Lista de obras - Michael Botchan - Dominio Público Uruguay

A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation

artículo científico publicado en 2013

A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activity

artículo científico publicado en 2003

A new class of disordered elements controls DNA replication through initiator self-assembly

artículo científico publicado en 2019

A papillomavirus E2 phosphorylation mutant exhibits normal transient replication and transcription but is defective in transformation and plasmid retention

artículo científico publicado en 1997

ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote

artículo científico publicado en 2012

Acidic transcription factors alleviate nucleosome-mediated repression of DNA replication of bovine papillomavirus type 1.

artículo científico publicado en 1994

Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins.

artículo científico publicado en 2010

Assembly of functionally active Drosophila origin recognition complex from recombinant proteins

artículo científico publicado en 1999

Biotechnology. A prudent path forward for genomic engineering and germline gene modification

artículo científico publicado en 2015

CDK phosphorylation inhibits the DNA-binding and ATP-hydrolysis activities of the Drosophila origin recognition complex

artículo científico publicado en 2005

CRISPR germline engineering--the community speaks

artículo científico publicado en 2015

Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement.

artículo científico publicado en 2015

Characterization of simian virus 40 T-antigen double hexamers bound to a replication fork. The active form of the helicase

artículo científico publicado en 2002

Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex.

artículo científico publicado en 2012

Chromatin reader L(3)mbt requires the Myb-MuvB/DREAM transcriptional regulatory complex for chromosomal recruitment

artículo científico publicado en 2014

Climate change and the integrity of science

artículo científico publicado en 2010

Competition for DNA binding sites between the short and long forms of E2 dimers underlies repression in bovine papillomavirus type 1 DNA replication control.

artículo científico publicado en 1998

Conformational control and DNA-binding mechanism of the metazoan origin recognition complex

article published in the Proceedings of the National Academy of Sciences of the United States of America

Crystal structure of the eukaryotic origin recognition complex

artículo científico publicado en 2015

DNA Replication: Making Two Forks from One Prereplication Complex ⬇️

artículo científico publicado el 22 de diciembre de 2010

DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome.

artículo científico publicado en 2014

DNA topology, not DNA sequence, is a critical determinant for Drosophila ORC-DNA binding

artículo científico publicado en 2004

DNA-binding domain of bovine papillomavirus type 1 E1 helicase: structural and functional aspects.

artículo científico publicado en 1993

Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription

artículo científico publicado en 1991

Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B.

artículo científico publicado en 2007

Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication

artículo científico publicado en 2004

Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex

artículo científico publicado en 2012

E1 protein of bovine papillomavirus type 1 interferes with E2 protein-mediated tethering of the viral DNA to mitotic chromosomes

artículo científico publicado en 2002

Functional analysis of mutant and wild-type Drosophila origin recognition complex

artículo científico publicado en 2001

Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells

artículo científico publicado en 2007

Grainyhead and Zelda compete for binding to the promoters of the earliest-expressed Drosophila genes

artículo científico publicado en 2010

Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex

artículo científico publicado en 2004

Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner

artículo científico publicado en 1997

Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase

artículo científico publicado en 2006

Mechanisms and regulation of DNA replication initiation in eukaryotes

artículo científico publicado en 2017

Mechanisms for initiating cellular DNA replication

artículo científico publicado en 2017

Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome

scientific article published on 01 September 2019

Not just Salk

artículo científico publicado en 2017

Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex.

artículo científico publicado en 2006

Role for a Drosophila Myb-containing protein complex in site-specific DNA replication.

artículo científico publicado en 2002

Segregation of viral plasmids depends on tethering to chromosomes and is regulated by phosphorylation ⬇️

artículo científico publicado el 14 de abril de 1998

Single particle EM studies of the Drosophila melanogaster origin recognition complex and evidence for DNA wrapping

scientific article published on 11 September 2008

Site-specific DNA-binding proteins important for replication and transcription have multiple activities

scientific article published on 01 January 1993

Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression.

artículo científico publicado en 2011

Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association

artículo científico publicado en 2006

The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase

artículo científico publicado en 1993

The E1 replication protein of bovine papillomavirus type 1 contains an extended nuclear localization signal that includes a p34cdc2 phosphorylation site.

artículo científico publicado en 1993

The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2.

scientific article published on 02 August 2004

The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication

artículo científico publicado en 1993

The activation domain of the bovine papillomavirus E2 protein mediates association of DNA-bound dimers to form DNA loops

artículo científico publicado en 1991

The cellular DNA polymerase alpha-primase is required for papillomavirus DNA replication and associates with the viral E1 helicase

artículo científico publicado en 1994

The minichromosome maintenance replicative helicase

artículo científico publicado en 2013

The retinoblastoma gene product regulates Sp1-mediated transcription

artículo científico publicado en 1992

The structural basis for MCM2-7 helicase activation by GINS and Cdc45.

artículo científico publicado en 2011

Zelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition

artículo científico publicado en 2011

cis-Acting components of human papillomavirus (HPV) DNA replication: linker substitution analysis of the HPV type 11 origin

artículo científico publicado en 1995

humpty dumpty is required for developmental DNA amplification and cell proliferation in Drosophila

artículo científico publicado en 2005

p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner

artículo científico publicado en 1996

trans Activation of the simian virus 40 enhancer

artículo científico publicado en 1986

Lista de obras de Michael Botchan

A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation

A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activity

A new class of disordered elements controls DNA replication through initiator self-assembly

A papillomavirus E2 phosphorylation mutant exhibits normal transient replication and transcription but is defective in transformation and plasmid retention

ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote

Acidic transcription factors alleviate nucleosome-mediated repression of DNA replication of bovine papillomavirus type 1.

Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins.

Assembly of functionally active Drosophila origin recognition complex from recombinant proteins

Biotechnology. A prudent path forward for genomic engineering and germline gene modification

CDK phosphorylation inhibits the DNA-binding and ATP-hydrolysis activities of the Drosophila origin recognition complex

CRISPR germline engineering--the community speaks

Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement.

Characterization of simian virus 40 T-antigen double hexamers bound to a replication fork. The active form of the helicase

Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex.

Chromatin reader L(3)mbt requires the Myb-MuvB/DREAM transcriptional regulatory complex for chromosomal recruitment

Climate change and the integrity of science

Competition for DNA binding sites between the short and long forms of E2 dimers underlies repression in bovine papillomavirus type 1 DNA replication control.

Conformational control and DNA-binding mechanism of the metazoan origin recognition complex

Crystal structure of the eukaryotic origin recognition complex

DNA Replication: Making Two Forks from One Prereplication Complex ⬇️

DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome.

DNA topology, not DNA sequence, is a critical determinant for Drosophila ORC-DNA binding

DNA-binding domain of bovine papillomavirus type 1 E1 helicase: structural and functional aspects.

Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription

Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B.

Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication

Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex

E1 protein of bovine papillomavirus type 1 interferes with E2 protein-mediated tethering of the viral DNA to mitotic chromosomes

Functional analysis of mutant and wild-type Drosophila origin recognition complex

Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells

Grainyhead and Zelda compete for binding to the promoters of the earliest-expressed Drosophila genes

Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex

Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner

Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase

Mechanisms and regulation of DNA replication initiation in eukaryotes

Mechanisms for initiating cellular DNA replication

Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome

Not just Salk

Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex.

Role for a Drosophila Myb-containing protein complex in site-specific DNA replication.

Segregation of viral plasmids depends on tethering to chromosomes and is regulated by phosphorylation ⬇️

Single particle EM studies of the Drosophila melanogaster origin recognition complex and evidence for DNA wrapping

Site-specific DNA-binding proteins important for replication and transcription have multiple activities

Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression.

Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association

The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase

The E1 replication protein of bovine papillomavirus type 1 contains an extended nuclear localization signal that includes a p34cdc2 phosphorylation site.

The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2.

The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication

The activation domain of the bovine papillomavirus E2 protein mediates association of DNA-bound dimers to form DNA loops

The cellular DNA polymerase alpha-primase is required for papillomavirus DNA replication and associates with the viral E1 helicase

The minichromosome maintenance replicative helicase

The retinoblastoma gene product regulates Sp1-mediated transcription

The structural basis for MCM2-7 helicase activation by GINS and Cdc45.

Zelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition

cis-Acting components of human papillomavirus (HPV) DNA replication: linker substitution analysis of the HPV type 11 origin

humpty dumpty is required for developmental DNA amplification and cell proliferation in Drosophila

p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner

trans Activation of the simian virus 40 enhancer