Lista de obras - Tim Clausen - Dominio Público Uruguay

A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

artículo científico publicado en 2020

A new mechanism for the control of a prokaryotic transcriptional regulator: antagonistic binding of positive and negative effectors

artículo científico

A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors

artículo científico publicado en 2013

Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control

artículo científico publicado en 2008

Arginine phosphorylation marks proteins for degradation by a Clp protease

artículo científico publicado en 2016

Augmenting β-augmentation: structural basis of how BamB binds BamA and may support folding of outer membrane proteins

artículo científico publicado en 2011

Characterization of recombinant Arabidopsis thaliana threonine synthase

artículo científico publicado en 1999

Chasing Phosphoarginine Proteins: Development of a Selective Enrichment Method Using a Phosphatase Trap

artículo científico publicado en 2014

Chemical Biology Interrogates Protein Arginine Phosphorylation

artículo científico publicado en 2016

Cloning, Purification and Characterisation of Cystathionine γ-Synthase from Nicotiana tabacum

scholarly article by Tim Clausen published in January 1999

Cloning, purification, and crystallization of Escherichia coli cystathionine beta-lyase

artículo científico publicado en 1996

Cloning, purification, crystallization, and preliminary X-ray diffraction analysis of cystathionine gamma-synthase from E. coli.

artículo científico publicado en 1997

Conversion of a regulatory into a degradative protease

artículo científico publicado en 2010

Crystal structure of 12-oxophytodienoate reductase 3 from tomato: self-inhibition by dimerization

artículo científico publicado en 2006

Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine

artículo científico publicado en 2002

Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution

artículo científico publicado en 1998

Crystal structure of a NifS-like protein from Thermotoga maritima: implications for iron sulphur cluster assembly

artículo científico publicado en 2000

Crystal structure of cystalysin from Treponema denticola: a pyridoxal 5'-phosphate-dependent protein acting as a haemolytic enzyme

artículo científico publicado en 2000

Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease

artículo científico publicado en 2004

Crystal structure of the cystine C-S lyase from Synechocystis: stabilization of cysteine persulfide for FeS cluster biosynthesis

artículo científico publicado en 2000

Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes

artículo científico publicado en 2004

Crystal structure of the pyridoxal-5'-phosphate dependent cystathionine beta-lyase from Escherichia coli at 1.83 A

artículo científico publicado en 1996

Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor

artículo científico publicado en 2001

Crystallization and preliminary X-ray crystallographic analysis of PdxJ, the pyridoxine 5′-phosphate synthesizing enzyme

scientific article published on 01 August 2000

CtpB Assembles a Gated Protease Tunnel Regulating Cell-Cell Signaling during Spore Formation in Bacillus subtilis

artículo científico publicado en 2013

Determinants of amyloid fibril degradation by the PDZ protease HTRA1.

artículo científico publicado en 2015

Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine gamma-lyase from yeast and intrafamiliar structure comparison

artículo científico publicado en 2003

Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis

artículo científico publicado en 2002

Glutaconate CoA-transferase from Acidaminococcus fermentans: the crystal structure reveals homology with other CoA-transferases

artículo científico publicado en 1997

HTRA proteases: regulated proteolysis in protein quality control

artículo científico publicado en 2011

HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain

artículo científico publicado en 2021

Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria

artículo científico publicado en 2024

HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues

artículo científico publicado en 2010

Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function

artículo científico publicado en 2014

Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates

artículo científico publicado en 2012

Implications of the serine protease HtrA1 in amyloid precursor protein processing

artículo científico publicado en 2005

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins

artículo científico publicado en 2008

Involvement of Tyr24 and Trp108 in substrate binding and substrate specificity of glycolate oxidase

artículo científico publicado en 1995

Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration

artículo científico publicado en 1999

McsB is a protein arginine kinase that phosphorylates and inhibits the heat-shock regulator CtsR

artículo científico publicado en 2009

Mode of action of cystathionine beta-lyase

artículo científico publicado en 1997

Molecular Adaptation of the DegQ Protease to Exert Protein Quality Control in the Bacterial Cell Envelope

artículo científico publicado en 2011

Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin

scientific article published on 21 October 2019

Molecular machines for protein degradation

artículo científico publicado en 2005

Molecular shredders: how proteasomes fulfill their role

artículo científico publicado en 2003

Molecular transformers in the cell: lessons learned from the DegP protease-chaperone

artículo científico publicado en 2010

Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

artículo científico publicado en 2020

Mutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities

artículo científico publicado en 2012

Myosin chaperones

artículo científico publicado en 2014

Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ

artículo científico publicado en 2012

Protein quality control in the bacterial periplasm

artículo científico publicado en 2011

Proteolysis as a regulatory mechanism

artículo científico publicado en 2004

Quantitative phosphoproteomics reveals the role of protein arginine phosphorylation in the bacterial stress response

artículo científico publicado en 2013

RNA specificity and regulation of catalysis in the eukaryotic polynucleotide kinase Clp1

artículo científico publicado en 2014

Rational correction of pathogenic conformational defects in HTRA1

artículo científico publicado en 2024

Regulation of the E stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress

artículo científico publicado en 2007

Slow-binding inhibition of Escherichia coli cystathionine beta-lyase by L-aminoethoxyvinylglycine: a kinetic and X-ray study

artículo científico publicado en 1997

Snapshots of the cystine lyase C-DES during catalysis. Studies in solution and in the crystalline state

artículo científico publicado en 2003

Spectroscopic and kinetic analyses reveal the pyridoxal 5'-phosphate binding mode and the catalytic features of Treponema denticola cystalysin

artículo científico publicado en 2002

Stress-induced GSK3 regulates the redox stress response by phosphorylating glucose-6-phosphate dehydrogenase in Arabidopsis.

artículo científico publicado en 2012

Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure

artículo científico publicado en 2011

Structural and functional impairment of an Old Yellow Enzyme homologue upon affinity tag incorporation

artículo científico publicado en 2004

Structural basis for recognizing phosphoarginine and evolving residue-specific protein phosphatases in gram-positive bacteria

artículo científico publicado en 2013

Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex

artículo científico publicado en 2023

Structural basis for the disaggregase activity and regulation of Hsp104.

artículo científico publicado en 2016

Structural basis for the function of pyridoxine 5'-phosphate synthase

artículo científico publicado en 2001

Structural basis for the regulated protease and chaperone function of DegP

artículo científico publicado en 2008

Structural basis of substrate specificity of plant 12-oxophytodienoate reductases

artículo científico publicado en 2009

Structure and function of threonine synthase from yeast

artículo científico publicado en 2002

Structure of McsB, a protein kinase for regulated arginine phosphorylation

artículo científico publicado en 2019

Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli

scientific article published on 18 August 2009

Substrate-induced remodeling of the active site regulates human HTRA1 activity

artículo científico publicado en 2011

The 1.3 A crystal structure of the flavoprotein YqjM reveals a novel class of Old Yellow Enzymes

artículo científico publicado en 2005

The HtrA Family of Proteases

scientific article (publication date: September 2002)

The Myosin Chaperone UNC-45 Is Organized in Tandem Modules to Support Myofilament Formation in C. elegans

artículo científico publicado en 2013

The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression

artículo científico publicado en 2015

The crystal structure of Deg9 reveals a novel octameric-type HtrA protease.

artículo científico publicado en 2017

The crystal structure of cystathionine gamma-synthase from Nicotiana tabacum reveals its substrate and reaction specificity

artículo científico publicado en 1999

The role of human HtrA1 in arthritic disease

artículo científico publicado en 2006

UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins

artículo científico publicado en 2018

Versatile in vitro system to study translocation and functional integration of bacterial outer membrane proteins

artículo científico publicado en 2014

X-ray structure of 12-oxophytodienoate reductase 1 provides structural insight into substrate binding and specificity within the family of OYE

artículo científico publicado en 2001

X-ray structure of MalY from Escherichia coli: a pyridoxal 5′-phosphate-dependent enzyme acting as a modulator in mal gene expression

artículo científico publicado en 2000

Lista de obras de Tim Clausen

A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

A new mechanism for the control of a prokaryotic transcriptional regulator: antagonistic binding of positive and negative effectors

A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors

Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control

Arginine phosphorylation marks proteins for degradation by a Clp protease

Augmenting β-augmentation: structural basis of how BamB binds BamA and may support folding of outer membrane proteins

Characterization of recombinant Arabidopsis thaliana threonine synthase

Chasing Phosphoarginine Proteins: Development of a Selective Enrichment Method Using a Phosphatase Trap

Chemical Biology Interrogates Protein Arginine Phosphorylation

Cloning, Purification and Characterisation of Cystathionine γ-Synthase from Nicotiana tabacum

Cloning, purification, and crystallization of Escherichia coli cystathionine beta-lyase

Cloning, purification, crystallization, and preliminary X-ray diffraction analysis of cystathionine gamma-synthase from E. coli.

Conversion of a regulatory into a degradative protease

Crystal structure of 12-oxophytodienoate reductase 3 from tomato: self-inhibition by dimerization

Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine

Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution

Crystal structure of a NifS-like protein from Thermotoga maritima: implications for iron sulphur cluster assembly

Crystal structure of cystalysin from Treponema denticola: a pyridoxal 5'-phosphate-dependent protein acting as a haemolytic enzyme

Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease

Crystal structure of the cystine C-S lyase from Synechocystis: stabilization of cysteine persulfide for FeS cluster biosynthesis

Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes

Crystal structure of the pyridoxal-5'-phosphate dependent cystathionine beta-lyase from Escherichia coli at 1.83 A

Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor

Crystallization and preliminary X-ray crystallographic analysis of PdxJ, the pyridoxine 5′-phosphate synthesizing enzyme

CtpB Assembles a Gated Protease Tunnel Regulating Cell-Cell Signaling during Spore Formation in Bacillus subtilis

Determinants of amyloid fibril degradation by the PDZ protease HTRA1.

Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine gamma-lyase from yeast and intrafamiliar structure comparison

Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis

Glutaconate CoA-transferase from Acidaminococcus fermentans: the crystal structure reveals homology with other CoA-transferases

HTRA proteases: regulated proteolysis in protein quality control

HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain

Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria

HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues

Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function

Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates

Implications of the serine protease HtrA1 in amyloid precursor protein processing

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins

Involvement of Tyr24 and Trp108 in substrate binding and substrate specificity of glycolate oxidase

Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration

McsB is a protein arginine kinase that phosphorylates and inhibits the heat-shock regulator CtsR

Mode of action of cystathionine beta-lyase

Molecular Adaptation of the DegQ Protease to Exert Protein Quality Control in the Bacterial Cell Envelope

Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin

Molecular machines for protein degradation

Molecular shredders: how proteasomes fulfill their role

Molecular transformers in the cell: lessons learned from the DegP protease-chaperone

Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

Mutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities

Myosin chaperones

Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ

Protein quality control in the bacterial periplasm

Proteolysis as a regulatory mechanism

Quantitative phosphoproteomics reveals the role of protein arginine phosphorylation in the bacterial stress response

RNA specificity and regulation of catalysis in the eukaryotic polynucleotide kinase Clp1

Rational correction of pathogenic conformational defects in HTRA1

Regulation of the E stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress

Slow-binding inhibition of Escherichia coli cystathionine beta-lyase by L-aminoethoxyvinylglycine: a kinetic and X-ray study

Snapshots of the cystine lyase C-DES during catalysis. Studies in solution and in the crystalline state

Spectroscopic and kinetic analyses reveal the pyridoxal 5'-phosphate binding mode and the catalytic features of Treponema denticola cystalysin

Stress-induced GSK3 regulates the redox stress response by phosphorylating glucose-6-phosphate dehydrogenase in Arabidopsis.

Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure

Structural and functional impairment of an Old Yellow Enzyme homologue upon affinity tag incorporation

Structural basis for recognizing phosphoarginine and evolving residue-specific protein phosphatases in gram-positive bacteria

Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex

Structural basis for the disaggregase activity and regulation of Hsp104.

Structural basis for the function of pyridoxine 5'-phosphate synthase

Structural basis for the regulated protease and chaperone function of DegP

Structural basis of substrate specificity of plant 12-oxophytodienoate reductases

Structure and function of threonine synthase from yeast

Structure of McsB, a protein kinase for regulated arginine phosphorylation

Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli

Substrate-induced remodeling of the active site regulates human HTRA1 activity

The 1.3 A crystal structure of the flavoprotein YqjM reveals a novel class of Old Yellow Enzymes

The HtrA Family of Proteases

The Myosin Chaperone UNC-45 Is Organized in Tandem Modules to Support Myofilament Formation in C. elegans

The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression

The crystal structure of Deg9 reveals a novel octameric-type HtrA protease.

The crystal structure of cystathionine gamma-synthase from Nicotiana tabacum reveals its substrate and reaction specificity

The role of human HtrA1 in arthritic disease