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Lista de obras de Kai Kaarniranta

2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process

artículo científico publicado en 2015

5'-Adenosine monophosphate-activated protein kinase--mammalian target of rapamycin axis as therapeutic target for age-related macular degeneration.

artículo científico

A mouse model for Stickler's syndrome: ocular phenotype of mice carrying a targeted heterozygous inactivation of type II (pro)collagen gene (Col2a1).

artículo científico publicado en 2006

A novel proteotoxic stress associated mechanism for macular corneal dystrophy.

artículo científico publicado en 2015

A prospective study on postoperative pain after cataract surgery

artículo científico publicado en 2013

A randomized phase I clinical study of cis-urocanic acid eye drops in healthy adult subjects

artículo científico publicado en 2015

A rat experimental model of glaucoma incorporating rapid-onset elevation of intraocular pressure

artículo científico publicado en 2014

ADAMTS9locus associates with increased risk of wet AMD

artículo científico publicado en 2014

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

artículo científico

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

artículo científico publicado en 2011

AMP-activated protein kinase: a potential player in Alzheimer's disease

artículo científico publicado en 2011

AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms

artículo científico publicado en 2016

AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions

artículo científico publicado en 2016

Absence of collagen XVIII in mice causes age-related insufficiency in retinal pigment epithelium proteostasis

artículo científico publicado en 2016

Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

artículo científico publicado en 2007

Adiponectin receptor 1 gene (ADIPOR1) variant is associated with advanced age-related macular degeneration in Finnish population

article

Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways

artículo científico publicado en 2016

Age-related macular degeneration (AMD): Alzheimer's disease in the eye?

artículo científico publicado en 2011

Age-related macular degeneration--a difficult problem for the patient and for the ophthalmologist

artículo científico publicado en 2003

Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors

artículo científico publicado en 2008

Ageing of the vitreous: From acute onset floaters and flashes to retinal detachment

artículo científico

All-Trans Retinoic Acid Modulates DNA Damage Response and the Expression of the VEGF-A and MKI67 Genes in ARPE-19 Cells Subjected to Oxidative Stress

artículo científico publicado en 2016

Alpha-lipoic Acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney.

artículo científico publicado en 2007

Altered calcium signaling in an experimental model of glaucoma

artículo científico publicado en 2010

Amyloid-beta oligomers set fire to inflammasomes and induce Alzheimer's pathology

scientific article published on 13 September 2008

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

artículo científico publicado en 2013

Apoptosis and aging: increased resistance to apoptosis enhances the aging process

artículo científico publicado en 2010

Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype

artículo científico publicado en 2011

Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells

artículo científico publicado en 2013

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

artículo científico publicado en 2013

Autophagy in DNA damage response

artículo científico publicado en 2015

Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration.

artículo científico publicado en 2012

Autophagy--hot topic in AMD.

artículo científico publicado en 2010

Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: impact on the aging process

artículo científico

Benefits of switching from latanoprost to preservative-free tafluprost eye drops: a meta-analysis of two Phase IIIb clinical trials

artículo científico publicado en 2016

Best-corrected visual acuity and retinal thickness are associated with improved cortical visual processing in treated wet AMD patients

artículo científico publicado en 2015

Biocompatibility of different poly(lactide-coglycolide) polymers implanted into the subconjunctival space in rats

artículo científico publicado en 2011

Cationorm shows good tolerability on human HCE-2 corneal epithelial cell cultures

artículo científico publicado en 2014

Celastrol regulates innate immunity response via NF-κB and Hsp70 in human retinal pigment epithelial cells

artículo científico publicado en 2011

Celastrol: Molecular targets of Thunder God Vine

artículo científico publicado en 2010

Cellular and molecular mechanisms of age-related macular degeneration: from impaired autophagy to neovascularization.

artículo científico publicado en 2013

Changes in neurophysiologic markers of visual processing following beneficial anti-VEGF treatment in macular degeneration

artículo científico publicado en 2013

Clearance of misfolded and aggregated proteins by aggrephagy and implications for aggregation diseases

artículo científico publicado en 2014

Climatic droplet keratopathy: an old disease in new clothes.

artículo científico publicado en 2015

Comparison of three intraocular pressure measurement methods including biomechanical properties of the cornea.

artículo científico publicado en 2014

Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process

artículo científico publicado en 2012

Control of p53 and NF-κB signaling by WIP1 and MIF: role in cellular senescence and organismal aging

artículo científico publicado en 2010

Corneal epithelium as a platform for secretion of transgene products after transfection with liposomal gene eyedrops

artículo científico publicado en 2007

Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells

artículo científico publicado en 2008

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process

artículo científico publicado en 2013

Cytoskeleton and Proteoglycan Synthesis in Chondrocytes Under Hydrostatic Pressure

Decline in cellular clearance systems induces inflammasome signaling in human ARPE-19 cells

artículo científico publicado en 2014

Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration.

artículo científico publicado en 2015

ER stress and hormetic regulation of the aging process

artículo científico publicado en 2010

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

artículo científico publicado en 2009

Efflux protein expression in human retinal pigment epithelium cell lines.

artículo científico publicado en 2009

Efflux protein expression in human stem cell-derived retinal pigment epithelial cells

artículo científico publicado en 2012

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP).

artículo científico publicado en 2011

Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease

artículo científico publicado en 2011

Endoplasmic reticulum stress in age-related macular degeneration: trigger for neovascularization

scientific article published on 27 July 2010

Epigenetic regulation of ASC/TMS1 expression: potential role in apoptosis and inflammasome function

artículo científico publicado en 2013

Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells

artículo científico publicado en 2007

Estrogen signalling in the pathogenesis of age-related macular degeneration.

artículo científico publicado en 2014

FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process

artículo científico publicado en 2016

Filter-cultured ARPE-19 cells as outer blood-retinal barrier model

artículo científico publicado en 2010

Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation.

artículo científico publicado en 2015

Geldanamycin activates Hsp70 response and attenuates okadaic acid-induced cytotoxicity in human retinal pigment epithelial cells

artículo científico publicado en 2005

Geldanamycin increases 4-hydroxynonenal (HNE)-induced cell death in human retinal pigment epithelial cells

artículo científico publicado en 2005

Genetic variability in DNA repair proteins in age-related macular degeneration

artículo científico publicado en 2012

Genetics vs. entropy: longevity factors suppress the NF-kappaB-driven entropic aging process

artículo científico publicado en 2009

Glycolysis links p53 function with NF-kappaB signaling: impact on cancer and aging process

artículo científico publicado en 2010

Guidelines for the use and interpretation of assays for monitoring autophagy

artículo científico publicado en 2012

HYALURONAN STIMULATES KERATINOCYTE MIGRATION AND ACTIVATES THE TRANSCRIPTION FACTOR AP-1 IN KERATINOCYTES THROUGH THE JNK PATHWAY

Health-related quality of life after cataract surgery with the phacoemulsification technique and intraocular lens implantation

artículo científico publicado en 2015

Heat shock proteins as gatekeepers of proteolytic pathways-Implications for age-related macular degeneration (AMD).

scientific article published on April 2009

Herpes simplex virus types 1 and 2 modulate autophagy in SIRC corneal cells

artículo científico publicado en 2014

High pressure effects on cellular expression profile and mRNA stability. A cDNA array analysis

artículo científico publicado en 2002

Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process

artículo científico publicado en 2014

Histopathology of the three implanted degradable biopolymers in rabbit eye.

artículo científico publicado en 2009

Hormetic Heat Shock Enhances Autophagy through HSF1 in Retinal Pigment Epithelium Cells

artículo científico publicado en 2022

Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation

artículo científico publicado en 1998

Hsp90 inhibitor geldanamycin increases hsp70 mRNA stabilisation but fails to activate HSF1 in cells exposed to hydrostatic pressure

artículo científico publicado en 2005

Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease

artículo científico publicado en 2010

Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium-Role in Dead Cell Clearance and Inflammation

scientific article published on 20 February 2019

Hydrostatic pressure-induced changes in cellular protein synthesis.

artículo científico publicado en 2004

Hypoxic conditions stimulate the release of B-type natriuretic peptide from human retinal pigment epithelium cell culture.

artículo científico publicado en 2014

Imiquimod in the treatment of eyelid basal cell carcinoma

artículo científico publicado en 2007

Immunolocalization of EMMPRIN (CD147) in the human eye and detection of soluble form of EMMPRIN in ocular fluids.

artículo científico publicado en 2006

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

artículo científico publicado en 2013

Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape

artículo científico

In vitro biocompatibility of degradable biopolymers in cell line cultures from various ocular tissues: direct contact studies

artículo científico publicado en 2007

In vitro biocompatibility of degradable biopolymers in cell line cultures from various ocular tissues: extraction studies

artículo científico publicado en 2007

Increased IL-6 levels are not related to NF-κB or HIF-1α transcription factors activity in the vitreous of proliferative diabetic retinopathy

artículo científico publicado en 2011

Inflammation and its role in age-related macular degeneration

artículo científico publicado en 2016

Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors

scientific article published on February 2009

Influence of Hsp90 and HDAC inhibition and tubulin acetylation on perinuclear protein aggregation in human retinal pigment epithelial cells

artículo científico publicado en 2010

Influence of selective estrogen receptor modulators on interleukin-6 expression in human retinal pigment epithelial cells (ARPE-19).

artículo científico publicado en 2010

Inhibition of BET bromodomains alleviates inflammation in human RPE cells.

artículo científico publicado en 2016

Inhibition of DNA methyltransferase or histone deacetylase protects retinal pigment epithelial cells from DNA damage induced by oxidative stress by the stimulation of antioxidant enzymes.

artículo científico publicado en 2016

Innate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90.

artículo científico publicado en 2008

Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling

artículo científico publicado en 2009

Interaction of aging-associated signaling cascades: inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1.

artículo científico publicado en 2008

Krebs cycle dysfunction shapes epigenetic landscape of chromatin: novel insights into mitochondrial regulation of aging process

artículo científico

Krebs cycle intermediates regulate DNA and histone methylation: epigenetic impact on the aging process

artículo científico publicado en 2014

Leucine 7−proline 7 polymorphism in the signal peptide of neuropeptide Y is not a risk factor for exudative age-related macular degeneration

artículo científico publicado en 2007

Long-term topical application of preservative-free prostaglandin analogues evokes macrophage infiltration in the ocular adnexa.

artículo científico publicado en 2016

Lysosomes: Regulators of autophagy in the retinal pigmented epithelium

artículo científico publicado en 2015

Maturation of autophagosomes and endosomes: a key role for Rab7.

artículo científico publicado en 2012

Melatonin in Retinal Physiology and Pathology: The Case of Age-Related Macular Degeneration

artículo científico publicado en 2016

Mitochondrial and nuclear DNA damage and repair in age-related macular degeneration

artículo científico publicado en 2013

Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases

artículo científico

Mitomycin C in revision endoscopic dacryocystorhinostomy: a prospective randomized study

artículo científico publicado en 2011

Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration.

artículo científico publicado en 2011

Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration

artículo científico publicado en 2008

NEMO shuttle: a link between DNA damage and NF-kappaB activation in progeroid syndromes?

artículo científico publicado en 2008

NF-kappaB signaling as a putative target for omega-3 metabolites in the prevention of age-related macular degeneration (AMD).

artículo científico publicado en 2009

NF-kappaB signaling in the aging process

artículo científico publicado en 2009

Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress.

artículo científico publicado en 2014

Neuronal cells show regulatory differences in the hsp70 gene response

artículo científico publicado en 2002

Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells

artículo científico publicado en 2016

Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells--implications for age-related macular degeneration (AMD).

artículo científico publicado en 2012

Oxidative stress protection by exogenous delivery of rhHsp70 chaperone to the retinal pigment epithelium (RPE), a possible therapeutic strategy against RPE degeneration.

artículo científico publicado en 2014

Oxidative stress, hypoxia, and autophagy in the neovascular processes of age-related macular degeneration.

artículo científico publicado en 2014

Pharmacokinetics, Efficacy, and Safety of the Preservative-free Fixed Combination of Tafluprost 0.0015% and Timolol 0.5% in Healthy Volunteers: A Phase I Comparison vs. the Corresponding Preservative-free Monotherapies

artículo científico publicado en 2016

Pharmacokinetics, efficacy and safety profiles of preserved and preservative-free tafluprost in healthy volunteers

artículo científico publicado en 2008

Phytochemicals suppress nuclear factor-κB signaling: impact on health span and the aging process

artículo científico publicado en 2012

Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases

artículo científico publicado en 2015

Postoperative pain after cataract surgery

artículo científico

Primary chondrocytes resist hydrostatic pressure-induced stress while primary synovial cells and fibroblasts show modified Hsp70 response

article

Protein synthesis is required for stabilization of hsp70 mRNA upon exposure to both hydrostatic pressurization and elevated temperature

artículo científico publicado en 2000

Protein-oxidized phospholipid interactions in cellular signaling for cell death: from biophysics to clinical correlations

artículo científico publicado en 2012

Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells

artículo científico publicado en 2015

ROCK, PAK, and Toll of synapses in Alzheimer's disease

artículo científico publicado en 2008

Radicicol but not geldanamycin evokes oxidative stress response and efflux protein inhibition in ARPE-19 human retinal pigment epithelial cells

artículo científico publicado en 2008

Recovery after cataract surgery

artículo científico publicado en 2016

Recovery and patient satisfaction after cataract surgery. A one-year prospective follow-up study

artículo científico publicado en 2014

Regression of necrotizing scleritis in Wegener’s granulomatosis after infliximab treatment

artículo científico publicado en 2009

Regulation of ER alpha signaling pathway in neuronal HN10 cells: role of protein acetylation and Hsp90.

artículo científico publicado en 2008

Regulation of the aging process by autophagy

artículo científico publicado en 2009

Regulatory role of HIF-1alpha in the pathogenesis of age-related macular degeneration (AMD).

artículo científico publicado en 2009

Relation of biometric eye profile with intraocular pressure corrections in healthy myopes

artículo científico publicado en 2012

Reperfusion but Not Acute Ischemia in Pig Small Intestine Induces Transcriptionally Mediated Heat Shock Response in situ

artículo científico publicado en 2002

Retinal arterial macroaneurysms

artículo científico publicado en 2013

Retinal haemorrhages in shaken baby syndrome

artículo científico publicado en 2008

Role of Mitochondrial DNA Damage in ROS-Mediated Pathogenesis of Age-Related Macular Degeneration (AMD)

artículo científico publicado en 2019

Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD)

artículo científico publicado en 2013

Role of the Cell Cycle Re-Initiation in DNA Damage Response of Post-Mitotic Cells and Its Implication in the Pathogenesis of Neurodegenerative Diseases

article

SIRT1 longevity factor suppresses NF-κB -driven immune responses: regulation of aging via NF-κB acetylation?

article

SIRT1 regulates the ribosomal DNA locus: epigenetic candles twinkle longevity in the Christmas tree

artículo científico publicado en 2008

SIRT1: regulation of longevity via autophagy

artículo científico publicado en 2009

Siglec receptors and hiding plaques in Alzheimer's disease

scientific article published on 24 April 2009

Specific induction of heat shock protein 90beta by high hydrostatic pressure

artículo científico publicado en 2003

Stage-specific expression and cellular localization of the heat shock factor 2 isoforms in the rat seminiferous epithelium

artículo científico publicado en 1998

Stress responses of mammalian cells to high hydrostatic pressure.

artículo científico publicado en 2003

Structure and barrier properties of human embryonic stem cell-derived retinal pigment epithelial cells are affected by extracellular matrix protein coating

artículo científico publicado en 2014

Switching from a preserved to a preservative-free prostaglandin preparation in topical glaucoma medication

artículo científico publicado en 2010

Symptom score questionnaire for nasolacrimal duct obstruction in adults--a novel tool to assess the outcome after endoscopic dacryocystorhinostomy

artículo científico publicado en 2010

Terpenoids: natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential

artículo científico publicado en 2008

The Aging Stress Response and Its Implication for AMD Pathogenesis

artículo científico publicado en 2020

The effect of 17beta-estradiol on IL-6 secretion and NF-kappaB DNA-binding activity in human retinal pigment epithelial cells

artículo científico publicado en 2007

The expression of heat shock protein 27 in retinal ganglion and glial cells in a rat glaucoma model

artículo científico publicado en 2007

The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells

artículo científico publicado en 2015

The role of vision-related problems in fatal road accidents in Finland

artículo científico publicado en 2020

Upregulation of inflammatory genes in the nasal mucosa of patients undergoing endonasal dacryocystorhinostomy.

artículo científico publicado en 2014

Visual recovery of the amblyopic eye in an adult patient after loss of the dominant eye

artículo científico publicado en 2003

Zinc and Autophagy in Age-Related Macular Degeneration ⬇️

scientific article published on 15 July 2020

cDNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure

artículo científico publicado en 2002

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