Lista de obras - Stephen J Haggarty - Dominio Público Uruguay

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies

scientific article published on 17 October 2019

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

scientific article published on 01 March 2019

A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas

artículo científico publicado en 2015

A high-throughput screen for Wnt/β-catenin signaling pathway modulators in human iPSC-derived neural progenitors

artículo científico publicado en 2012

A polygenic burden of rare disruptive mutations in schizophrenia

artículo científico publicado en 2014

A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests

artículo científico publicado en 2013

Activity-dependent Regulation of Histone Lysine Demethylase KDM1A by a Putative Thiol/Disulfide Switch

artículo científico publicado en 2016

Antidepressant actions of histone deacetylase inhibitors

artículo científico publicado en 2009

Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles

artículo científico publicado en 2014

Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate

scientific article published on 26 December 2019

Brain-penetrant LSD1 inhibitors can block memory consolidation.

artículo científico publicado en 2011

CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors

artículo científico publicado en 2014

Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling

artículo científico publicado en 2010

Chemical genomic profiling of biological networks using graph theory and combinations of small molecule perturbations

artículo científico publicado en 2003

Chemical phylogenetics of histone deacetylases

artículo científico publicado en 2010

Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory

artículo científico publicado en 2018

Detecting binding interactions using microarrays of natural product extracts

artículo científico publicado en 2007

Development of [18F]Maleimide-Based Glycogen Synthase Kinase-3β Ligands for Positron Emission Tomography Imaging.

artículo científico publicado en 2017

Disruption of a large intergenic noncoding RNA in subjects with neurodevelopmental disabilities

artículo científico publicado en 2012

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

artículo científico publicado en 2003

Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.

artículo científico publicado en 2010

Epigenetic Characterization of the FMR1 Gene and Aberrant Neurodevelopment in Human Induced Pluripotent Stem Cell Models of Fragile X Syndrome ⬇️

artículo científico publicado el 12 de octubre de 2011

Essential role of the histone methyltransferase G9a in cocaine-induced plasticity

artículo científico publicado en 2010

Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration

artículo científico publicado en 2021

Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips

artículo científico publicado en 2004

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease

artículo científico publicado en 2020

HDAC2 negatively regulates memory formation and synaptic plasticity.

artículo científico publicado en 2009

High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology

artículo científico publicado en 2018

High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications

artículo científico publicado en 1999

Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli

scientific journal article

Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice

scientific article published on 29 September 2020

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability

artículo científico publicado en 2016

Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein

artículo científico publicado en 2020

Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors.

artículo científico publicado en 2014

Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia

artículo científico publicado en 2017

Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease

artículo científico publicado en 2009

Insights into neuroepigenetics through human histone deacetylase PET imaging.

artículo científico publicado en 2016

Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression

artículo científico publicado en 2019

Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers

artículo científico publicado en 2015

Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity ⬇️

artículo científico publicado el 27 de abril de 2011

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

artículo científico publicado en 2020

Rapid behavior-based identification of neuroactive small molecules in the zebrafish

artículo científico publicado en 2010

Revealing complex traits with small molecules and naturally recombinant yeast strains

artículo científico publicado en 2006

SpectralNET--an application for spectral graph analysis and visualization

artículo científico publicado en 2005

Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery

artículo científico publicado en 2019

Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models

artículo científico publicado en 2019

Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies

scientific article published on 25 November 2020

The principle of complementarity: chemical versus biological space

artículo científico publicado en 2005

Traditional and systems biology based drug discovery for the rare tumor syndrome neurofibromatosis type 2.

artículo científico publicado en 2018

WNT/β-Catenin Pathway and Epigenetic Mechanisms Regulate the Pitt-Hopkins Syndrome and Schizophrenia Risk Gene TCF4.

artículo científico publicado en 2017

Will cell alliance breed bureaucracy and leave contributors out?

artículo científico publicado en 2000

Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation

artículo científico publicado en 2010

Lista de obras de Stephen J Haggarty

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas

A high-throughput screen for Wnt/β-catenin signaling pathway modulators in human iPSC-derived neural progenitors

A polygenic burden of rare disruptive mutations in schizophrenia

A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests

Activity-dependent Regulation of Histone Lysine Demethylase KDM1A by a Putative Thiol/Disulfide Switch

Antidepressant actions of histone deacetylase inhibitors

Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles

Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate

Brain-penetrant LSD1 inhibitors can block memory consolidation.

CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors

Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling

Chemical genomic profiling of biological networks using graph theory and combinations of small molecule perturbations

Chemical phylogenetics of histone deacetylases

Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory

Detecting binding interactions using microarrays of natural product extracts

Development of [18F]Maleimide-Based Glycogen Synthase Kinase-3β Ligands for Positron Emission Tomography Imaging.

Disruption of a large intergenic noncoding RNA in subjects with neurodevelopmental disabilities

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.

Epigenetic Characterization of the FMR1 Gene and Aberrant Neurodevelopment in Human Induced Pluripotent Stem Cell Models of Fragile X Syndrome ⬇️

Essential role of the histone methyltransferase G9a in cocaine-induced plasticity

Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration

Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease

HDAC2 negatively regulates memory formation and synaptic plasticity.

High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology

High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications

Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli

Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability

Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein

Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors.

Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia

Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease

Insights into neuroepigenetics through human histone deacetylase PET imaging.

Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression

Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers

Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity ⬇️

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

Rapid behavior-based identification of neuroactive small molecules in the zebrafish

Revealing complex traits with small molecules and naturally recombinant yeast strains

SpectralNET--an application for spectral graph analysis and visualization

Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery

Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models

Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies

The principle of complementarity: chemical versus biological space

Traditional and systems biology based drug discovery for the rare tumor syndrome neurofibromatosis type 2.

WNT/β-Catenin Pathway and Epigenetic Mechanisms Regulate the Pitt-Hopkins Syndrome and Schizophrenia Risk Gene TCF4.

Will cell alliance breed bureaucracy and leave contributors out?

Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation