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Lista de obras de Simon Lovestone

5-HT2A and 5-HT2C receptor polymorphisms and psychopathology in late onset Alzheimer's disease.

artículo científico publicado en 1998

A Decade of Blood Biomarkers for Alzheimer's Disease Research: An Evolving Field, Improving Study Designs, and the Challenge of Replication

artículo científico publicado en 2018

A Multi-Cohort Study of ApoE ɛ4 and Amyloid-β Effects on the Hippocampus in Alzheimer's Disease

artículo científico publicado en 2017

A Multiple Indicators Multiple Causes (MIMIC) model of Behavioural and Psychological Symptoms in Dementia (BPSD).

artículo científico publicado en 2009

A Pathway Based Classification Method for Analyzing Gene Expression for Alzheimer's Disease Diagnosis

artículo científico publicado en 2015

A Subset of Cerebrospinal Fluid Proteins from a Multi-Analyte Panel Associated with Brain Atrophy, Disease Classification and Prediction in Alzheimer's Disease

artículo científico publicado en 2015

A blood gene expression marker of early Alzheimer's disease

artículo científico publicado en 2013

A call for comparative effectiveness research to learn whether routine clinical care decisions can protect from dementia and cognitive decline

artículo científico publicado en 2016

A comparison of mental state examination documentation by junior clinicians in electronic health records before and after the introduction of a semi-structured assessment template (OPCRIT+).

artículo científico publicado en 2015

A comprehensive testing protocol for MRI neuroanatomical segmentation techniques: Evaluation of a novel lateral ventricle segmentation method

artículo científico publicado en 2011

A feasibility and tolerability study of lithium in Alzheimer's disease

artículo científico publicado en 2008

A full genome scan for late onset Alzheimer's disease

artículo científico publicado en 1999

A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort

scientific article published on 18 December 2019

A phase II trial of tideglusib in Alzheimer's disease

artículo científico publicado en 2015

A proposed metabolic strategy for monitoring disease progression in Alzheimer's disease

scholarly article by Nicola Greenberg et al published April 2009 in Electrophoresis

A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease

artículo científico publicado en 2005

APOE ε2 allele is associated with larger regional cortical thicknesses and volumes

artículo científico publicado en 2010

APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer's disease

artículo científico publicado en 2020

Abnormalities of Wnt signalling in schizophrenia – evidence for neurodevelopmental abnormality ⬇️

artículo científico publicado el 11 de mayo de 1998

Abnormally phosphorylated tau protein in senile dementia of Lewy body type and Alzheimer disease: evidence that the disorders are distinct

artículo científico publicado en 1995

Acetylcholinesterase treatment--modelling potential demand and auditing practice.

artículo científico publicado en 2001

AddNeuroMed and ADNI: similar patterns of Alzheimer's atrophy and automated MRI classification accuracy in Europe and North America

artículo científico publicado en 2011

Advanced glycation end products, dementia, and diabetes

scientific article published on 25 March 2014

Advances in dementia research: Edited by Kurt A Jellinger, Reinhold Schmidt, and Manfred Windisch (Pp 336, US$99.00). Published by Springer, Wien, 2000. ISBN 3-211-83513-X

article

Ageing increases vulnerability to aβ42 toxicity in Drosophila

artículo científico publicado en 2012

Alleles that increase risk for type 2 diabetes mellitus are not associated with increased risk for Alzheimer's disease

artículo científico publicado en 2014

Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimerʼs disease

article

Alpha-2 macroglobulin gene and Alzheimer disease

artículo científico publicado en 1999

Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease

artículo científico publicado en 2004

Alzheimer risk variant CLU and brain function during aging

artículo científico publicado en 2012

Alzheimer's disease and Down's syndrome: an in vivo MRI study

artículo científico publicado en 2008

Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation

article

Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology

artículo científico publicado en 2014

Alzheimer's disease biomarker discovery using in silico literature mining and clinical validation

artículo científico publicado en 2012

Alzheimer's disease in humans and other animals: A consequence of postreproductive life span and longevity rather than aging

artículo científico publicado en 2017

Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood

artículo científico publicado en 2013

Alzheimer's disease-do tauists and baptists finally shake hands?

artículo científico publicado en 2002

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

artículo científico publicado en 1994

An MRI-based index to measure the severity of Alzheimer's disease-like structural pattern in subjects with mild cognitive impairment.

artículo científico publicado en 2013

Analysis of regional MRI volumes and thicknesses as predictors of conversion from mild cognitive impairment to Alzheimer's disease

artículo científico publicado en 2010

Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transporters

artículo científico publicado en 2001

Apathy and cortical atrophy in Alzheimer's disease

artículo científico publicado en 2010

Apolipoprotein E (apoE) uptake and distribution in mammalian cell lines is dependent upon source of apoE and can be monitored in living cells.

artículo científico publicado en 2003

Apolipoprotein E gene and Alzheimer's disease: is tau the link?

artículo científico publicado en 2001

Apolipoprotein E genotype, vascular risk and early cognitive impairment in an African Caribbean population

artículo científico publicado en 2001

Apolipoprotein E genotyping in Alzheimer's disease. The UK Alzheimer's Disease Genetic consortium

artículo científico publicado en 1996

Apolipoprotein E-∈A allele and Alzheimer's disease

artículo científico publicado en 1993

Apolipoprotein E: depressive illness, depressive symptoms, and Alzheimer's disease.

artículo científico publicado en 1998

Apolipoprotein E: non-cognitive symptoms and cognitive decline in late onset Alzheimer's disease

artículo científico publicado en 1996

Application of a MRI based index to longitudinal atrophy change in Alzheimer disease, mild cognitive impairment and healthy older individuals in the AddNeuroMed cohort

artículo científico publicado en 2014

Are abnormal premorbid personality traits associated with Alzheimer's disease? - A case-control study

artículo científico publicado en 2010

Are premorbid abnormal personality traits associated with behavioural and psychological symptoms in dementia?

artículo científico publicado en 2016

Arylsulphatase A pseudo-deficiency in vascular dementia and Alzheimerʼs disease ⬇️

artículo científico publicado el 28 de julio de 1997

Assessment scales in old age psychiatry

artículo científico publicado en 1999

Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease

artículo científico publicado en 2008

Association analysis of dynamin-binding protein (DNMBP) on chromosome 10q with late onset Alzheimer's disease in a large caucasian UK sample.

artículo científico publicado en 2009

Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease

artículo científico publicado en 2016

Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study

artículo científico publicado en 2004

Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis

artículo científico publicado en 2016

Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family

artículo científico publicado en 2004

Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease

artículo científico publicado en 2010

Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia

artículo científico publicado en 2010

Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme

artículo científico publicado en 2005

Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease

artículo científico publicado en 2007

Association study of the 5-HT(2A) receptor gene polymorphism, T102C and essential hypertension

artículo científico publicado en 2001

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 01 September 2019

Automated Hippocampal Subfield Measures as Predictors of Conversion from Mild Cognitive Impairment to Alzheimer's Disease in Two Independent Cohorts

artículo científico publicado en 2014

Automated hippocampal shape analysis predicts the onset of dementia in mild cognitive impairment

artículo científico publicado en 2011

Better together for better dementia research and care

artículo científico publicado en 2016

Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study

scientific article published on 13 September 2019

Biomarkers for Alzheimer's disease therapeutic trials

artículo científico publicado en 2010

Biomarkers for Alzheimer's disease trials--biomarkers for what? A discussion paper

artículo científico publicado en 2009

Biomarkers for disease modification trials--the innovative medicines initiative and AddNeuroMed.

artículo científico publicado en 2007

Biomarkers in Alzheimer's disease

scientific article published on 01 March 2006

Biomarkers in brain disease. Preface

artículo científico publicado en 2009

Blood Protein Markers of Neocortical Amyloid-β Burden: A Candidate Study Using SOMAscan Technology

artículo científico publicado en 2015

Blood biomarkers for Alzheimer's disease

artículo científico publicado en 2014

Blood metabolite markers of neocortical amyloid-β burden: discovery and enrichment using candidate proteins

artículo científico publicado en 2016

Blood protein predictors of brain amyloid for enrichment in clinical trials?

artículo científico publicado en 2015

Blood-Based Biomarker Candidates of Cerebral Amyloid Using PiB PET in Non-Demented Elderly.

artículo científico publicado en 2016

Blood-Based Proteomic Biomarkers of Alzheimer's Disease Pathology

artículo científico publicado en 2015

Blood-based biomarkers of Alzheimer's disease: challenging but feasible

artículo científico publicado en 2010

Boosting translational research on Alzheimer's disease in Europe: The Innovative Medicine Initiative AD research platform

artículo científico publicado en 2015

Brain anatomy and ageing in non-demented adults with Down's syndrome: an in vivo MRI study

artículo científico publicado en 2009

CERAD Neuropsychological Total Scores Reflect Cortical Thinning in Prodromal Alzheimer's Disease

artículo científico publicado en 2013

CERAD neuropsychological battery total score in multinational mild cognitive impairment and control populations: the AddNeuroMed study

artículo científico publicado en 2010

CERAD neuropsychological compound scores are accurate in detecting prodromal alzheimer's disease: a prospective AddNeuroMed study

artículo científico publicado en 2014

Can we afford to develop treatments for dementia?

artículo científico publicado en 2002

Candidate blood proteome markers of Alzheimer's disease onset and progression: a systematic review and replication study

artículo científico

Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study.

artículo científico publicado en 2005

Candidate gene association studies of the alpha 4 (CHRNA4) and beta 2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease

artículo científico publicado en 2004

Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci

artículo científico publicado en 2007

Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease

artículo científico publicado en 2007

Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum

artículo científico publicado en 2019

Chloroquine-induced mania

artículo científico publicado en 1991

Circulating Proteomic Signatures of Chronological Age.

artículo científico publicado en 2014

Classification and prediction of clinical diagnosis of Alzheimer's disease based on MRI and plasma measures of α-/γ-tocotrienols and γ-tocopherol.

artículo científico publicado en 2013

Clinical predictors of aggressive behaviour in Alzheimer's disease.

artículo científico publicado en 1998

Clusterin as an Alzheimer Biomarker ⬇️

artículo científico publicado el 1 de noviembre de 2011

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

artículo científico publicado en 2012

Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups--the AddNeuroMed study

artículo científico publicado en 2009

Combinatorial markers of mild cognitive impairment conversion to Alzheimer's disease--cytokines and MRI measures together predict disease progression

artículo científico publicado en 2011

Combining MRI and MRS to distinguish between Alzheimer's disease and healthy controls

artículo científico publicado en 2010

Common brain disorders are associated with heritable patterns of apparent aging of the brain

scientific article published on 24 September 2019

Common genetic variants influence human subcortical brain structures

artículo científico publicado en 2015

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

artículo científico publicado en 2011

Commonly prescribed drugs associate with cognitive function: a cross-sectional study in UK Biobank

artículo científico publicado en 2016

Community care: Italian style.

artículo científico publicado en 1988

Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges

artículo científico publicado en 2016

Complement Biomarkers as Predictors of Disease Progression in Alzheimer's Disease

artículo científico publicado en 2016

Complement activation as a biomarker for Alzheimer's disease

artículo científico

Complement factor H Y402H polymorphism is not associated with late-onset Alzheimer's disease

artículo científico publicado en 2007

Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop

artículo científico publicado en 1996

Correction to "Glycosylation of Human Plasma Clusterin Yields a Novel Candidate Biomarker of Alzheimer's Disease".

artículo científico publicado en 2016

Correction: Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease.

artículo científico publicado en 2011

Correction: Harnessing Clinical Psychiatric Data with an Electronic Assessment Tool (OPCRIT+): The Utility of Symptom Dimensions.

artículo científico publicado en 2013

Correction: Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease

artículo científico publicado en 2012

Corrigendum to “Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH” [Neurosci. Lett. 533 (2013) 96–99].

artículo científico publicado en 2013

Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain.

artículo científico publicado en 2014

Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease

artículo científico publicado en 2016

Cytoskeletal abnormalities in Alzheimer's disease.

artículo científico publicado en 1992

DAPK1 variants are associated with Alzheimer's disease and allele-specific expression

artículo científico publicado en 2006

DISCOVERY AND VALIDATION OF MULTIMODAL BIOMARKER SIGNATURES RELATING TO ALZHEIMER'S DISEASE PATHOLOGY AND PROGRESSION

scholarly article by Sarah Westwood et al published July 2017 in Alzheimer's and Dementia

Deep sequencing of the Nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's disease

artículo científico publicado en 2011

Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH.

artículo científico publicado en 2012

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

scientific journal article

Delusional bovine spongiform encephalopathy

artículo científico publicado en 1990

Dementia in Down's syndrome: an MRI comparison with Alzheimer's disease in the general population

artículo científico publicado en 2013

Dementia,2nd edition.

artículo científico publicado en 2001

Depression in Alzheimer's disease: the effect of serotonin receptor gene variation

artículo científico publicado en 2003

Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7.

artículo científico publicado en 2017

Determining the Molecular Pathways Underlying the Protective Effect of Non-Steroidal Anti-Inflammatory Drugs for Alzheimer's Disease: A Bioinformatics Approach

artículo científico publicado en 2016

Developing a new model for patient recruitment in mental health services: a cohort study using Electronic Health Records

artículo científico publicado en 2014

Developing novel blood-based biomarkers for Alzheimer's disease

artículo científico publicado en 2014

Development and Application of Ultra-Performance Liquid Chromatography-TOF MS for Precision Large Scale Urinary Metabolic Phenotyping.

artículo científico publicado en 2016

Development of interventions for the secondary prevention of Alzheimer's dementia: the European Prevention of Alzheimer's Dementia (EPAD) project

artículo científico

Diabetes and dementia: is the brain another site of end-organ damage?

artículo científico publicado en 1999

Diagnosing Alzheimer's disease--non-clinicians and computerised algorithms together are as accurate as the best clinical practice

artículo científico publicado en 2007

Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology

artículo científico publicado en 2020

Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease

artículo científico publicado en 2009

Different multivariate techniques for automated classification of MRI data in Alzheimer's disease and mild cognitive impairment

artículo científico publicado en 2013

Differential effects of apolipoprotein E isoforms on phosphorylation at specific sites on tau by glycogen synthase kinase-3β identified by nano-electrospray mass spectrometry

artículo científico publicado en 2000

Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay

artículo científico publicado en 2019

Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase.

artículo científico publicado en 2001

Disturbance of Notch-1 and Wnt signalling proteins in neuroglial balloon cells and abnormal large neurons in focal cortical dysplasia in human cortex

article

Do antidepressants regulate how cortisol affects the brain?

artículo científico publicado en 2004

Down syndrome with and without dementia: an in vivo proton Magnetic Resonance Spectroscopy study with implications for Alzheimer's disease

artículo científico publicado en 2011

Dynamic properties of APC-decorated microtubules in living cells

artículo científico publicado en 2003

Dynamin protein in stroke and vascular dementia

artículo científico publicado en 2014

Editorial: EADC (European Alzheimer Disease Consortium) recommendations for future Alzheimer disease research in Europe.

artículo científico publicado en 2008

Education increases reserve against Alzheimer's disease--evidence from structural MRI analysis

artículo científico publicado en 2012

Education, occupation and retirement age effects on the age of onset of Alzheimer's disease

artículo científico publicado en 2010

Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study

artículo científico publicado en 2010

Effects of freezer storage time on levels of complement biomarkers

artículo científico publicado en 2017

Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology

article

Entorhinal cortex thickness predicts cognitive decline in Alzheimer's disease

artículo científico publicado en 2013

Ernest Saunders: diagnostic dilemma

artículo científico publicado en 1992

Erratum to "Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease." [Neurobiol. Aging 32 (2011) 1977-1989].

artículo científico publicado en 2015

Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

scholarly article published in Nature Genetics

Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

article

Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding

artículo científico publicado en 2007

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

artículo científico publicado en 2012

Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants

article

Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease

artículo científico publicado en 2013

Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease

artículo científico publicado en 2008

Evidence that variation in the oligodendrocyte lineage transcription factor 2 (OLIG2) gene is associated with psychosis in Alzheimer's disease

artículo científico publicado en 2009

FASTKD2 is associated with memory and hippocampal structure in older adults

artículo científico publicado en 2014

Familial influence on variation in age of onset and behavioural phenotype in Alzheimer's disease.

artículo científico publicado en 2000

Familial psychiatric presentation of Huntington's disease

artículo científico publicado en 1996

Fleshing out the amyloid cascade hypothesis: the molecular biology of Alzheimer's disease.

artículo científico

Four components describe behavioral symptoms in 1,120 individuals with late-onset Alzheimer's disease

artículo científico publicado en 2006

Frontotemporal atrophy associated with paranoid delusions in women with Alzheimer's disease.

artículo científico publicado en 2011

Full genome screen for Alzheimer disease: Stage II analysis

article

Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood

artículo científico publicado en 2012

GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt.

artículo científico publicado en 2006

Gait in Mild Alzheimer's Disease: Feasibility of Multi-Center Measurement in the Clinic and Home with Body-Worn Sensors: A Pilot Study

artículo científico publicado en 2018

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

artículo científico publicado en 2014

Generalizability of the disease state index prediction model for identifying patients progressing from mild cognitive impairment to Alzheimer's disease

artículo científico publicado en 2015

Genes related to vascular disease (APOE, VLDL-R, DCP-1) and other vascular factors in late-life depression

artículo científico publicado en 2004

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

scholarly article published 28 August 2017

Genetic architecture of subcortical brain structures in 38,851 individuals

scientific article published on 21 October 2019

Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease

artículo científico publicado en 2005

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease

artículo científico publicado en 2010

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

artículo científico publicado en 2019

Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a Mendelian randomization analysis

artículo científico publicado en 2014

Genetic risk of Alzheimer's disease: advising relatives.

artículo científico publicado en 2001

Genetic studies on chromosome 12 in late-onset Alzheimer disease

artículo científico publicado en 1998

Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease.

artículo científico publicado en 2002

Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS).

artículo científico publicado en 2012

Genetics and dementia nosology

artículo científico publicado en 2006

Genetics consortiums can offer views facilitating best practice in Alzheimer's disease ⬇️

artículo científico publicado el 15 de agosto de 1998

Genetics of brain age suggest an overlap with common brain disorders

article

Genetics, molecular biology, neuropathology and phenotype of frontal lobe dementia: a case history

artículo científico publicado en 2002

Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease

artículo científico publicado en 2005

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

artículo científico publicado en 2009

Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset

artículo científico publicado en 2020

Genome-wide association study of Alzheimer's disease with psychotic symptoms

artículo científico publicado en 2011

Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.

artículo científico publicado en 2010

Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease

article

Giving dementia a voice.

artículo científico publicado en 2010

Glycogen synthase kinase-3 inhibition is integral to long-term potentiation

artículo científico publicado en 2007

Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease

artículo científico publicado en 2005

Glycogen synthase kinase-3beta and tau genes interact in Alzheimer's disease

artículo científico publicado en 2008

Glycogen synthase kinase-3beta immunoreactivity is reduced in the prefrontal cortex in schizophrenia.

artículo científico publicado en 2001

Glycosylation of Human Plasma Clusterin Yields a Novel Candidate Biomarker of Alzheimer's Disease

artículo científico publicado en 2015

Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research

artículo científico publicado en 2015

Guidelines on drug treatments for Alzheimer's disease

artículo científico publicado en 1997

Harnessing clinical psychiatric data with an electronic assessment tool (OPCRIT+): the utility of symptom dimensions

artículo científico publicado en 2013

Head injury as a risk factor for Alzheimer's disease: the evidence 10 years on; a partial replication.

artículo científico publicado en 2003

Heterogeneous patterns of brain atrophy in Alzheimer's disease

artículo científico publicado en 2018

Hippocampal glutamate-glutamine (Glx) in adults with Down syndrome: a preliminary study using in vivo proton magnetic resonance spectroscopy ((1)H MRS).

artículo científico publicado en 2014

Hippocampal myo-inositol and cognitive ability in adults with Down syndrome: an in vivo proton magnetic resonance spectroscopy study

artículo científico publicado en 2005

Hippocampal proton MR spectroscopy in early Alzheimer's disease and mild cognitive impairment

artículo científico publicado en 2011

Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella

artículo científico publicado en 2007

Identification of cis-regulatory variation influencing protein abundance levels in human plasma.

artículo científico publicado en 2012

Identification of functional variants from whole-exome sequencing, combined with neuroimaging genetics

artículo científico publicado en 2013

Imaging Aβ and tau in early stage Alzheimer's disease with [18F]AV45 and [18F]AV1451.

artículo científico publicado en 2018

Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis

artículo científico publicado en 2007

Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration

scholarly article by Nicholas J Ashton et al published 9 January 2019 in Acta neuropathologica communications

Inflammatory biomarkers in Alzheimer's disease plasma.

artículo científico publicado en 2019

Inflammatory proteins in plasma are associated with severity of Alzheimer's disease

artículo científico publicado en 2013

Influence of age, disease onset and ApoE4 on visual medial temporal lobe atrophy cut-offs

artículo científico publicado en 2013

Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease

artículo científico publicado en 2010

Insight, cognition and quality of life in Alzheimer's disease

artículo científico publicado en 2009

Insulin signalling in Alzheimer's disease and diabetes: from epidemiology to molecular links.

artículo científico publicado en 2016

Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease

artículo científico publicado en 2007

Is MCI really just early dementia? A systematic review of conversion studies.

artículo científico publicado en 2004

K variant of butyrycholinesterase and late-onset Alzheimer's disease

artículo científico publicado en 1998

Linking Genetics of Brain Changes to Alzheimer's Disease: Sparse Whole Genome Association Scan of Regional MRI Volumes in the ADNI and AddNeuroMed Cohorts

artículo científico publicado en 2015

Lithium reduces tau phosphorylation: effects in living cells and in neurons at therapeutic concentrations.

artículo científico publicado en 1999

Long-term cognitive and functional decline in late onset Alzheimer's disease: therapeutic implications

artículo científico publicado en 2003

Long-term predictors of cognitive outcome in a cohort of older people with hypertension

artículo científico publicado en 2000

Longitudinal Protein Changes in Blood Plasma Associated with the Rate of Cognitive Decline in Alzheimer's Disease

artículo científico publicado en 2015

MRI measures of Alzheimer's disease and the AddNeuroMed study

artículo científico publicado en 2009

MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker Discovery study

scholarly article by Mara Ten Kate et al published 27 September 2018 in Alzheimers Research & Therapy

Magnetic resonance imaging and magnetic resonance spectroscopy for detection of early Alzheimer's disease

artículo científico publicado en 2011

Management of breast cancer

artículo científico publicado en 1992

Measuring Global Brain Atrophy with the Brain Volume/Cerebrospinal Fluid Index: Normative Values, Cut-Offs and Clinical Associations

artículo científico publicado en 2015

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

artículo científico publicado en 2013

Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders

artículo científico publicado en 2021

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

artículo científico publicado en 2014

Midlife Neuroticism and the age of onset of Alzheimer's disease.

artículo científico publicado en 2008

Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood

artículo científico publicado en 2012

Mitochondrial genes are altered in blood early in Alzheimer's disease

artículo científico publicado en 2017

Moderate to severe HIV-associated neurocognitive impairment: A randomized placebo-controlled trial of lithium.

artículo científico publicado en 2016

Modulation of PHF-like tau phosphorylation in cultured neurones and transfected cells

artículo científico publicado en 1995

Multivariate analysis of MRI data for Alzheimer's disease, mild cognitive impairment and healthy controls

artículo científico publicado en 2010

Muscarinic agonists reduce tau phosphorylation in non-neuronal cells via GSK-3beta inhibition and in neurons

artículo científico publicado en 2000

Muscarinic therapies in Alzheimer's disease; from palliative treatments to disease modification

artículo científico publicado en 1997

Mutant presenilin 1 proteins induce cell death and reduce tau-dependent processes outgrowth.

artículo científico publicado en 2003

Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation

artículo científico publicado en 1999

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

artículo científico publicado en 2017

Neurofibrillary tangles and tau phosphorylation.

artículo científico publicado en 2001

Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system

artículo científico publicado en 2008

Nicastrin gene polymorphisms, cognitive ability level and cognitive ageing

artículo científico publicado en 2005

No Evidence to Suggest that the Use of Acetylcholinesterase Inhibitors Confounds the Results of Two Blood-Based Biomarker Studies in Alzheimer's Disease

artículo científico publicado en 2015

No Genetic Overlap Between Circulating Iron Levels and Alzheimer's Disease

artículo científico publicado en 2017

No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease

artículo científico publicado en 1999

No association of salivary total tau concentration with Alzheimer's disease

scientific article published on 20 June 2018

No differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents

artículo científico publicado en 2014

No evidence that extended tracts of homozygosity are associated with Alzheimer's disease

artículo científico publicado en 2011

Novel genetic loci associated with hippocampal volume

scientific article published on 18 January 2017

Novel genetic loci underlying human intracranial volume identified through genome-wide association

artículo científico publicado en 2016

OPCRIT+: an electronic system for psychiatric diagnosis and data collection in clinical and research settings

artículo científico publicado en 2011

Out of sight out of mind? Support and information given to distant and near relatives of those with dementia

artículo científico publicado en 2002

Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions

artículo científico publicado en 2005

PET Tau and Amyloid-β Burden in Mild Alzheimer's Disease: Divergent Relationship with Age, Cognition, and Cerebrospinal Fluid Biomarkers

artículo científico

PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3.

artículo científico publicado en 2006

Periodic psychosis associated with the menstrual cycle and childbirth

scientific article published on 01 March 1993

Phosphorylation of tau by glycogen synthase kinase-3β in intact mammalian cells: The effects on the organization and stability of microtubules

artículo científico publicado en 1996

Plasma based markers of [11C] PiB-PET brain amyloid burden

artículo científico publicado en 2012

Plasma biomarkers for Alzheimer's disease: much needed but tough to find

artículo científico publicado en 2012

Plasma biomarkers of brain atrophy in Alzheimer's disease

artículo científico publicado en 2011

Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment

artículo científico publicado en 2011

Plasma gelsolin is decreased and correlates with rate of decline in Alzheimer's disease

artículo científico publicado en 2010

Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer's disease

artículo científico publicado en 2015

Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes

artículo científico publicado en 2015

Plasma proteins predict conversion to dementia from prodromal disease

artículo científico publicado en 2014

Plasma transthyretin as a candidate marker for Alzheimer's disease

artículo científico publicado en 2012

Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease

artículo científico publicado en 2006

Positional pathway screen of wnt signaling genes in schizophrenia: association with DKK4.

artículo científico publicado en 2007

Practical cut-offs for visual rating scales of medial temporal, frontal and posterior atrophy in Alzheimer's disease and mild cognitive impairment

artículo científico publicado en 2015

Practical psychiatry of old age, 3rd edn.

artículo científico publicado en 2002

Precompetitive Data Sharing as a Catalyst to Address Unmet Needs in Parkinson's Disease

artículo científico publicado en 2015

Predicting progression of Alzheimer's disease using ordinal regression

artículo científico publicado en 2014

Predictors of care home and hospital admissions and their costs for older people with Alzheimer's disease: findings from a large London case register

artículo científico publicado en 2016

Premorbid cognitive testing predicts the onset of dementia and Alzheimer's disease better than and independently of APOE genotype

artículo científico publicado en 2004

Premorbid personality and behavioral and psychological symptoms in probable Alzheimer disease

artículo científico publicado en 2007

Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage

artículo científico publicado en 2015

Prevention of sporadic Alzheimer's disease: lessons learned from clinical trials and future directions

artículo científico

Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort

scientific article published on 08 May 2019

Protective effect of antirheumatic drugs on dementia in rheumatoid arthritis patients

artículo científico publicado en 2017

Protective variant for hippocampal atrophy identified by whole exome sequencing

artículo científico publicado en 2015

Protein aggregates and dementia: is there a common toxicity?

artículo científico publicado en 2002

Proteome-based identification of plasma proteins associated with hippocampal metabolism in early Alzheimer's disease

artículo científico publicado en 2008

Proteome-based plasma biomarkers for Alzheimer's disease

artículo científico publicado en 2006

Proteome-based plasma markers of brain amyloid-β deposition in non-demented older individuals

artículo científico publicado en 2010

Proteomics of Alzheimer's disease: understanding mechanisms and seeking biomarkers

artículo científico publicado en 2007

Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variation

artículo científico publicado en 2001

Psychotic genes or forgetful ones?

artículo científico publicado en 2002

Publisher Correction: Common brain disorders are associated with heritable patterns of apparent aging of the brain

scientific article published on 01 February 2020

Quantitative validation of a visual rating scale for frontal atrophy: associations with clinical status, APOE e4, CSF biomarkers and cognition

artículo científico publicado en 2015

Random Forest ensembles for detection and prediction of Alzheimer's disease with a good between-cohort robustness

artículo científico publicado en 2014

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

artículo científico publicado en 2017

Rate of progression of cognitive decline in Alzheimer's disease: effect of butyrylcholinesterase K gene variation

artículo científico publicado en 2005

Registries and Cohorts to Accelerate Early Phase Alzheimer's Trials. A Report from the E.U./U.S. Clinical Trials in Alzheimer's Disease Task Force.

artículo científico publicado en 2016

Risk of developing dementia in people with diabetes and mild cognitive impairment

artículo científico publicado en 2010

SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease

artículo científico publicado en 2010

SORL1 variants and risk of late-onset Alzheimer's disease

artículo científico publicado en 2008

Schizophrenia as a GSK-3 dysregulation disorder

artículo científico publicado en 2007

School students as Drosophila experimenters

artículo científico publicado en 2005

Searching for biomarkers in neurodegeneration ⬇️

artículo científico publicado el 1 de diciembre de 2010

Sensitivity and specificity of medial temporal lobe visual ratings and multivariate regional MRI classification in Alzheimer's disease

artículo científico publicado en 2011

Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease

artículo científico publicado en 2003

Sites of phosphorylation in tau and factors affecting their regulation.

artículo científico publicado en 2001

Smell identification function as a severity and progression marker in Alzheimer's disease.

artículo científico publicado en 2013

Smell identification test as a treatment response marker in patients with Alzheimer disease receiving donepezil.

artículo científico publicado en 2009

Stimulation of MAP kinase by v-raf transformation of fibroblasts fails to induce hyperphosphorylation of transfected tau.

artículo científico publicado en 1995

Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease.

artículo científico publicado en 2001

Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease

artículo científico publicado en 2010

Susceptibility locus for Alzheimer's disease on chromosome 10.

artículo científico publicado en 2000

TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones.

artículo científico publicado en 2006

TAp73alpha induces tau phosphorylation in HEK293a cells via a transcription-dependent mechanism

artículo científico publicado en 2006

Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease

artículo científico publicado en 2017

Tau phosphorylation both in vitro and in cells

artículo científico publicado en 2000

Tau proteins with frontotemporal dementia-17 mutations have both altered expression levels and phosphorylation profiles in differentiated neuroblastoma cells ⬇️

artículo científico publicado el 1 de enero de 2001

The AddNeuroMed framework for multi-centre MRI assessment of Alzheimer's disease: experience from the first 24 months

artículo científico publicado en 2011

The BDNF Val66Met polymorphism is not associated with late onset Alzheimer's disease in three case-control samples

artículo científico publicado en 2005

The C9ORF72 expansion mutation is a common cause of ALS+/-FTD in Europe and has a single founder

artículo científico publicado en 2012

The EMIF-AD Multimodal Biomarker Discovery study: design, methods and cohort characteristics

artículo científico publicado en 2018

The Edinburgh Consensus: preparing for the advent of disease-modifying therapies for Alzheimer's disease

artículo científico publicado en 2017

The Effect of Age Correction on Multivariate Classification in Alzheimer's Disease, with a Focus on the Characteristics of Incorrectly and Correctly Classified Subjects

artículo científico publicado en 2015

The GSK3 hypothesis of Alzheimer's disease

artículo científico publicado en 2008

The NEO-FFI is a reliable measure of premorbid personality in patients with probable Alzheimer's disease

artículo científico publicado en 2006

The Notch intracellular domain represses CRE-dependent transcription

artículo científico publicado en 2014

The Notch-1 intracellular domain is found in sub-nuclear bodies in SH-SY5Y neuroblastomas and in primary cortical neurons

artículo científico publicado en 2007

The South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLAM BRC) case register: development and descriptive data

artículo científico publicado en 2009

The Trieste experience

artículo científico publicado en 1986

The antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neurones

artículo científico publicado en 2003

The clinical phenotype of familial and sporadic late onset Alzheimer's disease

artículo científico publicado en 2002

The dementias

artículo científico publicado en 2002

The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume

artículo científico publicado en 2016

The effects of commonly prescribed drugs in patients with Alzheimer's disease on the rate of deterioration

artículo científico publicado en 2006

The extended haplotype of the microtubule associated protein tau gene is not associated with Pick's disease.

artículo científico publicado en 2001

The function of the microtubule-associated protein tau is variably modulated by graded changes in glycogen synthase kinase-3β activity

artículo científico publicado en 2000

The future of blood-based biomarkers for Alzheimer's disease

artículo científico publicado en 2013

The impact of a novel apolipoprotein E and amyloid-β protein precursor-interacting protein on the production of amyloid-β.

artículo científico publicado en 2011

The importance of tau phosphorylation for neurodegenerative diseases

artículo científico publicado en 2013

The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology

artículo científico publicado en 2017

The interactive effect of demographic and clinical factors on hippocampal volume: A multicohort study on 1958 cognitively normal individuals

artículo científico publicado en 2017

The intracellular fate of apolipoprotein E is tau dependent and apoe allele-specific.

artículo científico publicado en 1996

The midlife cognitive profiles of adults at high risk of late-onset Alzheimer's disease: The PREVENT study

artículo científico publicado en 2017

The phosphorylation of tau: a critical stage in neurodevelopment and neurodegenerative processes.

artículo científico publicado en 1997

The role of premorbid personality and cognitive factors in awareness of illness, memory, and behavioural functioning in Alzheimer's disease

artículo científico publicado en 2011

The role of the father in parental postnatal mental health.

artículo científico publicado en 1995

The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease

artículo científico publicado en 2012

The thiazolidinedione pioglitazone increases cholesterol biosynthetic gene expression in primary cortical neurons by a PPARgamma-independent mechanism

artículo científico

The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice

artículo científico publicado en 2011

Therapy with the elderly: introducing psychodynamic psychotherapy to the multi-disciplinary team.

artículo científico publicado en 2000

Tocopherols and tocotrienols plasma levels are associated with cognitive impairment

Tract Based Spatial Statistic Reveals No Differences in White Matter Microstructural Organization between Carriers and Non-Carriers of the APOE ɛ4 and ɛ2 Alleles in Young Healthy Adolescents

artículo científico publicado en 2015

Trait, state, and mechanism: looking back, looking forward, and understanding why.

artículo científico publicado en 2013

Transcriptomic profiles of Wnt3a and insulin in primary cultured rat cortical neurones

Truncated apoE forms tangle-like structures in a neuronal cell line

artículo científico publicado en 2002

UK Alzheimer's disease genetics consortium

artículo científico publicado en 1999

Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease

artículo científico publicado en 2006

Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort

scientific article published on 01 January 2020

Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease

article

Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.

artículo científico publicado en 2004

Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment

artículo científico publicado en 2013

Wnt3a induces exosome secretion from primary cultured rat microglia.

artículo científico publicado en 2012

p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells

artículo científico publicado en 2007

β-Amyloid precursor protein and tau protein levels are differently regulated in human cerebellum compared to brain regions vulnerable to Alzheimer's type neurodegeneration

artículo científico publicado en 2010

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