Lista de obras - David J. Bearss - Dominio Público Uruguay

A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis ⬇️

artículo científico publicado el 1 de enero de 1998

A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors

artículo científico publicado en 2007

Activators of PKM2 in cancer metabolism

artículo científico publicado en 2014

An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance

artículo científico publicado en 2012

Aurora-A over-expression in high-grade PIN lesions and prostate cancer

artículo científico

Camptothecin analogs with bulky, hydrophobic substituents at the 7-position via a Grignard reaction

artículo científico publicado en 2004

Characterization of Burkholderia pseudomallei Strains Using a Murine Intraperitoneal Infection Model and In Vitro Macrophage Assays.

artículo científico publicado en 2015

Chemical genetic screen reveals a role for desmosomal adhesion in mammary branching morphogenesis.

artículo científico publicado en 2012

Competitive enhancement of HGF-induced epithelial scattering by accessory growth factors ⬇️

artículo científico publicado el 11 de noviembre de 2010

Design, Synthesis, and Biological Evaluation of a Series of Novel AXL Kinase Inhibitors ⬇️

artículo científico publicado el 8 de diciembre de 2011

Different expression of placental pyruvate kinase in normal, preeclamptic and intrauterine growth restriction pregnancies

artículo científico publicado en 2014

Discovery of biologically active oncologic and immunologic small molecule therapies using zebrafish: overview and example of modulation of T cell activation

artículo científico publicado en 2013

Genetic determinants of response to chemotherapy in transgenic mouse mammary and salivary tumors

scientific article published on 01 February 2000

High-throughput virtual screening identifies novel N'-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors

artículo científico publicado en 2013

Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells

artículo científico publicado en 2014

Hydrophilic camptothecin analogs that form extremely stable cleavable complexes with DNA and topoisomerase I.

artículo científico publicado en 2004

Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach

artículo científico publicado en 2006

In vitro and in vivo characterization of SGI-1252, a small molecule inhibitor of JAK2.

artículo científico publicado en 2010

Inhibition of Nek2 by small molecules affects proteasome activity

artículo científico publicado en 2014

Laminin-5 beta3A expression in LNCaP human prostate carcinoma cells increases cell migration and tumorigenicity

artículo científico publicado en 2004

MP470, a novel receptor tyrosine kinase inhibitor, in combination with Erlotinib inhibits the HER family/PI3K/Akt pathway and tumor growth in prostate cancer

artículo científico publicado en 2009

Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma

artículo científico publicado en 2012

Mitochondrial priming of chronic lymphocytic leukemia patients associates Bcl-xL dependence with alvocidib response

artículo científico publicado en 2014

Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue

scholarly article

Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue

artículo científico publicado en 2005

NEK2 Induces Drug Resistance Mainly through Activation of Efflux Drug Pumps and Is Associated with Poor Prognosis in Myeloma and Other Cancers ⬇️

artículo científico publicado el 14 de enero de 2013

New drugs for patients with pancreatic cancer

artículo científico publicado en 2002

Pdx-1-driven overexpression of aurora a kinase induces mild ductal dysplasia of pancreatic ducts near islets in transgenic mice

artículo científico publicado en 2008

Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes

artículo científico publicado en 2009

Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells

artículo científico publicado en 2009

Potential mouse tumor model for pre-clinical testing of mage-specific breast cancer vaccines

artículo científico publicado en 2002

Receptor tyrosine kinase Axl is required for resistance of leukemic cells to FLT3-targeted therapy in acute myeloid leukemia

artículo científico publicado en 2015

Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancer

artículo científico publicado en 1998

S110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth

artículo científico publicado en 2010

S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis)

artículo científico publicado en 2010

Shining the light on aurora-a kinase as a drug target in pancreatic cancer.

artículo científico publicado en 2011

Structure-based design of novel anti-cancer agents targeting aurora kinases

artículo científico publicado en 2003

Syntheses of 2,3-diarylated 2H-benzo[e][1,2]thiazine 1,1-dioxides and their 3,4-dihydro derivatives, and assessment of their inhibitory activity against MCF-7 breast cancer cells

artículo científico publicado en 2011

TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase

artículo científico publicado en 2013

Targeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apoptosis and Shows Synergistic/Additive Effects in Combination with BTK Inhibitors

artículo científico publicado en 2015

Targeting Axl and Mer Kinases in Cancer ⬇️

artículo científico publicado el 20 de septiembre de 2011

Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma

artículo científico publicado en 2011

Telomere inhibition and telomere disruption as processes for drug targeting

artículo científico publicado en 2002

Telomere maintenance mechanisms as a target for drug development

artículo científico publicado en 2000

Telomeres and telomerases as drug targets

artículo científico publicado en 2002

The Pim kinases: new targets for drug development

artículo científico publicado en 2011

The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells

artículo científico publicado en 2009

The inefficiency of incisions of ecteinascidin 743-DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent

artículo científico publicado en 2001

The tumor suppressor axis p53/miR-34a regulates Axl expression in B-cell chronic lymphocytic leukemia: implications for therapy in p53-defective CLL patients

artículo científico publicado en 2013

Topoisomerase I-DNA complex stability induced by camptothecins and its role in drug activity

artículo científico publicado en 2004

Use of a bacteriophage lysin to identify a novel target for antimicrobial development ⬇️

artículo científico publicado en 2013

alpha-Tocopheryl succinate sensitizes established tumors to vaccination with nonmatured dendritic cells

artículo científico publicado en 2004

Lista de obras de David J. Bearss

A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis ⬇️

A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors

Activators of PKM2 in cancer metabolism

An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance

Aurora-A over-expression in high-grade PIN lesions and prostate cancer

Camptothecin analogs with bulky, hydrophobic substituents at the 7-position via a Grignard reaction

Characterization of Burkholderia pseudomallei Strains Using a Murine Intraperitoneal Infection Model and In Vitro Macrophage Assays.

Chemical genetic screen reveals a role for desmosomal adhesion in mammary branching morphogenesis.

Competitive enhancement of HGF-induced epithelial scattering by accessory growth factors ⬇️

Design, Synthesis, and Biological Evaluation of a Series of Novel AXL Kinase Inhibitors ⬇️

Different expression of placental pyruvate kinase in normal, preeclamptic and intrauterine growth restriction pregnancies

Discovery of biologically active oncologic and immunologic small molecule therapies using zebrafish: overview and example of modulation of T cell activation

Genetic determinants of response to chemotherapy in transgenic mouse mammary and salivary tumors

High-throughput virtual screening identifies novel N'-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors

Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells

Hydrophilic camptothecin analogs that form extremely stable cleavable complexes with DNA and topoisomerase I.

Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach

In vitro and in vivo characterization of SGI-1252, a small molecule inhibitor of JAK2.

Inhibition of Nek2 by small molecules affects proteasome activity

Laminin-5 beta3A expression in LNCaP human prostate carcinoma cells increases cell migration and tumorigenicity

MP470, a novel receptor tyrosine kinase inhibitor, in combination with Erlotinib inhibits the HER family/PI3K/Akt pathway and tumor growth in prostate cancer

Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma

Mitochondrial priming of chronic lymphocytic leukemia patients associates Bcl-xL dependence with alvocidib response

Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue

Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue

NEK2 Induces Drug Resistance Mainly through Activation of Efflux Drug Pumps and Is Associated with Poor Prognosis in Myeloma and Other Cancers ⬇️

New drugs for patients with pancreatic cancer

Pdx-1-driven overexpression of aurora a kinase induces mild ductal dysplasia of pancreatic ducts near islets in transgenic mice

Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes

Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells

Potential mouse tumor model for pre-clinical testing of mage-specific breast cancer vaccines

Receptor tyrosine kinase Axl is required for resistance of leukemic cells to FLT3-targeted therapy in acute myeloid leukemia

Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancer

S110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth

S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis)

Shining the light on aurora-a kinase as a drug target in pancreatic cancer.

Structure-based design of novel anti-cancer agents targeting aurora kinases

Syntheses of 2,3-diarylated 2H-benzo[e][1,2]thiazine 1,1-dioxides and their 3,4-dihydro derivatives, and assessment of their inhibitory activity against MCF-7 breast cancer cells

TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase

Targeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apoptosis and Shows Synergistic/Additive Effects in Combination with BTK Inhibitors

Targeting Axl and Mer Kinases in Cancer ⬇️

Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma

Telomere inhibition and telomere disruption as processes for drug targeting

Telomere maintenance mechanisms as a target for drug development

Telomeres and telomerases as drug targets

The Pim kinases: new targets for drug development

The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells

The inefficiency of incisions of ecteinascidin 743-DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent

The tumor suppressor axis p53/miR-34a regulates Axl expression in B-cell chronic lymphocytic leukemia: implications for therapy in p53-defective CLL patients

Topoisomerase I-DNA complex stability induced by camptothecins and its role in drug activity

Use of a bacteriophage lysin to identify a novel target for antimicrobial development ⬇️

alpha-Tocopheryl succinate sensitizes established tumors to vaccination with nonmatured dendritic cells