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Lista de obras de Benedikt M. Kessler

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

artículo científico publicado en 2018

A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN.

artículo científico publicado en 2017

A Novel Role for Triglyceride Metabolism in Foxp3 Expression

scientific article published on 13 August 2019

A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis

scientific article published on 31 August 2009

A cell-permeable inhibitor and activity-based probe for the caspase-like activity of the proteasome

artículo científico publicado en 2007

A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae

artículo científico publicado en 2005

A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts

artículo científico publicado en 1994

A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14

artículo científico publicado en 2001

A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins

artículo científico publicado en 2007

A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance

artículo científico publicado en 2017

A novel workflow combining plaque imaging, plaque and plasma proteomics identifies biomarkers of human coronary atherosclerotic plaque disruption

artículo científico publicado en 2017

A photoreactive small-molecule probe for 2-oxoglutarate oxygenases

artículo científico publicado en 2011

A pivotal heme-transfer reaction intermediate in cytochrome c biogenesis

artículo científico publicado en 2011

A quantitative label-free analysis of the extracellular proteome of human supraspinatus tendon reveals damage to the pericellular and elastic fibre niches in torn and aged tissue

artículo científico publicado en 2017

A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors

artículo científico publicado en 2013

A robust mass spectrometry method for rapid profiling of erythrocyte ghost membrane proteomes.

artículo científico publicado en 2018

A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L

scientific journal article

A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance

artículo científico publicado en 2012

A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes

artículo científico publicado en 2018

ABPP-HT - High-Throughput Activity-Based Profiling of Deubiquitylating Enzyme Inhibitors in a Cellular Context

artículo científico publicado en 2021

ATM and Chk2 kinase target the p53 cofactor Strap

artículo científico publicado en 2008

ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage

artículo científico publicado en 2012

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

artículo científico publicado en 2011

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

artículo científico publicado en 2004

Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication

article

Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury.

artículo científico publicado en 2006

Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib

artículo científico publicado en 2005

Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes

artículo científico publicado en 2011

Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells

artículo científico publicado en 2004

Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism

scientific article published on 18 March 2019

Adiponectin as a link between type 2 diabetes and vascular NADPH oxidase activity in the human arterial wall: the regulatory role of perivascular adipose tissue.

artículo científico publicado en 2014

Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions

artículo científico publicado en 2020

An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains.

artículo científico publicado en 2018

Ancient proteins resolve the evolutionary history of Darwin’s South American ungulates

artículo científico publicado en 2015

Ankylosing spondylitis monocytes show upregulation of proteins involved in inflammation and the ubiquitin proteasome pathway.

artículo científico publicado en 2008

Apoptotic microparticles generated during acute HIV-1 infection inhibit human dendritic cells via CD44.

artículo científico publicado en 2012

Applications for chemical probes of proteolytic activity

artículo científico publicado en 2004

Arginine methylation controls growth regulation by E2F-1

artículo científico publicado en 2012

Arginine methylation regulates the p53 response

scientific journal article

Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1.

artículo científico publicado en 2013

Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor

artículo científico publicado en 2011

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

artículo científico publicado en 2007

Assessing the quality and reproducibility of a proteomic platform for clinical stroke biomarker discovery

artículo científico publicado en 2010

Association of Distinct Fine Specificities of Anti-Citrullinated Peptide Antibodies With Elevated Immune Responses to Prevotella intermedia in a Subgroup of Patients With Rheumatoid Arthritis and Periodontitis

artículo científico publicado en 2017

Ataxin-3 Links NOD2 and TLR2 Mediated Innate Immune Sensing and Metabolism in Myeloid Cells

artículo científico publicado en 2019

Author Correction: Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions

artículo científico publicado en 2020

Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia

artículo científico publicado en 2015

BMP signaling inhibition in Drosophila secondary cells remodels the seminal proteome and self and rival ejaculate functions

scientific article published on 18 November 2019

Biochemical and Mass Spectrometry-Based Approaches to Profile SUMOylation in Human Cells

artículo científico publicado en 2017

Bioorthogonal organic chemistry in living cells: novel strategies for labeling biomolecules

artículo científico publicado en 2004

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

artículo científico publicado en 2020

CBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine Acetylation

artículo científico publicado en 2017

CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer

artículo científico publicado en 2015

CPFP: a central proteomics facilities pipeline

artículo científico publicado en 2010

CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis

scientific article published on 17 August 2020

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

artículo científico publicado en 2004

Capturing the dynamics of genome replication on individual ultra-long nanopore sequence reads

Capturing the dynamics of genome replication on individual ultra-long nanopore sequence reads

scientific article published on 22 April 2019

Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation

artículo científico publicado en 2019

Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability

artículo científico publicado en 2015

Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis

artículo científico publicado en 2018

Challenges ahead for mass spectrometry and proteomics applications in epigenetics

artículo científico publicado en 2010

Characterization of exosomes in peritoneal fluid of endometriosis patients

artículo científico publicado en 2020

Characterization of in vivo expanded OspA-specific human T-cell clones

artículo científico publicado en 2005

Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy

artículo científico publicado en 2003

Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family

artículo científico publicado en 2002

Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases

artículo científico publicado en 2004

Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation

artículo científico publicado en 2021

Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response

artículo científico publicado en 2016

Cks1 activates transcription by binding to the ubiquitylated proteasome

artículo científico publicado en 2010

Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.

artículo científico publicado en 2014

Colonic epithelial cell diversity in health and inflammatory bowel disease

scientific article published on 27 February 2019

Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix

artículo científico publicado en 2018

Comparative evaluation of label-free SINQ normalized spectral index quantitation in the central proteomics facilities pipeline

artículo científico publicado en 2011

Comparison of CID versus ETD based MS/MS fragmentation for the analysis of protein ubiquitination.

artículo científico publicado en 2009

Comparison of neutralizing antibody responses elicited from highly diverse polyvalent heterotrimeric HIV-1 gp140 cocktail immunogens versus a monovalent counterpart in rhesus macaques

artículo científico publicado en 2014

Complete primary structure of chicken collagen XIV.

artículo científico publicado en 1993

Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells

artículo científico publicado en 2019

Comprehensive Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics

artículo científico publicado en 2019

Control of cross-presentation during dendritic cell maturation

artículo científico publicado en 2004

Correction. The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated.

artículo científico publicado en 2015

Correction: PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes

artículo científico publicado en 2017

Correction: Protein Profiling in Hepatocellular Carcinoma by Label-Free Quantitative Proteomics in Two West African Populations.

artículo científico publicado en 2013

Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27.

artículo científico publicado en 2014

Crystal structure of HslUV complexed with a vinyl sulfone inhibitor: corroboration of a proposed mechanism of allosteric activation of HslV by HslU

artículo científico publicado en 2002

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

artículo científico publicado en 2011

DNA modification under mild conditions by Suzuki-Miyaura cross-coupling for the generation of functional probes

artículo científico publicado en 2013

DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair

artículo científico publicado en 2015

DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic Targets

artículo científico publicado en 2016

Deacetylation Inhibition Reverses PABPN1-Dependent Muscle Wasting

artículo científico publicado en 2019

Debridement and implant retention in the management of hip periprosthetic joint infection: outcomes following guided and rapid treatment at a single centre

artículo científico publicado en 2017

Defining the HLA class I-associated viral antigen repertoire from HIV-1-infected human cells

artículo científico publicado en 2015

Defining the T cell antigen proteome of wasp venom

artículo científico publicado en 2006

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

scientific article published on 07 December 2018

Detection of BK virus in urine from renal transplant subjects by mass spectrometry.

artículo científico publicado en 2012

Detection of multiple autoantibodies in patients with ankylosing spondylitis using nucleic acid programmable protein arrays

artículo científico publicado en 2012

Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease.

scientific article published on 21 July 2016

Deubiquitinating enzyme specificity for ubiquitin chain topology profiled by di-ubiquitin activity probes

artículo científico publicado en 2013

Development and validation of response markers to predict survival and pleurodesis success in patients with malignant pleural effusion (PROMISE): a multicohort analysis

scientific article published on 13 June 2018

Development of a T-cell Receptor Mimic Antibody against Wild-Type p53 for Cancer Immunotherapy

artículo científico publicado en 2017

Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases

artículo científico publicado en 2004

Dia2 controls transcription by mediating assembly of the RSC complex

artículo científico publicado en 2011

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors

artículo científico publicado en 2011

Discovery and validation of biomarkers to guide clinical management of pneumonia in African children

artículo científico publicado en 2014

Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7.

artículo científico publicado en 2017

Discovery of a selective allosteric inhibitor targeting macrodomain 2 of poly-adenosine-diphosphate-ribose polymerases 14.

artículo científico publicado en 2017

Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis

artículo científico publicado en 2011

Discrimination Between Human Leukocyte Antigen Class I-Bound and Co-Purified HIV-Derived Peptides in Immunopeptidomics Workflows.

artículo científico publicado en 2018

Distinct contributions of DNA methylation and histone acetylation to the genomic occupancy of transcription factors

artículo científico publicado en 2020

Divergent allocation of sperm and the seminal proteome along a competition gradient in Drosophila melanogaster

artículo científico publicado en 2019

E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition

scientific article published on 19 August 2019

E3 Ligase cIAP2 Mediates Downregulation of MRE11 and Radiosensitization in Response to HDAC Inhibition in Bladder Cancer

artículo científico publicado en 2017

E3 ligases determine ubiquitination site and conjugate type by enforcing specificity on E2 enzymes

artículo científico publicado en 2011

Early Kinetics of the HLA Class I-Associated Peptidome of MVA.HIVconsv-Infected Cells

artículo científico publicado en 2015

Effective control of recalcitrant pruritus by bevacizumab: a possible role for vascular endothelial growth factor in chronic itch?

artículo científico publicado en 2013

Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells

artículo científico publicado en 2005

Effects of epitope modification on T cell receptor-ligand binding and antigen recognition by seven H-2Kd-restricted cytotoxic T lymphocyte clones specific for a photoreactive peptide derivative

artículo científico publicado en 1997

Effects of proteasome inhibitors MG132, ZL3VS and AdaAhx3L3VS on protein metabolism in septic rats

artículo científico publicado en 2004

Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection

artículo científico publicado en 2010

Erratum: OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo

artículo científico publicado en 2015

Expanding Proteome Coverage with CHarge Ordered Parallel Ion aNalysis (CHOPIN) Combined with Broad Specificity Proteolysis.

artículo científico publicado en 2017

Expanding the yeast protein arginine methylome

artículo científico publicado en 2015

Expression of PHA polymerase genes of Pseudomonas putida in Escherichia coli and its effect on PHA formation.

artículo científico publicado en 2005

Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis

artículo científico publicado en 2015

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits

artículo científico publicado en 2001

FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration

artículo científico publicado en 2018

FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment.

artículo científico publicado en 2018

FBXL19 recruits CDK-Mediator to CpG islands of developmental genes to prime them for activation during lineage commitment

article

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains

artículo científico publicado en 2011

First Report on Ex Vivo Delivery of Paracrine Active Human Mesenchymal Stromal Cells to Liver Grafts During Machine Perfusion

artículo científico publicado en 2020

Fluorescence-based active site probes for profiling deubiquitinating enzymes

scientific article published on 28 March 2012

Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly

artículo científico publicado en 2014

From herbal small RNAs to one medicine

artículo científico publicado en 2019

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

artículo científico publicado en 2017

Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs.

scientific article published on 17 June 2016

Functional proteomics of the active cysteine protease content in Drosophila S2 cells

artículo científico publicado en 2003

GOAT--a simple LC-MS/MS gradient optimization tool

artículo científico publicado en 2014

Gel-aided sample preparation (GASP)--a simplified method for gel-assisted proteomic sample generation from protein extracts and intact cells

artículo científico publicado en 2015

Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib*

article

Genetic control of differential acetylation in diabetic rats

artículo científico publicado en 2014

Glutamate receptor δ2 serum antibodies in pediatric opsoclonus myoclonus ataxia syndrome

HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44

artículo científico publicado en 2012

Hand Compartment Syndrome Due to N-acetylcysteine Extravasation.

artículo científico publicado en 2017

Human Platelet Protein Ubiquitylation and Changes following GPVI Activation

scientific article published on 31 December 2018

Human TNF-related apoptosis-inducing ligand-expressing dendritic cells from transgenic pigs attenuate human xenogeneic T cell responses

article

Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy

artículo científico publicado en 2014

Hypoxia induces a lipogenic cancer cell phenotype via HIF1α-dependent and -independent pathways

artículo científico publicado en 2015

Hypoxia metabolism in ageing

artículo científico publicado en 2015

Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis

artículo científico publicado en 2014

INS-eGFP transgenic pigs: a novel reporter system for studying maturation, growth and vascularisation of neonatal islet-like cell clusters.

artículo científico publicado en 2017

Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein

artículo científico publicado en 2018

Identification of an immunodominant peptide from citrullinated tenascin-C as a major target for autoantibodies in rheumatoid arthritis

artículo científico publicado en 2015

Identification of distinct circulating exosomes in Parkinson's disease

artículo científico publicado en 2015

Identification of proteins associated with murine cytomegalovirus virions

artículo científico publicado en 2004

Identification of the target self-antigens in reperfusion injury

artículo científico publicado en 2006

Immune Control of Burkholderia pseudomallei--Common, High-Frequency T-Cell Responses to a Broad Repertoire of Immunoprevalent Epitopes.

artículo científico publicado en 2018

Immunodominance of cytotoxic T lymphocyte epitopes co-injected in vivo and modulation by interleukin-12.

artículo científico publicado en 1996

Immunopeptidomic Profiling of HLA-A2-Positive Triple Negative Breast Cancer Identifies Potential Immunotherapy Target Antigens

artículo científico publicado en 2018

Improved profiling of polyamines using two-dimensional gas chromatography mass spectrometry

scientific article published on 18 February 2019

In vitro binding of HFE to the cation-independent mannose-6 phosphate receptor.

artículo científico publicado en 2009

Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency

artículo científico publicado en 2013

Integrated Physiological and Biochemical Assessments for the Prediction of Growth of Abdominal Aortic Aneurysms in Humans

artículo científico publicado en 2019

Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity

artículo científico publicado en 2000

Integrative Phosphoproteomics Links IL-23R Signaling with Metabolic Adaptation in Lymphocytes

artículo científico publicado en 2016

Integrative omics reveals subtle molecular perturbations following ischemic conditioning in a porcine kidney transplant model

artículo científico publicado en 2022

Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

artículo científico publicado en 2020

Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.

artículo científico publicado en 2007

Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein

artículo científico publicado en 2011

Iron load and redox stress in skeletal muscle of aged rats

artículo científico publicado en 2007

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

artículo científico publicado en 2018

Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing

artículo científico publicado en 2009

Jumonji domain containing protein 6 (Jmjd6) modulates splicing and specifically interacts with arginine-serine-rich (RS) domains of SR- and SR-like proteins

artículo científico publicado en 2014

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands.

artículo científico publicado en 2012

Label-free quantitative proteomics reveals differentially regulated proteins influencing urolithiasis

artículo científico publicado en 2011

Label-free quantitative proteomics reveals regulation of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) and 5'-3'-exoribonuclease 2 (XRN2) during respiratory syncytial virus infection

artículo científico

Learning to Use an Alphabetic Writing System

artículo científico publicado en 2013

Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function

artículo científico publicado en 2017

Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity

artículo científico publicado en 2007

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

scientific journal article

Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl

artículo científico publicado en 2010

MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis

artículo científico publicado en 2019

MHC class I antigen processing regulated by cytosolic proteolysis-short cuts that alter peptide generation

artículo científico publicado en 2002

Male reproductive aging arises via multifaceted mating-dependent sperm and seminal proteome declines, but is postponable in Drosophila

artículo científico publicado en 2020

Mapping protein interactions of sodium channel NaV1.7 using epitope-tagged gene-targeted mice.

artículo científico publicado en 2018

Matrix metalloproteinase-9 regulates tumor cell invasion through cleavage of protease nexin-1

artículo científico publicado en 2010

Mechanisms by which Porphyromonas gingivalis evades innate immunity

artículo científico publicado en 2017

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair

artículo científico publicado en 2016

Mitochondrial proteome analysis reveals altered expression of voltage dependent anion channels in pancreatic β-cells exposed to high glucose

artículo científico publicado en 2010

Modeling lethal X-linked genetic disorders in pigs with ensured fertility.

artículo científico publicado en 2018

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

artículo científico publicado en 2017

Molecular insights into an ancient form of Paget's disease of bone.

artículo científico publicado en 2019

Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway

artículo científico publicado en 2010

Neuronal loss and brain atrophy in mice lacking cathepsins B and L

artículo científico publicado en 2002

New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes

artículo científico publicado en 2010

Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation

scientific article published on 01 July 2019

Novel MMP-9 substrates in cancer cells revealed by a label-free quantitative proteomics approach

artículo científico publicado en 2008

OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation

artículo científico publicado en 2014

OS045. Multi-dimensional protein identification technology analysis of syncytiotrophoblast vesicles released from perfused preeclampsia placentas

article

OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo

artículo científico publicado en 2015

Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells

artículo científico publicado en 2008

Optimal translational termination requires C4 lysyl hydroxylation of eRF1.

scientific article published on 30 January 2014

Optimizing 2D gas chromatography mass spectrometry for robust tissue, serum and urine metabolite profiling

artículo científico publicado en 2017

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans

artículo científico publicado en 2012

P10-05. Suppression of human dendritic cell function during acute HIV infection

article

P17-28 LB. The antiviral efficacy of HIV-specific CD8+ T-cells to a conserved epitope is heavily dependent on the infecting HIV-1 isolate

article

PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes.

artículo científico publicado en 2017

PTMs in conversation: activity and function of deubiquitinating enzymes regulated via post-translational modifications

artículo científico publicado en 2011

Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne

artículo científico publicado en 2016

Pathways accessory to proteasomal proteolysis are less efficient in major histocompatibility complex class I antigen production

artículo científico publicado en 2002

Peptide modification or blocking of CD8, resulting in weak TCR signaling, can activate CTL for Fas- but not perforin-dependent cytotoxicity or cytokine production

article

PfHPRT: a new biomarker candidate of acute Plasmodium falciparum infection

artículo científico publicado en 2013

Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases

artículo científico publicado en 2011

Phosphorylation Induces Structural Changes in the Autographa californica Nucleopolyhedrovirus P10 Protein

artículo científico publicado en 2017

Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress

artículo científico publicado en 2012

Photoactivable peptides for identifying enzyme–substrate and protein–protein interactions

artículo científico publicado en 2010

Plasma Biomarker Profile Alterations during Variable Blood Storage.

artículo científico publicado en 2016

Plasma degradome affected by variable storage of human blood

artículo científico publicado en 2016

Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion

artículo científico publicado en 2010

Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity.

artículo científico publicado en 2016

Probing the proteasome cavity in three steps: bio-orthogonal photo-reactive suicide substrates

artículo científico publicado en 2010

Processing of human toll-like receptor 7 by furin-like proprotein convertases is required for its accumulation and activity in endosomes

artículo científico publicado en 2013

Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes

artículo científico publicado en 2012

Protein arginine methylation: a prominent modification and its demethylation

artículo científico publicado en 2017

Protein profiling in hepatocellular carcinoma by label-free quantitative proteomics in two west African populations

artículo científico publicado en 2013

Protein sequences bound to mineral surfaces persist into deep time ⬇️

artículo científico publicado en 2016

Proteo-metabolomics reveals compensation between ischemic and non-injured contralateral kidneys after reperfusion.

artículo científico publicado en 2018

Proteome changes induced by knock-down of the deubiquitylating enzyme HAUSP/USP7.

artículo científico publicado en 2007

Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake

artículo científico publicado en 2009

Proteomic analysis reveals a proteolytic feedback loop in murine seminal fluid

artículo científico publicado en 2013

Proteomic changes in response to crystal formation in Drosophila Malpighian tubules

artículo científico publicado en 2016

Proteomic identification of host and parasite biomarkers in saliva from patients with uncomplicated Plasmodium falciparum malaria

artículo científico publicado en 2012

Proteomic profiling of the brain of mice with experimental cerebral malaria

artículo científico publicado en 2017

Proteomic profiling of the plasma of Gambian children with cerebral malaria

artículo científico publicado en 2018

Proteomics analysis of the matrisome from MC38 experimental mouse liver metastases

artículo científico publicado en 2019

Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

artículo científico publicado en 2008

Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases

artículo científico publicado en 2018

Putting proteomics on target: activity-based profiling of ubiquitin and ubiquitin-like processing enzymes

artículo científico publicado en 2006

QuaNCAT: quantitating proteome dynamics in primary cells.

artículo científico publicado en 2013

Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation.

artículo científico publicado en 2011

Quantitative proteomics identification of seminal fluid proteins in male

scientific article published on 04 October 2018

Quantitative proteomics identification of seminal fluid proteins in male Drosophila melanogaster

RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes.

artículo científico publicado en 2016

Re-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors b-AP15 and VLX1570: A Paradigmatic Example of Unspecific Protein Cross-linking with Michael Acceptor Motif-Containing Drugs

artículo científico publicado en 2020

Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase

artículo científico publicado en 2004

Regulation of SUMO2 target proteins by the proteasome in human cells exposed to replication stress

artículo científico publicado en 2015

Regulation of the endosomal SNX27-retromer by OTULIN

artículo científico publicado en 2019

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

artículo científico publicado en 2011

Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP.

artículo científico publicado en 2016

Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP

artículo científico publicado en 2013

Role of CD8 in aberrant function of cytotoxic T lymphocytes

artículo científico publicado en 1997

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.

artículo científico publicado en 2016

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

artículo científico publicado en 2016

Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche

scientific journal article

Selective Binding of AIRAPL Tandem UIMs to Lys48-Linked Tri-Ubiquitin Chains

artículo científico publicado en 2016

Selective and reversible inhibitors of ubiquitin-specific protease 7: a patent evaluation (WO2013030218).

artículo científico publicado en 2014

Sequential targeting of CFTR by BAC vectors generates a novel pig model of cystic fibrosis

artículo científico publicado en 2011

Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex

artículo científico publicado en 2014

Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases

artículo científico publicado en 2005

Small-molecule-based inhibition of histone demethylation in cells assessed by quantitative mass spectrometry

artículo científico publicado en 2010

Snapin promotes HIV-1 transmission from dendritic cells by dampening TLR8 signaling

artículo científico publicado en 2017

Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins

artículo científico publicado en 2004

Statistical Learning and Spelling: Older Prephonological Spellers Produce More Wordlike Spellings Than Younger Prephonological Spellers

artículo científico publicado en 2017

Strong xenoprotective function by single-copy transgenes placed sequentially at a permissive locus.

artículo científico publicado en 2018

Structural basis and specificity of human otubain 1-mediated deubiquitination

artículo científico publicado en 2009

Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6

artículo científico publicado en 2023

Structure and reactivity of an asymmetric complex between HslV and I-domain deleted HslU, a prokaryotic homolog of the eukaryotic proteasome

artículo científico publicado en 2003

Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib

artículo científico publicado en 2016

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)

artículo científico publicado en 2011

Subclinical effects of remote ischaemic conditioning in human kidney transplants revealed by quantitative proteomics

scientific article published on 02 November 2020

Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells

artículo científico publicado en 2020

T cell recognition of hapten. Anatomy of T cell receptor binding of a H-2kd-associated photoreactive peptide derivative.

artículo científico publicado en 1999

TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts

artículo científico publicado en 2020

TLR Adaptor Protein MYD88 Mediates Sensitivity to HDAC Inhibitors via a Cytokine-Dependent Mechanism

artículo científico publicado en 2016

Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation

artículo científico publicado en 2018

The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks

artículo científico publicado en 2021

The Chemoselective One-Step Alkylation and Isolation of Thiophosphorylated Cdk2 Substrates in the Presence of Native Cysteine

artículo científico publicado en 2011

The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis

artículo científico publicado en 2019

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity

artículo científico publicado en 2012

The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases

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The N-terminal domain of a tick evasin is critical for chemokine binding and neutralization and confers specific binding activity to other evasins.

artículo científico publicado en 2018

The PR/SET domain zinc finger protein Prdm4 regulates gene expression in embryonic stem cells but plays a nonessential role in the developing mouse embryo

scientific journal article

The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels

artículo científico publicado en 2011

The Succinated Proteome of FH-Mutant Tumours

artículo científico publicado en 2014

The antiviral efficacy of HIV-specific CD8⁺ T-cells to a conserved epitope is heavily dependent on the infecting HIV-1 isolate

artículo científico publicado en 2011

The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function

artículo científico publicado en 2021

The deubiquitinase TRABID stabilises the K29/K48-specific E3 ubiquitin ligase HECTD1

artículo científico publicado en 2020

The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage

artículo científico publicado en 2018

The efficiency of antigen recognition by CD8+ CTL clones is determined by the frequency of serial TCR engagement.

artículo científico publicado en 1998

The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages

artículo científico publicado en 2015

The identification of archaeological eggshell using peptide markers

scholarly article by Samantha Presslee published in January 2017

The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum

artículo científico publicado en 2015

The polyserine domain of the lysyl-5 hydroxylase Jmjd6 mediates subnuclear localization

artículo científico publicado en 2013

The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated.

artículo científico publicado en 2015

The treatment and outcome of peri-prosthetic infection of the ankle: a single cohort-centre experience of 34 cases

artículo científico publicado en 2014

The why and how of amino acid analytics in cancer diagnostics and therapy.

artículo científico publicado en 2016

Thioester Hydrolysis and CC Bond Formation by Carboxymethylproline Synthase from the Crotonase Superfamily

artículo científico publicado en 2008

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy

artículo científico publicado en 2013

Two birds with one stone: doing metabolomics with your proteomics kit.

artículo científico publicado en 2013

Tyrosine dephosphorylation is required for Bak activation in apoptosis

artículo científico publicado en 2010

UFLC-derived CSF extracellular vesicle origin and proteome

scientific article published on 10 December 2018

USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7

scientific article published on 29 March 2019

USP4 Auto-Deubiquitylation Promotes Homologous Recombination

artículo científico publicado en 2015

USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β

artículo científico publicado en 2011

Ubiquitin - omics reveals novel networks and associations with human disease

artículo científico

Ubiquitin and ubiquitin-like specific proteases targeted by infectious pathogens: Emerging patterns and molecular principles

scientific article published on 10 September 2008

Ubiquitin ligase ARF-BP1/Mule modulates base excision repair

artículo científico publicado en 2009

Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability

artículo científico publicado en 2011

Ultra-fast tandem mass spectrometry scanning combined with monolithic column liquid chromatography increases throughput in proteomic analysis.

artículo científico publicado en 2006

Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity

artículo científico publicado en 2024

Urinary peptide profiling identifies a panel of putative biomarkers for diagnosing and staging endometriosis

artículo científico publicado en 2011

Using an Integrated -Omics Approach to Identify Key Cellular Processes That Are Disturbed in the Kidney After Brain Death.

artículo científico publicado en 2015

Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation.

artículo científico publicado en 2014

miR-193a-3p interaction with HMGB1 downregulates human endothelial cell proliferation and migration

scientific article published on 09 March 2017

p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation

artículo científico publicado en 2021

z-VAD-fmk inhibits peptide:N-glycanase and may result in ER stress

artículo científico publicado en 2006

β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression

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