Lista de obras - Ben Lehner - Dominio Público Uruguay

5,000 RNAi experiments on a chip

artículo científico publicado en 2004

A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression

artículo científico publicado en 2016

A first-draft human protein-interaction map

artículo científico publicado en 2004

A protein interaction framework for human mRNA degradation

artículo científico publicado en 2004

A simple principle concerning the robustness of protein complex activity to changes in gene expression

artículo científico publicado en 2008

A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans.

artículo científico publicado en 2008

Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region

artículo científico publicado en 2004

Antisense transcripts in the human genome

artículo científico publicado en 2002

Author Correction: Changes in gene expression predictably shift and switch genetic interactions

artículo científico publicado en 2019

Beyond genotype to phenotype: why the phenotype of an individual cannot always be predicted from their genome sequence and the environment that they experience

artículo científico publicado en 2012

Biophysical ambiguities prevent accurate genetic prediction

scientific article published on 01 October 2020

Cancer type-dependent genetic interactions between cancer driver alterations indicate plasticity of epistasis across cell types

artículo científico publicado en 2015

Cancer: Exploiting collateral damage

artículo científico publicado en 2012

Changes in gene expression predictably shift and switch genetic interactions

artículo científico publicado en 2019

Chromatin organization in sperm may be the major functional consequence of base composition variation in the human genome

artículo científico publicado en 2011

Chromatin organization is a major influence on regional mutation rates in human cancer cells.

artículo científico publicado en 2012

Co-option of the piRNA pathway for germline-specific alternative splicing of C. elegans TOR.

artículo científico publicado en 2014

Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution

artículo científico publicado en 2006

Compensatory Cell Movements Confer Robustness to Mechanical Deformation during Embryonic Development

artículo científico publicado en 2016

Comprehensive single cell-resolution analysis of the role of chromatin regulators in early C. elegans embryogenesis

artículo científico publicado en 2014

Conflict between Noise and Plasticity in Yeast ⬇️

artículo científico publicado el 4 de noviembre de 2010

Conserved noncoding elements and the evolution of animal body plans

artículo científico publicado en 2009

Conserved substitution patterns around nucleosome footprints in eukaryotes and Archaea derive from frequent nucleosome repositioning through evolution

artículo científico publicado en 2013

Determining protein structures using deep mutagenesis

artículo científico publicado en 2019

Determining protein structures using genetics

article

DiMSum: an error model and pipeline for analyzing deep mutational scanning data and diagnosing common experimental pathologies

artículo científico publicado en 2020

Differential DNA mismatch repair underlies mutation rate variation across the human genome

artículo científico publicado en 2015

Dissecting the calcium-induced differentiation of human primary keratinocytes stem cells by integrative and structural network analyses

artículo científico publicado en 2015

Empirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise

scientific article published on 18 July 2019

Empirical noise-mean fitness landscapes and the evolution of gene expression

article

Epigenetic epistatic interactions constrain the evolution of gene expression

artículo científico publicado en 2013

Evolutionary plasticity of genetic interaction networks

article by Julia Tischler et al published 23 March 2008 in Nature Genetics

Fitness Trade-Offs and Environmentally Induced Mutation Buffering in Isogenic C. elegans

scientific article published in Science

Fluctuation and response in biology

artículo científico publicado en 2010

Generating transgenic nematodes by bombardment and antibiotic selection

Genes confer similar robustness to environmental, stochastic, and genetic perturbations in yeast

artículo científico publicado en 2010

Genotype to phenotype: lessons from model organisms for human genetics

artículo científico

Harmonious genetic combinations rewire regulatory networks and flip gene essentiality

artículo científico publicado en 2019

Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers

artículo científico publicado en 2021

Human epidermal stem cell function is regulated by circadian oscillations.

artículo científico publicado en 2013

Human genes with CpG island promoters have a distinct transcription-associated chromatin organization

artículo científico publicado en 2012

Hydroxymethylated cytosines are associated with elevated C to G transversion rates

artículo científico publicado en 2014

Impaired DNA replication derepresses chromatin and generates a transgenerationally inherited epigenetic memory

artículo científico publicado en 2017

In search of antisense

artículo científico publicado en 2004

Inferring gene function from evolutionary change in signatures of translation efficiency

artículo científico publicado en 2014

Integrated genome-scale prediction of detrimental mutations in transcription networks

artículo científico publicado en 2011

Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity.

artículo científico publicado en 2009

Loss of G9a preserves mutation patterns but increases chromatin accessibility, genomic instability and aggressiveness in skin tumours

artículo científico publicado en 2018

Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference

artículo científico publicado en 2006

MUFFINN: cancer gene discovery via network analysis of somatic mutation data

artículo científico publicado en 2016

Model-based approach for tracking embryogenesis in Caenorhabditis elegans fluorescence microscopy data.

artículo científico publicado en 2009

Modelling genotype-phenotype relationships and human disease with genetic interaction networks

artículo científico publicado en 2007

Molecular mechanisms of epistasis within and between genes

artículo científico publicado en 2011

Mutations primarily alter the inclusion of alternatively spliced exons

artículo científico publicado en 2020

Network evolution hinges on history

artículo científico publicado en 2015

Network-guided genetic screening: building, testing and using gene networks to predict gene function

artículo científico publicado en 2008

Noise control is a primary function of microRNAs and post-transcriptional regulation

Nucleoid-associated proteins affect mutation dynamics in E. coli in a growth phase-specific manner

artículo científico publicado en 2012

Parallel evolution of conserved non-coding elements that target a common set of developmental regulatory genes from worms to humans

artículo científico publicado en 2007

Predicting genetic modifier loci using functional gene networks

artículo científico publicado en 2010

Predicting mutation outcome from early stochastic variation in genetic interaction partners

artículo científico publicado en 2011

Predicting phenotypic variation from genotypes, phenotypes and a combination of the two.

artículo científico publicado en 2013

Predicting phenotypic variation in yeast from individual genome sequences

artículo científico publicado en 2011

Protein domains enriched in mammalian tissue-specific or widely expressed genes

article

RNAi screens in Caenorhabditis elegans in a 96-well liquid format and their application to the systematic identification of genetic interactions

Rapid selection of transgenic C. elegans using antibiotic resistance

artículo científico publicado en 2010

Reaching the limit

artículo científico publicado en 2018

Reconstructing and analysing cellular states, space and time from gene expression profiles of many cells and single cells

artículo científico

Selection to minimise noise in living systems and its implications for the evolution of gene expression

artículo científico publicado en 2008

Single and dual drug selection for transgenes following bombardment of Caenorhabditis species

artículo científico publicado en 2014

Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming

scientific article published on 12 March 2019

Single cell functional genomics reveals the importance of mitochondria in cell-to-cell phenotypic variation

Single cell functional genomics reveals the importance of mitochondria in cell-to-cell variation in proliferation, drug resistance and mutation outcome

Slow-growing cells within isogenic populations have increased RNA polymerase error rates and DNA damage

artículo científico publicado en 2015

Synonymous Mutations Frequently Act as Driver Mutations in Human Cancers

article

Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits.

artículo científico publicado en 2018

Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways

Systems Biology of Caenorhabditis elegans

Systems biology: where it's at in 2005

artículo científico publicado en 2005

The effects of genetic variation on gene expression dynamics during development

artículo científico publicado en 2013

The genetic landscape of a physical interaction.

artículo científico publicado en 2018

The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy

scientific article published on 28 October 2019

The impact of rare germline variants on human somatic mutation processes

artículo científico publicado en 2022

The mutational landscape of a prion-like domain

artículo científico publicado en 2019

The roles of intersubunit interactions in exosome stability

artículo científico publicado en 2003

The rules and impact of nonsense-mediated mRNA decay in human cancers

artículo científico publicado en 2016

Tissue specificity and the human protein interaction network

artículo científico publicado en 2009

Transgenerational transmission of environmental information in C. elegans

artículo científico publicado en 2017

Widespread conservation of genetic redundancy during a billion years of eukaryotic evolution

artículo científico publicado en 2008

Lista de obras de Ben Lehner

5,000 RNAi experiments on a chip

A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression

A first-draft human protein-interaction map

A protein interaction framework for human mRNA degradation

A simple principle concerning the robustness of protein complex activity to changes in gene expression

A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans.

Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region

Antisense transcripts in the human genome

Author Correction: Changes in gene expression predictably shift and switch genetic interactions

Beyond genotype to phenotype: why the phenotype of an individual cannot always be predicted from their genome sequence and the environment that they experience

Biophysical ambiguities prevent accurate genetic prediction

Cancer type-dependent genetic interactions between cancer driver alterations indicate plasticity of epistasis across cell types

Cancer: Exploiting collateral damage

Changes in gene expression predictably shift and switch genetic interactions

Chromatin organization in sperm may be the major functional consequence of base composition variation in the human genome

Chromatin organization is a major influence on regional mutation rates in human cancer cells.

Co-option of the piRNA pathway for germline-specific alternative splicing of C. elegans TOR.

Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution

Compensatory Cell Movements Confer Robustness to Mechanical Deformation during Embryonic Development

Comprehensive single cell-resolution analysis of the role of chromatin regulators in early C. elegans embryogenesis

Conflict between Noise and Plasticity in Yeast ⬇️

Conserved noncoding elements and the evolution of animal body plans

Conserved substitution patterns around nucleosome footprints in eukaryotes and Archaea derive from frequent nucleosome repositioning through evolution

Determining protein structures using deep mutagenesis

Determining protein structures using genetics

DiMSum: an error model and pipeline for analyzing deep mutational scanning data and diagnosing common experimental pathologies

Differential DNA mismatch repair underlies mutation rate variation across the human genome

Dissecting the calcium-induced differentiation of human primary keratinocytes stem cells by integrative and structural network analyses

Empirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise

Empirical noise-mean fitness landscapes and the evolution of gene expression

Epigenetic epistatic interactions constrain the evolution of gene expression

Evolutionary plasticity of genetic interaction networks

Fitness Trade-Offs and Environmentally Induced Mutation Buffering in Isogenic C. elegans

Fluctuation and response in biology

Generating transgenic nematodes by bombardment and antibiotic selection

Genes confer similar robustness to environmental, stochastic, and genetic perturbations in yeast

Genotype to phenotype: lessons from model organisms for human genetics

Harmonious genetic combinations rewire regulatory networks and flip gene essentiality

Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers

Human epidermal stem cell function is regulated by circadian oscillations.

Human genes with CpG island promoters have a distinct transcription-associated chromatin organization

Hydroxymethylated cytosines are associated with elevated C to G transversion rates

Impaired DNA replication derepresses chromatin and generates a transgenerationally inherited epigenetic memory

In search of antisense

Inferring gene function from evolutionary change in signatures of translation efficiency

Integrated genome-scale prediction of detrimental mutations in transcription networks

Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity.

Loss of G9a preserves mutation patterns but increases chromatin accessibility, genomic instability and aggressiveness in skin tumours

Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference

MUFFINN: cancer gene discovery via network analysis of somatic mutation data

Model-based approach for tracking embryogenesis in Caenorhabditis elegans fluorescence microscopy data.

Modelling genotype-phenotype relationships and human disease with genetic interaction networks

Molecular mechanisms of epistasis within and between genes

Mutations primarily alter the inclusion of alternatively spliced exons

Network evolution hinges on history

Network-guided genetic screening: building, testing and using gene networks to predict gene function

Noise control is a primary function of microRNAs and post-transcriptional regulation

Nucleoid-associated proteins affect mutation dynamics in E. coli in a growth phase-specific manner

Parallel evolution of conserved non-coding elements that target a common set of developmental regulatory genes from worms to humans

Predicting genetic modifier loci using functional gene networks

Predicting mutation outcome from early stochastic variation in genetic interaction partners

Predicting phenotypic variation from genotypes, phenotypes and a combination of the two.

Predicting phenotypic variation in yeast from individual genome sequences

Protein domains enriched in mammalian tissue-specific or widely expressed genes

RNAi screens in Caenorhabditis elegans in a 96-well liquid format and their application to the systematic identification of genetic interactions

Rapid selection of transgenic C. elegans using antibiotic resistance

Reaching the limit

Reconstructing and analysing cellular states, space and time from gene expression profiles of many cells and single cells

Selection to minimise noise in living systems and its implications for the evolution of gene expression

Single and dual drug selection for transgenes following bombardment of Caenorhabditis species

Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming

Single cell functional genomics reveals the importance of mitochondria in cell-to-cell phenotypic variation

Single cell functional genomics reveals the importance of mitochondria in cell-to-cell variation in proliferation, drug resistance and mutation outcome

Slow-growing cells within isogenic populations have increased RNA polymerase error rates and DNA damage

Synonymous Mutations Frequently Act as Driver Mutations in Human Cancers

Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits.

Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways

Systems Biology of Caenorhabditis elegans

Systems biology: where it's at in 2005