating PCSK9: Cross-sectional and interventional studies in humans

scientific article published on 07 April 2015

Renin-angiotensin system in chronically hypophysectomized rats

artículo científico publicado en 1972

Request for hormone-producing tumour material

artículo científico publicado en 1968

Request for hormone-producing tumour material

scientific article published on 01 November 1968

Request for hormone-producing tumour material.

artículo científico publicado en 1969

Residues unique to the pro-hormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity

artículo científico publicado en 1998

Response of Human Aldosteronoma Cells in Culture to the N-Terminal Glycopeptide of Pro-Opiomelanocortin and γ3-MSH

article

Secretory protein 7B2 is associated with pancreatic hormones within normal islets and some experimentally induced tumors

artículo científico publicado en 1988

Selective cleavage of human ACTH, beta-lipotropin, and the N-terminal glycopeptide at pairs of basic residues by IRCM-serine protease 1. Subcellular localization in small and large vesicles

artículo científico publicado en 1986

Selective cleavage of proenkephalin-derived peptides (less than 23,300 daltons) by plasma kallikrein ⬇️

artículo científico publicado el 5 de septiembre de 1988

Sequence determination of a protein with N-terminal glutamic acid after modification of carboxyl groups with carbodiimide as the coupling agent.

artículo científico publicado en 1974

Species specificity of the inhibition of adenylate cyclase activation by products of ACTH-stimulated fat cells.

artículo científico publicado en 1973

Specific cleavage of beta-LPH and ACTH by tonin: release of an opiate-like peptide beta-LPH (61-78).

artículo científico publicado en 1979

Specific release of a novel pituitary polypeptide, 7B2, from rat anterior pituitary cells in vitro by luteinizing hormone-releasing hormone

artículo científico publicado en 1986

Structural and biochemical investigation of heptad repeat derived peptides of human SARS corona virus (hSARS-CoV) spike protein

artículo científico publicado en 2008

Structural and immunological homology of human and porcine pituitary and plasma IRCM-serine protease 1 to plasma kallikrein: marked selectivity for pairs of basic residues suggests a widespread role in pro-hormone and pro-enzyme processing

artículo científico publicado en 1988

Structure and maturation process of pro-opiomelanocortin: a model for other neuropeptides

artículo científico publicado en 1980

Structure of the carboxyl propeptide of chicken type II procollagen determined by DNA and protein sequence analysis

scientific article published in 1984

Structure-function analysis of the prosegment of the proprotein convertase PC5A.

artículo científico publicado en 2002

Subcellular fractionation of pituitary neurointermediate lobes: revelation of various basic proteases

artículo científico publicado en 1984

Substrate specificity of the enzyme tonin: cleavage of substance P

artículo científico publicado en 1980

Synergistical effects of ovine corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) on the release of pro-opiomelanocortin (POMC) related peptides by pituitary adenoma of a patient with Nelson's syndrome in vitro

artículo científico publicado el 1 de enero de 1984

Targeted production of proprotein convertase PC1 enhances mammary development and tumorigenesis in transgenic mice

artículo científico publicado en 2009

The Effect of PCSK9 Loss-of-Function Variants on the Postprandial Lipid and ApoB-Lipoprotein Response.

artículo científico publicado en 2017

The French Language Medical Association of Canada and medical research

artículo científico publicado el 1 de abril de 1979

The IRCM: a model of organization in the quest for scientific excellence. Interview by Robert Henry

artículo científico publicado en 1988

The Importance of Axonal Transport and Endoplasmic Reticulum in the Function of Cholinergic Synapse in Normal and Pathological Conditions

artículo científico publicado el 1 de enero de 1979

The LIM homeobox protein mLIM3/Lhx3 induces expression of the prolactin gene by a Pit‐1/GHF‐1‐independent pathway in corticotroph AtT20 cells ⬇️

artículo científico publicado el 24 de julio de 1998

The Prohormone Theory and the Proprotein Convertases: It Is All About Serendipity ⬇️

artículo científico publicado el 1 de enero de 2011

The amino acid sequences of frog heart atrial natriuretic-like peptide and mammalian ANF are closely related

artículo científico publicado en 1988

The apoB-to-PCSK9 ratio: A new index for metabolic risk in humans.

artículo científico publicado en 2015

The carboxy terminus of the precursor to vasopressin and neurophysin: immunocytochemistry in rat brain

artículo científico publicado en 1982

The clinical investigator of the 1990's.

artículo científico publicado en 1986

The complete amino acid sequence of rat submaxillary gland tonin does contain the aspartic acid at the active site: confirmation by protein sequence analysis

artículo científico publicado en 1987

The enigma of soluble LDLR: could inflammation be the key?

artículo científico publicado en 2020

The ever-expanding saga of the proprotein convertases and their roles in body homeostasis: emphasis on novel proprotein convertase subtilisin kexin number 9 functions and regulation

artículo científico publicado en 2018

The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury

artículo científico publicado en 2020

The major 40-kDa glycoprotein in human prostatic fluid is identical to Zn-alpha 2-glycoprotein

artículo científico publicado en 1987

The major androgen-dependent protease in dog prostate belongs to the kallikrein family: confirmation by partial amino acid sequencing

scientific article published on 01 September 1984

The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing.

artículo científico publicado en 2004

The mouse homeoprotein mLIM-3 is expressed early in cells derived from the neuroepithelium and persists in adult pituitary.

artículo científico publicado en 1994

The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions

artículo científico publicado en 2013

The neuroendocrine precursor 7B2 is a sulfated protein proteolytically processed by a ubiquitous furin-like convertase

scientific article published on 01 July 1994

The pituitary and morphinomimetic peptides

artículo científico publicado el 1 de abril de 1977

The primary structure of human beta-lipotropin. Further peptide sequencing resolves the controversy and suggests the existence of only one human beta-lipotropin

artículo científico publicado en 1982

The propeptide Asn1-Tyr126 is the storage form of rat atrial natriuretic factor

artículo científico publicado en 1987

The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.

artículo científico publicado en 2003

The role of research centers and institutes for biomedical contemporary research

artículo científico publicado en 1992

The role of the NH2-terminal portion of pro-opiomelanocortin as a biomarker for human lung cancer

artículo científico publicado en 1987

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

artículo científico publicado en 2003

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis

artículo científico publicado en 2003

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis

The structure of type IX collagen.

artículo científico publicado en 1985

The use of biomarkers in the prediction of survival in patients with pulmonary carcinoma

artículo científico publicado en 1990

Thyrotropin releasing hormone (TRH)-induced release of 7B2 (neuroendocrine polypeptide) in vivo and in vitro using adenoma cells of a patient with acromegaly

artículo científico publicado en 1991

Tissue distribution and molecular forms of a novel pituitary protein in the rat.

artículo científico publicado en 1984

Tri-dimensional structure of the forming face of the Golgi apparatus as seen in the high voltage electron microscope after osmium impregnation of the small nerve cells in the semilunar ganglion of the trigeminal nerve ⬇️

artículo científico publicado el 1 de enero de 1973

Two anatomical pathways for the renewal of surface glycoproteins in chloride cells of fish gills

artículo científico publicado en 1983

Two glycosylation sites on the N-terminal segment of porcine pars distalis pro-opiomelanocortin

artículo científico publicado en 1980

Ultrastructural localization of secretory granule constituent chromogranin and 7 B 2

artículo científico publicado en 1988

Urinary levels of immunoreactive NH2-terminal of pro-opiomelanocortin in patients with malignant pulmonary disease

artículo científico publicado en 1989

Urinary molecular forms of human N-terminal of proopiomelanocortin: possible deglycosylation and degradation by the kidney

artículo científico publicado en 1984

Value of plasma NH2-terminal fragment of pro-opiomelanocortin in marking human lung cancer in various clinical settings

artículo científico publicado en 1989

Variable effects of gender and Western diet on lipid and glucose homeostasis in aged PCSK9-deficient C57BL/6 mice CSK9PC57BL/6.

artículo científico publicado en 2014

White Adipose Tissue Surface Expression of LDLR and CD36 is Associated with Risk Factors for Type 2 Diabetes in Adults with Obesity

artículo científico publicado en 2020

[Antidiuretic effect of clofibrate in diabetes insipidus]

scientific article published on 01 October 1971

[Corticoadrenal insufficiency (Addison's disease)]

artículo científico publicado en 1984

[Decrease in the immunoreactivity of protein 7B2 in vasopressinergic cells in the supraoptic nucleus and in fibers of the neurohypophysis, in Brattleboro rats]

artículo científico publicado en 1988

[Endorphins 1989: neuroendocrine aspects]

scientific article published on 01 January 1989

[Endorphins: structure, role and biogenesis]

scientific article published on 01 December 1983

[Evaluation of the change process during treatment of adolescent psychotics]

artículo científico publicado en 1990

[In vitro biosynthesis of bovine beta-lipotropic hormone]

artículo científico publicado en 1974

[Physiological roles of endorphins in 1987]

scientific article published on 01 February 1988

beta 2-Inhibin contains the active core of human seminal plasma beta-inhibin: synthesis and bioactivity

artículo científico publicado en 1985

pH-induced conformational transitions of a molten-globule-like state of the inhibitory prodomain of furin: implications for zymogen activation.

artículo científico publicado en 2001

β-Endorphin concentrations in serum, hypothalamus and central gray of hypophysectomized and mediobasal hypothalamus lesioned rats ⬇️

artículo científico publicado el 7 de enero de 1982

β-Estradiol results in a proprotein convertase subtilisin/kexin type 9-dependent increase in low-density lipoprotein receptor levels in human hepatic HuH7 cells

artículo científico publicado en 2015

‘Acrylamide-induced‘ neuropathy and impairment of axonal transport of proteins. II. Abnormal accumulations of smooth endoplasmic reticulum as sites of focal retention of fast transported proteins. Electron microscope radioautographic study ⬇️

artículo científico publicado el 26 de enero de 1981

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