Lista de obras - Tim J. Yen - Dominio Público Uruguay

A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression

scientific journal article

A modified HSP70 inhibitor shows broad activity as an anticancer agent

artículo científico publicado en 2013

A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells

artículo científico publicado en 2014

Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle bundle in mammalian cells, whereas completion of furrowing does not

artículo científico publicado en 2004

Abnormal cytokinesis after X-irradiation in tumor cells that override the G2 DNA damage checkpoint

artículo científico publicado en 2008

Active MAP Kinase in Mitosis: Localization at Kinetochores and Association with the Motor Protein CENP-E ⬇️

artículo científico publicado el 21 de septiembre de 1998

Anti-CENP-H antibodies in patients with Sjogren's syndrome

artículo científico publicado en 2005

Anti-CENPI autoantibodies in scleroderma patients with features of autoimmune liver diseases

artículo científico publicado en 2011

Astrin regulates Aurora-A localization.

artículo científico publicado en 2008

Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs

artículo científico publicado en 1987

BUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional mitotic checkpoint complex

artículo científico publicado en 2011

CENP-E function at kinetochores is essential for chromosome alignment.

artículo científico publicado en 1997

CENP-F is a novel microtubule-binding protein that is essential for kinetochore attachments and affects the duration of the mitotic checkpoint delay

artículo científico publicado en 2006

Centromere fragmentation is a common mitotic defect of S and G2 checkpoint override

artículo científico publicado en 2013

Changing the selectivity of p300 by acetyl-CoA modulation of histone acetylation

artículo científico publicado en 2014

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

artículo científico publicado en 1998

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

artículo científico publicado en 2001

Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24-->q25 and 1q32-->q41, respectively, by fluorescence in situ hybridization

artículo científico publicado en 1994

Chromosome instability in tumor cells due to defects in Aurora B mediated error correction at kinetochores

artículo científico publicado en 2018

Closed MAD2 (C-MAD2) is selectively incorporated into the mitotic checkpoint complex (MCC)

artículo científico publicado en 2011

Cohesin associates with spindle poles in a mitosis-specific manner and functions in spindle assembly in vertebrate cells

scientific article published on 30 December 2008

Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition.

artículo científico publicado en 2013

Coupling of DNA synthesis and histone synthesis in S phase independent of cyclin/cdk2 activity

artículo científico publicado en 2002

Crystal structure of the motor domain of the human kinetochore protein CENP-E

artículo científico publicado en 2004

DNA damage in HeLa cells induced arrest at a discrete point in G2 phase as defined by CENP-F localization

artículo científico publicado en 2003

Detection of repair activity during the DNA damage-induced G2 delay in human cancer cells

artículo científico publicado en 2001

Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31(comet).

artículo científico publicado en 2014

Dose dependent effects on cell cycle checkpoints and DNA repair by bendamustine

artículo científico publicado en 2012

Dual inhibition of SRC and Aurora kinases induces postmitotic attachment defects and cell death

artículo científico publicado en 2011

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

artículo científico publicado en 2013

Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response

artículo científico publicado en 2003

Expression and behaviour of CENP-E at kinetochores during mouse spermatogenesis

scientific article published on 01 March 2002

G Protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression

artículo científico publicado en 2012

HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells.

artículo científico publicado en 2006

Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response

artículo científico publicado en 2003

HuR posttranscriptionally regulates WEE1: implications for the DNA damage response in pancreatic cancer cells

artículo científico publicado en 2014

Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC

artículo científico publicado en 1999

Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis

artículo científico publicado en 2003

Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores

artículo científico publicado en 2003

Immunolocalization of alpha-tubulin, gamma-tubulin, and CENP-E in male rat and male mouse meiotic divisions: pathway of meiosis I spindle formation in mammalian spermatocytes

artículo científico publicado en 1998

Interaction between ATM protein and c-Abl in response to DNA damage

artículo científico publicado en 1997

Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype

artículo científico publicado en 1997

Kinetochore function: molecular motors, switches and gates

artículo científico publicado en 1996

Kinetochore structure and function

artículo científico publicado en 2005

Lack of correlation between ATM protein expression and tumour cell radiosensitivity

artículo científico publicado en 1998

Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission

artículo científico publicado en 2013

Live cell imaging reveals distinct roles in cell cycle regulation for Nek2A and Nek2B.

artículo científico publicado en 2005

Localization of CENP-E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase ⬇️

artículo científico publicado el 1 de diciembre de 1997

Localization of the Drosophila checkpoint control protein Bub3 to the kinetochore requires Bub1 but not Zw10 or Rod.

artículo científico publicado en 1998

Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells

artículo científico publicado en 2006

Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence.

artículo científico publicado en 2011

Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit

artículo científico publicado en 2008

Polo delivers a PICH to the kinetochore

artículo científico publicado en 2007

Protein architecture of the human kinetochore microtubule attachment site

artículo científico publicado en 2009

RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability

artículo científico publicado en 2003

Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints

artículo científico publicado en 2014

Replication stress and mitotic dysfunction in cells expressing simian virus 40 large T antigen

artículo científico publicado en 2013

Role of the tetradecapeptide repeat domain of human histone deacetylase 6 in cytoplasmic retention.

artículo científico publicado en 2004

Sequences that confer beta-tubulin autoregulation through modulated mRNA stability reside within exon 1 of a beta-tubulin mRNA.

artículo científico publicado en 1987

Specific regulation of CENP-E and kinetochores during meiosis I/meiosis II transition in pig oocytes

artículo científico publicado en 2000

Targeting mitosis for anti-cancer therapy

artículo científico publicado en 2007

Targeting the kinetochore for mitosis-specific inhibitors.

artículo científico publicado en 2003

The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo

artículo científico publicado en 2004

The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.

artículo científico publicado en 2001

The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis

artículo científico publicado en 1998

The role of mitotic checkpoint in maintaining genomic stability

artículo científico publicado en 2003

Thyroid hormone receptor interacting protein 13 (TRIP13) AAA-ATPase is a novel mitotic checkpoint-silencing protein

artículo científico publicado en 2014

Timeless links replication termination to mitotic kinase activation

artículo científico publicado en 2011

Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments

artículo científico publicado en 2007

Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20

artículo científico publicado en 2008

Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses.

artículo científico publicado en 2001

Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions

artículo científico publicado en 2003

Lista de obras de Tim J. Yen

A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression

A modified HSP70 inhibitor shows broad activity as an anticancer agent

A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells

Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle bundle in mammalian cells, whereas completion of furrowing does not

Abnormal cytokinesis after X-irradiation in tumor cells that override the G2 DNA damage checkpoint

Active MAP Kinase in Mitosis: Localization at Kinetochores and Association with the Motor Protein CENP-E ⬇️

Anti-CENP-H antibodies in patients with Sjogren's syndrome

Anti-CENPI autoantibodies in scleroderma patients with features of autoimmune liver diseases

Astrin regulates Aurora-A localization.

Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs

BUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional mitotic checkpoint complex

CENP-E function at kinetochores is essential for chromosome alignment.

CENP-F is a novel microtubule-binding protein that is essential for kinetochore attachments and affects the duration of the mitotic checkpoint delay

Centromere fragmentation is a common mitotic defect of S and G2 checkpoint override

Changing the selectivity of p300 by acetyl-CoA modulation of histone acetylation

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24-->q25 and 1q32-->q41, respectively, by fluorescence in situ hybridization

Chromosome instability in tumor cells due to defects in Aurora B mediated error correction at kinetochores

Closed MAD2 (C-MAD2) is selectively incorporated into the mitotic checkpoint complex (MCC)

Cohesin associates with spindle poles in a mitosis-specific manner and functions in spindle assembly in vertebrate cells

Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition.

Coupling of DNA synthesis and histone synthesis in S phase independent of cyclin/cdk2 activity

Crystal structure of the motor domain of the human kinetochore protein CENP-E

DNA damage in HeLa cells induced arrest at a discrete point in G2 phase as defined by CENP-F localization

Detection of repair activity during the DNA damage-induced G2 delay in human cancer cells

Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31(comet).

Dose dependent effects on cell cycle checkpoints and DNA repair by bendamustine

Dual inhibition of SRC and Aurora kinases induces postmitotic attachment defects and cell death

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response

Expression and behaviour of CENP-E at kinetochores during mouse spermatogenesis

G Protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression

HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells.

Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response

HuR posttranscriptionally regulates WEE1: implications for the DNA damage response in pancreatic cancer cells

Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC

Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis

Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores

Immunolocalization of alpha-tubulin, gamma-tubulin, and CENP-E in male rat and male mouse meiotic divisions: pathway of meiosis I spindle formation in mammalian spermatocytes

Interaction between ATM protein and c-Abl in response to DNA damage

Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype

Kinetochore function: molecular motors, switches and gates

Kinetochore structure and function

Lack of correlation between ATM protein expression and tumour cell radiosensitivity

Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission

Live cell imaging reveals distinct roles in cell cycle regulation for Nek2A and Nek2B.

Localization of CENP-E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase ⬇️

Localization of the Drosophila checkpoint control protein Bub3 to the kinetochore requires Bub1 but not Zw10 or Rod.

Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells

Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence.

Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit

Polo delivers a PICH to the kinetochore

Protein architecture of the human kinetochore microtubule attachment site

RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability

Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints

Replication stress and mitotic dysfunction in cells expressing simian virus 40 large T antigen

Role of the tetradecapeptide repeat domain of human histone deacetylase 6 in cytoplasmic retention.

Sequences that confer beta-tubulin autoregulation through modulated mRNA stability reside within exon 1 of a beta-tubulin mRNA.

Specific regulation of CENP-E and kinetochores during meiosis I/meiosis II transition in pig oocytes

Targeting mitosis for anti-cancer therapy

Targeting the kinetochore for mitosis-specific inhibitors.

The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo

The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.

The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis

The role of mitotic checkpoint in maintaining genomic stability

Thyroid hormone receptor interacting protein 13 (TRIP13) AAA-ATPase is a novel mitotic checkpoint-silencing protein

Timeless links replication termination to mitotic kinase activation

Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments

Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20

Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses.

Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions