Lista de obras - Manuel Irimia - Dominio Público Uruguay

5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary

artículo científico publicado en 2012

A comparative transcriptomic analysis reveals conserved features of stem cell pluripotency in planarians and mammals

artículo científico publicado en 2012

A compendium of RNA-binding motifs for decoding gene regulation.

artículo científico publicado en 2013

A developmentally programmed splicing failure contributes to DNA damage response attenuation during mammalian zygotic genome activation

scientific article published on 13 April 2022

A global regulatory mechanism for activating an exon network required for neurogenesis

artículo científico publicado en 2014

A highly conserved program of neuronal microexons is misregulated in autistic brains

artículo científico publicado en 2014

A novel protein domain in an ancestral splicing factor drove the evolution of neural microexons

artículo científico publicado en 2019

Algal genomes reveal evolutionary mosaicism and the fate of nucleomorphs

artículo científico publicado en 2012

Alternative splicing landscapes in Arabidopsis thaliana across tissues and stress conditions highlight major functional differences with animals

artículo científico publicado en 2021

Alternative splicing: decoding an expansive regulatory layer

artículo científico

An alternative splicing event amplifies evolutionary differences between vertebrates

artículo científico publicado en 2015

An ancient genomic regulatory block conserved across bilaterians and its dismantling in tetrapods by retrogene replacement

artículo científico publicado en 2012

Ancient cis-regulatory constraints and the evolution of genome architecture

artículo científico publicado en 2013

Coevolution of genomic intron number and splice sites

artículo científico publicado en 2007

Comparative genomics of the Hedgehog loci in chordates and the origins of Shh regulatory novelties

artículo científico publicado en 2012

Complex selection on 5' splice sites in intron-rich organisms

artículo científico publicado en 2009

Conservative route to genome compaction in a miniature annelid

artículo científico publicado en 2020

Conserved developmental expression of Fezf in chordates and Drosophila and the origin of the Zona Limitans Intrathalamica (ZLI) brain organizer

artículo científico publicado en 2010

Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians

scientific article published on 09 August 2016

Contrasting 5' and 3' evolutionary histories and frequent evolutionary convergence in Meis/hth gene structures

artículo científico publicado en 2011

Convergent evolution of clustering of Iroquois homeobox genes across metazoans.

artículo científico publicado en 2008

CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer

artículo científico publicado en 2004

Deep conservation of cis-regulatory elements in metazoans

artículo científico publicado en 2013

Differences in enhancer activity in mouse and zebrafish reporter assays are often associated with changes in gene expression

artículo científico publicado en 2012

Distinct and redundant expression and transcriptional diversity of MEIS gene paralogs during chicken development.

artículo científico publicado en 2011

Distinct types of disorder in the human proteome: functional implications for alternative splicing

artículo científico publicado en 2013

Diversity and evolution of spliceosomal systems

artículo científico publicado en 2014

Elephant shark genome provides unique insights into gnathostome evolution

artículo científico publicado en 2014

Erratum: Corrigendum: Elephant shark genome provides unique insights into gnathostome evolution

artículo científico publicado en 2014

Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development

artículo científico publicado en 2015

Evolution of alternative splicing regulation: changes in predicted exonic splicing regulators are not associated with changes in alternative splicing levels in primates.

artículo científico publicado en 2009

Evolutionarily conserved A-to-I editing increases protein stability of the alternative splicing factor Nova1.

artículo científico publicado en 2012

Evolutionary convergence on highly-conserved 3' intron structures in intron-poor eukaryotes and insights into the ancestral eukaryotic genome

artículo científico publicado en 2008

Evolutionary origin and functional divergence of totipotent cell homeobox genes in eutherian mammals

artículo científico publicado en 2016

Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes.

artículo científico publicado en 2017

ExOrthist: a tool to infer exon orthologies at any evolutionary distance

artículo científico publicado en 2021

Extensive conservation of ancient microsynteny across metazoans due to cis-regulatory constraints

artículo científico publicado en 2012

From the American to the European amphioxus: towards experimental Evo-Devo at the origin of chordates.

artículo científico publicado en 2009

Functional and evolutionary analysis of alternatively spliced genes is consistent with an early eukaryotic origin of alternative splicing

artículo científico publicado en 2007

Functional genomics evidence unearths new moonlighting roles of outer ring coat nucleoporins

artículo científico publicado en 2014

Gene Regulatory Networks of Epidermal and Neural Fate Choice in a Chordate

artículo científico publicado en 2022

Gene expansion and retention leads to a diverse tyrosine kinase superfamily in amphioxus

artículo científico publicado en 2008

Genome Evolution: Where Do New Introns Come From? ⬇️

artículo científico publicado el 10 de julio de 2012

Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling

artículo científico publicado en 2013

Genomic adaptations to aquatic and aerial life in mayflies and the origin of insect wings

scientific article published on 26 May 2020

High qualitative and quantitative conservation of alternative splicing in Caenorhabditis elegans and Caenorhabditis briggsae

artículo científico publicado en 2007

Impact of gene gains, losses and duplication modes on the origin and diversification of vertebrates

artículo científico

In response to letter from Benoit Chabot

article

Internal and external paralogy in the evolution of tropomyosin genes in metazoans

artículo científico publicado en 2010

José Luis Gómez-Skarmeta (1966-2020)

scientific article published on 04 November 2020

MBNL proteins repress ES-cell-specific alternative splicing and reprogramming.

artículo científico publicado en 2013

Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain

artículo científico publicado en 2017

Mystery of intron gain: new data and new models

artículo científico publicado en 2008

Neuronal-specific microexon splicing of TAF1 mRNA is directly regulated by SRRM4/nSR100

scientific article published on 27 September 2019

Origin of exon skipping-rich transcriptomes in animals driven by evolution of gene architecture

article

Origin of introns by ‘intronization’ of exonic sequences

article

Origin of spliceosomal introns and alternative splicing

artículo científico publicado en 2014

Origins of Human Malaria: Rare Genomic Changes and Full Mitochondrial Genomes Confirm the Relationship of Plasmodium falciparum to Other Mammalian Parasites but Complicate the Origins of Plasmodium vivax

scholarly article by S. W. Roy & Manuel Irimia published 21 August 2008 in Molecular Biology and Evolution

Origins of human malaria: rare genomic changes and full mitochondrial genomes confirm the relationship of Plasmodium falciparum to other mammalian parasites but complicate the origins of Plasmodium vivax

artículo científico publicado en 2008

Parallel evolution of a splicing program controlling neuronal excitability in flies and mammals

artículo científico publicado en 2022

Postnatal isoform switch and protein localization of LEF1 and TCF7L2 transcription factors in cortical, thalamic, and mesencephalic regions of the adult mouse brain

artículo científico publicado en 2012

Publisher Correction: Conservative route to genome compaction in a miniature annelid

artículo científico publicado en 2020

Quantitative regulation of alternative splicing in evolution and development

artículo científico publicado en 2009

RES complex is associated with intron definition and required for zebrafish early embryogenesis

artículo científico publicado en 2018

Rare Genomic Characters Do Not Support Coelomata: RGC_CAMs

article

Rare coding sequence changes are consistent with Ecdysozoa, not Coelomata.

artículo científico publicado en 2007

Rare genomic characters do not support Coelomata: intron loss/gain

artículo científico publicado en 2008

Regulated aggregative multicellularity in a close unicellular relative of metazoa

artículo científico publicado en 2013

Retention of paternal DNA methylome in the developing zebrafish germline

scientific article published on 11 July 2019

Spliceosomal introns as tools for genomic and evolutionary analysis

artículo científico publicado en 2008

Splicing in the eukaryotic ancestor: form, function and dysfunction

artículo científico publicado en 2009

Stability depends on positive autoregulation in Boolean gene regulatory networks

artículo científico publicado en 2014

Stepwise assembly of the Nova-regulated alternative splicing network in the vertebrate brain.

artículo científico publicado en 2011

The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians

artículo científico publicado en 2022

The alternative splicing factor Nova2 regulates vascular development and lumen formation

artículo científico publicado en 2015

The evolutionary landscape of alternative splicing in vertebrate species

artículo científico publicado en 2012

Tissue-specific alternative splicing remodels protein-protein interaction networks

artículo científico publicado en 2012

Transphyletic conservation of developmental regulatory state in animal evolution

artículo científico publicado en 2011

Very little intron gain in Entamoeba histolytica genes laterally transferred from prokaryotes

artículo científico publicado en 2006

When good transcripts go bad: artifactual RT-PCR 'splicing' and genome analysis

artículo científico publicado en 2008

Widespread Evolutionary Conservation of Alternatively Spliced Exons in Caenorhabditis

scientific article published in 2007

Widespread intron retention in mammals functionally tunes transcriptomes

artículo científico publicado en 2014

Widespread recurrent evolution of genomic features

artículo científico publicado en 2012

Lista de obras de Manuel Irimia

5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary

A comparative transcriptomic analysis reveals conserved features of stem cell pluripotency in planarians and mammals

A compendium of RNA-binding motifs for decoding gene regulation.

A developmentally programmed splicing failure contributes to DNA damage response attenuation during mammalian zygotic genome activation

A global regulatory mechanism for activating an exon network required for neurogenesis

A highly conserved program of neuronal microexons is misregulated in autistic brains

A novel protein domain in an ancestral splicing factor drove the evolution of neural microexons

Algal genomes reveal evolutionary mosaicism and the fate of nucleomorphs

Alternative splicing landscapes in Arabidopsis thaliana across tissues and stress conditions highlight major functional differences with animals

Alternative splicing: decoding an expansive regulatory layer

An alternative splicing event amplifies evolutionary differences between vertebrates

An ancient genomic regulatory block conserved across bilaterians and its dismantling in tetrapods by retrogene replacement

Ancient cis-regulatory constraints and the evolution of genome architecture

Coevolution of genomic intron number and splice sites

Comparative genomics of the Hedgehog loci in chordates and the origins of Shh regulatory novelties

Complex selection on 5' splice sites in intron-rich organisms

Conservative route to genome compaction in a miniature annelid

Conserved developmental expression of Fezf in chordates and Drosophila and the origin of the Zona Limitans Intrathalamica (ZLI) brain organizer

Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians

Contrasting 5' and 3' evolutionary histories and frequent evolutionary convergence in Meis/hth gene structures

Convergent evolution of clustering of Iroquois homeobox genes across metazoans.

CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer

Deep conservation of cis-regulatory elements in metazoans

Differences in enhancer activity in mouse and zebrafish reporter assays are often associated with changes in gene expression

Distinct and redundant expression and transcriptional diversity of MEIS gene paralogs during chicken development.

Distinct types of disorder in the human proteome: functional implications for alternative splicing

Diversity and evolution of spliceosomal systems

Elephant shark genome provides unique insights into gnathostome evolution

Erratum: Corrigendum: Elephant shark genome provides unique insights into gnathostome evolution

Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development

Evolution of alternative splicing regulation: changes in predicted exonic splicing regulators are not associated with changes in alternative splicing levels in primates.

Evolutionarily conserved A-to-I editing increases protein stability of the alternative splicing factor Nova1.

Evolutionary convergence on highly-conserved 3' intron structures in intron-poor eukaryotes and insights into the ancestral eukaryotic genome

Evolutionary origin and functional divergence of totipotent cell homeobox genes in eutherian mammals

Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes.

ExOrthist: a tool to infer exon orthologies at any evolutionary distance

Extensive conservation of ancient microsynteny across metazoans due to cis-regulatory constraints

From the American to the European amphioxus: towards experimental Evo-Devo at the origin of chordates.

Functional and evolutionary analysis of alternatively spliced genes is consistent with an early eukaryotic origin of alternative splicing

Functional genomics evidence unearths new moonlighting roles of outer ring coat nucleoporins

Gene Regulatory Networks of Epidermal and Neural Fate Choice in a Chordate

Gene expansion and retention leads to a diverse tyrosine kinase superfamily in amphioxus

Genome Evolution: Where Do New Introns Come From? ⬇️

Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling

Genomic adaptations to aquatic and aerial life in mayflies and the origin of insect wings

High qualitative and quantitative conservation of alternative splicing in Caenorhabditis elegans and Caenorhabditis briggsae

Impact of gene gains, losses and duplication modes on the origin and diversification of vertebrates

In response to letter from Benoit Chabot

Internal and external paralogy in the evolution of tropomyosin genes in metazoans

José Luis Gómez-Skarmeta (1966-2020)

MBNL proteins repress ES-cell-specific alternative splicing and reprogramming.

Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain

Mystery of intron gain: new data and new models

Neuronal-specific microexon splicing of TAF1 mRNA is directly regulated by SRRM4/nSR100

Origin of exon skipping-rich transcriptomes in animals driven by evolution of gene architecture

Origin of introns by ‘intronization’ of exonic sequences

Origin of spliceosomal introns and alternative splicing

Origins of Human Malaria: Rare Genomic Changes and Full Mitochondrial Genomes Confirm the Relationship of Plasmodium falciparum to Other Mammalian Parasites but Complicate the Origins of Plasmodium vivax

Origins of human malaria: rare genomic changes and full mitochondrial genomes confirm the relationship of Plasmodium falciparum to other mammalian parasites but complicate the origins of Plasmodium vivax

Parallel evolution of a splicing program controlling neuronal excitability in flies and mammals

Postnatal isoform switch and protein localization of LEF1 and TCF7L2 transcription factors in cortical, thalamic, and mesencephalic regions of the adult mouse brain

Publisher Correction: Conservative route to genome compaction in a miniature annelid

Quantitative regulation of alternative splicing in evolution and development

RES complex is associated with intron definition and required for zebrafish early embryogenesis

Rare Genomic Characters Do Not Support Coelomata: RGC_CAMs

Rare coding sequence changes are consistent with Ecdysozoa, not Coelomata.

Rare genomic characters do not support Coelomata: intron loss/gain

Regulated aggregative multicellularity in a close unicellular relative of metazoa

Retention of paternal DNA methylome in the developing zebrafish germline

Spliceosomal introns as tools for genomic and evolutionary analysis

Splicing in the eukaryotic ancestor: form, function and dysfunction

Stability depends on positive autoregulation in Boolean gene regulatory networks

Stepwise assembly of the Nova-regulated alternative splicing network in the vertebrate brain.

The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians

The alternative splicing factor Nova2 regulates vascular development and lumen formation

The evolutionary landscape of alternative splicing in vertebrate species

Tissue-specific alternative splicing remodels protein-protein interaction networks

Transphyletic conservation of developmental regulatory state in animal evolution

Very little intron gain in Entamoeba histolytica genes laterally transferred from prokaryotes