Lista de obras - Nicholas R Casewell - Dominio Público Uruguay

A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite

artículo científico publicado en 2019

A ray of venom: Combined proteomic and transcriptomic investigation of fish venom composition using barb tissue from the blue-spotted stingray (Neotrygon kuhlii).

artículo científico publicado en 2014

A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite

artículo científico publicado en 2020

An analysis of preclinical efficacy testing of antivenoms for sub-Saharan Africa: Inadequate independent scrutiny and poor-quality reporting are barriers to improving snakebite treatment and management ⬇️

scientific article published on 20 August 2020

An interactive database for the investigation of high-density peptide microarray guided interaction patterns and antivenom cross-reactivity

artículo científico publicado en 2020

Anti-angiogenic activities of snake venom CRISP isolated from Echis carinatus sochureki.

artículo científico publicado en 2015

Antivenom Neutralization of Coagulopathic Snake Venom Toxins Assessed by Bioactivity Profiling Using Nanofractionation Analytics

scientific article published on 16 January 2020

Author Correction: A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite

artículo científico publicado en 2021

Bioactivity Profiling of Small-Volume Samples by Nano Liquid Chromatography Coupled to Microarray Bioassaying Using High-Resolution Fractionation

scientific article published on 02 August 2019

Biogeographic venom variation in Russell’s viper (Daboia russelii) and the preclinical inefficacy of antivenom therapy in snakebite hotspots

artículo científico publicado en 2021

Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy

artículo científico publicado en 2021

Coagulating Colubrids: Evolutionary, Pathophysiological and Biodiscovery Implications of Venom Variations between Boomslang (Dispholidus typus) and Twig Snake (Thelotornis mossambicanus).

artículo científico publicado en 2017

Coevolution takes the sting out of it: Evolutionary biology and mechanisms of toxin resistance in animals.

artículo científico publicado en 2017

Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis) reveal substantial intra-family gene diversity and novel venom transcripts

artículo científico publicado en 2009

Complex cocktails: the evolutionary novelty of venoms

artículo científico publicado en 2012

Correction: Molecular Evolution of Vertebrate Neurotrophins: Co-Option of the Highly Conserved Nerve Growth Factor Gene into the Advanced Snake Venom Arsenalf.

artículo científico publicado en 2013

Cytotoxic activities of [Ser⁴⁹]phospholipase A₂ from the venom of the saw-scaled vipers Echis ocellatus, Echis pyramidum leakeyi, Echis carinatus sochureki, and Echis coloratus

artículo científico publicado en 2013

Defining the pathogenic threat of envenoming by south african shield-nosed and coral snakes (genus aspidelaps), and revealing the likely efficacy of available antivenom

article

Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib

artículo científico publicado en 2024

Differential Evolution and Neofunctionalization of Snake Venom Metalloprotease Domains.

artículo científico publicado en 2012

Differential evolution and neofunctionalization of snake venom metalloprotease domains

artículo científico publicado en 2012

Differential procoagulant effects of saw-scaled viper (Serpentes: Viperidae: Echis) snake venoms on human plasma and the narrow taxonomic ranges of antivenom efficacies.

artículo científico publicado en 2017

Domain loss facilitates accelerated evolution and neofunctionalization of duplicate snake venom metalloproteinase toxin genes

artículo científico publicado en 2011

Dynamic evolution of venom proteins in squamate reptiles ⬇️

artículo científico publicado el 1 de enero de 2012

Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa

artículo científico publicado en 2011

Evaluation of the geographical utility of Eastern Russell's viper (Daboia siamensis) antivenom from Thailand and an assessment of its protective effects against venom-induced nephrotoxicity

artículo científico publicado en 2019

Evolution: Gene Co-option Underpins Venom Protein Evolution.

artículo científico publicado en 2017

Exploring the Utility of Recombinant Snake Venom Serine Protease Toxins as Immunogens for Generating Experimental Snakebite Antivenoms

artículo científico publicado en 2022

Exploring the Utility of ssDNA Aptamers Directed against Snake Venom Toxins as New Therapeutics for Snakebite Envenoming

artículo científico publicado en 2022

Expression of venom gene homologs in diverse python tissues suggests a new model for the evolution of snake venom.

artículo científico publicado en 2014

Extensive Variation in the Activities of Pseudocerastes and Eristicophis Viper Venoms Suggests Divergent Envenoming Strategies Are Used for Prey Capture

artículo científico publicado en 2021

Extreme venom variation in Middle Eastern vipers: a proteomics comparison of Eristicophis macmahonii, Pseudocerastes fieldi and Pseudocerastes persicus.

artículo científico publicado en 2014

Firing the sting: chemically induced discharge of cnidae reveals novel proteins and peptides from box jellyfish (Chironex fleckeri) venom

artículo científico publicado en 2015

Friends or Foes? Emerging Impacts of Biological Toxins

artículo científico publicado en 2019

Gene tree parsimony of multilocus snake venom protein families reveals species tree conflict as a result of multiple parallel gene loss

artículo científico publicado en 2010

Haemotoxic snake venoms: their functional activity, impact on snakebite victims and pharmaceutical promise.

artículo científico publicado en 2017

Immunological cross-reactivity and neutralisation of European viper venoms with the monospecific Vipera berus antivenom ViperaTAb

artículo científico publicado en 2014

In Vitro Immunological Cross-Reactivity of Thai Polyvalent and Monovalent Antivenoms with Asian Viper Venoms

artículo científico publicado en 2020

Intact protein mass spectrometry reveals intraspecies variations in venom composition of a local population of Vipera kaznakovi in Northeastern Turkey

artículo científico publicado en 2019

Liquid chromatographic nanofractionation with parallel mass spectrometric detection for the screening of plasmin inhibitors and (metallo)proteinases in snake venoms

scientific article published on 09 August 2018

Long-term physicochemical and immunological stability of a liquid formulated intact ovine immunoglobulin-based antivenom

artículo científico publicado en 2013

Mapping Enzyme Activity on Tissue by Functional Mass Spectrometry Imaging

artículo científico publicado en 2020

Mapping Enzyme Activity on Tissue by Functional Mass Spectrometry Imaging

artículo científico publicado en 2020

Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms

artículo científico publicado en 2014

Molecular adaptations for sensing and securing prey and insight into amniote genome diversity from the garter snake genome

artículo científico publicado en 2018

Molecular evolution of vertebrate neurotrophins: co-option of the highly conserved nerve growth factor gene into the advanced snake venom arsenalf

artículo científico publicado en 2013

Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling

artículo científico publicado en 2018

Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic Viperinae Snake Venom Toxins

artículo científico publicado en 2020

Novel Snakebite Therapeutics Must Be Tested in Appropriate Rescue Models to Robustly Assess Their Preclinical Efficacy

artículo científico publicado en 2020

Novel transcripts in the maxillary venom glands of advanced snakes

artículo científico publicado en 2012

On the ancestral recruitment of metalloproteinases into the venom of snakes ⬇️

artículo científico publicado el 3 de marzo de 2012

Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms

artículo científico publicado en 2021

Pre-clinical assays predict pan-African Echis viper efficacy for a species-specific antivenom

artículo científico publicado en 2010

Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa

artículo científico publicado en 2017

Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite

artículo científico publicado en 2020

Production and assessment of ovine antisera for the manufacture of a veterinary adder antivenom

artículo científico publicado en 2014

Profiling the Murine Acute Phase and Inflammatory Responses to African Snake Venom: An Approach to Inform Acute Snakebite Pathology

scientific article published on 23 March 2022

Rapid ligand fishing for identification of acetylcholinesterase-binding peptides in snake venom reveals new properties of dendrotoxins

artículo científico publicado en 2018

Research strategies to improve snakebite treatment: challenges and progress.

artículo científico publicado en 2011

Response to "Replies to Fry et al. (Toxicon 2012, 60/4, 434-448). Part A. Analyses of squamate reptile oral glands and their products: A call for caution in formal assignment of terminology designating biological function"

artículo científico publicado en 2012

Response to "Replies to Fry et al. (Toxicon 2012, 60/4, 434-448). Part B. Analyses of squamate reptile oral glands and their products: A call for caution in formal assignment of terminology designating biological function"

scientific article published on 07 January 2013

Single-reagent one-step procedures for the purification of ovine IgG, F(ab')2 and Fab antivenoms by caprylic acid

artículo científico publicado en 2013

Small Molecule Drug Discovery for Neglected Tropical Snakebite

artículo científico publicado en 2021

Snake antivenom trial

artículo científico publicado en 2014

Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals

scientific article published on 26 November 2019

Stabilising the Integrity of Snake Venom mRNA Stored under Tropical Field Conditions Expands Research Horizons

artículo científico publicado en 2016

Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins

artículo científico publicado en 2024

TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming phase 1 (safety, tolerability, pharmacokinetics and pharmacodynamics in healthy Kenyan adults)

artículo científico publicado en 2022

The Burmese python genome reveals the molecular basis for extreme adaptation in snakes

artículo científico publicado en 2013

The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes

artículo científico publicado en 2017

The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming

artículo científico publicado en 2021

The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system

artículo científico publicado en 2013

The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms

artículo científico publicado en 2017

The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms

article

The structural and functional diversification of the Toxicofera reptile venom system

artículo científico publicado en 2012

The time is now: a call for action to translate recent momentum on tackling tropical snakebite into sustained benefit for victims

scientific article published on 01 December 2019

The Cardiovascular and Neurotoxic Effects of the Venoms of Six Bony and Cartilaginous Fish Species

artículo científico publicado en 2017

VTBuilder: a tool for the assembly of multi isoform transcriptomes.

artículo científico publicado en 2014

Venom Complexity in a Pitviper Produced by Facultative Parthenogenesis

artículo científico publicado en 2018

Venom Evolution: Gene Loss Shapes Phenotypic Adaptation

artículo científico publicado en 2016

Venom-related transcripts from Bothrops jararaca tissues provide novel molecular insights into the production and evolution of snake venom

artículo científico publicado en 2014

Vintage venoms: proteomic and pharmacological stability of snake venoms stored for up to eight decades

artículo científico publicado en 2014

Visual Pigments, Ocular Filters and the Evolution of Snake Vision.

artículo científico publicado en 2016

What killed Karl Patterson Schmidt? Combined venom gland transcriptomic, venomic and antivenomic analysis of the South African green tree snake (the boomslang), Dispholidus typus

scientific article published on 24 January 2017

Widespread convergence in toxin resistance by predictable molecular evolution

artículo científico publicado en 2015

Widespread vulnerability of Malagasy predators to the toxins of an introduced toad

artículo científico publicado en 2018

Widespread vulnerability of Malagasy predators to the toxins of an introduced toad

artículo científico publicado en 2018

Lista de obras de Nicholas R Casewell

A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite

A ray of venom: Combined proteomic and transcriptomic investigation of fish venom composition using barb tissue from the blue-spotted stingray (Neotrygon kuhlii).

A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite

An analysis of preclinical efficacy testing of antivenoms for sub-Saharan Africa: Inadequate independent scrutiny and poor-quality reporting are barriers to improving snakebite treatment and management ⬇️

An interactive database for the investigation of high-density peptide microarray guided interaction patterns and antivenom cross-reactivity

Anti-angiogenic activities of snake venom CRISP isolated from Echis carinatus sochureki.

Antivenom Neutralization of Coagulopathic Snake Venom Toxins Assessed by Bioactivity Profiling Using Nanofractionation Analytics

Author Correction: A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite

Bioactivity Profiling of Small-Volume Samples by Nano Liquid Chromatography Coupled to Microarray Bioassaying Using High-Resolution Fractionation

Biogeographic venom variation in Russell’s viper (Daboia russelii) and the preclinical inefficacy of antivenom therapy in snakebite hotspots

Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy

Coagulating Colubrids: Evolutionary, Pathophysiological and Biodiscovery Implications of Venom Variations between Boomslang (Dispholidus typus) and Twig Snake (Thelotornis mossambicanus).

Coevolution takes the sting out of it: Evolutionary biology and mechanisms of toxin resistance in animals.

Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis) reveal substantial intra-family gene diversity and novel venom transcripts

Complex cocktails: the evolutionary novelty of venoms

Correction: Molecular Evolution of Vertebrate Neurotrophins: Co-Option of the Highly Conserved Nerve Growth Factor Gene into the Advanced Snake Venom Arsenalf.

Cytotoxic activities of [Ser⁴⁹]phospholipase A₂ from the venom of the saw-scaled vipers Echis ocellatus, Echis pyramidum leakeyi, Echis carinatus sochureki, and Echis coloratus

Defining the pathogenic threat of envenoming by south african shield-nosed and coral snakes (genus aspidelaps), and revealing the likely efficacy of available antivenom

Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib

Differential Evolution and Neofunctionalization of Snake Venom Metalloprotease Domains.

Differential evolution and neofunctionalization of snake venom metalloprotease domains

Differential procoagulant effects of saw-scaled viper (Serpentes: Viperidae: Echis) snake venoms on human plasma and the narrow taxonomic ranges of antivenom efficacies.

Domain loss facilitates accelerated evolution and neofunctionalization of duplicate snake venom metalloproteinase toxin genes

Dynamic evolution of venom proteins in squamate reptiles ⬇️

Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa

Evaluation of the geographical utility of Eastern Russell's viper (Daboia siamensis) antivenom from Thailand and an assessment of its protective effects against venom-induced nephrotoxicity

Evolution: Gene Co-option Underpins Venom Protein Evolution.

Exploring the Utility of Recombinant Snake Venom Serine Protease Toxins as Immunogens for Generating Experimental Snakebite Antivenoms

Exploring the Utility of ssDNA Aptamers Directed against Snake Venom Toxins as New Therapeutics for Snakebite Envenoming

Expression of venom gene homologs in diverse python tissues suggests a new model for the evolution of snake venom.

Extensive Variation in the Activities of Pseudocerastes and Eristicophis Viper Venoms Suggests Divergent Envenoming Strategies Are Used for Prey Capture

Extreme venom variation in Middle Eastern vipers: a proteomics comparison of Eristicophis macmahonii, Pseudocerastes fieldi and Pseudocerastes persicus.

Firing the sting: chemically induced discharge of cnidae reveals novel proteins and peptides from box jellyfish (Chironex fleckeri) venom

Friends or Foes? Emerging Impacts of Biological Toxins

Gene tree parsimony of multilocus snake venom protein families reveals species tree conflict as a result of multiple parallel gene loss

Haemotoxic snake venoms: their functional activity, impact on snakebite victims and pharmaceutical promise.

Immunological cross-reactivity and neutralisation of European viper venoms with the monospecific Vipera berus antivenom ViperaTAb

In Vitro Immunological Cross-Reactivity of Thai Polyvalent and Monovalent Antivenoms with Asian Viper Venoms

Intact protein mass spectrometry reveals intraspecies variations in venom composition of a local population of Vipera kaznakovi in Northeastern Turkey

Liquid chromatographic nanofractionation with parallel mass spectrometric detection for the screening of plasmin inhibitors and (metallo)proteinases in snake venoms

Long-term physicochemical and immunological stability of a liquid formulated intact ovine immunoglobulin-based antivenom

Mapping Enzyme Activity on Tissue by Functional Mass Spectrometry Imaging

Mapping Enzyme Activity on Tissue by Functional Mass Spectrometry Imaging

Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms

Molecular adaptations for sensing and securing prey and insight into amniote genome diversity from the garter snake genome

Molecular evolution of vertebrate neurotrophins: co-option of the highly conserved nerve growth factor gene into the advanced snake venom arsenalf

Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling

Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic Viperinae Snake Venom Toxins

Novel Snakebite Therapeutics Must Be Tested in Appropriate Rescue Models to Robustly Assess Their Preclinical Efficacy

Novel transcripts in the maxillary venom glands of advanced snakes

On the ancestral recruitment of metalloproteinases into the venom of snakes ⬇️

Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms

Pre-clinical assays predict pan-African Echis viper efficacy for a species-specific antivenom

Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa

Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite

Production and assessment of ovine antisera for the manufacture of a veterinary adder antivenom

Profiling the Murine Acute Phase and Inflammatory Responses to African Snake Venom: An Approach to Inform Acute Snakebite Pathology

Rapid ligand fishing for identification of acetylcholinesterase-binding peptides in snake venom reveals new properties of dendrotoxins

Research strategies to improve snakebite treatment: challenges and progress.

Response to "Replies to Fry et al. (Toxicon 2012, 60/4, 434-448). Part A. Analyses of squamate reptile oral glands and their products: A call for caution in formal assignment of terminology designating biological function"

Response to "Replies to Fry et al. (Toxicon 2012, 60/4, 434-448). Part B. Analyses of squamate reptile oral glands and their products: A call for caution in formal assignment of terminology designating biological function"

Single-reagent one-step procedures for the purification of ovine IgG, F(ab')2 and Fab antivenoms by caprylic acid

Small Molecule Drug Discovery for Neglected Tropical Snakebite

Snake antivenom trial

Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals

Stabilising the Integrity of Snake Venom mRNA Stored under Tropical Field Conditions Expands Research Horizons

Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins

TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming phase 1 (safety, tolerability, pharmacokinetics and pharmacodynamics in healthy Kenyan adults)

The Burmese python genome reveals the molecular basis for extreme adaptation in snakes

The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes

The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming

The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system

The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms

The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms

The structural and functional diversification of the Toxicofera reptile venom system

The time is now: a call for action to translate recent momentum on tackling tropical snakebite into sustained benefit for victims

The Cardiovascular and Neurotoxic Effects of the Venoms of Six Bony and Cartilaginous Fish Species

VTBuilder: a tool for the assembly of multi isoform transcriptomes.

Venom Complexity in a Pitviper Produced by Facultative Parthenogenesis