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Lista de obras de Christa E Müller

1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases

artículo científico publicado en 2013

1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists

artículo científico publicado en 2002

1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.

artículo científico publicado en 2009

2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.

artículo científico publicado en 2010

2-Amino[1,2,4]triazolo[1,5-c]quinazolines and Derived Novel Heterocycles: Syntheses and Structure-Activity Relationships of Potent Adenosine Receptor Antagonists.

artículo científico publicado en 2016

2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at Human A3 adenosine receptors.

artículo científico publicado en 2003

2-Substituted α,β-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes

artículo científico publicado en 2020

2-phenyl-1-[4-(2-piperidine-1-yl-ethoxy)benzyl]-1H-benzimidazoles as ligands for the estrogen receptor: synthesis and pharmacological evaluation.

artículo científico publicado en 2010

3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17

scientific article published on 05 September 2018

6-(Ar)Alkylamino-Substituted Uracil Derivatives: Lipid Mimetics with Potent Activity at the Orphan G Protein-Coupled Receptor 84 (GPR84).

artículo científico publicado en 2018

6-Bromo-8-(4-[(3)H]methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic Acid: a powerful tool for studying orphan G protein-coupled receptor GPR35.

artículo científico publicado en 2013

7-Alkyl-3-benzylcoumarins: a versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists.

artículo científico publicado en 2012

7-Deazaadenines Bearing Polar Substituents: Structure−Activity Relationships of New A1and A3Adenosine Receptor Antagonists†

scientific article published on 01 November 2000

8-(Sulfostyryl)xanthines: water-soluble A2A-selective adenosine receptor antagonists.

artículo científico publicado en 1998

8-Benzamidochromen-4-one-2-carboxylic acids: potent and selective agonists for the orphan G protein-coupled receptor GPR35.

artículo científico publicado en 2013

8-Benzyltetrahydropyrazino[2,1-f]purinediones: water-soluble tricyclic xanthine derivatives as multitarget drugs for neurodegenerative diseases.

artículo científico publicado en 2014

8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors

artículo científico publicado en 2016

A capillary electrophoresis method for the characterization of ecto-nucleoside triphosphate diphosphohydrolases (NTPDases) and the analysis of inhibitors by in-capillary enzymatic microreaction

artículo científico publicado en 2005

A capillary electrophoresis method with dynamic pH junction stacking for the monitoring of cerebroside sulfotransferase

artículo científico publicado en 2015

A detailed behavioral analysis of the acute motor effects of caffeine in the rat: involvement of adenosine A1 and A2A receptors

artículo científico publicado en 2005

A highly sensitive CE-UV method with dynamic coating of silica-fused capillaries for monitoring of nucleotide pyrophosphatase/phosphodiesterase reactions

artículo científico publicado en 2008

A highly sensitive capillary electrophoresis method using p-nitrophenyl 5′-thymidine monophosphate as a substrate for the monitoring of nucleotide pyrophosphatase/phosphodiesterase activities

article

A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists

artículo científico publicado en 2006

A new, sensitive ecto-5'-nucleotidase assay for compound screening

artículo científico publicado en 2013

A novel receptor cross-talk between the ATP receptor P2Y2 and formyl peptide receptors reactivates desensitized neutrophils to produce superoxide

artículo científico publicado en 2014

A1 adenosine receptors and their ligands: overview and recent developments

artículo científico publicado en 2001

A2A adenosine receptor deletion is protective in a mouse model of Tauopathy

artículo científico publicado en 2014

A2A and A2B adenosine receptors: The extracellular loop 2 determines high (A2A) or low affinity (A2B) for adenosine

artículo científico publicado en 2019

A2B Adenosine Receptor Antagonists with Picomolar Potency

artículo científico publicado en 2019

Adenosine A(2A) agonist and A(2B) antagonist mediate an inhibition of inflammation-induced contractile disturbance of a rat gastrointestinal preparation

artículo científico publicado en 2009

Adenosine A(2A) receptor antagonism reverses the effects of dopamine receptor antagonism on instrumental output and effort-related choice in the rat: implications for studies of psychomotor slowing

artículo científico publicado en 2006

Adenosine A(2A) receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation.

artículo científico publicado en 2012

Adenosine A2A receptor antagonism and genetic deletion attenuate the effects of dopamine D2 antagonism on effort-based decision making in mice.

artículo científico publicado en 2012

Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms.

artículo científico publicado en 2008

Adenosine A2A receptor blockade prevents memory dysfunction caused by beta-amyloid peptides but not by scopolamine or MK-801.

artículo científico publicado en 2007

Adenosine A2A receptor contributes to the anti-inflammatory effect of the fixed herbal combination STW 5 (Iberogast®) in rat small intestinal preparations.

artículo científico publicado en 2011

Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors

artículo científico publicado en 2014

Adenosine receptor agonists: from basic medicinal chemistry to clinical development

artículo científico publicado en 2003

Adenosine receptor antagonists including caffeine alter fetal brain development in mice

artículo científico publicado en 2013

Adenosine receptor subtype-selective antagonists in inflammation and hyperalgesia

artículo científico publicado en 2008

Adenosine receptors and their modulators

artículo científico publicado en 1993

Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling

artículo científico publicado en 2009

Adenosine/dopamine interaction: implications for the treatment of Parkinson's disease

scientific article published on 01 July 2001

Adenosinrezeptor-Liganden — Arzneistoffe der Zukunft?

scientific article published on 01 May 1989

Advances in immobilized enzyme microbioreactors in capillary electrophoresis

artículo científico

Agonist-bound structure of the human P2Y12 receptor

artículo científico publicado en 2014

Alkynyl–coumarinyl ethers as MAO-B inhibitors

artículo científico publicado en 2014

Allosteric modulators of rhodopsin-like G protein-coupled receptors: Opportunities in drug development ⬇️

artículo científico publicado el 19 de junio de 2012

Ammonium-induced calcium mobilization in 1321N1 astrocytoma cells

artículo científico publicado en 2007

An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights

scientific article published on 27 November 2019

Analysis of the Staphylococcus aureus capsule biosynthesis pathway in vitro: characterization of the UDP-GlcNAc C6 dehydratases CapD and CapE and identification of enzyme inhibitors.

artículo científico publicado en 2014

Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti-SARS-CoV-2 Activity

artículo científico publicado en 2022

Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysis

artículo científico publicado en 2008

Antagonists for the orphan G-protein-coupled receptor GPR55 based on a coumarin scaffold

artículo científico publicado en 2013

Anthraquinones As Pharmacological Tools and Drugs

artículo científico publicado en 2016

Antinociceptive effects of novel A2B adenosine receptor antagonists.

artículo científico publicado en 2003

Antiparkinsonian Effects of Novel Adenosine A2A Receptor Antagonists

artículo científico publicado en 2010

Antiproliferative effects of selective adenosine receptor agonists and antagonists on human lymphocytes: evidence for receptor-independent mechanisms.

artículo científico publicado en 2013

Antithrombotic P2Y12 receptor antagonists: recent developments in drug discovery

scholarly article by Younis Baqi & Christa E Müller published October 2018 in Drug Discovery Today

Applying Molecular Networking for the Detection of Natural Sources and Analogues of the Selective Gq Protein Inhibitor FR900359

scholarly article by Raphael Reher et al published 26 June 2018 in Journal of Natural Products

Aza-analogs of 8-styrylxanthines as A2A-adenosine receptor antagonists

artículo científico publicado en 1997

BAY60-6583 acts as a partial agonist at adenosine A2B receptors

artículo científico publicado en 2014

Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology

artículo científico publicado en 2014

Benzothiazinones: a novel class of adenosine receptor antagonists structurally unrelated to xanthine and adenine derivatives

artículo científico publicado en 2012

Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55

article

Binding of [3H]MSX-2 (3-(3-hydroxypropyl)-7-methyl-8-(m-methoxystyryl)-1-propargylxanthine) to rat striatal membranes--a new, selective antagonist radioligand for A(2A) adenosine receptors

artículo científico publicado en 2000

Bioactive pyridoacridine alkaloids from the micronesian sponge Oceanapia sp.

artículo científico publicado en 1998

Bispidines for Dual Imaging

artículo científico publicado en 2014

CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells promotes hepatic metastatic tumor growth in mice

artículo científico publicado en 2010

CD39/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injury

artículo científico publicado en 2007

Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress

artículo científico publicado en 2015

Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life

artículo científico publicado en 2009

Capillary electrophoresis-based nanoscale assays for monitoring ecto-5′-nucleotidase activity and inhibition in preparations of recombinant enzyme and melanoma cell membranes

artículo científico publicado en 2007

Carbamazepine derivatives with P2X4 receptor-blocking activity.

artículo científico publicado en 2013

Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation.

artículo científico publicado en 2014

Catalepsy induced by a blockade of dopamine D1 or D2 receptors was reversed by a concomitant blockade of adenosine A(2A) receptors in the caudate-putamen of rats

artículo científico publicado en 2001

Catalyst-Free Microwave-Assisted Amination of 2-Chloro-5-nitrobenzoic Acid

scientific article published on 22 June 2007

Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors

artículo científico publicado en 2020

Cellular localization of adenine receptors in the rat kidney and their functional significance in the inner medullary collecting duct

artículo científico publicado en 2013

Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents

artículo científico publicado en 2014

Characterization of P2X4 receptor agonists and antagonists by calcium influx and radioligand binding studies

artículo científico publicado en 2016

Characterization of circulating microparticle-associated CD39 family ecto-nucleotidases in human plasma

artículo científico publicado en 2014

Characterization of human and rodent native and recombinant adenosine A(2B) receptors by radioligand binding studies

artículo científico publicado en 2006

Characterization of new G protein-coupled adenine receptors in mouse and hamster

artículo científico publicado en 2013

Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18

artículo científico publicado en 2016

Chiral pyrrolo[2,3-d]pyrimidine and pyrimido[4,5-b]indole derivatives: structure-activity relationships of potent, highly stereoselective A1-adenosine receptor antagonists

artículo científico publicado en 1996

Chronic A2A antagonist treatment alleviates parkinsonian locomotor deficiency in MitoPark mice

artículo científico publicado en 2010

Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain

artículo científico publicado en 2007

Clopidogrel attenuates lithium-induced alterations in renal water and sodium channels/transporters in mice.

artículo científico publicado en 2015

Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists

artículo científico publicado en 2007

Competitive mode and site of interaction of ticagrelor at the human platelet P2Y12 -receptor

artículo científico publicado en 2014

Computational Investigations on the Binding Mode of Ligands for the Cannabinoid-Activated G Protein-Coupled Receptor GPR18

scientific article published on 29 April 2020

Conditional neural knockout of the adenosine A(2A) receptor and pharmacological A(2A) antagonism reduce pilocarpine-induced tremulous jaw movements: studies with a mouse model of parkinsonian tremor

artículo científico publicado en 2012

Convergent Synthesis of the Potent P2Y Receptor Antagonist MG 50-3-1 Based on a Regioselective Ullmann Coupling Reaction ⬇️

artículo científico publicado el 5 de marzo de 2012

Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus

artículo científico publicado en 2019

Crystal structure of NTPDase2 in complex with the sulfoanthraquinone inhibitor PSB-071

artículo científico publicado en 2014

Cyclopropane-Containing Fatty Acids from the Marine Bacterium sp. 011 with Antimicrobial and GPR84 Activity ⬇️

artículo científico publicado en 2018

Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist

artículo científico publicado en 2013

Deep brain stimulation of the subthalamic nucleus reverses oral tremor in pharmacological models of parkinsonism: interaction with the effects of adenosine A2A antagonism

artículo científico publicado en 2013

Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y2 and GPR17

scientific article published on 18 October 2019

Development and validation of a capillary electrophoresis method for the characterization of herpes simplex virus type 1 (HSV-1) thymidine kinase substrates and inhibitors

artículo científico publicado en 2006

Development of Polar Adenosine A2A Receptor Agonists for Inflammatory Bowel Disease: Synergism with A2B Antagonists

artículo científico publicado en 2011

Development of Potent and Selective Antagonists for the UTP-Activated P2Y4 Receptor.

artículo científico publicado en 2017

Development of [(3)H]2-Carboxy-4,6-dichloro-1H-indole-3-propionic Acid ([(3)H]PSB-12150): A Useful Tool for Studying GPR17

artículo científico publicado en 2014

Development of a 5-hydroxytryptamine(2A) receptor binding assay for high throughput screening using 96-well microfilter plates

scientific article published on 01 August 2000

Development of a microbioreactor with ecto-nucleoside triphosphate diphosphohydrolase 2 (NTPDase2) immobilized on a polyacrylamide-coated capillary at the outlet

artículo científico publicado en 2009

Development of a selective and highly sensitive fluorescence assay for nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39)

article

Development of off-line and on-line capillary electrophoresis methods for the screening and characterization of adenosine kinase inhibitors and substrates

article

Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold

artículo científico publicado en 2010

Development of spin-labeled probes for adenosine receptors

artículo científico publicado en 2005

Differential allosteric modulation by amiloride analogues of agonist and antagonist binding at A(1) and A(3) adenosine receptors

artículo científico publicado en 2003

Diindolylmethane Derivatives: Potent Agonists of the Immunostimulatory Orphan G Protein-Coupled Receptor GPR84.

artículo científico publicado en 2017

Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor

artículo científico publicado en 2011

Dissection of P2X4 and P2X7 Receptor Current Components in BV-2 Microglia

artículo científico publicado en 2020

Domains for activation and inactivation in G protein-coupled receptors--a mutational analysis of constitutive activity of the adenosine A2B receptor

artículo científico publicado en 2014

Dopamine/adenosine interactions related to locomotion and tremor in animal models: possible relevance to parkinsonism

artículo científico publicado en 2008

Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences

artículo científico publicado en 2012

Dual target strategy: combining distinct non-dopaminergic treatments reduces neuronal cell loss and synergistically modulates L-DOPA-induced rotational behavior in a rodent model of Parkinson's disease

artículo científico publicado en 2015

Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones

artículo científico publicado en 2013

Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions

artículo científico publicado en 2013

Ecto-ATPase inhibition: ATP and adenosine release under physiological and ischemic in vivo conditions in the rat striatum

artículo científico publicado en 2011

Effect of subtype-selective adenosine receptor antagonists on basal or haloperidol-regulated striatal function: studies of exploratory locomotion and c-Fos immunoreactivity in outbred and A(2A)R KO mice

artículo científico publicado en 2013

Effect of the adenosine A2A receptor antagonist MSX-3 on motivational disruptions of maternal behavior induced by dopamine antagonism in the early postpartum rat

artículo científico publicado en 2010

Effects of GPR18 Ligands on Body Weight and Metabolic Parameters in a Female Rat Model of Excessive Eating

artículo científico publicado en 2021

Effort-related motivational effects of the VMAT-2 inhibitor tetrabenazine: implications for animal models of the motivational symptoms of depression.

artículo científico publicado en 2013

Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task

artículo científico publicado en 2013

Effort-related motivational effects of the pro-inflammatory cytokine interleukin-6: pharmacological and neurochemical characterization

artículo científico publicado en 2016

Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists

artículo científico publicado en 2019

Emerging structures and ligands for P2X3 and P2X4 receptors—towards novel treatments of neuropathic pain ⬇️

artículo científico publicado el 16 de mayo de 2010

Enabling role of adenosine A1 receptors in adenosine A2A receptor-mediated striatal expression of c-fos

artículo científico publicado en 2003

Enantiomerically enriched trans-diols from alkenes in one pot: a multicatalyst approach

artículo científico publicado en 2012

Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila: substrate specificity and requirement for virulence

artículo científico publicado en 2008

Epibatidin - ein nicotinartiges, analgetisch wirksames Alkaloid aus Pfeilgiftfröschen

artículo científico publicado en 1996

Erratum to: Characterization of circulating microparticle-associated CD39 family ecto-nucleotidases in human plasma.

artículo científico publicado en 2014

Erratum: A2A adenosine receptor deletion is protective in a mouse model of Tauopathy

article

Ethanol and Caffeine Effects on Social Interaction and Recognition in Mice: Involvement of Adenosine A2A and A1 Receptors

artículo científico publicado en 2016

Evaluation of anticonvulsant and analgesic effects of benzyl- and benzhydryl ureides

artículo científico publicado en 2006

Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues.

artículo científico publicado en 2004

Extracellular NAD(+) induces a rise in [Ca(2+)](i) in activated human monocytes via engagement of P2Y(1) and P2Y(11) receptors

artículo científico publicado en 2009

Extracellular metabolism of nucleotides in neuroblastoma x glioma NG108-15 cells determined by capillary electrophoresis

artículo científico publicado en 2003

Farnesyl pyrophosphate is an endogenous antagonist to ADP-stimulated P2Y₁₂ receptor-mediated platelet aggregation.

artículo científico publicado en 2012

Fast, efficient capillary electrophoresis method for measuring nucleotide degradation and metabolism

artículo científico publicado en 2002

Feature-Based Molecular Networking for the Targeted Identification of G<sub>q</sub>-Inhibiting FR900359 Derivatives

artículo científico publicado en 2021

Fluorescence polarization immunoassays for monitoring nucleoside triphosphate diphosphohydrolase (NTPDase) activity.

artículo científico publicado en 2015

Fluorescent-labeled selective adenosine A2B receptor antagonist enables competition binding assay by flow cytometry

artículo científico publicado en 2018

Focused screening to identify new adenosine kinase inhibitors

artículo científico publicado en 2016

G-Protein-Coupled Receptors: Sustained Signaling via Intracellular Megaplexes and Pathway-Specific Drugs

artículo científico publicado en 2016

GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A2B receptor

scholarly article published February 2011

GPR18 Inhibiting Amauromine and the Novel Triterpene Glycoside Auxarthonoside from the Sponge-Derived Fungus Auxarthron reticulatum

artículo científico publicado en 2015

General Synthesis of Unsymmetrical 3,3′-(Aza)diindolylmethane Derivatives

artículo científico publicado en 2018

Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity.

artículo científico publicado en 2018

High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors.

artículo científico publicado en 2009

High-sensitivity capillary electrophoresis method for monitoring purine nucleoside phosphorylase and adenosine deaminase reactions by a reversed electrode polarity switching mode

artículo científico publicado en 2011

Homology modelling of the human adenosine A2B receptor based on X-ray structures of bovine rhodopsin, the beta2-adrenergic receptor and the human adenosine A2A receptor

artículo científico publicado en 2009

Identification of a Potent and Selective Cannabinoid CB1 Receptor Antagonist from Auxarthron reticulatum. ⬇️

artículo científico publicado en 2011

Imidazo-thiazine, -diazinone and -diazepinone derivatives. Synthesis, structure and benzodiazepine receptor binding

artículo científico publicado en 2001

Imidazo[2,1-b]thiazepines: synthesis, structure and evaluation of benzodiazepine receptor binding.

artículo científico publicado en 2004

Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists

artículo científico publicado en 2002

Imidazopyridine- and purine-thioacetamide derivatives: potent inhibitors of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1).

artículo científico publicado en 2014

Impact of in vivo chronic blockade of adenosine A2A receptors on the BDNF-mediated facilitation of LTP.

artículo científico publicado en 2014

Impact of the aryl substituent kind and distance from pyrimido[2,1-f]purindiones on the adenosine receptor selectivity and antagonistic properties.

artículo científico publicado en 2003

Improving Potency, Selectivity, and Water Solubility of Adenosine A1 Receptor Antagonists: Xanthines Modified at Position 3 and Related Pyrimido[1,2,3-cd]purinediones

artículo científico publicado en 2006

Inactivation of adenosine A2A receptors reverses working memory deficits at early stages of Huntington's disease models

artículo científico publicado en 2015

Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency

artículo científico publicado en 2014

Indoloditerpenes from a marine-derived fungal strain of Dichotomomyces cejpii with antagonistic activity at GPR18 and cannabinoid receptors

artículo científico publicado en 2014

Induction of oral tremor in mice by the acetylcholinesterase inhibitor galantamine: Reversal with adenosine A2A antagonism

artículo científico publicado en 2015

Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication

artículo científico publicado en 2023

Inhibitors for the bacterial ectonucleotidase Lp1NTPDase from Legionella pneumophila

artículo científico publicado en 2016

Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y12 receptor

artículo científico publicado en 2009

Interaction of valerian extracts of different polarity with adenosine receptors: identification of isovaltrate as an inverse agonist at A1 receptors

artículo científico publicado en 2006

Interactions between adenosine and dopamine receptor antagonists with different selectivity profiles: Effects on locomotor activity

artículo científico publicado en 2010

Interactions of valerian extracts and a fixed valerian-hop extract combination with adenosine receptors

artículo científico publicado en 2002

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an update

artículo científico publicado en 2011

International conference on purinergic drugs and targets-4th joint german-italian purine club meeting, bonn, Germany, july 22-25, 2011.

artículo científico publicado en 2012

Investigation on 2',3'-O-Substituted ATP Derivatives and Analogs as Novel P2X3 Receptor Antagonists

scientific article published on 26 December 2018

Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration

artículo científico publicado en 2003

Involvement of adenosine A1 receptors in the discriminative-stimulus effects of caffeine in rats

artículo científico publicado en 2005

Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaine

artículo científico publicado en 2006

Iodine-catalyzed electrophilic substitution of indoles: Synthesis of (un)symmetrical diindolylmethanes with a quaternary carbon center

artículo científico publicado en 2021

Key determinants of nucleotide-activated G protein-coupled P2Y(2) receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling

artículo científico publicado en 2009

L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies

artículo científico publicado en 2014

L-DOPA-treatment in primates disrupts the expression of A(2A) adenosine-CB(1) cannabinoid-D(2) dopamine receptor heteromers in the caudate nucleus

artículo científico publicado en 2013

Lack of adenosine A1 and dopamine D2 receptor-mediated modulation of the cardiovascular effects of the adenosine A2A receptor agonist CGS 21680.

artículo científico publicado en 2004

Large-volume sample stacking with polarity switching for monitoring of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) reactions by capillary electrophoresis

scientific article published on 15 January 2014

Ligand-specific binding and activation of the human adenosine A(2B) receptor

artículo científico publicado en 2013

Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors

artículo científico publicado en 2002

Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55. ⬇️

artículo científico publicado en 2012

Mass spectrometric identification of modified urinary nucleosides used as potential biomedical markers by LC-ITMS coupling

artículo científico publicado en 2005

Medicinal chemistry of adenosine A3 receptor ligands

artículo científico publicado en 2003

Medicinal chemistry of adenosine, P2Y and P2X receptors

artículo científico publicado en 2015

Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striopallidal GABA pathway in rats. Interactions with adenosine A(2A) and dopamine D(2) receptors.

artículo científico publicado en 2002

Microwave-assisted ring closure reactions: synthesis of 8-substituted xanthine derivatives and related pyrimido- and diazepinopurinediones

artículo científico publicado en 2006

Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information

artículo científico publicado en 2015

Molecular Recognition of Agonists and Antagonists by the Nucleotide-Activated G Protein-Coupled P2Y2 Receptor.

artículo científico publicado en 2017

Motor effects induced by a blockade of adenosine A2A receptors in the caudate-putamen

artículo científico publicado en 1998

Multigram-scale syntheses, stability, and photoreactions of A2A adenosine receptor antagonists with 8-styrylxanthine structure: potential drugs for Parkinson's disease

artículo científico publicado en 2004

N-substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists.

artículo científico publicado en 2012

N9-benzyl-substituted 1,3-dimethyl- and 1,3-dipropyl-pyrimido[2,1-f]purinediones: synthesis and structure-activity relationships at adenosine A1 and A2A receptors

artículo científico publicado en 2007

Neuroprotective potential of adenosine A2A and cannabinoid CB1 receptor antagonists in an animal model of Parkinson disease.

artículo científico publicado en 2014

Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique adenosine derivative

artículo científico publicado en 2004

Novel, Dual Target-Directed Annelated Xanthine Derivatives Acting on Adenosine Receptors and Monoamine Oxidase B

scientific article published on 12 March 2020

Nucleoside-5'-monophosphates as prodrugs of adenosine A2A receptor agonists activated by ecto-5'-nucleotidase.

artículo científico publicado en 2009

Nucleus accumbens and effort-related functions: behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors.

artículo científico publicado en 2010

Oral tremor induced by galantamine in rats: a model of the parkinsonian side effects of cholinomimetics used to treat Alzheimer's disease

artículo científico publicado en 2011

Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX.

artículo científico publicado en 2009

P2-pyrimidinergic receptors and their ligands

artículo científico publicado en 2002

P2Y12 Receptor Localizes in the Renal Collecting Duct and Its Blockade Augments Arginine Vasopressin Action and Alleviates Nephrogenic Diabetes Insipidus.

artículo científico publicado en 2015

P2Y2 receptor agonist with enhanced stability protects the heart from ischemic damage in vitro and in vivo

artículo científico publicado en 2013

P2Y2 receptor modulates shear stress-induced cell alignment and actin stress fibers in human umbilical vein endothelial cells

artículo científico publicado en 2016

P2Y₂ and Gq/G₁₁ control blood pressure by mediating endothelial mechanotransduction.

artículo científico publicado en 2015

PURINES 2014: nucleotides, nucleosides and nucleobases - international conference on signalling, drugs and targets

artículo científico publicado en 2014

Past, present and future of A(2A) adenosine receptor antagonists in the therapy of Parkinson's disease.

artículo científico publicado en 2011

Pharmacological evaluation of new constituents of "Spice": synthetic cannabinoids based on indole, indazole, benzimidazole and carbazole scaffolds.

artículo científico publicado en 2018

Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice

artículo científico publicado en 2016

Phenylethyl-substituted pyrimido[2,1-f]purinediones and related compounds: Structure–activity relationships as adenosine A1 and A2A receptor ligands

artículo científico publicado en 2007

Polyoxometalates as Versatile Enzyme Inhibitors

Polyoxometalates--potent and selective ecto-nucleotidase inhibitors

artículo científico publicado en 2014

Polyoxometalates—a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors

artículo científico publicado en 2006

Potent Suppressive Effects of 1-Piperidinylimidazole Based Novel P2X7 Receptor Antagonists on Cancer Cell Migration and Invasion

artículo científico publicado en 2016

Preparation of enantiopure (R)-hydroxy metabolite of denbufylline using immobilized Lactobacillus kefiri DSM 20587 as a catalyst

artículo científico publicado en 2009

Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability

artículo científico publicado en 2004

Prodrug approaches for enhancing the bioavailability of drugs with low solubility

artículo científico publicado en 2009

Quantification of green fluorescent protein-(GFP-) tagged membrane proteins by capillary gel electrophoresis.

artículo científico publicado en 2017

Rapid and Efficient Microwave-Assisted Copper(0)-Catalyzed Ullmann Coupling Reaction: General Access to Anilinoanthraquinone Derivatives

article

Rapid microwave-assisted fluorination yielding novel 5′-deoxy-5′-fluorouridine derivatives

scientific article published on 07 September 2006

Recent developments in adenosine receptor ligands and their potential as novel drugs ⬇️

artículo científico publicado el 23 de diciembre de 2010

Regioselective synthesis of 7,8-dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives: A new drug-like heterocyclic scaffold

artículo científico publicado en 2012

Reinforcing and neurochemical effects of cannabinoid CB1 receptor agonists, but not cocaine, are altered by an adenosine A2A receptor antagonist

artículo científico publicado en 2010

Role of P2 purinergic receptors in synaptic transmission under normoxic and ischaemic conditions in the CA1 region of rat hippocampal slices

artículo científico publicado en 2007

Role of central and peripheral adenosine receptors in the cardiovascular responses to intraperitoneal injections of adenosine A1 and A2A subtype receptor agonists.

artículo científico publicado en 2005

Role of extracellular cysteine residues in the adenosine A2A receptor.

artículo científico publicado en 2016

Selective activation of adenosine A2A receptors on immune cells by a CD73-dependent prodrug suppresses joint inflammation in experimental rheumatoid arthritis

artículo científico publicado en 2012

Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide.

artículo científico publicado en 2008

Selectivity is species-dependent: Characterization of standard agonists and antagonists at human, rat, and mouse adenosine receptors

artículo científico publicado en 2015

Shear stress modulates endothelial KLF2 through activation of P2X4.

artículo científico publicado en 2015

Similarities and differences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors.

artículo científico publicado en 2016

Stimulant effects of adenosine antagonists on operant behavior: differential actions of selective A2A and A1 antagonists.

artículo científico publicado en 2011

Stimulation of calcium release by caffeine analogs in pheochromocytoma cells

artículo científico publicado en 1993

Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids

scientific journal article

Structural analogues of the natural products magnolol and honokiol as potent allosteric potentiators of GABA(A) receptors

artículo científico publicado en 2014

Structural and Conformational Studies on Carboxamides of 5,6-Diaminouracils-Precursors of Biologically Active Xanthine Derivatives

artículo científico publicado en 2019

Structural characterization and pharmacological evaluation of the new synthetic cannabinoid CUMYL-PEGACLONE.

artículo científico publicado en 2017

Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors

artículo científico publicado en 2011

Structure of the human P2Y12 receptor in complex with an antithrombotic drug

artículo científico publicado en 2014

Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5'-Nucleotidase (CD73) Inhibitors

scientific article published on 21 March 2019

Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.

artículo científico publicado en 2002

Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family

artículo científico publicado en 2009

Structure-activity relationships of anthraquinone derivatives derived from bromaminic acid as inhibitors of ectonucleoside triphosphate diphosphohydrolases (E-NTPDases).

artículo científico publicado en 2008

Substituted 4-phenylthiazoles: Development of potent and selective A1, A3 and dual A1/A3 adenosine receptor antagonists

artículo científico publicado en 2019

Substrate-Dependence of Competitive Nucleotide Pyrophosphatase/Phosphodiesterase1 (NPP1) Inhibitors

artículo científico publicado en 2017

Syntheses of 2-substituted 1-amino-4-bromoanthraquinones (bromaminic acid analogues) - precursors for dyes and drugs.

artículo científico publicado en 2015

Synthesis and Analgesic Activity of Annelated Xanthine Derivatives in Experimental Models in Rodents.

artículo científico publicado en 2015

Synthesis and biological activity of tricyclic aryloimidazo-, pyrimido-, and diazepinopurinediones

artículo científico publicado en 2006

Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones.

artículo científico publicado en 2011

Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists

artículo científico publicado en 2009

Synthesis and pharmacology of pyrido[2,3-d]pyrimidinediones bearing polar substituents as adenosine receptor antagonists

artículo científico publicado en 2006

Synthesis and preliminary evaluation of [3H]PSB-0413, a selective antagonist radioligand for platelet P2Y12 receptors

artículo científico publicado en 2005

Synthesis and preliminary evaluation of new 1- and 3-[1-(2-hydroxy-3-phenoxypropyl)]xanthines from 2-amino-2-oxazolines as potential A1 and A2A adenosine receptor antagonists

artículo científico publicado en 2005

Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonists

artículo científico publicado en 1997

Synthesis and structure-activity relationships of cerebroside analogues as substrates of cerebroside sulphotransferase and discovery of a competitive inhibitor

artículo científico publicado en 2020

Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists

artículo científico publicado en 1994

Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors

artículo científico publicado en 2006

Synthesis of BODIPY derivatives substituted with various bioconjugatable linker groups: a construction kit for fluorescent labeling of receptor ligands

artículo científico publicado en 2013

Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs

scientific article published on 13 February 2020

Synthesis of Novel Pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine Derivatives: Potent and Selective Adenosine A3Receptor Antagonists

artículo científico publicado en 2013

Synthesis of a hydrolytically stable, fluorescent-labeled ATP analog as a tool for probing adenylyl cyclases.

artículo científico publicado en 2009

Synthesis of alkyl- and aryl-amino-substituted anthraquinone derivatives by microwave-assisted copper(0)-catalyzed Ullmann coupling reactions

artículo científico publicado en 2010

Synthesis of computer graphic calculated high-anti-fixed pyrimidine nucleoside analogs with potential virostatic and antineoplastic action

artículo científico publicado en 1989

Synthesis of uracil nucleotide analogs with a modified, acyclic ribose moiety as P2Y(2) receptor antagonists

artículo científico publicado en 2009

Synthesis, biological activity and molecular modelling studies of tricyclic alkylimidazo-, pyrimido- and diazepinopurinediones

artículo científico publicado en 2013

Synthesis, characterization, and in vitro evaluation of the selective P2Y2 receptor antagonist AR-C118925.

artículo científico publicado en 2016

Targeting renal purinergic signalling for the treatment of lithium-induced nephrogenic diabetes insipidus.

artículo científico publicado en 2015

The 2016 Frontiers in Medicinal Chemistry Conference in Bonn

artículo científico publicado en 2017

The GPR18 Agonist PSB-KD-107 Exerts Endothelium-Dependent Vasorelaxant Effects

artículo científico publicado en 2021

The VMAT-2 inhibitor tetrabenazine affects effort-related decision making in a progressive ratio/chow feeding choice task: reversal with antidepressant drugs.

artículo científico publicado en 2014

The VMAT-2 inhibitor tetrabenazine alters effort-related decision making as measured by the T-maze barrier choice task: reversal with the adenosine A2A antagonist MSX-3 and the catecholamine uptake blocker bupropion

artículo científico publicado en 2014

The adenosine A2A antagonist MSX-3 reverses the effort-related effects of dopamine blockade: differential interaction with D1 and D2 family antagonists

artículo científico publicado en 2008

The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.

artículo científico publicado en 2016

The experimental power of FR900359 to study Gq-regulated biological processes

artículo científico publicado en 2015

The four cysteine residues in the second extracellular loop of the human adenosine A2B receptor: role in ligand binding and receptor function

artículo científico publicado en 2011

The map kinase ERK regulates renal activity of cyclin-dependent kinase 2 in experimental glomerulonephritis

article

The natural product magnolol as a lead structure for the development of potent cannabinoid receptor agonists

artículo científico publicado en 2013

The novel adenosine A(2A) antagonist prodrug MSX-4 is effective in animal models related to motivational and motor functions

artículo científico publicado en 2012

The nucleobase adenine as a signalling molecule in the kidney.

artículo científico publicado en 2015

The platelet P2Y(12) receptor under normal and pathological conditions. Assessment with the radiolabeled selective antagonist [(3)H]PSB-0413.

artículo científico publicado en 2012

The promiscuous ectonucleotidase NPP1: molecular insights into substrate binding and hydrolysis.

artículo científico publicado en 2016

The rat adenine receptor: pharmacological characterization and mutagenesis studies to investigate its putative ligand binding site

artículo científico publicado en 2013

The second extracellular loop of GPCRs determines subtype-selectivity and controls efficacy as evidenced by loop exchange study at A2 adenosine receptors

artículo científico publicado en 2013

The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: implications for pharmacological models of parkinsonian tremor.

artículo científico publicado en 2013

Thiazolo[3,2-a]benzimidazol-3(2H)-one derivatives: Structure-activity relationships of selective nucleotide pyrophosphatase/phosphodiesterase1 (NPP1) inhibitors

artículo científico publicado en 2016

Thioesterase-mediated side chain transesterification generates potent Gq signaling inhibitor FR900359

artículo científico publicado en 2021

Tricyclic oxazolo[2,3-f]purinediones: potency as adenosine receptor ligands and anticonvulsants.

artículo científico publicado en 2004

Tricyclic xanthine derivatives containing a basic substituent: adenosine receptor affinity and drug-related properties.

artículo científico publicado en 2018

Tritium-labeled brivaracetam with high specific activity: preparation, characterization and application in human brain samples.

artículo científico publicado en 2012

Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation

artículo científico publicado en 2018

Update of P2X receptor properties and their pharmacology: IUPHAR Review 30

artículo científico publicado en 2020

Update of P2Y Receptor Pharmacology: IUPHAR Review:27

artículo científico publicado en 2020

Uridine nucleotide receptors and their ligands: structural, physiological, and pathophysiological aspects, with special emphasis on the nervous system

artículo científico publicado en 1997

Virtual Screening Identifies Novel Sulfonamide Inhibitors of ecto-5′-Nucleotidase ⬇️

artículo científico publicado el 9 de julio de 2012

Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A(2A)-selective adenosine receptor antagonists

artículo científico publicado en 2000

Xanthines as Adenosine Receptor Antagonists ⬇️

artículo científico publicado el 1 de enero de 2011

[(3)H]8-Ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one ([(3)H]PSB-11), a novel high-affinity antagonist radioligand for human A(3) adenosine receptors

artículo científico publicado en 2002

[(3)H]Adenine is a suitable radioligand for the labeling of G protein-coupled adenine receptors but shows high affinity to bacterial contaminations in buffer solutions

artículo científico publicado en 2007

[H]BQ-123 binding to native endothelin ET(A) receptors in human astrocytoma 1321N1 cells and screening of potential ligands.

artículo científico publicado en 2005

α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors.

artículo científico publicado en 2015

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