Lista de obras - Charles E de Bock - Dominio Público Uruguay

A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing

scientific article published on 28 June 2018

A mitochondrial brake on vascular repair

scientific article published in Nature

A soluble form of the giant cadherin Fat1 is released from pancreatic cancer cells by ADAM10 mediated ectodomain shedding

artículo científico publicado en 2014

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

artículo científico publicado en 2014

Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo

artículo científico publicado en 2010

Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia

artículo científico publicado en 2015

Clinical significance of urokinase-type plasminogen activator receptor (uPAR) expression in cancer

artículo científico publicado en 2004

Defining the molecular basis of oncogenic cooperation between TAL1 expression and Pten deletion in T-ALL using a novel pro-T-cell model system.

artículo científico publicado en 2017

Dual processing of FAT1 cadherin protein by human melanoma cells generates distinct protein products

artículo científico publicado en 2011

Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress.

artículo científico publicado en 2011

Evidence for epidermal growth factor receptor-enhanced chemosensitivity in combinations of cisplatin and the new irreversible tyrosine kinase inhibitor CI-1033.

artículo científico publicado en 2001

Expression of urokinase-type plasminogen activator and its receptor is up-regulated during tendon healing

scientific journal article

FAT1 cadherin acts upstream of Hippo signalling through TAZ to regulate neuronal differentiation.

artículo científico publicado en 2015

FAT1 cadherin is multiply phosphorylated on its ectodomain but phosphorylation is not catalysed by the four-jointed homologue

artículo científico publicado en 2014

Fat1 cadherin provides a novel minimal residual disease marker in acute lymphoblastic leukemia

artículo científico publicado en 2013

Furin processing dictates ectodomain shedding of human FAT1 cadherin

artículo científico publicado en 2014

Gene expression changes in SNAP-stimulated and iNOS-transfected tenocytes—expression of extracellular matrix genes and its implications for tendon-healing

article

Generation of the Fip1l1-Pdgfra fusion gene using CRISPR/Cas genome editing

artículo científico publicado en 2016

HOXA9 cooperates with activated JAK/STAT signaling to drive leukemia development.

artículo científico publicado en 2018

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors

artículo científico publicado en 2016

Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells

artículo científico publicado en 2005

Interaction between urokinase receptor and heat shock protein MRJ enhances cell adhesion.

artículo científico publicado en 2010

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model

artículo científico publicado en 2014

JAK3 mutations and HOXA9 expression are important cooperating events in T-cell acute lymphoblastic leukemia

scientific article published on 04 April 2018

Macrophage migration inhibitory factor engages PI3K/Akt signalling and is a prognostic factor in metastatic melanoma

artículo científico publicado en 2014

Melanoma cell sensitivity to Docetaxel-induced apoptosis is determined by class III beta-tubulin levels

artículo científico publicado en 2007

Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia.

artículo científico

Mutant JAK3 signaling is increased by loss of wild type JAK3 or by acquiring secondary JAK3 mutations in T-ALL.

artículo científico publicado en 2017

Mutations in GDF6 are associated with vertebral segmentation defects in Klippel-Feil syndrome

artículo científico publicado en 2008

Novel protein interactors of urokinase-type plasminogen activator receptor

artículo científico publicado en 2010

Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia

scientific article published on 06 July 2021

PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma

artículo científico publicado en 2013

Palmitoylation of CD36/FAT regulates the rate of its post-transcriptional processing in the endoplasmic reticulum

artículo científico publicado en 2010

Protein interaction screening identifies SH3RF1 as a new regulator of FAT1 protein levels

artículo científico publicado en 2017

Quantitative phosphoproteomics uncovers synergy between DNA-PK and FLT3 inhibitors in acute myeloid leukaemia

artículo científico publicado en 2020

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition

artículo científico publicado en 2019

Shwachman-Bodian-Diamond syndrome (SBDS) protein is a direct inhibitor of protein phosphatase 2A (PP2A) activity and overexpressed in acute myeloid leukaemia

scientific article published on 08 April 2020

Sleeping giants: emerging roles for the fat cadherins in health and disease

artículo científico publicado en 2013

T-ALL: Home Is where the CXCL12 Is.

artículo científico publicado en 2015

T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development

artículo científico publicado en 2018

The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia

artículo científico publicado en 2011

The XPO1 inhibitor KPT-8602 synergizes with dexamethasone in acute lymphoblastic leukemia

scientific article published on 21 August 2020

The effect of DNA-alkylating agents on gene expression from two integrated reporter genes in a mouse mammary tumor line

artículo científico publicado en 2002

Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress.

artículo científico publicado en 2008

miR-139-5p modulates radiotherapy resistance in breast cancer by repressing multiple gene networks of DNA repair and ROS defense

artículo científico publicado en 2017

Lista de obras de Charles E de Bock

A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing

A mitochondrial brake on vascular repair

A soluble form of the giant cadherin Fat1 is released from pancreatic cancer cells by ADAM10 mediated ectodomain shedding

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo

Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia

Clinical significance of urokinase-type plasminogen activator receptor (uPAR) expression in cancer

Defining the molecular basis of oncogenic cooperation between TAL1 expression and Pten deletion in T-ALL using a novel pro-T-cell model system.

Dual processing of FAT1 cadherin protein by human melanoma cells generates distinct protein products

Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress.

Evidence for epidermal growth factor receptor-enhanced chemosensitivity in combinations of cisplatin and the new irreversible tyrosine kinase inhibitor CI-1033.

Expression of urokinase-type plasminogen activator and its receptor is up-regulated during tendon healing

FAT1 cadherin acts upstream of Hippo signalling through TAZ to regulate neuronal differentiation.

FAT1 cadherin is multiply phosphorylated on its ectodomain but phosphorylation is not catalysed by the four-jointed homologue

Fat1 cadherin provides a novel minimal residual disease marker in acute lymphoblastic leukemia

Furin processing dictates ectodomain shedding of human FAT1 cadherin

Gene expression changes in SNAP-stimulated and iNOS-transfected tenocytes—expression of extracellular matrix genes and its implications for tendon-healing

Generation of the Fip1l1-Pdgfra fusion gene using CRISPR/Cas genome editing

HOXA9 cooperates with activated JAK/STAT signaling to drive leukemia development.

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors

Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells

Interaction between urokinase receptor and heat shock protein MRJ enhances cell adhesion.

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model

JAK3 mutations and HOXA9 expression are important cooperating events in T-cell acute lymphoblastic leukemia

Macrophage migration inhibitory factor engages PI3K/Akt signalling and is a prognostic factor in metastatic melanoma

Melanoma cell sensitivity to Docetaxel-induced apoptosis is determined by class III beta-tubulin levels

Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia.

Mutant JAK3 signaling is increased by loss of wild type JAK3 or by acquiring secondary JAK3 mutations in T-ALL.

Mutations in GDF6 are associated with vertebral segmentation defects in Klippel-Feil syndrome

Novel protein interactors of urokinase-type plasminogen activator receptor

Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia

PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma

Palmitoylation of CD36/FAT regulates the rate of its post-transcriptional processing in the endoplasmic reticulum

Protein interaction screening identifies SH3RF1 as a new regulator of FAT1 protein levels

Quantitative phosphoproteomics uncovers synergy between DNA-PK and FLT3 inhibitors in acute myeloid leukaemia

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition

Shwachman-Bodian-Diamond syndrome (SBDS) protein is a direct inhibitor of protein phosphatase 2A (PP2A) activity and overexpressed in acute myeloid leukaemia

Sleeping giants: emerging roles for the fat cadherins in health and disease

T-ALL: Home Is where the CXCL12 Is.

T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development

The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia

The XPO1 inhibitor KPT-8602 synergizes with dexamethasone in acute lymphoblastic leukemia

The effect of DNA-alkylating agents on gene expression from two integrated reporter genes in a mouse mammary tumor line

Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress.

miR-139-5p modulates radiotherapy resistance in breast cancer by repressing multiple gene networks of DNA repair and ROS defense