Lista de obras - Russell S. Thomas - Dominio Público Uruguay

A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin

artículo científico publicado en 2010

A cellular genetics approach identifies gene-drug interactions and pinpoints drug toxicity pathway nodes

artículo científico publicado en 2014

A comparison of batch effect removal methods for enhancement of prediction performance using MAQC-II microarray gene expression data

artículo científico publicado en 2010

A comparison of transcriptomic and metabonomic technologies for identifying biomarkers predictive of two-year rodent cancer bioassays.

artículo científico publicado en 2006

A comprehensive statistical analysis of predicting in vivo hazard using high-throughput in vitro screening

artículo científico publicado en 2012

A functional map of NFkappaB signaling identifies novel modulators and multiple system controls

artículo científico publicado en 2007

A genomics-based analysis of relative potencies of dioxin-like compounds in primary rat hepatocytes.

artículo científico publicado en 2013

A method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure

artículo científico publicado en 2007

A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment

artículo científico publicado en 2013

A physiologically based pharmacodynamic analysis of hepatic foci within a medium-term liver bioassay using pentachlorobenzene as a promoter and diethylnitrosamine as an initiator.

artículo científico publicado en 2000

Accelerating the Pace of Chemical Risk Assessment.

artículo científico publicado en 2018

Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation

artículo científico publicado en 2009

All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin

artículo científico publicado en 2013

An integrated genomic analysis of aryl hydrocarbon receptor-mediated inhibition of B-cell differentiation

artículo científico publicado en 2010

Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

artículo científico publicado en 2016

Application of genomic biomarkers to predict increased lung tumor incidence in 2-year rodent cancer bioassays

artículo científico publicado en 2007

Application of transcriptional benchmark dose values in quantitative cancer and noncancer risk assessment

artículo científico publicado en 2010

Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology

artículo científico publicado en 2013

Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways

artículo científico publicado en 2014

Aryl hydrocarbon receptor knockout rats are insensitive to the pathological effects of repeated oral exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

artículo científico publicado en 2015

Aryl hydrocarbon receptor regulates cell cycle progression in human breast cancer cells via a functional interaction with cyclin-dependent kinase 4.

artículo científico publicado en 2009

BMDExpress: a software tool for the benchmark dose analyses of genomic data

artículo científico publicado en 2007

Basal gene expression in male and female Sprague-Dawley rat nasal respiratory and olfactory epithelium

artículo científico

Biological networks for predicting chemical hepatocarcinogenicity using gene expression data from treated mice and relevance across human and rat species

artículo científico publicado en 2013

Biological responses in rats exposed to cigarette smoke and Middle East sand (dust).

artículo científico publicado en 2012

Chemical mixture toxicology: from descriptive to mechanistic, and going on to in silico toxicology

artículo científico publicado en 2004

Comparison of microarrays and RNA-seq for gene expression analyses of dose-response experiments

artículo científico publicado en 2013

Concentration- and time-dependent genomic changes in the mouse urinary bladder following exposure to arsenate in drinking water for up to 12 weeks.

artículo científico publicado en 2011

Cross-species comparisons of transcriptomic alterations in human and rat primary hepatocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

artículo científico publicado en 2012

Cross-species transcriptomic analysis of mouse and rat lung exposed to chloroprene

artículo científico publicado en 2012

Determination of velocity correction factors for real-time air velocity monitoring in underground mines

artículo científico publicado en 2017

Developing toxicologically predictive gene sets using cDNA microarrays and Bayesian classification

artículo científico publicado en 2002

Development of 3D dynamic flow model of human liver and its application to prediction of metabolic clearance of 7-ethoxycoumarin

artículo científico publicado en 2014

Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages

artículo científico publicado en 2009

Dose-response modeling in reproductive toxicology in the systems biology era.

artículo científico publicado en 2005

EDGE: a centralized resource for the comparison, analysis, and distribution of toxicogenomic information

artículo científico publicado en 2005

Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

artículo científico publicado en 2016

Enhanced regional expression of glutathione S-transferase P1-1 with colocalized AP-1 and CYP 1A2 induction in chlorobenzene-induced porphyria

artículo científico publicado en 1998

Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment

artículo científico publicado en 2011

Evaluation of gene expression changes in human primary uroepithelial cells following 24-hr exposures to inorganic arsenic and its methylated metabolites

artículo científico publicado en 2012

Evidence for hepatocarcinogenic activity of pentachlorobenzene with intralobular variation in foci incidence.

artículo científico publicado en 1998

Expression profiling in canine osteosarcoma: identification of biomarkers and pathways associated with outcome

artículo científico publicado en 2010

Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound

artículo científico publicado en 2010

Functional analysis of multiple genomic signatures demonstrates that classification algorithms choose phenotype-related genes

artículo científico publicado en 2010

Gene expression changes following acute hydrogen sulfide (H2S)-induced nasal respiratory epithelial injury

artículo científico publicado en 2008

Genome-scale functional profiling of the mammalian AP-1 signaling pathway

artículo científico publicado en 2003

Genome-wide analysis of DNA methylation and gene expression changes in the mouse lung following subchronic arsenate exposure

artículo científico publicado en 2010

Genome-wide analysis of human HSF1 signaling reveals a transcriptional program linked to cellular adaptation and survival

artículo científico

Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitis

artículo científico publicado en 2007

Genomic signatures and dose-dependent transitions in nasal epithelial responses to inhaled formaldehyde in the rat.

artículo científico

IVT-seq reveals extreme bias in RNA sequencing

artículo científico publicado en 2014

Identification of gene expression predictors of occupational benzene exposure

artículo científico publicado en 2018

Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium

artículo científico publicado en 2015

Identifying genes that mediate anthracyline toxicity in immune cells

artículo científico publicado en 2015

Immune cell-based screening assay for response to anticancer agents: applications in pharmacogenomics

artículo científico publicado en 2015

In utero exposure to chloroquine alters sexual development in the male fetal rat.

artículo científico publicado en 2009

In vitro and modelling approaches to risk assessment from the U.S. Environmental Protection Agency ToxCast programme

artículo científico

Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing

artículo científico publicado en 2015

Incorporating Monte Carlo simulation into physiologically based pharmacokinetic models using advanced continuous simulation language (ACSL): a computational method

artículo científico publicado en 1996

Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.

artículo científico publicado en 2010

Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework.

artículo científico publicado en 2013

Incorporating population variability and susceptible subpopulations into dosimetry for high-throughput toxicity testing

artículo científico publicado en 2014

Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: a five chemical case study

artículo científico publicado en 2012

Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment

artículo científico publicado en 2011

Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice.

artículo científico publicado en 2013

Lineage-dependent effects of aryl hydrocarbon receptor agonists contribute to liver tumorigenesis.

artículo científico publicado en 2015

MYC is an early response regulator of human adipogenesis in adipose stem cells

artículo científico publicado en 2014

New directions in incidence-dose modeling

artículo científico publicado en 2005

Physiologically based pharmacokinetic/pharmacodynamic modeling of chemical mixtures and possible applications in risk assessment.

artículo científico publicado en 1995

Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and Kepone.

artículo científico publicado en 1996

Predicting hepatotoxicity using ToxCast in vitro bioactivity and chemical structure

artículo científico publicado en 2015

Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury

artículo científico publicado en 2010

Regulation of Bach2 by the aryl hydrocarbon receptor as a mechanism for suppression of B-cell differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin

artículo científico publicado en 2011

Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators

artículo científico publicado en 2009

Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays

artículo científico publicado en 2013

Research toward the development of a biologically based dose response assessment for inorganic arsenic carcinogenicity: a progress report

artículo científico publicado en 2007

Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model

artículo científico publicado en 2015

Sequence variation and phylogenetic history of the mouse Ahr gene

artículo científico publicado en 2002

Stochastic modeling of B lymphocyte terminal differentiation and its suppression by dioxin

artículo científico publicado en 2010

Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay

artículo científico publicado en 2003

Subchronic Hepatotoxicity Evaluation of 1,2,4-Tribromobenzene in Sprague-Dawley Rats

artículo científico publicado en 2012

Subchronic Hepatotoxicity Evaluation of Hydrazobenzene in Fischer 344 Rats

artículo científico publicado en 2012

Subchronic hepatotoxicity evaluation of 2,3,4,6-tetrachlorophenol in sprague dawley rats

artículo científico publicado en 2012

Subchronic hepatotoxicity evaluation of bromobenzene in Fischer 344 rats.

artículo científico publicado en 2012

Subchronic thyroid toxicity evaluation of 4,4'-methylenebis(N,N'-dimethyl)aniline in Fischer 344 rats

artículo científico publicado en 2012

Subchronic toxicity evaluation of anthraquinone in Fischer 344 rats

artículo científico publicado en 2013

Subchronic toxicity evaluation of potassium bromate in Fischer 344 rats.

artículo científico publicado en 2013

Subchronic urinary bladder toxicity evaluation of N-Nitrosodiphenylamine in Fischer 344 rats

artículo científico publicado en 2012

Systems pharmacology assessment of the 5-fluorouracil pathway

artículo científico publicado en 2011

Technical guide for applications of gene expression profiling in human health risk assessment of environmental chemicals.

artículo científico publicado en 2015

Temporal concordance between apical and transcriptional points of departure for chemical risk assessment.

artículo científico publicado en 2013

The Aryl-Hydrocarbon Receptor Protein Interaction Network (AHR-PIN) as Identified by Tandem Affinity Purification (TAP) and Mass Spectrometry

artículo científico publicado en 2013

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

artículo científico publicado en 2010

The Next Generation Blueprint of Computational Toxicology at the U.S. Environmental Protection Agency

artículo científico publicado en 2019

The SEURAT-1 approach towards animal free human safety assessment

artículo científico publicado en 2014

The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology

artículo científico publicado en 2020

The application of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling for exploring risk assessment approaches of chemical mixtures

artículo científico publicado en 1995

The aryl hydrocarbon receptor interacts with ATP5α1, a subunit of the ATP synthase complex, and modulates mitochondrial function

artículo científico publicado en 2011

The human toxome project

artículo científico publicado en 2015

The identification of protein kinase C iota as a regulator of the Mammalian heat shock response using functional genomic screens

artículo científico publicado en 2010

The use of physiologically-based pharmacokinetic/pharmacodynamic dosimetry models for chemical mixtures

artículo científico publicado en 1995

ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology

artículo científico publicado en 2016

Toxicokinetic Triage for Environmental Chemicals

artículo científico publicado en 2015

Transcriptional responses in the rat nasal epithelium following subchronic inhalation of naphthalene vapor

artículo científico publicado en 2014

Use of a medium-term liver focus bioassay to assess the hepatocarcinogenicity of 1,2,4,5-tetrachlorobenzene and 1,4-dichlorobenzene

artículo científico publicado en 1998

Use of short-term transcriptional profiles to assess the long-term cancer-related safety of environmental and industrial chemicals

artículo científico publicado en 2009

Lista de obras de Russell S. Thomas

A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin

A cellular genetics approach identifies gene-drug interactions and pinpoints drug toxicity pathway nodes

A comparison of batch effect removal methods for enhancement of prediction performance using MAQC-II microarray gene expression data

A comparison of transcriptomic and metabonomic technologies for identifying biomarkers predictive of two-year rodent cancer bioassays.

A comprehensive statistical analysis of predicting in vivo hazard using high-throughput in vitro screening

A functional map of NFkappaB signaling identifies novel modulators and multiple system controls

A genomics-based analysis of relative potencies of dioxin-like compounds in primary rat hepatocytes.

A method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure

A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment

A physiologically based pharmacodynamic analysis of hepatic foci within a medium-term liver bioassay using pentachlorobenzene as a promoter and diethylnitrosamine as an initiator.

Accelerating the Pace of Chemical Risk Assessment.

Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation

All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin

An integrated genomic analysis of aryl hydrocarbon receptor-mediated inhibition of B-cell differentiation

Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

Application of genomic biomarkers to predict increased lung tumor incidence in 2-year rodent cancer bioassays

Application of transcriptional benchmark dose values in quantitative cancer and noncancer risk assessment

Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology

Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways

Aryl hydrocarbon receptor knockout rats are insensitive to the pathological effects of repeated oral exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Aryl hydrocarbon receptor regulates cell cycle progression in human breast cancer cells via a functional interaction with cyclin-dependent kinase 4.

BMDExpress: a software tool for the benchmark dose analyses of genomic data

Basal gene expression in male and female Sprague-Dawley rat nasal respiratory and olfactory epithelium

Biological networks for predicting chemical hepatocarcinogenicity using gene expression data from treated mice and relevance across human and rat species

Biological responses in rats exposed to cigarette smoke and Middle East sand (dust).

Chemical mixture toxicology: from descriptive to mechanistic, and going on to in silico toxicology

Comparison of microarrays and RNA-seq for gene expression analyses of dose-response experiments

Concentration- and time-dependent genomic changes in the mouse urinary bladder following exposure to arsenate in drinking water for up to 12 weeks.

Cross-species comparisons of transcriptomic alterations in human and rat primary hepatocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Cross-species transcriptomic analysis of mouse and rat lung exposed to chloroprene

Determination of velocity correction factors for real-time air velocity monitoring in underground mines

Developing toxicologically predictive gene sets using cDNA microarrays and Bayesian classification

Development of 3D dynamic flow model of human liver and its application to prediction of metabolic clearance of 7-ethoxycoumarin

Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages

Dose-response modeling in reproductive toxicology in the systems biology era.

EDGE: a centralized resource for the comparison, analysis, and distribution of toxicogenomic information

Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

Enhanced regional expression of glutathione S-transferase P1-1 with colocalized AP-1 and CYP 1A2 induction in chlorobenzene-induced porphyria

Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment

Evaluation of gene expression changes in human primary uroepithelial cells following 24-hr exposures to inorganic arsenic and its methylated metabolites

Evidence for hepatocarcinogenic activity of pentachlorobenzene with intralobular variation in foci incidence.

Expression profiling in canine osteosarcoma: identification of biomarkers and pathways associated with outcome

Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound

Functional analysis of multiple genomic signatures demonstrates that classification algorithms choose phenotype-related genes

Gene expression changes following acute hydrogen sulfide (H2S)-induced nasal respiratory epithelial injury

Genome-scale functional profiling of the mammalian AP-1 signaling pathway

Genome-wide analysis of DNA methylation and gene expression changes in the mouse lung following subchronic arsenate exposure

Genome-wide analysis of human HSF1 signaling reveals a transcriptional program linked to cellular adaptation and survival

Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitis

Genomic signatures and dose-dependent transitions in nasal epithelial responses to inhaled formaldehyde in the rat.

IVT-seq reveals extreme bias in RNA sequencing

Identification of gene expression predictors of occupational benzene exposure

Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium

Identifying genes that mediate anthracyline toxicity in immune cells

Immune cell-based screening assay for response to anticancer agents: applications in pharmacogenomics

In utero exposure to chloroquine alters sexual development in the male fetal rat.

In vitro and modelling approaches to risk assessment from the U.S. Environmental Protection Agency ToxCast programme

Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing

Incorporating Monte Carlo simulation into physiologically based pharmacokinetic models using advanced continuous simulation language (ACSL): a computational method

Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.

Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework.

Incorporating population variability and susceptible subpopulations into dosimetry for high-throughput toxicity testing

Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: a five chemical case study

Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment

Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice.

Lineage-dependent effects of aryl hydrocarbon receptor agonists contribute to liver tumorigenesis.

MYC is an early response regulator of human adipogenesis in adipose stem cells

New directions in incidence-dose modeling

Physiologically based pharmacokinetic/pharmacodynamic modeling of chemical mixtures and possible applications in risk assessment.

Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and Kepone.

Predicting hepatotoxicity using ToxCast in vitro bioactivity and chemical structure

Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury

Regulation of Bach2 by the aryl hydrocarbon receptor as a mechanism for suppression of B-cell differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin

Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators

Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays

Research toward the development of a biologically based dose response assessment for inorganic arsenic carcinogenicity: a progress report

Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model

Sequence variation and phylogenetic history of the mouse Ahr gene

Stochastic modeling of B lymphocyte terminal differentiation and its suppression by dioxin