"Lock-in"-cycloSal-pronucleotides - a new generation of chemical Trojan Horses?
artículo científico publicado en 2004
"Second generation" of TSAO compounds directed against HIV-1 TSAO-resistant strains.
artículo científico publicado en 2001
(±)-7-deazaaristeromycin lacking the hydroxymethyl substituent
artículo científico publicado en 1993
1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: a new class of nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors with anti-HIV-1 activity
artículo científico publicado en 1998
1,2,4-Triazole Derivatives Inhibiting the Human Immunodeficiency Virus Type 1 (HIV-1) in vitro
article
1-Amino-3-(1H-1,2,3-triazol-1-yl)propylphosphonates as acyclic analogs of nucleotides
artículo científico publicado en 2014
1-Aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides and related adducts: A quest for selective cytotoxicity for malignant cells
artículo científico publicado en 2008
1-Arylmethyl-2,3-dioxo-2,3-dihydroindole thiosemicarbazones as leads for developing cytotoxins and anticonvulsants
1-[2-(2-Benzoyl- and 2-benzylphenoxy)ethyl]uracils as potent anti-HIV-1 agents
artículo científico publicado en 2011
1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) and 5-ethynyl-1-β-D-ribofuranosylimidazole-4-carboxamide (EICAR) markedly potentiate the inhibitory effect of 2′,3′-dideoxyinosine on human immunodeficiency virus in peripheral blood
artículo científico publicado en 1991
135 Safety Concerns for Cyanovirin as a Microbicidal Anti-HIV Agent
article
2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcri
artículo científico publicado en 1992
2'-Azido-2',3'-dideoxythymidine: synthesis and crystal structure of a 2'-substituted dideoxynucleoside.
artículo científico publicado en 1990
2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides: a novel cluster of tumor-specific cytotoxins which reverse multidrug resistance
artículo científico publicado en 2009
2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition
artículo científico publicado en 2017
2-Amino-3-methylcarboxy-5-heptyl-thiophene (TJ191) is a selective anti-cancer small molecule that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells
artículo científico publicado en 2017
2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization
artículo científico publicado en 2009
229
3',3'-Difluoro-3'-deoxythymidine: comparison of anti-HIV activity to 3'-fluoro-3'-deoxythymidine
artículo científico publicado en 1992
3'-(N-hydroxyimino)-2',3-dideoxynucleosides and their derivatives: synthesis, broad spectrum antiviral properties and synthetical application for the preparation of other nucleoside analogues
artículo científico publicado en 1999
3'-C-branched 2'-deoxy-5-methyluridines: synthesis, enzyme inhibition, and antiviral properties
artículo científico publicado en 1992
3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2', 5'-bis-O-(tert-butyldimethylsilyl)-.beta.-D-xylo- and -ribofuranose]-3'-spiro-5''-[4''-amino-1'', 2''-oxathiole 2''
3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase
artículo científico publicado en 2010
3,5-Bis(3-alkylaminomethyl-4-hydroxybenzylidene)-4-piperidones: A Novel Class of Potent Tumor-Selective Cytotoxins
artículo científico publicado en 2016
3,5-Bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones: a novel cluster of potent tumor-selective cytotoxins
artículo científico publicado en 2011
3,5-Bis(benzylidene)-4-oxo-1-phosphonopiperidines and related diethyl esters: Potent cytotoxins with multi-drug-resistance reverting properties
artículo científico publicado en 2009
4"-Benzoylureido-TSAO derivatives as potent and selective non-nucleoside HCMV inhibitors. Structure-activity relationship and mechanism of antiviral action
artículo científico publicado en 2008
4"-H-TSAO-T, a novel prototype in the HIV-1 specific TSAO family.
artículo científico publicado en 2001
4-Benzyloxy-gamma-sultone derivatives: discovery of a novel family of non-nucleoside inhibitors of human cytomegalovirus and varicella zoster virus
artículo científico publicado en 2009
4-Benzyloxy-γ-Sultone Derivatives: Discovery of a Novel Family of Non-Nucleoside Inhibitors of Human Cytomegalovirus and Varicella Zoster Virus
4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation
artículo científico publicado en 2010
5'-Nor carbocyclic 5'-deoxy-5'-(isobutylthio)adenosine and a 2',3'-dideoxy-2',3'-didehydro derivative
artículo científico publicado en 2001
5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity
artículo científico publicado en 1990
5-(1-Acetoxyvinyl)-cycloSaligenyl-2',3'-dideoxy-2',3'- didehydrothymidine monophosphates, a second type of new, enzymatically activated cycloSaligenyl pronucleotides
artículo científico publicado en 2008
5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series
artículo científico publicado en 2004
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity
artículo científico publicado en 2003
5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells
artículo científico publicado en 2007
6-Benzylidene-2-[4-(pyridin-3-ylcarboxy)benzylidene]cyclohexanones: A novel cluster of tumour-selective cytotoxins
artículo científico publicado en 2017
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity
artículo científico publicado en 2002
6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity
artículo científico publicado en 2004
6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains
artículo científico publicado en 2004
7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase
artículo científico publicado en 1998
9-(2-Phosphonylmethoxyethyl) adenine increases the survival of influenza virus-infected mice by an enhancement of the immune system
artículo científico publicado en 1994
9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo
artículo científico publicado en 1989
9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys
artículo científico publicado en 1991
9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections
artículo científico publicado en 1989
9-(2-Phosphonylmethoxyethyl)adenine induces tumor cell differentiation or cell death by blocking cell cycle progression through the S phase.
artículo científico publicado en 1999
9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo
artículo científico publicado en 1991
92 Ara-A-5′-phenyl methoxy alaninyl phosphate as a prodrug of the adenine arabinoside -monophosphate: synthesis and anti viral evaluation
artículo científico publicado en 2000
A Multitarget Approach toward the Development of 8-Substituted Purines for Photoprotection and Prevention of UV-Related Damage
artículo científico publicado en 2017
A highly reliable, sensitive, flow cytometric/fluorometric assay for the evaluation of the anti-HIV activity of antiviral compounds in MT-4 cells
artículo científico publicado en 1988
A mercapto analogue of 5'-noraristeromycin
artículo científico publicado en 2002
A multi-targeted drug candidate with dual anti-HIV and anti-HSV activity
artículo científico publicado en 2013
A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2
artículo científico publicado en 2010
A new four-component reaction involving the Michael addition and the Gewald reaction, leading to diverse biologically active 2-aminothiophenes
artículo científico publicado en 2017
A novel family of diarylpyrimidines (DAPYs) featuring a diatomic linker: Design, synthesis and anti-HIV activities
artículo científico publicado en 2015
A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine
artículo científico publicado en 1989
A novel mannose-binding tuber lectin from Typhonium divaricatum (L.) Decne (family Araceae) with antiviral activity against HSV-II and anti-proliferative effect on human cancer cell lines
artículo científico publicado en 2007
A novel selective broad-spectrum anti-DNA virus agent
artículo científico publicado en 1986
A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression
artículo científico publicado en 2007
A phenyl-thiadiazolylidene-amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virions
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artículo científico publicado el 12 de noviembre de 2012
A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity
artículo científico publicado en 2002
Abasic analogues of TSAO-T as the first sugar derivatives that specifically inhibit HIV-1 reverse transcriptase.
artículo científico publicado en 1998
Actinohivin, a broadly neutralizing prokaryotic lectin, inhibits HIV-1 infection by specifically targeting high-mannose-type glycans on the gp120 envelope
artículo científico publicado en 2010
Activity and mechanism of action of HDVD, a novel pyrimidine nucleoside derivative with high levels of selectivity and potency against gammaherpesviruses
artículo científico publicado en 2013
Activity of acyclic nucleoside phosphonate analogues against human immunodeficiency virus in monocyte/macrophages and peripheral blood lymphocytes
artículo científico publicado en 1991
Activity of different antiviral drug combinations against human cytomegalovirus replication in vitro
artículo científico publicado en 1992
Activity of reverse transcriptase inhibitors in monocyte-derived dendritic cells: a possible in vitro model for postexposure prophylaxis of sexual HIV transmission
artículo científico publicado en 2002
Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems
artículo científico publicado en 1996
Acute cytotoxicity of arabinofuranosyl nucleoside analogs is not dependent on mitochondrial DNA.
artículo científico publicado en 2009
Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase.
artículo científico publicado en 2002
Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: efficient synthesis and antiviral activity
artículo científico publicado en 2011
Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication
artículo científico publicado en 2011
Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents.
artículo científico publicado en 2001
Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues
artículo científico publicado en 2008
Additions and Corrections - Resolution of Aristeromycin Enantiomers
article
Alkenyl substituted bicyclic nucleoside analogues retain nanomolar potency against Varicella Zoster Virus
artículo científico publicado en 2009
Alkyloxyphenyl furano pyrimidines as potent and selective anti-VZV agents with enhanced water solubility
artículo científico publicado en 2002
All trans 1-(3-arylacryloyl)-3,5-bis(pyridin-4-ylmethylene)piperidin-4-ones as curcumin-inspired antineoplastics
artículo científico publicado en 2014
Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro
artículo científico publicado en 1991
Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics
artículo científico publicado en 2015
Altered deoxyribonucleotide pools in T-lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster
artículo científico publicado en 2005
An emerging understanding of the Janus face of the human microbiome: enhancement versus impairment of cancer therapy
artículo científico publicado en 2014
An epimer of 5'-noraristeromycin and its antiviral properties.
artículo científico publicado en 1994
An in situ pig liver esterase assay as a useful predictive tool for the likely in vitro anti viral activity of phosphoramidate pro-drugs
artículo científico publicado en 1999
An investigation into the anti-HIV activity of 2',3'-didehydro-2',3'-dideoxyuridine (d4U) and 2',3'-dideoxyuridine (ddU) phosphoramidate 'ProTide' derivatives.
artículo científico publicado en 2009
Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes
artículo científico publicado en 2000
Anti-HIV I/II activity and molecular cloning of a novel mannose/sialic acid-binding lectin from rhizome of Polygonatum cyrtonema Hua.
artículo científico publicado en 2006
Anti-HIV-1 activity of benzothiadiazine dioxide
artículo científico publicado en 2001
Anti-Hiv-1 Activity of 2',3'-Dideoxinucleoside Analogues : Structure-Activity Relationship
article
Anti-angiogenic activity of a novel multi-substrate analogue inhibitor of thymidine phosphorylase
artículo científico publicado en 2002
Anti-human immunodeficiency virus effects of cationic metalloporphyrin-ellipticine complexes
artículo científico publicado en 1992
Anti-retrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in vivo increases when it is less frequently administered
artículo científico publicado en 1990
Anti-varicella-zoster virus bicyclic nucleosides: replacement of furo by pyrro base reduces antiviral potency
artículo científico publicado en 2000
Antiadenovirus activities of several classes of nucleoside and nucleotide analogues
artículo científico publicado en 2005
Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione
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artículo científico publicado el 14 de marzo de 2013
Antiherpesvirus activities of two novel 4'-thiothymidine derivatives, KAY-2-41 and KAH-39-149, are dependent on viral and cellular thymidine kinases
artículo científico publicado en 2014
Antinociceptive and antitumor activity of novel synthetic mononuclear Ruthenium (II) compounds
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artículo científico publicado el 1 de marzo de 2013
Antiproliferative activities of halogenated pyrrolo[3,2-d]pyrimidines
artículo científico publicado en 2015
Antiproliferative and antiviral activity of three libraries of adamantane derivatives
artículo científico publicado en 2014
Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected [...]
artículo científico publicado en 1997
Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine
artículo científico publicado en 1996
Antiretroviral activity of semisynthetic derivatives of glycopeptide antibiotics
artículo científico publicado en 2003
Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates
artículo científico publicado en 2002
Antitumor Potential of Acyclic Nucleoside Phosphonates
artículo científico publicado en 1999
Antiviral Activity of Carbohydrate Binding Agents (CBAS) and the Role of DC-SIGN in Dengue Virus and HIV Infection
article
Antiviral activities of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4- carboxamide and related compounds
artículo científico publicado en 1991
Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCMV.
artículo científico publicado en 2007
Antiviral activity of carbohydrate-binding agents against Nidovirales in cell culture
artículo científico
Antiviral activity of carbohydrate-binding agents and the role of DC-SIGN in dengue virus infection
artículo científico publicado en 2009
Antiviral activity of cyclosaligenyl prodrugs of acyclovir, carbovir and abacavir
artículo científico publicado en 2001
Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines
artículo científico publicado en 1987
Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6.
artículo científico publicado en 1995
Antiviral activity of the 3'-amino derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine
artículo científico publicado en 1983
Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds
artículo científico publicado en 2007
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines
artículo científico publicado en 1992
Antiviral and cytostatic evaluation of the novel 6-acyclic chain substituted thymine derivatives
artículo científico publicado en 2005
Antiviral enantiomeric preference for 5'-noraristeromycin.
artículo científico publicado en 1994
Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines
artículo científico publicado en 2005
Application of phosphoramidate ProTide technology significantly improves antiviral potency of carbocyclic adenosine derivatives
artículo científico publicado en 2006
Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency
artículo científico publicado en 2005
Application of the Phosphoramidate Protide Approach to the Antiviral Drug Ribavirin
artículo científico publicado en 2008
Application of the dipeptidyl peptidase IV (DPPIV/CD26) based prodrug approach to different amine-containing drugs
artículo científico publicado en 2010
Aryl furano pyrimidines: the most potent and selective anti-VZV agents reported to date
artículo científico publicado en 2006
Aryl-substituted and benzo-annulated cyc/osal-derivatives of 2',3'-dideoxy-2',3'-didehydrothymidine monophosphate--correlation of structure, hydrolysis properties and anti-HIV activity
artículo científico publicado en 2002
Arylazolyl(azinyl)thioacetanilides. Part 10: design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors
artículo científico publicado en 2012
Arylazolyl(azinyl)thioacetanilides. Part 16: Structure-based bioisosterism design, synthesis and biological evaluation of novel pyrimidinylthioacetanilides as potent HIV-1 inhibitors
artículo científico publicado en 2014
Aryloxy phosphoramidate triesters as pro-tides
artículo científico publicado en 2004
Aryloxy phosphoramidate triesters: a technology for delivering monophosphorylated nucleosides and sugars into cells
artículo científico publicado en 2009
Benzylidene-bis-(4-hydroxycoumarin) and benzopyrano-coumarin derivatives: synthesis, ¹H/¹³C-NMR conformational and X-ray crystal structure studies and in vitro antiviral activity evaluations
artículo científico publicado en 2011
Benzylidene/2-chlorobenzylidene hydrazides: synthesis, antimicrobial activity, QSAR studies and antiviral evaluation
artículo científico publicado en 2010
Bicyclic anti-VZV nucleosides: thieno analogues bearing an alkylphenyl side chain have reduced antiviral activity
artículo científico publicado en 2004
Bicyclic furo pyrimidine nucleosides with aryloxyphenyl and halophenyl substituted side chains as potent and selective varicella-zoster virus inhibitors
artículo científico publicado en 2001
Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of a terminal halogen substitution in the side-chain.
artículo científico publicado en 2000
Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of terminal unsaturation in the side chain
artículo científico publicado en 2001
Bicyclic nucleoside inhibitors of Varicella-Zoster virus: the effect of branching in the p-alkylphenyl side chain
artículo científico publicado en 2005
Bicyclic nucleoside inhibitors of varicella-zoster virus (VZV): Pd-catalysed synthesis of 5-aryl derivatives and their biological evaluation
artículo científico publicado en 2001
Bicyclic nucleoside inhibitors of varicella-zoster virus (VZV): effect of terminal unsaturation in the side-chain
artículo científico publicado en 2001
Bicyclic nucleoside inhibitors of varicella-zoster virus: 5'-chloro and 3'-chloro derivatives
artículo científico publicado en 2003
Bicyclic nucleoside inhibitors of varicella-zoster virus: effect of terminal aryl substitution in the side-chain
artículo científico publicado en 2002
Bicyclic nucleoside inhibitors of varicella-zoster virus: synthesis and biological evaluation of 2',3'-dideoxy-3'-fluoro and 2'-deoxy-xylo derivatives
artículo científico publicado en 2003
Bicyclic pyrimidine nucleoside analogues (BCNAs) as highly selective and potent inhibitors of varicella-zoster virus replication
artículo científico publicado en 2002
Bioinformatics analyses of the mannose-binding lectins from Polygonatum cyrtonema, Ophiopogon japonicus and Liparis noversa with antiproliferative and apoptosis-inducing activities
artículo científico publicado en 2009
Bis(benzoyloxybenzyl)-DiPPro nucleoside diphosphates of anti-HIV active nucleoside analogues
artículo científico publicado en 2015
Bis-cycloSal-d4T-monophosphates: drugs that deliver two molecules of bioactive nucleotides
artículo científico publicado en 2007
Bis[3,5-bis(benzylidene)-4-oxo-1-piperidinyl]amides: a novel class of potent cytotoxins
artículo científico publicado en 2011
Branched-chain C-cyano pyranonucleosides: Synthesis of 3′-C-cyano & 3′-C-cyano-3′-deoxy pyrimidine pyranonucleosides as novel cytotoxic agents
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artículo científico publicado el 1 de septiembre de 2011
Broad antiviral activity of carbohydrate-binding agents against the four serotypes of dengue virus in monocyte-derived dendritic cells
artículo científico publicado en 2011
Broad-spectrum antiviral activities of neplanocin A, 3-deazaneplanocin A, and their 5'-nor derivatives
artículo científico publicado en 1989
Broad-spectrum antiviral activity and mechanism of antiviral action of the fluoroquinolone derivative K-12.
artículo científico publicado en 1998
Capture and transmission of HIV-1 by the C-type lectin L-SIGN (DC-SIGNR) is inhibited by carbohydrate-binding agents and polyanions
artículo científico publicado en 2009
Carbocyclic 5'-nor "reverse" fleximers. Design, synthesis, and preliminary biological activity
scientific article published on July 2011
Carbocyclic analogues of nucleosides from bis-(Hydroxymethyl)-cyclopentane: synthesis, antiviral and cytostatic activities of adenosine, inosine and uridine analogues
artículo científico publicado en 2003
Carbohydrate-binding Agents Cause Deletions of Highly Conserved Glycosylation Sites in HIV GP120
scientific article published in Journal of Biological Chemistry
Carbohydrate-binding agents efficiently prevent dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN)-directed HIV-1 transmission to T lymphocytes
artículo científico publicado en 2006
Carbohydrate‐binding agents act as potent trypanocidals that elicit modifications in VSG glycosylation and reduced virulence in Trypanosoma brucei
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artículo científico publicado el 14 de octubre de 2013
Cell-dependent interference of a series of new 6-aminoquinolone derivatives with viral (HIV/CMV) transactivation
artículo científico publicado en 2005
Cellular uptake of phosphonylmethoxyalkylpurine derivatives
artículo científico publicado en 1991
Characterization and carbohydrate specificity of pradimicin S.
artículo científico publicado en 2012
Characterization and structural analysis of novel mutations in human immunodeficiency virus type 1 reverse transcriptase involved in the regulation of resistance to nonnucleoside inhibitors
artículo científico publicado en 2007
Characterization of herpes simplex virus type 1 thymidine kinase mutants selected under a single round of high-dose brivudin
artículo científico publicado en 2005
Characterization of pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis: implications for the clinical efficacy of nucleoside analogues
artículo científico publicado en 2012
Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine
artículo científico publicado en 1999
Characterization of the catalytic subunit of the human herpesvirus 6 (HHV-6) DNA polymerase expressed in an in vitro transcription/translation assay
artículo científico publicado en 2003
ChemInform Abstract: Design, Synthesis and Enzymatic Activity of Highly Selective Human Mitochondrial Thymidine Kinase Inhibitors
Chemo-enzymatic synthesis of 3-deoxy-beta-D-ribofuranosyl purines and study of their biological properties
artículo científico publicado en 2003
Chemotherapy of varicella-zoster virus by a novel class of highly specific anti-VZV bicyclic pyrimidine nucleosides
artículo científico publicado en 2002
Chimeric human immunodeficiency virus type 1 and feline immunodeficiency virus reverse transcriptases: role of the subunits in resistance/sensitivity to non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2002
Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors
artículo científico publicado en 2012
Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathies
artículo científico publicado en 2006
Combination of Antiretroviral Drugs as Microbicides
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artículo científico publicado el 1 de enero de 2012
Combinations of griffithsin with other carbohydrate-binding agents demonstrate superior activity against HIV Type 1, HIV Type 2, and selected carbohydrate-binding agent-resistant HIV Type 1 strains
artículo científico publicado en 2012
Comparative inhibitory effects of suramin and other selected compounds on the infectivity and replication of human T-cell lymphotropic virus (HTLV-III)/lymphadenopathy-associated virus (LAV)
artículo científico publicado en 1986
Comparative study of bis(benzyl)phosphate triesters of 2',3'-dideoxy-2',3'-didehydrothymidine (d4T) and cyclosal-d4TMP--hydrolysis, mechanistic insights and anti-HIV activity
artículo científico publicado en 2002
Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT.
artículo científico publicado en 2005
Concise synthesis and biological evaluation of 2-Aroyl-5-amino benzo[b]thiophene derivatives as a novel class of potent antimitotic agents
artículo científico publicado en 2013
Conservation of antiviral activity and improved selectivity in PMEO-DAPym upon pyrimidine to triazine scaffold hopping
artículo científico publicado en 2015
Conversion of acyclic nucleoside phosphonates to their diphosphate derivatives by 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetase.
artículo científico publicado en 1991
Correction: Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products
artículo científico publicado en 2017
Correlations between cytotoxicity and topography of some 2-arylidenebenzocycloalkanones determined by X-ray crystallography.
artículo científico publicado en 2002
Crucial role of the N-glycans on the viral E-envelope glycoprotein in DC-SIGN-mediated dengue virus infection
artículo científico publicado en 2012
Crystal Structure and Thermal Stability of Silver Selenite
Crystal Structure of tert -Butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in Complex with HIV-1 Reverse Transcriptase (RT) Redefines the Elastic Limits of the Non-nucleoside Inhibitor-Binding Pocket
artículo científico publicado en 2011
Crystal structure of poxvirus thymidylate kinase: An unexpected dimerization has implications for antiviral therapy
artículo científico publicado en 2008
Crystal structure of varicella zoster virus thymidine kinase
artículo científico publicado en 2003
Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives
artículo científico publicado en 1998
Crystal structures of the mitochondrial deoxyribonucleotidase in complex with two specific inhibitors
artículo científico publicado en 2004
Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors
artículo científico publicado en 2015
CycloSal-2'-ara(ribo)-fluoro-2',3'-dideoxyadenosine monophosphates--an effort to solve the structure-activity relationship of 2'-fluoro-ddA
artículo científico publicado en 1999
Cyclopentene carbocyclic nucleosides related to the antitumor nucleoside clitocine and their conversion to 8-Aza-neplanocin analogues. Synthesis and antiviral activity
artículo científico publicado en 1993
Cytosolic and mitochondrial deoxyribonucleotidases: activity with substrate analogs, inhibitors and implications for therapy
artículo científico publicado en 2003
Cytostatic activity of novel 4′-aminochalcone-based imides
scientific article published in 2007
Cytostatic and antiviral activity evaluations of hydroxamic derivatives of some non-steroidal anti-inflammatory drugs
artículo científico publicado en 2009
Cytotoxic 1,3-diarylidene-2-tetralones and related compounds
scientific article published on 01 October 2002
Cytotoxic 1,4-bis(2-oxo-1-cycloalkylmethylene)benzenes and related compounds
artículo científico publicado en 2002
Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds
artículo científico publicado en 2006
Cytotoxic N-[4-(3-aryl-3-oxo-1-propenyl)phenylcarbonyl]-3,5-bis(phenylmethylene)-4-piperidones and related compounds
artículo científico publicado en 2002
Cytotoxic analogues of 2,6-bis(arylidene)cyclohexanones
artículo científico publicado en 2003
Cytotoxic and anticonvulsant aryloxyaryl Mannich bases and related compounds
artículo científico publicado en 2004
DC-SIGN increases the affinity of HIV-1 envelope glycoprotein interaction with CD4.
artículo científico publicado en 2011
Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods
artículo científico publicado en 2002
Deletion of the highly conserved N-glycan at Asn260 of HIV-1 gp120 affects folding and lysosomal degradation of gp120, and results in loss of viral infectivity
artículo científico publicado en 2014
Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore
artículo científico publicado en 2010
Design and Discovery of a Novel Dipeptidyl-peptidase IV (CD26)-Based Prodrug Approach
article by Carlos García-Aparicio et al published August 2006 in Journal of Medicinal Chemistry
Design and development of curcumin bioconjugates as antiviral agents
artículo científico publicado en 2008
Design and synthesis of N₁-aryl-benzimidazoles 2-substituted as novel HIV-1 non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2013
Design and synthesis of a new series of cyclopropylamino-linking diarylpyrimidines as HIV non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2014
Design and synthesis of a new series of modified CH-diarylpyrimidines as drug-resistant HIV non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2014
Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR
artículo científico publicado en 1999
Design and synthesis of phosphonoacetic acid (PPA) ester and amide bioisosters of ribofuranosylnucleoside diphosphates as potential ribonucleotide reductase inhibitors and evaluation of their enzyme inhibitory, cytostatic and antiviral activity
artículo científico publicado en 2003
Design, Synthesis and Biological Evaluation of Novel Acyclovir ProTides
scientific article published in 2008
Design, Synthesis and Evaluation of Novel Anti-VZV BCNAs
scientific article published in 2008
Design, Synthesis, Antiviral, and Cytotoxic Evaluation of Novel Phosphonylated 1,2,3-Triazoles as Acyclic Nucleotide Analogues
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artículo científico publicado el 1 de abril de 2012
Design, Synthesis, and Biological Evaluation of Novel Fluoro Derivatives of BCNA
artículo científico publicado en 2009
Design, synthesis and antiproliferative activity of novel heterobivalent hybrids based on imidazo[2,1-b][1,3,4]thiadiazole and imidazo[2,1-b][1,3]thiazole scaffolds
artículo científico publicado en 2015
Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells
artículo científico publicado en 2007
Design, synthesis and bioevaluation of novel candidate selective estrogen receptor modulators
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artículo científico publicado el 30 de mayo de 2011
Design, synthesis and bioevaluation of novel maleamic amino acid ester conjugates of 3,5-bisarylmethylene-4-piperidones as cytostatic agents
artículo científico publicado en 2009
Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides
artículo científico publicado en 2011
Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents
artículo científico publicado en 2013
Design, synthesis and biological evaluation of 3-benzyloxy-linked pyrimidinylphenylamine derivatives as potent HIV-1 NNRTIs
artículo científico publicado en 2013
Design, synthesis and biological evaluation of N2,N4-disubstituted-1,1,3-trioxo-2H,4H-pyrrolo[1,2-b][1,2,4,6]thiatriazine derivatives as HIV-1 NNRTIs
artículo científico publicado en 2013
Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs
artículo científico publicado en 2011
Design, synthesis and biological evaluation of substituted guanidine indole derivatives as potential inhibitors of HIV-1 Tat-TAR interaction
artículo científico publicado en 2014
Design, synthesis and cytotoxic properties of novel 1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones and related compounds
artículo científico publicado en 2006
Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs
artículo científico publicado en 2013
Design, synthesis and preliminary antiviral screening of new N-phenylpyrazole and dihydroisoxazole derivatives
article
Design, synthesis of new β-carboline derivatives and their selective anti-HIV-2 activity
artículo científico publicado en 2015
Design, synthesis, and SAR of naphthyl-substituted Diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase
artículo científico publicado en 2009
Design, synthesis, and anti-HIV activity of 2′,3′-didehydro-2′,3′-dideoxyuridine (d4U), 2′,3′-dideoxyuridine (ddU) phosphoramidate ‘ProTide’ derivatives
article
Design, synthesis, and biological evaluation of C1–phosphonamidate analogues of 2-deoxy-d-ribose-1-phosphate
Design, synthesis, and biological evaluation of hybrid molecules containing alpha-methylene-gamma-butyrolactones and polypyrrole minor groove binders
artículo científico publicado en 2004
Design, synthesis, and biological evaluation of novel 3,5-disubstituted-1,2,6-thiadiazine-1,1-dione derivatives as HIV-1 NNRTIs
artículo científico publicado en 2013
Design, synthesis, and biological evaluation of thiophene analogues of chalcones
artículo científico publicado en 2008
Design, synthesis, and biological evaluation of unconventional aminopyrimidine, aminopurine, and amino-1,3,5-triazine methyloxynucleosides
artículo científico publicado en 2014
Design, synthesis, and cytostatic activity of novel cyclic curcumin analogues
artículo científico publicado en 2007
Design, synthesis, and enzymatic evaluation of multisubstrate analogue inhibitors of Escherichia coli thymidine phosphorylase
artículo científico publicado en 2000
Design, synthesis, antiviral and cytostatic activity of ω-(1H-1,2,3-triazol-1-yl)(polyhydroxy)alkylphosphonates as acyclic nucleotide analogues
artículo científico publicado en 2014
Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker
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artículo científico publicado el 20 de noviembre de 2011
Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a carbamoyl linker
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artículo científico publicado el 16 de enero de 2013
Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3',4',5'-trimethoxyphenyl)-3-(2'-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach
scholarly article by Delia Preti et al published December 2018 in Journal of Enzyme Inhibition and Medicinal Chemistry
Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents
artículo científico publicado en 2002
Diastereoselective Synthesis of Aryloxy Phosphoramidate Prodrugs of 3′-Deoxy-2′,3′-didehydrothymidine Monophosphate
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artículo científico publicado el 11 de noviembre de 2010
Differences in the mannose oligomer specificities of the closely related lectins from Galanthus nivalis and Zea mays strongly determine their eventual anti-HIV activity
artículo científico publicado en 2011
Different evolution of genotypic resistance profiles to emtricitabine versus lamivudine in tenofovir-containing regimens
artículo científico publicado en 2010
Different pattern of activity of inhibitors of the human immunodeficiency virus in lymphocytes and monocyte/macrophages
artículo científico publicado el 1 de abril de 1992
Differential activities of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives against different human immunodeficiency virus type 1 mutant strains
artículo científico publicado en 1995
Differential activity of candidate microbicides against early steps of HIV-1 infection upon complement virus opsonization
artículo científico publicado en 2010
Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine
artículo científico publicado en 1993
Differential in vitro inhibitory activity against HIV-1 of alpha-(1-3)- and alpha-(1-6)-D-mannose specific plant lectins: implication for microbicide development
artículo científico publicado en 2007
Differential inhibition of retroviral reverse transcriptase by poly(2-fluoroadenylic acid), a template analogue
artículo científico publicado en 1991
Differential inhibition of various deoxyribonucleic acid polymerases by Evans blue and aurintricarboxylic acid
artículo científico publicado en 1988
Differential inhibitory effects of several pyrimidine 2',3'-dideoxynucleoside 5'-triphosphates on the activities of reverse transcriptase and various cellular DNA polymerases
artículo científico publicado en 1989
Differential inhibitory effects of sulfated polysaccharides and polymers on the replication of various myxoviruses and retroviruses, depending on the composition of the target amino acid sequences of the viral envelope glycoproteins
artículo científico publicado en 1991
Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds
artículo científico publicado en 1989
Dinucleoside monophosphates containing AZT and 1-methyladenosine or 7-methylguanosine
artículo científico publicado en 2003
Dipeptidyl peptidase IV dependent water-soluble prodrugs of highly lipophilic bicyclic nucleoside analogues
artículo científico publicado en 2011
Dipeptidyl peptidase IV-activated prodrugs of anti-varicella zoster virus bicyclic nucleoside analogues containing different self-cleavage spacer systems
artículo científico publicado en 2012
Dipeptidyl-peptidase IV (DPP IV/CD26)-activated prodrugs: a successful strategy for improving water solubility and oral bioavailability
artículo científico publicado en 2015
Discovery and SAR studies of a novel class of cytotoxic 1,4-disubstituted piperidines via Ugi reaction
artículo científico publicado en 2014
Discovery of 2-pyridone derivatives as potent HIV-1 NNRTIs using molecular hybridization based on crystallographic overlays
artículo científico publicado en 2014
Discovery of 8-methoxypyrazino[1,2-a]indole as a New Potent Antiproliferative Agent Against Human Leukemia K562 Cells. A Structure-Activity Relationship Study
scientific article published on June 2009
Discovery of TSAO derivatives with an unusual HIV-1 activity/resistance profile
artículo científico publicado en 2006
Discovery of a nanomolar inhibitor of lung adenocarcinoma in vitro
artículo científico publicado en 2014
Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains
artículo científico publicado en 2007
Discovery of novel diarylpyrimidines as potent HIV NNRTIs via a structure-guided core-refining approach
artículo científico publicado en 2014
Discovery of piperidine-linked pyridine analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors
artículo científico publicado en 2013
Doubly loaded cycloSaligenyl-pronucleotides - 5,5'-Bis-(cycloSaligenyl-2',3'-dideoxy-2',3'-didehydrothymidine monophosphates).
artículo científico publicado en 2009
E,E,E-1-(4-Arylamino-4-oxo-2-butenoyl)-3,5-bis(arylidene)-4-piperidones: a topographical study of some novel potent cytotoxins
artículo científico publicado en 2007
E,E-2-Benzylidene-6-(nitrobenzylidene)cyclohexanones: syntheses, cytotoxicity and an examination of some of their electronic, steric, and hydrophobic properties
artículo científico publicado en 2008
Efficacy and adverse effects of the antiviral compound plerixafor in feline immunodeficiency virus-infected cats
artículo científico publicado en 2012
Efficacy of the acyclic nucleoside phosphonates (S)-9-(3-fluoro-2-phosphonylmethoxypropyl)adenine (FPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against feline immunodeficiency virus
artículo científico publicado en 1998
Efficient conversion of tetrapeptide-based TSAO prodrugs to the parent drug by dipeptidyl-peptidase IV (DPPIV/CD26).
artículo científico publicado en 2007
Efficient synthesis of exomethylene- and keto-exomethylene-d-glucopyranosyl nucleoside analogs as potential cytotoxic agents
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artículo científico publicado el 30 de octubre de 2010
Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis
artículo científico publicado en 1993
Enantioselective syntheses of carbocyclic nucleosides 5′-homocarbovir, epi-4′-homocarbovir, and their cyclopropylamine analogs using facially selective Pd-mediated allylations
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artículo científico publicado el 4 de febrero de 2011
Engineering of a single conserved amino acid residue of herpes simplex virus type 1 thymidine kinase allows a predominant shift from pyrimidine to purine nucleoside phosphorylation
artículo científico publicado en 2006
Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line.
artículo científico publicado en 1998
Enhancement of natural killer activity and interferon induction by different acyclic nucleoside phosphonates
artículo científico publicado en 1994
Entry of hepatitis C virus and human immunodeficiency virus is selectively inhibited by carbohydrate-binding agents but not by polyanions
artículo científico publicado en 2007
Enzymatically activated cycloSal-d4T-monophosphates: The third generation of cycloSal-pronucleotides
artículo científico publicado en 2007
Erratum: Modification of the antibiotic olivomycin I at the 2′-keto group of the side chain. Novel derivatives, antitumor and topoisomerase I-poisoning activity
scholarly article published in The Journal of Antibiotics
Establishment of a bioassay to determine serum levels of dextran sulfate and pentosan polysulfate, two potent inhibitors of human immunodeficiency virus
artículo científico publicado en 1990
Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: synthesis, antiviral activity and decomposition study
artículo científico publicado en 2013
Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity
artículo científico publicado en 2007
Evaluating Clinical Isolates for Their Phenotypic and Genotypic Resistance Against Anti-HIV Drugs
artículo científico publicado en 2000
Evaluation of in vitro biological activity of O-alkylated hydroxamic derivatives of some nonsteroidal anti-inflammatory drugs
artículo científico publicado el 1 de octubre de 2010
Evidence for distinction of the differentiation-inducing activities and cytostatic properties of 9-(2-phosphonylmethoxyethyl)adenine and a variety of differentiation-inducing agents in human erythroleukemia K562 cells.
artículo científico publicado en 1996
Evidence for the Involvement of the Small Subunit of HIV-1 Reverse Transcriptase (RT) in the TSAO-Resistance
article
Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV.
artículo científico publicado en 2001
Exploring the purine core of 3'-C-ethynyladenosine (EAdo) in search of novel nucleoside therapeutics
artículo científico publicado en 2016
Exploring the role of the α-carboxyphosphonate moiety in the HIV-RT activity of α-carboxy nucleoside phosphonates
artículo científico
Exposure of HIV-1 to a combination of two carbohydrate-binding agents markedly delays drug resistance development and selects for virus strains with compromised fitness
artículo científico publicado en 2013
Expression analysis of the nucleocytoplasmic lectin 'Orysata' from rice in Pichia pastoris
artículo científico publicado en 2011
FV100 as a new approach for the possible treatment of varicella-zoster virus infection
artículo científico publicado en 2009
Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products
artículo científico publicado en 2017
First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication
artículo científico publicado en 2005
Fluorosubstitution and 7-alkylation as prospective modifications of biologically active 6-aryl derivatives of tricyclic acyclovir and ganciclovir analogues.
artículo científico publicado en 2005
From norbornane-based nucleotide analogs locked in South conformation to novel inhibitors of feline herpes virus
artículo científico publicado en 2014
From β-Amino-γ-Sultone to New Bicyclic Pyridine and Pyrazine Heterocyclic Systems: Discovery of a Novel Class of HIV-1 Non-nucleoside Inhibitors
article
From β-Amino-γ-sultone to Unusual Bicyclic Pyridine and Pyrazine Heterocyclic Systems: Synthesis and Cytostatic and Antiviral Activities
article
Furano pyrimidines as novel potent and selective anti-VZV agents
artículo científico publicado en 2001
Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches
artículo científico publicado en 2015
Glycan deletions in the HIV-1 gp120 V1/V2 domain compromise viral infectivity, sensitize the mutant virus strains to carbohydrate-binding agents and represent a specific target for therapeutic intervention
artículo científico publicado en 2008
Glycine-amide is an active metabolite of the antiretroviral tripeptide glycyl-prolyl-glycine-amide
artículo científico publicado en 2005
Guanine α-carboxy nucleoside phosphonate (G-α-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses
artículo científico publicado en 2017
HIV-1 envelope trimer has similar binding characteristics for carbohydrate-binding agents as monomeric gp120.
artículo científico publicado en 2013
Halophenyl furanopyrimidines as potent and selective anti-VZV agents
artículo científico publicado en 2003
High mannose-specific lectin Msl mediates key interactions of the vaginal Lactobacillus plantarum isolate CMPG5300.
artículo científico publicado en 2016
High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations
artículo científico publicado en 2005
Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100
artículo científico publicado en 1994
Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain
artículo científico publicado en 2000
Highly stereoselective synthesis and biological properties of nucleoside analogues bearing a spiro inserted oxirane ring
artículo científico publicado en 2000
Hiv-1 Specific Reverse Transcriptase Inhibitors: why are Tsao-Nucleosides so Unique?
article
How a modification (8-aza-3-deaza-2'-deoxyguanosine) influences the quadruplex structure of Hotoda's 6-mer TGGGAG with 5'- and 3'-end modifications
artículo científico publicado en 2004
Human glutaredoxin-1 catalyzes the reduction of HIV-1 gp120 and CD4 disulfides and its inhibition reduces HIV-1 replication
artículo científico publicado en 2008
Human immunodeficiency virus 1 (HIV-1)-specific reverse transcriptase (RT) inhibitors may suppress the replication of specific drug-resistant (E138K)RT HIV-1 mutants or select for highly resistant (Y181C-->C181I)RT HIV-1 mutants
artículo científico publicado en 1994
Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-[Spiro[4"-amino-2",2" -dioxo-1",2" -oxathiole-5",3'-[2', 5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]]]-3-ethylthy mine
artículo científico publicado en 2000
Human mitochondrial thymidine kinase is selectively inhibited by 3'-thiourea derivatives of beta-thymidine: identification of residues crucial for both inhibition and catalytic activity
artículo científico publicado en 2009
Hybrid alpha-bromoacryloylamido chalcones. Design, synthesis and biological evaluation
artículo científico publicado en 2009
Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy
artículo científico publicado en 2010
Hybrids of [TSAO-T]-[foscarnet]: The first conjugate of foscarnet with a non-nucleoside reverse transcriptase inhibitor through a labile covalent ester bond
artículo científico publicado en 2004
Hydantoin derivatives of L- and D-amino acids: synthesis and evaluation of their antiviral and antitumoral activity
artículo científico publicado en 2006
Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase
artículo científico publicado en 2001
Identification of a putative binding site for [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase.
artículo científico publicado en 2001
Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor
artículo científico publicado en 2016
Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule "crystallization chaperone" 5'-O-tritylinosine (KIN59).
artículo científico publicado en 2009
Identification of novel thiocarboxanilide derivatives that suppress a variety of drug-resistant mutant human immunodeficiency virus type 1 strains at a potency similar to that for wild-type virus
artículo científico publicado en 1996
Imidazothiadiazine dioxides: synthesis and antiviral activity
artículo científico publicado en 1999
Immunomodulatory activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA), a potent anti-HIV nucleotide analogue, on in vivo murine models
artículo científico publicado en 1991
Improving the antiviral efficacy and selectivity of HIV-1 reverse transcriptase inhibitor TSAO-T by the introduction of functional groups at the N-3 position
artículo científico publicado en 2005
Improving the selectivity of acyclic nucleoside analogues as inhibitors of human mitochondrial thymidine kinase: replacement of a triphenylmethoxy moiety with substituted amines and carboxamides
artículo científico publicado en 2003
In Vitro -Selected Drug-Resistant Varicella-Zoster Virus Mutants in the Thymidine Kinase and DNA Polymerase Genes Yield Novel Phenotype-Genotype Associations and Highlight Differences between Antiherpesvirus Drugs
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artículo científico publicado el 21 de diciembre de 2011
In search of specific inhibitors of retrovirus replication
artículo científico publicado en 1985
In vitro activity of polyhydroxycarboxylates against herpesviruses and HIV.
artículo científico publicado en 2001
In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides
artículo científico publicado en 2004
In vitro synergistic activity against CCR5-tropic HIV-1 with combinations of potential candidate microbicide molecules HHA, KRV2110 and enfuvirtide (T20).
artículo científico publicado en 2009
Inactivity of the bicyclic pyrimidine nucleoside analogues against simian varicella virus (SVV) does not correlate with their substrate activity for SVV-encoded thymidine kinase
artículo científico publicado en 2004
Increased mitochondrial DNA copy-number in CEM cells resistant to delayed toxicity of 2',3'-dideoxycytidine
artículo científico
Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide
artículo científico publicado en 2011
Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus
artículo científico publicado en 2009
Influence of 2-substituent on the activity of imidazo[1,2-a] pyridine derivatives against human cytomegalovirus
artículo científico publicado en 2002
Influence of Fluorination of the Sugar Moiety on the Anti-HIV-1 Activity of 2',3'-Dideoxynucleosides
article
Inhibition of cell-to-cell transmission of human T-cell lymphotropic virus type 1 in vitro by carbohydrate-binding agents
artículo científico publicado en 2008
Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics
artículo científico publicado en 2006
Inhibition of human immunodeficiency virus by a new class of pyridine oxide derivatives
artículo científico publicado en 2003
Inhibition of human immunodeficiency virus type 1 transcription by N-aminoimidazole derivatives
artículo científico publicado en 2007
Inhibition of pyrimidine and purine nucleoside phosphorylases by a 3,5-dichlorobenzoyl-substituted 2-deoxy-D-ribose-1-phosphate derivative
artículo científico publicado en 2012
Inhibition of the in vitro growth of Plasmodium falciparum by acyclic nucleoside phosphonates
artículo científico publicado en 1999
Inhibitory effect of 9-(2-phosphonylmethoxyethyl)-adenine (PMEA) on human and duck hepatitis B virus infection
artículo científico publicado en 1993
Inhibitory effect of 9-(2-phosphonylmethoxyethyl)adenine on visna virus infection in lambs: a model for in vivo testing of candidate anti-human immunodeficiency virus drugs
artículo científico publicado en 1995
Inhibitory effects of 9-(2-phosphonylmethoxyethyl)adenine and 3'-azido-2',3'-dideoxythymidine on tumor development in mice inoculated intracerebrally with Moloney murine sarcoma virus
artículo científico publicado en 1990
Inhibitory effects of acyclic nucleoside phosphonates on human hepatitis B virus and duck hepatitis B virus infections in tissue culture
artículo científico publicado en 1994
Inhibitory effects of potent inhibitors of human immunodeficiency virus and cytomegalovirus on the growth of human granulocyte-macrophage progenitor cells in vitro
artículo científico publicado en 1990
Initial studies on the cellular pharmacology of 2',3-dideoxycytidine, an inhibitor of HTLV-III infectivity
artículo científico publicado en 1986
Interaction of cycloSal-pronucleotides with cholinesterases from different origins. A structure-activity relationship
artículo científico publicado en 2004
Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound
artículo científico publicado en 1991
Intracellular trapping of cycloSal-pronucleotides: modification of prodrugs with amino acid esters
artículo científico publicado en 2008
Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway
artículo científico publicado en 2012
Introduction to the Special Issue dedicated to Prof. Erik De Clercq for reaching the Professor Emeritus status at the Katholieke Universiteit Leuven
artículo científico publicado en 2006
Investigation of fatty acid conjugates of 3,5-bisarylmethylene-4-piperidone derivatives as antitumor agents and human topoisomerase-IIα inhibitors
artículo científico publicado en 2014
KAY-2-41, a novel nucleoside analogue inhibitor of orthopoxviruses in vitro and in vivo
scientific article published on 14 October 2013
Kinetic analysis of novel multisubstrate analogue inhibitors of thymidine phosphorylase.
artículo científico publicado en 2000
Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5 "- (4"-amino-1",2"-oxathiole-2",2"-di
artículo científico publicado en 1992
Knocking-out concentrations of HIV-1-specific inhibitors completely suppress HIV-1 infection and prevent the emergence of drug-resistant virus.
artículo científico publicado en 1993
Lack of susceptibility of bicyclic nucleoside analogs, highly potent inhibitors of varicella-zoster virus, to the catabolic action of thymidine phosphorylase and dihydropyrimidine dehydrogenase
artículo científico publicado en 2002
Lead optimization of diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase
artículo científico publicado en 2010
Lectin-Like Molecules of Lactobacillus rhamnosus GG Inhibit Pathogenic Escherichia coli and Salmonella Biofilm Formation
artículo científico publicado en 2016
Limited development and progression of resistance of HIV-1 to the nucleoside analogue reverse transcriptase inhibitor lamivudine in human primary macrophages
artículo científico publicado en 2005
Lipophilic prodrugs of nucleoside triphosphates as biochemical probes and potential antivirals
artículo científico publicado en 2015
Long-lasting enfuvirtide carrier pentasaccharide conjugates with potent anti-human immunodeficiency virus type 1 activity
artículo científico publicado en 2009
Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors
artículo científico publicado en 2000
Macrophages and HIV infection: therapeutical approaches toward this strategic virus reservoir
artículo científico publicado en 2002
Mannose-specific plant lectins from the Amaryllidaceae family qualify as efficient microbicides for prevention of human immunodeficiency virus infection
artículo científico publicado en 2004
Marked depletion of glycosylation sites in HIV-1 gp120 under selection pressure by the mannose-specific plant lectins of Hippeastrum hybrid and Galanthus nivalis.
artículo científico publicado en 2005
Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent
artículo científico publicado en 1989
Measuring cooperative Rev protein-protein interactions on Rev responsive RNA by fluorescence resonance energy transfer
artículo científico publicado en 2011
Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives
artículo científico publicado en 1996
Mechanism of anti-human immunodeficiency virus action of polyoxometalates, a class of broad-spectrum antiviral agents
artículo científico publicado en 1992
Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro
artículo científico publicado en 1988
Mechanism of the potentiating effect of ribavirin on the activity of 2',3'-dideoxyinosine against human immunodeficiency virus
artículo científico publicado en 1991
Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase
scientific article published on 09 June 2009
Mechanisms underlying activity of antiretroviral drugs in HIV-1-infected macrophages: new therapeutic strategies
artículo científico publicado en 2006
Membrane-permeable Triphosphate Prodrugs of Nucleoside Analogues
artículo científico publicado en 2016
Meningoradiculoneuritis due to acyclovir-resistant varicella-zoster virus in a patient with AIDS.
artículo científico publicado en 1993
Metabolic activation of nucleoside and nucleotide reverse transcriptase inhibitors in dendritic and Langerhans cells
artículo científico publicado en 2002
Metabolic and pharmacological characteristics of the bicyclic nucleoside analogues (BCNAs) as highly selective inhibitors of varicella-zoster virus (VZV).
artículo científico publicado en 2003
Metabolism and anti-HIV activity of phosphoramidate derivatives of D4T-MP with variations in the amino acid moiety
artículo científico publicado en 1998
Methyl-2-arylidene hydrazinecarbodithioates: synthesis and biological activity
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Microvirin, a novel alpha(1,2)-mannose-specific lectin isolated from Microcystis aeruginosa, has anti-HIV-1 activity comparable with that of cyanovirin-N but a much higher safety profile
artículo científico publicado en 2010
Mitochondrial expression of the Drosophila melanogaster multisubstrate deoxyribonucleoside kinase
artículo científico publicado en 2007
Mitochondrial thymidine kinase inhibitors
artículo científico publicado en 2005
Modification of the antibiotic olivomycin I at the 2'-keto group of the side chain. Novel derivatives, antitumor and topoisomerase I-poisoning activity
artículo científico publicado en 2009
Molecular modifications of 2-arylidene-1-indanones leading to increased cytotoxic potencies
artículo científico publicado en 2007
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs
artículo científico publicado en 2000
Mutational analysis of trp-229 of human immunodeficiency virus type 1 reverse transcriptase (RT) identifies this amino acid residue as a prime target for the rational design of new non-nucleoside RT inhibitors
artículo científico publicado en 2000
Mutational pathways, resistance profile, and side effects of cyanovirin relative to human immunodeficiency virus type 1 strains with N-glycan deletions in their gp120 envelopes
artículo científico publicado en 2006
Mutations at amino acid positions 63, 189, and 396 of human immunodeficiency virus type 1 reverse transcriptase (RT) partially restore the DNA polymerase activity of a Trp229Tyr mutant RT.
artículo científico publicado en 2001
Mutations distal to the substrate site can affect varicella zoster virus thymidine kinase activity: implications for drug design
artículo científico publicado en 2006
Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs
artículo científico publicado en 2015
Mycoplasma hyorhinis-encoded purine nucleoside phosphorylase: kinetic properties and its effect on the cytostatic potential of purine-based anticancer drugs
artículo científico publicado en 2013
Mycoplasmas and cancer: focus on nucleoside metabolism
artículo científico publicado en 2014
N(4)-Acyl derivatives as lipophilic prodrugs of cidofovir and its 5-azacytosine analogue, (S)-HPMP-5-azaC: chemistry and antiviral activity
artículo científico publicado en 2014
N-3 substituted TSAO derivatives as a probe to explore the dimeric interface of HIV-1 reverse transcriptase
artículo científico publicado en 2003
N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action
artículo científico publicado en 2003
NICTABA and UDA, two GlcNAc-binding lectins with unique antiviral activity profiles
artículo científico publicado en 2015
Nebrodeolysin, a novel hemolytic protein from mushroom Pleurotus nebrodensis with apoptosis-inducing and anti-HIV-1 effects
artículo científico publicado en 2008
New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity
artículo científico publicado en 2012
New developments of the "lock-in" modified cycloSal-d4TMPs
artículo científico publicado en 2007
New neplanocin analogues. 1. Synthesis of 6'-modified neplanocin A derivatives as broad-spectrum antiviral agents
artículo científico publicado en 1992
New neplanocin analogues. 7. Synthesis and antiviral activity of 2-halo derivatives of neplanocin A.
artículo científico publicado en 1996
New prodrugs of Adefovir and Cidofovir
artículo científico publicado en 2011
New sorafenib derivatives: synthesis, antiproliferative activity against tumour cell lines and antimetabolic evaluation
artículo científico publicado en 2012
Niacin esters of chalcones with tumor-selective properties
artículo científico publicado en 2016
Non-Nucleoside HIV-1 Reverse-Transcriptase Inhibitors. Part 10
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Non-nucleoside HIV reverse transcriptase inhibitors, Part 6[1]: synthesis and anti-HIV activity of novel 2-[(arylcarbonylmethyl)thio]-6-arylthio DABO analogues
artículo científico publicado en 2005
Non-nucleoside HIV-1 reverse transcriptase inhibitors, Part 7. Synthesis, antiviral activity, and 3D-QSAR investigations of novel 6-(1-naphthoyl) HEPT analogues
artículo científico publicado en 2006
Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 11: structural modulations of diaryltriazines with potent anti-HIV activity
artículo científico publicado en 2007
Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 13: synthesis of fluorine-containing diaryltriazine derivatives for in vitro anti-HIV evaluation against wild-type strain
artículo científico publicado en 2009
Non-nucleoside inhibitors of mitochondrial thymidine kinase (TK-2) differentially inhibit the closely related herpes simplex virus type 1 TK and Drosophila melanogaster multifunctional deoxynucleoside kinase
artículo científico publicado en 2003
Non-nucleoside structures retain full anti-HCMV potency of the dideoxy furanopyrimidine family.
artículo científico publicado en 2004
Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors, Part 4[1]. Synthesis and Anti-HIV Activity of N-1-β-Carbonyl-6-naphthyl-methyl Analogues of HEPT
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Nonnucleoside HIV-1 reverse transcriptase inhibitors: Part I. Synthesis and structure-activity relationship of 1-alkoxymethyl-5-alkyl-6-naphthylmethyl uracils as HEPT analogues
artículo científico publicado en 2003
Nonnucleoside HIV-1 reverse transcriptase inhibitors; part 3. Synthesis and antiviral activity of 5-alkyl-2-[(aryl and alkyloxyl-carbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones
artículo científico publicado en 2004
Nonnucleoside HIV-1 reverse-transcriptase inhibitors, part 5. Synthesis and anti-HIV-1 activity of novel 6-naphthylthio HEPT analogues
artículo científico publicado en 2005
Novel 1,2,4-triazole and Purine Acyclic Cyclopropane Nucleoside Analogues: Synthesis, Antiviral and Cytostatic Activity Evaluations
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artículo científico publicado el 4 de julio de 2011
Novel 1,2,4-triazole and imidazole derivatives of L-ascorbic and imino-ascorbic acid: synthesis, anti-HCV and antitumor activity evaluations
artículo científico publicado en 2012
Novel 1-acyl-4-substituted semicarbazide derivatives of primaquine - synthesis, cytostatic, antiviral and antioxidative studies
artículo científico publicado en 2012
Novel 3,5-bis(arylidene)-4-oxo-1-piperidinyl dimers: structure-activity relationships and potent antileukemic and antilymphoma cytotoxicity
artículo científico publicado en 2014
Novel 5-arylcarbamoyl-2-methylisoxazolidin-3-yl-3-phosphonates as nucleotide analogues
artículo científico publicado en 2014
Novel 6-azapyrimidine-2'-deoxy-4'-thionucleosides: synthesis, biological evaluation and conformational analysis
artículo científico publicado en 1999
Novel 9-Arylpurines, as Selective Inhibitors of In Vitro Enterovirus Replication
scientific article published in 2009
Novel Analogues of the Anti-HIV-1 Agent TSAO-T Modified at the 3′-Spiro Moiety
article
Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations
artículo científico publicado en 2007
Novel Carbocyclic Nucleosides Containing a Cyclopentyl Ring. Adenosine and Uridine Analogues
scientific article published on 01 August 1997
Novel Tsao Derivatives. Synthesis and Anti-HIV-1 Activity of Allofuranosyl-TSAO-T Analogues
article
Novel [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2" -dioxide) derivatives with anti-HIV-1 and anti-human-cytomegalovirus activity.
artículo científico publicado en 2005
Novel acyclic phosphonylated 1,2,3-triazolonucleosides with an acetamidomethyl linker: synthesis and biological activity
artículo científico publicado en 2014
Novel adamantylated pyrimidines and their preliminary biological evaluations.
artículo científico publicado en 2004
Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates
artículo científico publicado en 2011
Novel aryl substituted bicyclic furo nucleosides as extremely potent and selective anti-VZV agents
artículo científico publicado en 2001
Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity
artículo científico publicado en 2003
Novel bicyclic sugar modified nucleosides: synthesis, conformational analysis and antiviral evaluation
artículo científico publicado en 2004
Novel conjugated unsaturated ketones with submicromolar potencies towards some leukemic and colon cancer cells
artículo científico publicado en 2019
Novel human immunodeficiency virus (HIV) inhibitors that have a dual mode of anti-HIV action
artículo científico publicado en 2003
Novel imidazo[1,2-c]pyrimidine base-modified nucleosides: synthesis and antiviral evaluation
artículo científico publicado en 2004
Novel in vivo model for the study of human immunodeficiency virus type 1 transcription inhibitors: evaluation of new 6-desfluoroquinolone derivatives
artículo científico publicado en 2007
Novel isoxazolidine analogues of homonucleosides and homonucleotides
artículo científico publicado en 2016
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation
artículo científico publicado en 1989
Novel lipophilic hydroxyurea derivatives: synthesis, cytostatic and antiviral activity evaluations
artículo científico publicado en 2008
Novel multi-targeting anthra[2,3-b]thiophene-5,10-diones with guanidine-containing side chains: interaction with telomeric G-quadruplex, inhibition of telomerase and topoisomerase I and cytotoxic properties
artículo científico publicado en 2014
Novel non-nucleoside human cytomegalovirus inhibitors based upon TSAO nucleoside derivatives: structure-activity relationships
artículo científico publicado en 2007
Novel piperidinylamino-diarylpyrimidine derivatives with dual structural conformations as potent HIV-1 non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2013
Novel potential agents for human cytomegalovirus infection: synthesis and antiviral activity evaluation of benzothiadiazine dioxide acyclonucleosides
artículo científico publicado en 1999
Novel ribofuranosylnucleoside lead compounds for potent and selective inhibitors of mitochondrial thymidine kinase-2
artículo científico publicado en 2000
Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity
artículo científico publicado en 2007
Novel series of TSAO-T derivatives. Synthesis and anti-HIV-1 activity of 4-, 5-, and 6-substituted pyrimidine analogues.
artículo científico publicado en 1994
Novel series of [ddN]-[TSAO-T] heterodimers as potential bi-functional inhibitors of HIV-1 RT. Studies in the linker and ddN region
artículo científico publicado en 1999
Novel water-soluble prodrugs of acyclovir cleavable by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme
artículo científico publicado en 2013
Nucleoside Diphosphate Prodrugs: Nonsymmetric DiPPro-Nucleotides
artículo científico publicado en 2015
Nucleoside diphosphate prodrugs
artículo científico publicado en 2008
Nucleoside mono- and diphosphate prodrugs of 2',3'-dideoxyuridine and 2',3'-dideoxy-2',3'-didehydrouridine
artículo científico publicado en 2014
Nucleoside-catabolizing enzymes in mycoplasma-infected tumor cell cultures compromise the cytostatic activity of the anticancer drug gemcitabine
artículo científico publicado en 2014
Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)).
artículo científico publicado en 2004
One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazole: a unique, highly active antimicrotubule agent
artículo científico publicado en 2011
Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies
artículo científico publicado en 2014
PMPA and PMEA prodrugs for the treatment of HIV infections and human papillomavirus (HPV) associated neoplasia and cancer
artículo científico publicado en 2014
Palladium-Catalyzed Aryl Amination Reactions of 6-Bromo- and 6-Chloropurine Nucleosides
artículo científico publicado en 2010
Palladium-catalyzed synthesis of (E)-5-(2-acylvinyl)-2′-deoxyuridines and their antiviral and cytotoxic activities
artículo científico publicado en 1995
Particular characteristics of the anti-human cytomegalovirus activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in vitro
artículo científico publicado en 1991
Pharmacokinetics in mice of the anti-retrovirus agent 9-(2-phosphonylmethoxyethyl)adenine
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artículo científico publicado el 1 de septiembre de 1992
Phenylboronic-Acid-Based Carbohydrate Binders as Antiviral Therapeutics: Bisphenylboronic Acids
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artículo científico publicado el 1 de enero de 2011
Phenylboronic-acid-based carbohydrate binders as antiviral therapeutics: monophenylboronic acids
artículo científico publicado en 2010
Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents
artículo científico publicado en 1988
Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside
artículo científico publicado en 2011
Phosphoramidate derivatives of 2′,3′-didehydro-2′,3′-dideoxyadenosine [d4A] have markedly improved anti-HIV potency and selectivity
article
Phosphoramidate derivatives of d4T with improved anti-HIV efficacy retain full activity in thymidine kinase-deficient cells
article
Phosphoramidate derivatives of stavudine as inhibitors of HIV: unnatural amino acids may substitute for alanine
artículo científico publicado en 2000
Phosphoramidates of 2'-beta-D-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism
artículo científico publicado en 2010
Phosphorolysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted-2'-deoxyuridines by purified human thymidine phosphorylase and intact blood platelets
artículo científico publicado en 1983
Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase
artículo científico publicado en 2009
Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle
artículo científico publicado en 2007
Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2',3'-dideoxyuridine-5'-triphosphate
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artículo científico publicado el 1 de febrero de 1990
Potent and selective anti-HTLV-III/LAV activity of 2',3'-dideoxycytidinene, the 2',3'-unsaturated derivative of 2',3'-dideoxycytidine
artículo científico publicado en 1986
Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event
artículo científico publicado en 1992
Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base
artículo científico publicado en 1999
Potent inhibition of human immunodeficiency virus and herpes simplex virus type 1 by 9-(2-phosphonylmethoxyethyl)adenine in primary macrophages is determined by drug metabolism, nucleotide pools, and cytokines
artículo científico publicado en 1996
Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside region
artículo científico publicado en 1999
Potential prodrug derivatives of 2',3'-didehydro-2',3'-dideoxynucleosides. Preparations and antiviral activities
artículo científico publicado en 1992
Potentiating effect of ribavirin on the anti-retrovirus activity of 3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside in vitro and in vivo
artículo científico publicado en 1989
Potentiating effect of ribavirin on the in vitro and in vivo antiretrovirus activities of 2',3'-dideoxyinosine and 2',3'-dideoxy-2,6-diaminopurine riboside
artículo científico publicado en 1990
Pradimicin A, a carbohydrate-binding nonpeptidic lead compound for treatment of infections with viruses with highly glycosylated envelopes, such as human immunodeficiency virus
artículo científico publicado en 2006
Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
artículo científico publicado en 2010
Preclinical development of bicyclic nucleoside analogues as potent and selective inhibitors of varicella zoster virus
artículo científico publicado en 2007
Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET.
artículo científico publicado en 2012
Preparation of Chloro and Sulfanyl Derivatives of 1-(2-Deoxy-4-C-hydroxymethyl-α-L-threo-Pentofuranosyl)uracil
Pridine Oxide Derivatives: Structure‐Activity Relationship for Inhibition of Human Immunodeficiency Virus and Cytomegalovirus Replication in Cell Culture
artículo científico publicado en 2002
ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites
artículo científico publicado en 2016
Prodrugs of Antiviral Nucleosides Cleavable by Dipeptidyl-Peptidase-IV (CD26)
scientific article published in 2008
Profile of resistance of human immunodeficiency virus to mannose-specific plant lectins
artículo científico publicado en 2004
Prognostic value of pretransplantation positron emission tomography using fluorine 18-fluorodeoxyglucose in patients with aggressive lymphoma treated with high-dose chemotherapy and stem cell transplantation
artículo científico publicado en 2003
Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates
artículo científico publicado en 2015
Pronounced anti-proliferative activity and tumor cell selectivity of 5-alkyl-2-amino-3-methylcarboxylate thiophenes
artículo científico publicado en 2017
Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines
artículo científico publicado en 2006
Pyridine N-oxide derivatives are inhibitory to the human SARS and feline infectious peritonitis coronavirus in cell culture
artículo científico publicado en 2005
Pyridine N-oxide derivatives inhibit viral transactivation by interfering with NF-kappaB binding
artículo científico publicado en 2006
Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action
artículo científico publicado en 2005
Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds
artículo científico publicado en 1988
Rational Development of Nucleoside Diphosphate Prodrugs: DiPPro-Compounds
artículo científico
Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth
artículo científico publicado en 2007
Reaction of the antitumor antibiotic olivomycin I with aryl diazonium salts. Synthesis, cytotoxic and antiretroviral potency of 5-aryldiazenyl-6-O-deglycosyl derivatives of olivomycin I.
artículo científico publicado en 2009
Recent advances in thymidine kinase 2 (TK2) inhibitors and new perspectives for potential applications
artículo científico
Red blood cells mediated delivery of 9-(2-phosphonylmethoxyethyl)adenine to primary macrophages: efficiency metabolism and activity against human immunodeficiency virus or herpes simplex virus
artículo científico publicado en 1997
Reduced levels of mitochondrial DNA increases the toxicity of 9-beta-D-arabinofuranosylguanine (araG).
artículo científico publicado en 2008
Regiospecific synthesis and anti-human immunodeficiency virus activity of novel 5-substituted N-alkylcarbamoyl and N,N-dialkylcarbamoyl 1,2,3-triazole-TSAO analogues
artículo científico publicado en 1998
Related lectins from snowdrop and maize differ in their carbohydrate-binding specificity
artículo científico publicado en 2009
Resistance of HIV-1 to the broadly HIV-1-neutralizing, anti-carbohydrate antibody 2G12.
artículo científico publicado en 2006
Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720
artículo científico publicado en 1994
Resistance to the nucleotide analogue cidofovir in HPV(+) cells: a multifactorial process involving UMP/CMP kinase 1
artículo científico publicado en 2016
Retained sensitivity to cytotoxic pyrimidine nucleoside analogs in thymidine kinase 2 deficient human fibroblasts
artículo científico publicado en 2010
Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro
artículo científico publicado en 1987
Ribavirin inhibits in vitro hepatitis E virus replication through depletion of cellular GTP pools and is moderately synergistic with alpha interferon
artículo científico publicado en 2013
Role of Cations in the Interaction of Pradimicins with HIV-1 Envelope gp120
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artículo científico publicado el 1 de agosto de 2013
Role of MRP4 and MRP5 in biology and chemotherapy
artículo científico publicado en 2002
Role of histidine-85 in the catalytic mechanism of thymidine phosphorylase as assessed by targeted molecular dynamics simulations and quantum mechanical calculations.
artículo científico publicado en 2004
Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir)
artículo científico publicado en 2013
Role of the Carbohydrate-Binding Sites of Griffithsin in the Prevention of DC-SIGN-Mediated Capture and Transmission of HIV-1
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artículo científico publicado el 31 de mayo de 2013
S-Adenosyl-L-homocysteine Hydrolase Inhibitors as Anti-Viral Agents: 5′-Deoxyaristeromycin
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SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus
artículo científico publicado en 1997
Safety concerns for the potential use of cyanovirin-N as a microbicidal anti-HIV agent
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Screening Platform toward New Anti-HIV Aptamers Set on Molecular Docking and Fluorescence Quenching Techniques
artículo científico publicado en 2016
Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA).
artículo científico publicado en 1998
Selective inhibition of Human Immunodeficiency Virus type 1 (HIV-1) by a novel family of tricyclic nucleosides
artículo científico publicado en 2011
Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG).
artículo científico publicado en 1990
Several N-Glycans on the HIV Envelope Glycoprotein gp120 Preferentially Locate Near Disulphide Bridges and Are Required for Efficient Infectivity and Virus Transmission
artículo científico publicado en 2015
Side-chain derivatives of biologically active nucleosides. 1. Side-chain analogs of 3'-azido-3'-deoxythymidine (AZT)
artículo científico publicado en 1992
Simian immunodeficiency virus is susceptible to inhibition by carbohydrate-binding agents in a manner similar to that of HIV: implications for further preclinical drug development
artículo científico publicado en 2008
Single-Crystal Neutron Diffraction Study of Diammonium Hexaaquacopper Disulfate at 15 and 293 K. Investigation of Anharmonic Thermal Motion
Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo
artículo científico publicado en 1991
Sodium and potassium benzeneazophosphonate complexes with crown ethers: Solid-state microwave synthesis, characterization and biological activity
Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase
artículo científico publicado en 2002
Spirobipyridopyrans, spirobinaphthopyrans, indolinospiropyridopyrans, indolinospironaphthopyrans and indolinospironaphtho-1,4-oxazines: synthesis, study of X-ray crystal structure, antitumoral and antiviral evaluation.
artículo científico publicado en 2004
Stereocontrolled Facile Synthesis and Biological Evaluation of (3′S) and (3′R)-3′-Amino (and Azido)-3′-Deoxy Pyranonucleosides
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artículo científico publicado el 1 de enero de 2012
Stereoselective Synthesis and Antiviral Activity of Methyl-SubstitutedcycloSal-Pronucleotides
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artículo científico publicado el 3 de agosto de 2012
Stereospecific Synthesis and NMR Conformational Studies of .gamma.-Butyrolactones of Nucleosides as Chiral Synthons for the Preparation of 2'-C- and 3'-C-Branched-Chain Nucleosides
Stereospecific synthesis and antiviral activities of beta-L-2',3'-dideoxy-5-chloropyrimidine nucleoside derivatives
artículo científico publicado en 1999
Structural basis for the specificity of thymidylate kinases from human pathogens: implications for nucleotide analogues activation
artículo científico publicado en 2009
Structural modification of diarylpyrimidine derivatives as HIV-1 reverse transcriptase inhibitors
Structural modifications of DAPY analogues with potent anti-HIV-1 activity
artículo científico publicado en 2009
Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design
artículo científico publicado en 2006
Structure-activity relationship of brominated 3-alkyl-5-methylene-2(5H)-furanones and alkylmaleic anhydrides as inhibitors of Salmonella biofilm formation and quorum sensing regulated bioluminescence in Vibrio harveyi
artículo científico publicado en 2010
Structure-activity relationship of tumor-selective 5-substituted 2-amino-3-carboxymethylthiophene derivatives
artículo científico publicado en 2014
Structure-activity relationship studies of a series of antiviral and antibacterial aglycon derivatives of the glycopeptide antibiotics vancomycin, eremomycin, and dechloroeremomycin
artículo científico publicado en 2005
Structure-activity relationship studies on a novel family of specific HIV-1 reverse transcriptase inhibitors.
artículo científico publicado en 2003
Structure-activity relationship study on anti-HIV 6-desfluoroquinolones
artículo científico publicado en 2008
Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base
artículo científico publicado en 1999
Studies on enzyme-cleavable dialkoxymethyl-cyclosaligenyl-2',3'-dideoxy-2',3'-didehydrothymidine monophosphates
artículo científico publicado en 2008
Substituted naphthalen-1-yl-acetic acid hydrazides: synthesis, antimicrobial evaluation and QSAR analysis
artículo científico publicado en 2013
Substrate specificity of feline and canine herpesvirus thymidine kinase
artículo científico publicado en 2008
Substrate specificity of vaccinia virus thymidylate kinase
artículo científico publicado en 2005
Successful kinase bypass with new acyclovir phosphoramidate prodrugs
artículo científico publicado en 2008
Successful treatment of progressive mucocutaneous infection due to acyclovir- and foscarnet-resistant herpes simplex virus with (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC).
artículo científico publicado en 1994
Sugar and Base-Modified 2',3'-Dideoxynucleosides as Potential Anti-Aids Drugs
article
Sugar-binding proteins potently inhibit dendritic cell human immunodeficiency virus type 1 (HIV-1) infection and dendritic-cell-directed HIV-1 transfer
artículo científico publicado en 2005
Suppression of feline immunodeficiency virus infection in vivo by 9-(2-phosphonomethoxyethyl)adenine
artículo científico publicado en 1990
Suppression of the breakthrough of human immunodeficiency virus type 1 (HIV-1) in cell culture by thiocarboxanilide derivatives when used individually or in combination with other HIV-1-specific inhibitors (i.e., TSAO derivatives)
artículo científico publicado en 1995
Susceptibilities of several clinical varicella-zoster virus (VZV) isolates and drug-resistant VZV strains to bicyclic furano pyrimidine nucleosides
artículo científico publicado en 2005
Susceptibility of feline immunodeficiency virus/human immunodeficiency virus type 1 reverse transcriptase chimeras to non-nucleoside RT inhibitors
artículo científico publicado en 2004
Synergistic in vitro anti-HIV type 1 activity of tenofovir with carbohydrate-binding agents (CBAs).
artículo científico publicado en 2011
Syntheses and anti-HIV activities of (+/-)-norcarbovir and (+/-)-norabacavir
artículo científico publicado en 2007
Syntheses et Activites Biologiques de Nouvelles (E)-Alcenyl-5 Desoxy-2′ Uridines
Synthesis and Anti-HIV Evaluation of Novel 1,2,4-triazole Derivatives as Potential Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors
article
Synthesis and Anti-HIV-1 Activity of 4- and 5-Substituted 1,2,3-Triazole-TSAO Derivatives
article
Synthesis and Antiviral Activities of Some New 5-Heteroaromatic Substituted Derivatives of 2'-Deoxyuridine
Synthesis and Antiviral Activities of Some Novel Carbocyclic Nucleosides
Synthesis and Antiviral Activity of Acyclic Nucleotide Analogues Derived from 6-(Aminomethyl)purines and Purine-6-carboxamidines
Synthesis and Antiviral Activity of Various N4-Acyl Derivatives of Cidofovir and its 5-Azacytosine Counterpart, 1-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]-5-Azacytosine
artículo científico publicado en 2008
Synthesis and Antiviral Evaluation of 3'-Substituted Thymidine Analogues Derived from 3'-Amino-3'-deoxythymidine
Synthesis and Antiviral and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclobutane Ring
artículo científico publicado en 1999
Synthesis and Biological Activity of the Mono- and Diamino Analogues of 2′-Deoxyadenosine, Cordycepin, 9-(3-Deoxy-α-D-Threo-Pentofuranosyl)-Adenine (A Structural Component of Agrocin 84) and 9-(2-Deoxy-α-D-Threo-Pentofuranosyl)Adenine
Synthesis and Biological Evaluation of 1,2-Disubstituted Carbonucleosides of 6-Substituted Purine and 8-Azapurine
artículo científico publicado en 1999
Synthesis and Biological Evaluation of Acyclic Nucleotide Analogues of Bicyclic Pyrimidine Bases
scientific article published in 2009
Synthesis and Biological Evaluation of Novel 1,2,3‐Triazolonucleotides
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artículo científico publicado el 21 de febrero de 2013
Synthesis and Evaluation of Antiviral Activity of 3'-C-Cyano-3'-Deoxynucleosides
Synthesis and Evaluation of Novel Acyclovir Phosphoramidates as Anti-HIV Agents
article
Synthesis and NMR conformational studies of stable analogues of 2-deoxy-α-D-ribose-1-phosphate
Synthesis and SAR of 2',3'-bis-O-substituted N(6), 5'-bis-ureidoadenosine derivatives: implications for prodrug delivery and mechanism of action
artículo científico publicado en 2012
Synthesis and SAR studies on azetidine-containing dipeptides as HCMV inhibitors
article
Synthesis and an antiviral activity evaluation of nucleoside 5´-O-(N-acyl) phosphoramidates
artículo científico publicado en 2011
Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof
artículo científico publicado en 2013
Synthesis and anti-HIV activity evaluation of 1-[(alkenyl or alkynyl or alkyloxy)methyl]-5-alkyl-6-(1-naphthoyl)-2,4-pyrimidinediones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
artículo científico publicado en 2006
Synthesis and anti-HIV activity of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazines (TTDs): a new family of HIV-1 specific non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 1999
Synthesis and anti-HIV activity of 2-naphthyl substituted DAPY analogues as non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2010
Synthesis and anti-HIV activity of 4'-C-ethynyl-2'-deoxy-4'-thio-nucleosides
artículo científico publicado en 2009
Synthesis and anti-HIV activity of 4-(naphthalen-1-yl)-1,2,5-thiadiazol-3-hydroxyl derivatives
artículo científico publicado en 2014
Synthesis and anti-HIV activity of aryl-2-[(4-cyanophenyl)amino]-4-pyrimidinone hydrazones as potent non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2011
Synthesis and anti-HIV activity of some novel chain-extended phosphoramidate derivatives of d4T (stavudine): esterase hydrolysis as a rapid predictive test for antiviral potency
artículo científico publicado en 1998
Synthesis and anti-HIV evaluation of 2',3'-dideoxyribo-5-chloropyrimidine analogues: reduced toxicity of 5-chlorinated 2',3'-dideoxynucleosides
artículo científico publicado en 1990
Synthesis and anti-HIV studies of 2- and 3-adamantyl-substituted thiazolidin-4-ones
artículo científico publicado en 2008
Synthesis and anti-HIV studies of 2-adamantyl-substituted thiazolidin-4-ones
artículo científico publicado en 2007
Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or alpha-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
artículo científico publicado en 2007
Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives
artículo científico publicado en 2006
Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds
artículo científico publicado en 2008
Synthesis and anti-herpetic activity of phosphoramidate ProTides
artículo científico publicado en 2013
Synthesis and anti-varicella-zoster virus activity of some novel bicyclic nucleoside inhibitors: effect of enhanced aqueous solubility
artículo científico publicado en 2000
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
artículo científico publicado en 1993
Synthesis and antiretrovirus properties of 5'-isocyano-5'-deoxythymidine, 5'-isocyano-2',5'-dideoxyuridine, 3'-azido-5'-isocyano-3',5'-dideoxythymidine, and 3'-azido-5'-isocyano-2',3',5'-trideoxyuridine
artículo científico publicado en 1991
Synthesis and antitumor molecular mechanism of agents based on amino 2-(3',4',5'-trimethoxybenzoyl)benzo[b]furan: inhibition of tubulin and induction of apoptosis
artículo científico publicado en 2011
Synthesis and antiviral activities of 1,2,3-triazole functionalized thymidines: 1,3-dipolar cycloaddition for efficient regioselective diversity generation
artículo científico publicado en 2005
Synthesis and antiviral activities of 3-aralkylthiomethylimidazo[1,2-b]pyridazine derivatives
artículo científico publicado en 2003
Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety
artículo científico publicado en 2012
Synthesis and antiviral activities of new acyclic and "double-headed" nucleoside analogues
artículo científico publicado en 2006
Synthesis and antiviral activity evaluation of acyclic 2'-azanucleosides bearing a phosphonomethoxy function in the side chain.
artículo científico publicado en 2009
Synthesis and antiviral activity of 1,3-disubstituted uracils against HIV-1 and HCMV.
artículo científico publicado en 2003
Synthesis and antiviral activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil against HIV-1.
artículo científico publicado en 2004
Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds
artículo científico publicado en 2004
Synthesis and antiviral activity of 3'-heterocyclic substituted 3'-deoxythymidines
artículo científico publicado en 1990
Synthesis and antiviral activity of 6-benzoyl-benzoxazolin-2-one and 6-benzoyl-benzothiazolin-2-one derivatives
artículo científico publicado en 1999
Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines
artículo científico publicado en 2011
Synthesis and antiviral activity of boranophosphonate isosteres of AZT and d4T monophosphates
artículo científico publicado en 2009
Synthesis and antiviral activity of highly water-soluble polycarboxylic derivatives of [70]fullerene
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artículo científico publicado el 10 de junio de 2011
Synthesis and antiviral activity of imidazo[1,2-a]pyridines
Synthesis and antiviral activity of monofluorinated cyclopropanoid nucleosides
artículo científico publicado en 2003
Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
artículo científico publicado en 2009
Synthesis and antiviral activity of phosphonate derivatives of enantiomeric dihydro-2H-pyranyl nucleosides
scientific article published in 1995
Synthesis and antiviral activity of some 5'-N-phthaloyl-3'-azido-2',3'-dideoxythymidine analogues
artículo científico publicado en 2003
Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives
artículo científico publicado en 1992
Synthesis and antiviral activity of the carbocyclic analogue of the highly potent and selective anti-VZV bicyclo furano pyrimidines
artículo científico publicado en 2007
Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine
artículo científico publicado en 1989
Synthesis and antiviral activity of three pyrazole analogues of distamycin A.
artículo científico publicado en 1994
Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives
artículo científico publicado en 2007
Synthesis and antiviral and cytostatic properties of 3'-deoxy-3'-fluoro- and 2'-azido-3'-fluoro-2',3'-dideoxy-D-ribofuranosides of natural heterocyclic bases
artículo científico publicado en 1991
Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives
artículo científico publicado en 2003
Synthesis and antiviral evaluation of 3′-substituted thymidine analogues derived from 3′-amino-3′-deoxythymidine
Synthesis and antiviral evaluation of 4'-alkoxy analogues of 9-(beta-D-xylofuranosyl)adenine
artículo científico publicado en 2009
Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core
artículo científico publicado en 2007
Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4′-phosphono-but-2′-en-1′-yl]purine nucleosides
article
Synthesis and antiviral evaluation of cis-substituted cyclohexenyl and cyclohexanyl nucleosides.
artículo científico publicado en 2005
Synthesis and antiviral evaluation of cyclic and acyclic 2-methyl-3-hydroxy-4-pyridinone nucleoside derivatives
artículo científico publicado en 2006
Synthesis and antiviral evaluation of phosphoramidate derivatives of (E)-5-(2-bromovinyl)-2'-deoxyuridine
artículo científico publicado en 2001
Synthesis and antiviral evaluation of some 3'-fluoro bicyclic nucleoside analogues
artículo científico publicado en 2004
Synthesis and antiviral evaluation of some beta-L-2', 3'-dideoxy-5-chloropyrimidine nucleosides and pronucleotides
artículo científico publicado en 2000
Synthesis and antiviral evaluation of α-L-2'-deoxythreofuranosyl nucleosides
artículo científico publicado en 2011
Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design
artículo científico publicado en 1992
Synthesis and biological activity of novel 1H,3H-thiazolo[3,4-a]benzimidazoles: non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors
artículo científico publicado en 1999
Synthesis and biological activity of strongly fluorescent tricyclic analogues of acyclovir and ganciclovir
artículo científico publicado en 2002
Synthesis and biological activity of tricyclic analogues of 9-[[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]guanine
artículo científico publicado en 2006
Synthesis and biological evaluation of 1-methyl-2-(3',4',5'-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors
artículo científico publicado en 2008
Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors
artículo científico publicado en 2006
Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives as antimitotic agents and inhibitors of tubulin polymerization
artículo científico publicado en 2008
Synthesis and biological evaluation of 2-aroyl-4-phenyl-5-hydroxybenzofurans as a new class of antitubulin agents
artículo científico publicado en 2008
Synthesis and biological evaluation of 3,3-difluoropyridine-2,4(1H,3H)-dione and 3-deaza-3-fluorouracil base and nucleoside derivatives
artículo científico publicado en 2009
Synthesis and biological evaluation of 4-(hydroxyimino)arylmethyl diarylpyrimidine analogues as potential non-nucleoside reverse transcriptase inhibitors against HIV.
artículo científico publicado en 2010
Synthesis and biological evaluation of 5-(alkyn-1-yl)-1-(p-toluenesulfonyl)uracil derivatives
article
Synthesis and biological evaluation of 6-(alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one base and nucleoside derivatives
artículo científico publicado en 2006
Synthesis and biological evaluation of N- and O-alkylated bicyclic furanopyrimidines as non-nucleosidic inhibitors of human cytomegalovirus.
artículo científico publicado en 2005
Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2'-deoxy nucleoside analogues
artículo científico publicado en 2012
Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides
artículo científico publicado en 2005
Synthesis and biological evaluation of acyclic nucleotide analogues with a furo[2,3-d]pyrimidin-2(3H)-one base
Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging
artículo científico publicado en 2007
Synthesis and biological evaluation of dinucleoside methylphosphonates of 3'-azido-3'-deoxythymidine and 2', 3'-dideoxycytidine
artículo científico publicado en 1990
Synthesis and biological evaluation of iodinated and fluorinated 9-(2-hydroxypropyl) and 9-(2-hydroxyethoxy)methyl purine nucleoside analogues
artículo científico publicado en 2003
Synthesis and biological evaluation of isonucleosides derived from methyl 3,5-anhydro-2-O-(2-fluorobenzyl)-D-xylofuranosides
artículo científico publicado en 2002
Synthesis and biological evaluation of new conformationally restricted S-DABO hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase
article
Synthesis and biological evaluation of novel 1'-branched and spironucleoside analogues.
artículo científico publicado en 2004
Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors
artículo científico publicado en 2008
Synthesis and biological evaluation of phosphoramidate prodrugs of two analogues of 2-deoxy-d-ribose-1-phosphate directed to the discovery of two carbasugars as new potential anti-HIV leads
artículo científico publicado en 2014
Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors
artículo científico publicado en 2012
Synthesis and biological evaluation of prodrugs of 2-fluoro-2-deoxyribose-1-phosphate and 2,2-difluoro-2-deoxyribose-1-phosphate
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artículo científico publicado el 14 de marzo de 2013
Synthesis and biological evaluation of purine 2'-fluoro-2'-deoxyriboside ProTides as anti-influenza virus agents
artículo científico publicado en 2013
Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs
artículo científico publicado en 2013
Synthesis and biological evaluation of pyrimidine nucleoside monophosphate prodrugs targeted against influenza virus
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artículo científico publicado el 28 de enero de 2012
Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase
artículo científico publicado en 2011
Synthesis and biological properties of C-2 triazolylinosine derivatives
artículo científico publicado en 2012
Synthesis and broad spectrum antiviral evaluation of bis(POM) prodrugs of novel acyclic nucleosides
artículo científico publicado en 2013
Synthesis and cellular pharmacology studies of a series of 2-amino-3-aroyl-4-substituted thiophene derivatives
artículo científico publicado en 2010
Synthesis and cytostatic and antiviral activities of 1-beta-D-ribofuranosyl-5-alkylcytosine (5-alkylcytidine) cyclic 3',5'-monophosphates
artículo científico publicado en 1989
Synthesis and cytostatic evaluation of 4-N-alkanoyl and 4-N-alkyl gemcitabine analogues
artículo científico publicado en 2013
Synthesis and cytotoxic evaluation of some styryl ketones and related compounds
Synthesis and cytotoxic properties of 4,11-bis[(aminoethyl)amino]anthra[2,3-b]thiophene-5,10-diones, novel analogues of antitumor anthracene-9,10-diones
artículo científico publicado en 2009
Synthesis and evaluation of a (99m)Tc-MAMA-propyl-thymidine complex as a potential probe for in vivo visualization of tumor cell proliferation with SPECT.
artículo científico publicado en 2007
Synthesis and evaluation of new antitumor 3-aminomethyl-4,11-dihydroxynaphtho[2,3-f]indole-5,10-diones
artículo científico publicado en 2014
Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA.
artículo científico publicado en 2001
Synthesis and evaluation of thymine-derived carboxamides against mitochondrial thymidine kinase (TK-2) and related enzymes
artículo científico publicado en 2004
Synthesis and fluorescent properties of 6-(4-biphenylyl)-3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purine analogues of acyclovir and ganciclovir
artículo científico publicado en 2003
Synthesis and fluorescent properties of the tricyclic analogues of acyclovir linked with nitrogen hetbrocyclic units
artículo científico publicado en 2005
Synthesis and in vitro activity of novel N-3 acylated TSAO-T compounds against HIV-1 and HCV.
artículo científico publicado en 2011
Synthesis and in vitro anti-HIV evaluation of a new series of 6-arylmethyl-substituted S-DABOs as potential non-nucleoside HIV-1 reverse transcriptase inhibitors
artículo científico publicado en 2008
Synthesis and in vitro cytotoxic and antiviral activities of 1-(2,5,6-trideoxy-6-halogenohept-5-enofuranurononitrile)thymine and derivatives
artículo científico publicado en 2002
Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles
artículo científico publicado en 2005
Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography
artículo científico publicado en 2007
Synthesis and structure-activity relationship of novel diarylpyrimidines with hydromethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs
artículo científico publicado en 2011
Synthesis of 2?-Deoxy-5-(isothiazol-5-yl)uridine and Its Interaction with the HSV-1 Thymidine Kinase
article
Synthesis of 3' '-substituted TSAO derivatives with anti-HIV-1 and anti-HIV-2 activity through an efficient palladium-catalyzed cross-coupling approach
artículo científico publicado en 2002
Synthesis of 3',4'-difluoro-3'-deoxyribonucleosides and its evaluation of the biological activities: discovery of a novel type of anti-HCV agent 3',4'-difluorocordycepin
artículo científico publicado en 2014
Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents
artículo científico publicado en 2003
Synthesis of 3'-Fluoro-3'-Deoxyribonucleosides; Anti-HIV-1 and Cytostatic Properties
article
Synthesis of 3-fluoro-6-S-(2-S-pyridyl) nucleosides as potential lead cytostatic agents
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artículo científico publicado el 17 de agosto de 2010
Synthesis of 4,6-dideoxy-3-fluoro-2-keto-beta-D-glucopyranosyl analogues of 5-fluorouracil, N6-benzoyl adenine, uracil, thymine, N4-benzoyl cytosine and evaluation of their antitumor activities
artículo científico publicado en 2009
Synthesis of 5-substituted 2'-deoxyuridine-5'- phosphonate analogues and evaluation of their antiviral activity
artículo científico publicado en 2012
Synthesis of O2- and N3-(2-Phosphonomethoxy)ethyl Derivatives of 6-Phenyl- and 6-Pyridinyl-5-azacytosine
article
Synthesis of [1-[2',5'-bis-O-(t-Butyldimethylsilyl)-β- L-ribofuranosyl] thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (L-TSAO-T)
article published in 1995
Synthesis of [1-[3′,5′-Bis-O-(tert-butyldimethylsilyl)-β-d-arabino- and β-d-ribofuranosyl]cytosine]-2′-spiro-5″-(4″-amino-1″,2″-oxathiole-2″,2″-dioxide). Analogues of the highly specific anti-HIV-1 agent TSAO-T
article
Synthesis of adamantane spiro sultones as potential antiviral agents
artículo científico publicado en 1992
Synthesis of an apionucleoside family and discovery of a prodrug with anti-HIV activity
artículo científico publicado en 2014
Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents
artículo científico publicado en 2010
Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents
artículo científico publicado en 2004
Synthesis of new C5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2'-deoxyuridines and their antiviral evaluation
artículo científico publicado en 2010
Synthesis of novel 6-azapyrimidine acyclic nucleoside analogues and antiviral evaluation
artículo científico publicado en 2010
Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivatives
artículo científico publicado en 2010
Synthesis of novel carbocyclic nucleosides with a modified cyclopentane ring and evaluation of their antiviral activity
artículo científico publicado en 1999
Synthesis of purine and 7-deazapurine nucleoside analogues of 6-N-(4-Nitrobenzyl)adenosine; inhibition of nucleoside transport and proliferation of cancer cells
artículo científico publicado en 2014
Synthesis of unusual bicyclic nucleosides bearing an unsaturated side-chain, as potential inhibitors of varicella-zoster virus (VZV).
artículo científico publicado en 2003
Synthesis, Biological Evaluation, and Structure Analysis of a Series of New 1,5-Anhydrohexitol Nucleosides
article
Synthesis, Characterization and Antiviral Properties of Pd(II) Complexes With Penciclovir
artículo científico publicado en 2001
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin
artículo científico publicado en 1989
Synthesis, SAR, and preliminary mechanistic evaluation of novel antiproliferative N6,5′-bis-ureido- and 5′-carbamoyl-N6-ureidoadenosine derivatives
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artículo científico publicado el 2 de diciembre de 2011
Synthesis, X-ray crystal structural study, antiviral and cytostatic evaluations of the novel unsaturated acyclic and epoxide nucleoside analogues
artículo científico publicado en 2006
Synthesis, X-ray crystal structure study, and cytostatic and antiviral evaluation of the novel cycloalkyl-N-aryl-hydroxamic acids.
artículo científico publicado en 2005
Synthesis, anti-HIV and cytostatic evaluation of 3'-deoxy-3'-fluorothymidine (FLT) pro-nucleotides
artículo científico publicado en 2014
Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound
artículo científico publicado en 2008
Synthesis, anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T).
artículo científico publicado en 1998
Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid
artículo científico publicado en 2010
Synthesis, anticancer and cytostatic activity of some 6H-indolo[2,3-b]quinoxalines
artículo científico publicado en 2009
Synthesis, anticancer, and cytotoxic activities of some mononuclear Ru(II) compounds
artículo científico publicado en 2007
Synthesis, antimicrobial and antiviral activity of substituted benzimidazoles
artículo científico publicado en 2009
Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives
artículo científico publicado en 2008
Synthesis, antimycobacterial, antiviral, antimicrobial activity and QSAR studies of N(2)-acyl isonicotinic acid hydrazide derivatives
artículo científico publicado en 2013
Synthesis, antineoplastic and cytotoxic activities of some mononuclear Ru(II) complexes
artículo científico publicado en 2010
Synthesis, antiretrovirus effects, and phosphorylation kinetics of 3'-isocyano-3'-deoxythymidine and 3'-isocyano-2',3'-dideoxyuridine
artículo científico publicado en 1990
Synthesis, antiviral and cytostatic activities, of carbocyclic nucleosides incorporating a modified cyclopentane ring. IV. Adenosine and uridine analogues
artículo científico publicado en 2002
Synthesis, biological activity, pharmacokinetic properties and molecular modelling studies of novel 1H,3H-oxazolo[3,4-a]benzimidazoles: non-nucleoside HIV-1 reverse transcriptase inhibitors
artículo científico publicado en 2001
Synthesis, conformational analysis and antiviral and antitumoral activity of new 1,2-disubstituted carbocyclic nucleosides.
artículo científico publicado en 2002
Synthesis, modeling and evaluation of 3'-(1-aryl-1H-tetrazol-5-ylamino)-substituted 3'-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors
artículo científico publicado en 2010
Synthesis, solution conformation and anti-HIV activity of novel 3'-substituted-2',3'-dideoxy-5-hydroxymethyluridines and their 4,5-substituted analogues
artículo científico publicado en 2003
Synthesis, structural studies, and biological evaluation of some purine substituted 1-aminocyclopropane-1-carboxylic acids and 1-amino-1-hydroxymethylcyclopropanes.
artículo científico publicado en 2003
TSAO Derivatives: Highly Specific Inhibitors of Human Immunodeficiency Virus Type-1 (HIV-1) Replication
article
TSAO analogues. 3. Synthesis and anti-HIV-1 activity of 2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl 3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) purine and purine-modified nucleosides.
artículo científico publicado en 1993
TSAO analogues. Stereospecific synthesis and anti-HIV-1 activity of 1-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro -5''- (4''-amino-1'',2''-oxathiole 2'',2''-dioxide) pyrimidine and pyrimidine-modified nucleosides
artículo científico publicado en 1992
TSAO compounds: the comprehensive story of a unique family of HIV-1 specific inhibitors of reverse transcriptase
artículo científico publicado en 2004
TSAO-T analogues bearing amino acids at position N-3 of thymine: synthesis and anti-human immunodeficiency virus activity
artículo científico publicado en 2000
Targeting HIV entry through interaction with envelope glycoprotein 120 (gp120): synthesis and antiviral evaluation of 1,3,5-triazines with aromatic amino acids
artículo científico publicado en 2011
Targeting platelet-derived endothelial cell growth factor/thymidine phosphorylase for cancer therapy
artículo científico publicado en 2007
The 2',3'-dideoxyriboside of 2,6-diaminopurine and its 2',3'-didehydro derivative inhibit the deamination of 2',3'-dideoxyadenosine, an inhibitor of human immunodeficiency virus (HIV) replication
artículo científico publicado en 1987
The 2',3'-dideoxyriboside of 2,6-diaminopurine selectively inhibits human immunodeficiency virus (HIV) replication in vitro
artículo científico publicado en 1987
The A167Y mutation converts the herpes simplex virus type 1 thymidine kinase into a guanosine analogue kinase
artículo científico publicado en 2002
The Application of Phosphoramidate Protide Technology to Acyclovir confers Novel Anti-HIV Inhibition
article
The Cellular Thioredoxin-1/Thioredoxin Reductase-1 Driven Oxidoreduction Represents a Chemotherapeutic Target for HIV-1 Entry Inhibition
artículo científico publicado en 2016
The DiPPro approach: synthesis, hydrolysis, and antiviral activity of lipophilic d4T diphosphate prodrugs
artículo científico publicado en 2014
The Highly Conserved Glycan at Asparagine 260 of HIV-1 gp120 Is Indispensable for Viral Entry
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artículo científico publicado el 17 de octubre de 2011
The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs
artículo científico publicado en 2005
The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization
artículo científico publicado en 2010
The amino acid Asn136 in HIV-1 reverse transcriptase (RT) maintains efficient association of both RT subunits and enables the rational design of novel RT inhibitors
artículo científico publicado en 2005
The antiretroviral and cytostatic activity, and metabolism of 3'-azido-2',3'-dideoxythymidine, 3'-fluoro-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly cell type-dependent.
artículo científico publicado en 1989
The cytostatic activity of NUC-3073, a phosphoramidate prodrug of 5-fluoro-2'-deoxyuridine, is independent of activation by thymidine kinase and insensitive to degradation by phosphorolytic enzymes
artículo científico publicado en 2011
The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones
artículo científico publicado en 2008
The design, synthesis and antiviral evaluation of a series of 5-trimethylsilyl-1-beta-D-(arabinofuranosyl)uracil phosphoramidate ProTides
artículo científico publicado en 2010
The dual role of thymidine phosphorylase in cancer development and chemotherapy
artículo científico publicado en 2009
The effect of a methyl or 2-fluoroethyl substituent at the N-3 position of thymidine, 3'-fluoro-3'-deoxythymidine and 1-beta-D-arabinosylthymine on their antiviral and cytostatic activity in cell culture
artículo científico publicado en 2006
The first series of 4,11-bis[(2-aminoethyl)amino]anthra[2,3-b]furan-5,10-diones: Synthesis and anti-proliferative characteristics
artículo científico publicado en 2010
The griffithsin dimer is required for high-potency inhibition of HIV-1: evidence for manipulation of the structure of gp120 as part of the griffithsin dimer mechanism
artículo científico publicado en 2013
The human immunodeficiency virus(HIV) inhibitor 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a strong inducer of differentiation of several tumor cell lines
artículo científico publicado en 1995
The journey towards elucidating the anti-HCMV activity of alkylated bicyclic furano pyrimidines.
artículo científico
The lantibiotic peptide labyrinthopeptin A1 demonstrates broad anti-HIV and anti-HSV activity with potential for microbicidal applications
artículo científico publicado en 2013
The molecular basis of resilience to the effect of the Lys103Asn mutation in non-nucleoside HIV-1 reverse transcriptase inhibitors studied by targeted molecular dynamics simulations
artículo científico publicado en 2005
The monomeric and dimeric mannose-binding proteins from the Orchidaceae species Listera ovata and Epipactis helleborine: sequence homologies and differences in biological activities
artículo científico publicado en 1994
The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations
artículo científico publicado en 2006
The novel L- and D-amino acid derivatives of hydroxyurea and hydantoins: synthesis, X-ray crystal structure study, and cytostatic and antiviral activity evaluations.
artículo científico publicado en 2005
The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations
artículo científico publicado en 2008
The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: synthesis, cytostatic and antiviral activity evaluations.
artículo científico publicado en 2007
The novel pyrimidine and purine derivatives of l-ascorbic acid: synthesis, one- and two-dimensional 1H and 13C NMR study, cytostatic and antiviral evaluation
artículo científico publicado en 2005
The nucleoside derivative 5'-O-trityl-inosine (KIN59) suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action
artículo científico publicado en 2004
The phenylmethylthiazolylthiourea nonnucleoside reverse transcriptase (RT) inhibitor MSK-076 selects for a resistance mutation in the active site of human immunodeficiency virus type 2 RT.
artículo científico publicado en 2004
The phthalocyanine prototype derivative Alcian Blue is the first synthetic agent with selective anti-human immunodeficiency virus activity due to its gp120 glycan-binding potential
artículo científico publicado en 2009
The potential of acyclic nucleoside phosphonates as broad-spectrum antiviral agents.
artículo científico publicado en 1995
The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase
artículo científico publicado en 2005
The pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis and how it may affect nucleoside-based therapy
artículo científico publicado en 2014
The rare HIV-1 gp41 mutations 43T and 50V elevate enfuvirtide resistance levels of common enfuvirtide resistance mutations that did not impact susceptibility to sifuvirtide
artículo científico publicado en 2010
The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention
artículo científico publicado en 2006
The role of N-glycans of HIV-1 gp41 in virus infectivity and susceptibility to the suppressive effects of carbohydrate-binding agents
artículo científico publicado en 2014
The role of Thr139 in the human immunodeficiency virus type 1 reverse transcriptase sensitivity to (+)-calanolide A.
artículo científico publicado en 2005
The role of individual carbohydrate-binding sites in the function of the potent anti-HIV lectin griffithsin
artículo científico publicado en 2012
The synthesis, antiviral, cytostatic and cytotoxic evaluation of a new series of acyclonucleotide analogues with a 1,2,3-triazole linker
artículo científico publicado en 2013
The thymidine phosphorylase inhibitor 5'-O-tritylinosine (KIN59) is an antiangiogenic multitarget fibroblast growth factor-2 antagonist
artículo científico publicado en 2012
Therapeutic strategies towards HIV-1 infection in macrophages
artículo científico publicado en 2006
Thermal characterization of the antiviral drug UC-781 and stability of its glass
Thienothiadiazine 2,2-dioxide acyclonucleosides: synthesis and antiviral activity
artículo científico publicado en 2000
Thioredoxin-1 and protein disulfide isomerase catalyze the reduction of similar disulfides in HIV gp120.
artículo científico publicado en 2012
Thiosugars. X. Novel nucleoside analogues derived from 4-thio-L-lyxofuranose
artículo científico publicado en 2003
Thiosugars. XII. Synthesis of new 3'-O-substituted 2',5'-anhydro-2'-thio-alpha-D-pentofuranosyl nucleoside analogues.
artículo científico publicado en 2004
Thymidine analogs as potential antiviral agents
artículo científico publicado en 2008
Thymidine phosphorylase inhibitors: recent developments and potential therapeutic applications
artículo científico publicado en 2005
Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: synthesis, biological investigation and molecular modeling studies
artículo científico publicado en 2013
Treatment of visna virus infection in lambs with the acyclic nucleoside phosphonate analogue 9-(2-phosphonylmethoxyethyl)adenine (PMEA).
artículo científico publicado en 1998
Tumour-specific cytotoxicity and structure-activity relationships of novel 1-[3-(2-methoxyethylthio)propionyl]-3,5-bis(benzylidene)-4-piperidones
artículo científico publicado en 2016
Unusual lability of 5'-O-tert-butyldimethylsilyl group on 4''-acyl TSAO derivatives
artículo científico publicado en 2003
Vaginal microbiota and its role in HIV transmission and infection
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artículo científico publicado el 1 de septiembre de 2013
Virtual screening of acyclovir derivatives as potential antiviral agents: design, synthesis and biological evaluation of new acyclic nucleoside ProTides
artículo científico publicado en 2017
Viruses as key regulators of angiogenesis
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artículo científico publicado el 1 de mayo de 2011
[(18)F]FDG PET monitoring of tumour response to chemotherapy: does [(18)F]FDG uptake correlate with the viable tumour cell fraction?
artículo científico publicado en 2003
[2',5'-Bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of purine and pyrimidinenucleosides as potent and selective inhibitors of human immunodeficiency virus type 1
artículo científico publicado en 1992
cycloSal-PMEA and cycloAmb-PMEA: potentially new phosphonate prodrugs based on the cycloSal-pronucleotide approach
artículo científico publicado en 2005
cycloSal-Pronucleotides of 2',3'-dideoxyadenosine and 2', 3'-dideoxy-2',3'-didehydroadenosine: synthesis and antiviral evaluation of a highly efficient nucleotide delivery system
artículo científico publicado en 1999
cycloSal-Pronucleotides of 2'-fluoro-ara- and 2'-fluoro-ribo-2',3'- dideoxyadenosine as a strategy to bypass a metabolic blockade
artículo científico publicado en 1999
cycloSal-d4TMP pronucleotides structural variations, mechanistic insights and antiviral activity.
artículo científico publicado en 2002