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Lista de obras de Christopher G. Proud

A New Link in the Chain from Amino Acids to mTORC1 Activation ⬇️

artículo científico publicado el 7 de octubre de 2011

A conserved loop in the catalytic domain of eukaryotic elongation factor 2 kinase plays a key role in its substrate specificity

artículo científico publicado en 2014

A high-throughput screening assay for eukaryotic elongation factor 2 kinase inhibitors

artículo científico publicado en 2016

A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin

artículo científico publicado en 2004

A novel mechanism for the control of translation initiation by amino acids, mediated by phosphorylation of eukaryotic initiation factor 2B.

artículo científico publicado en 2007

A quantitative molecular model for modulation of mammalian translation by the eIF4E-binding protein 1.

artículo científico publicado en 2001

A sharper instrument for dissecting signalling events: a specific AGC kinase inhibitor

artículo científico publicado en 2007

A synthetic peptide substrate for initiation factor-2 kinases

artículo científico publicado en 1991

ABC50 mutants modify translation start codon selection

artículo científico publicado en 2015

ABC50 promotes translation initiation in mammalian cells

artículo científico publicado en 2009

ANG II activates effectors of mTOR via PI3-K signaling in human coronary smooth muscle cells

artículo científico publicado en 2004

ATP depletion increases phosphorylation of elongation factor eEF2 in adult cardiomyocytes independently of inhibition of mTOR signalling

artículo científico publicado en 2002

Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte

artículo científico publicado en 2004

Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis

artículo científico publicado en 2002

Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)

artículo científico publicado en 2005

Activation of translation initiation factor eIF2B by insulin requires phosphatidyl inositol 3-kinase

scientific article published on 01 June 1997

Adult-onset leukoencephalopathies with vanishing white matter with novel missense mutations in EIF2B2, EIF2B3, and EIF2B5

artículo científico publicado en 2011

Amino acid sequence analysis of the beta- and gamma-subunits of eukaryotic initiation factor eIF-2. Identification of regions interacting with GTP

artículo científico publicado en 1991

Amino acid sequences at the two sites on glycogen synthetase phosphorylated by cyclic AMP-dependent protein kinase and their dephosphorylation by protein phosphatase-III

artículo científico publicado en 1977

Amino acids and mTOR signalling in anabolic function

artículo científico publicado en 2007

Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.

artículo científico publicado en 2005

Analysis of the regulatory motifs in eukaryotic initiation factor 4E-binding protein 1.

artículo científico publicado en 2008

Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation

artículo científico publicado en 2014

BDNF stimulation of protein synthesis in cortical neurons requires the MAP kinase-interacting kinase MNK1.

artículo científico publicado en 2015

Biochemical effects of mutations in the gene encoding the alpha subunit of eukaryotic initiation factor (eIF) 2B associated with Vanishing White Matter disease

artículo científico publicado en 2015

Blocking eukaryotic initiation factor 4F complex formation does not inhibit the mTORC1-dependent activation of protein synthesis in cardiomyocytes

artículo científico publicado en 2008

Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes

artículo científico publicado en 2003

Casein kinase-2 phosphorylates serine-2 in the beta-subunit of initiation factor-2

scientific article published on 01 March 1989

Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif

artículo científico publicado en 2002

Cell signaling. mTOR, unleashed

artículo científico publicado en 2007

Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors

artículo científico publicado en 2002

Changes in the phosphorylation of initiation factor eIF-2alpha, elongation factor eEF-2 and p70 S6 kinase after transient focal cerebral ischaemia in mice.

artículo científico publicado en 2001

Characterization of p75 neurotrophin receptor expression in human dental pulp stem cells.

artículo científico publicado en 2016

Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster

artículo científico publicado en 2000

Chloroquine and bafilomycin A mimic lysosomal storage disorders and impair mTORC1 signaling

scientific article published on 14 April 2020

Cleavage of translation initiation factor 4AI (eIF4AI) but not eIF4AII by foot-and-mouth disease virus 3C protease: identification of the eIF4AI cleavage site

artículo científico publicado en 2001

Cloning of cDNA for the beta-subunit of rabbit translation initiation factor-2 using PCR.

artículo científico publicado en 1993

Comparative analysis of the regulation of the interferon-inducible protein kinase PKR by Epstein-Barr virus RNAs EBER-1 and EBER-2 and adenovirus VAI RNA

artículo científico publicado en 1993

Control of the translational machinery by amino acids

artículo científico publicado en 2013

Control of the translational machinery in mammalian cells

artículo científico publicado en 2002

Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress

artículo científico publicado en 2012

Cyclosporin A but not FK506 activates the integrated stress response in human cells

artículo científico publicado en 2020

Decreased insulin binding to mononuclear leucocytes and erythrocytes from dogs after S-nitroso-N-acetypenicillamine administration

artículo científico publicado en 2002

Defective translation initiation causes vanishing of cerebral white matter

artículo científico publicado en 2006

Depletion of ribosomal protein S19 causes a reduction of rRNA synthesis

artículo científico publicado en 2016

Detailed analysis of the phosphorylation of the human La (SS-B) autoantigen. (De)phosphorylation does not affect its subcellular distribution

artículo científico publicado en 2000

Differing effects of rapamycin and mTOR kinase inhibitors on protein synthesis

artículo científico publicado en 2011

Differing effects of the protein phosphatase inhibitors okadaic acid and microcystin on translation in reticulocyte lysates

artículo científico publicado en 1991

Differing substrate specificities of members of the DYRK family of arginine-directed protein kinases

artículo científico publicado en 2002

Dissecting the signaling pathways that mediate cancer in PTEN and LKB1 double-knockout mice

artículo científico

Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins

artículo científico publicado en 2005

Distinct signalling pathways mediate insulin and phorbol ester-stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells.

artículo científico publicado en 2000

Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation?

artículo científico publicado en 2002

Dynamic balancing: DEPTOR tips the scales

artículo científico publicado en 2009

Dynamics of elongation factor 2 kinase regulation in cortical neurons in response to synaptic activity

artículo científico publicado en 2015

Elongation Factor 2 Kinase Is Regulated by Proline Hydroxylation and Protects Cells during Hypoxia

artículo científico publicado en 2015

Elongation factor 2 kinase promotes cell survival by inhibiting protein synthesis without inducing autophagy

artículo científico

Engineering mRNA translation initiation to enhance transient gene expression in chinese hamster ovary cells

artículo científico publicado en 2003

Eukaryotic Elongation Factor 2 Kinase Activity Is Required for the Phenotypes of the Rpl24 Mouse

artículo científico publicado en 2022

Eukaryotic elongation factor 2 kinase activity is controlled by multiple inputs from oncogenic signaling

artículo científico publicado en 2014

Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseases

artículo científico publicado en 2016

Eukaryotic elongation factor 2 kinase regulates the synthesis of microtubule-related proteins in neurons

artículo científico publicado en 2015

Eukaryotic elongation factor 2 kinase, an unusual enzyme with multiple roles

artículo científico

Eukaryotic initiation factor 2 from rat liver: no apparent function for the beta-subunit in the formation of initiation complexes

scientific article published on 01 October 1986

Eukaryotic initiation factor 2B (eIF2B).

artículo científico publicado en 1997

Eukaryotic translation initiation factor 5 (eIF5) acts as a classical GTPase-activator protein.

artículo científico publicado en 2001

Evaluation of mTOR-regulated mRNA translation.

artículo científico publicado en 2012

Evidence for a role for protein kinase C in the stimulation of protein synthesis by insulin in swiss 3T3 fibroblasts.

artículo científico publicado en 1993

Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin

artículo científico publicado en 2002

Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of men

article by Adam J. Rose et al published 15 November 2005 in Journal of Physiology

Features in the N and C termini of the MAPK-interacting kinase Mnk1 mediate its nucleocytoplasmic shuttling

artículo científico publicado en 2003

Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties

artículo científico publicado en 2005

Functional analysis of recently identified mutations in eukaryotic translation initiation factor 2Bɛ (eIF2Bɛ) identified in Chinese patients with vanishing white matter disease

artículo científico publicado en 2011

GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism

scientific article published on 14 June 2016

GSK3: a SHAGGY frog story

scientific article published on 01 July 1996

Glucose and amino acids modulate translation factor activation by growth factors in PC12 cells

artículo científico publicado en 2000

Glucose exerts a permissive effect on the regulation of the initiation factor 4E binding protein 4E-BP1

artículo científico publicado en 2001

Glucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans

scientific journal article

Glycine restores the anabolic response to leucine in a mouse model of acute inflammation

artículo científico publicado en 2016

Growth-factor dependent expression of the translationally controlled tumour protein TCTP is regulated through the PI3-K/Akt/mTORC1 signalling pathway.

artículo científico publicado en 2015

Guanine nucleotide exchange factor for eukaryotic initiation factor-2. Cloning of cDNA for the delta-subunit of rabbit translation initiation factor-2B.

artículo científico publicado en 1994

Heat shock increases the association of binding protein-1 with initiation factor 4E

artículo científico publicado en 1997

Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase

artículo científico publicado en 2012

Identification of residues that underpin interactions within the eukaryotic initiation factor (eIF2) 2B complex

artículo científico publicado en 2012

Identification of the phosphorylation sites in elongation factor-2 from rabbit reticulocytes

scientific article published on 01 May 1991

Impaired associative taste learning and abnormal brain activation in kinase-defective eEF2K mice

artículo científico publicado en 2012

Impairing eukaryotic elongation factor 2 kinase activity decreases atherosclerotic plaque formation.

artículo científico publicado en 2014

Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors

artículo científico publicado en 2014

Insights into the regulation of eukaryotic elongation factor 2 kinase and the interplay between its domains

artículo científico publicado en 2012

Insulin-stimulated phosphorylation of initiation factor 4E is mediated by the MAP kinase pathway

artículo científico publicado en 1996

Interplay between insulin and nutrients in the regulation of translation factors

artículo científico publicado en 2001

Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner

artículo científico publicado en 2002

Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: implications for glucose metabolism

artículo científico publicado en 1997

Isolation and characterisation of the guanine nucleotide exchange factor from rat liver

artículo científico publicado en 1987

Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats

artículo científico publicado en 2011

Localisation and regulation of the eIF4E-binding protein 4E-BP3.

artículo científico publicado en 2002

MAP kinase-interacting kinases--emerging targets against cancer

artículo científico publicado en 2014

MAPK-interacting kinase 2 (MNK2) regulates adipocyte metabolism independently of its catalytic activity

artículo científico publicado en 2020

MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways

artículo científico publicado en 2016

Mechanisms underlying suppression of protein synthesis induced by transient focal cerebral ischemia in mouse brain

artículo científico publicado en 2002

Metabolite-induced activation of hepatic phosphofructokinase ⬇️

artículo científico publicado el 30 de enero de 1984

Methods for studying signal-dependent regulation of translation factor activity

artículo científico publicado en 2007

Mnks, eIF4E phosphorylation and cancer

artículo científico publicado en 2014

Molecular Mechanism for the Control of Eukaryotic Elongation Factor 2 Kinase by pH: Role in Cancer Cell Survival

artículo científico publicado en 2015

Molecular mechanisms in the control of translation by hormones and growth factors

artículo científico publicado en 1994

Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase

artículo científico publicado en 2003

Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways

artículo científico publicado en 2004

Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2

scientific article published on 18 May 2012

Nerve and epidermal growth factor induce protein synthesis and eIF2B activation in PC12 cells

scientific article published on 01 March 1998

Nutrient control of TORC1, a cell-cycle regulator

scientific article published on 04 May 2009

Nutrients differentially regulate multiple translation factors and their control by insulin

artículo científico publicado en 1999

On the Diversification of the Translation Apparatus across Eukaryotes

artículo científico publicado en 2012

Oxidized LDL-mediated macrophage survival involves elongation factor-2 kinase.

artículo científico publicado en 2008

PKR: a new name and new roles.

artículo científico publicado en 1995

PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

artículo científico publicado en 2007

Peptide substrates suitable for assaying glycogen synthase kinase-3 in crude cell extracts.

artículo científico publicado en 1997

Peptide-chain elongation in eukaryotes

artículo científico publicado en 1994

Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by

artículo científico publicado en 2011

Phosphorylated seryl and threonyl, but not tyrosyl, residues are efficient specificity determinants for GSK-3beta and Shaggy.

artículo científico publicado en 1999

Phosphorylation of elongation factor-2 from the lepidopteran insect, Spodoptera frugiperda

artículo científico publicado en 1993

Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA.

artículo científico publicado en 2001

Phosphorylation of only serine-51 in protein synthesis initiation factor-2 is associated with inhibition of peptide-chain initiation in reticulocyte lysates

artículo científico publicado en 1991

Phosphorylation of protein synthesis initiation factor-2. Identification of the site in the alpha-subunit phosphorylated in reticulocyte lysates

artículo científico publicado en 1990

Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization.

artículo científico publicado en 2003

Protein kinase D is a key regulator of cardiomyocyte lipoprotein lipase secretion after diabetes

artículo científico publicado en 2008

Protein synthesis and its control in neuronal cells with a focus on vanishing white matter disease

artículo científico publicado en 2009

Purification and characterisation of an initiation-factor-2 kinase from uninduced mouse erythroleukaemia cells

artículo científico publicado en 1993

Purification and phosphorylation of initiation factor eIF-2 from rabbit skeletal muscle

artículo científico publicado en 1982

Quantitative Non-canonical Amino Acid Tagging (QuaNCAT) Proteomics Identifies Distinct Patterns of Protein Synthesis Rapidly Induced by Hypertrophic Agents in Cardiomyocytes, Revealing New Aspects of Metabolic Remodeling.

artículo científico publicado en 2016

Quantitative proteomics identifies Gemin5, a scaffolding protein involved in ribonucleoprotein assembly, as a novel partner for eukaryotic initiation factor 4E

artículo científico publicado en 2006

Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a).

artículo científico publicado en 2013

Rapamycin-resistant phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in v-SRC-transformed hamster fibroblasts

artículo científico publicado en 1999

Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E.

artículo científico publicado en 2000

Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy

artículo científico publicado en 2004

Ras/Erk signaling is essential for activation of protein synthesis by Gq protein-coupled receptor agonists in adult cardiomyocytes

artículo científico publicado en 2002

Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling

artículo científico publicado en 2008

Regulated stability of eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity

artículo científico publicado en 2015

Regulation and roles of elongation factor 2 kinase

artículo científico

Regulation of binding of initiator tRNA to eukaryotic initiation factor eIF-2. Effects of the haem-controlled repressor on the kinetics of ternary complex formation

artículo científico publicado en 1982

Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1.

artículo científico publicado en 2007

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

artículo científico publicado en 2001

Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin

artículo científico publicado en 1998

Regulation of mammalian translation factors by nutrients

artículo científico publicado en 2002

Regulation of peptide-chain elongation in mammalian cells

artículo científico publicado en 2002

Regulation of polypeptide-chain initiation in rat skeletal muscle. Starvation does not alter the activity or phosphorylation state of initiation factor eIF-2

artículo científico publicado en 1988

Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal fat cells. Activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms

scientific article published on 01 March 1997

Regulation of protein synthesis by insulin

artículo científico publicado en 2006

Regulation of protein synthesis in lymphoblasts from vanishing white matter patients

artículo científico publicado en 2005

Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability

artículo científico publicado en 2003

Regulation of the phosphorylation of elongation factor 2 by MEK-dependent signalling in adult rat cardiomyocytes

artículo científico publicado en 2002

Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids

artículo científico publicado en 2014

Resonance assignment for the N-terminal region of the eukaryotic initiation factor 5 (eIF5)

artículo científico publicado en 2006

Rheb activates protein synthesis and growth in adult rat ventricular cardiomyocytes

artículo científico publicado en 2008

Ribosomal stress activates eEF2K-eEF2 pathway causing translation elongation inhibition and recruitment of terminal oligopyrimidine (TOP) mRNAs on polysomes

artículo científico publicado en 2014

Role of AMPK in regulation of LC3 lipidation as a marker of autophagy in skeletal muscle

artículo científico publicado en 2016

Roles of the mammalian target of rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesis.

artículo científico publicado en 2012

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling

artículo científico publicado en 2009

Serine 209, not serine 53, is the major site of phosphorylation in initiation factor eIF-4E in serum-treated Chinese hamster ovary cells

scientific article published on 01 September 1995

Severity of vanishing white matter disease does not correlate with deficits in eIF2B activity or the integrity of eIF2B complexes.

artículo científico publicado en 2011

Shut-down of translation, a global neuronal stress response: mechanisms and pathological relevance

artículo científico publicado en 2007

Signaling crosstalk between the mTOR complexes

artículo científico publicado en 2014

Signalling to translation: how signal transduction pathways control the protein synthetic machinery

artículo científico publicado en 2007

Stable isotope-labelling analysis of the impact of inhibition of the mammalian target of rapamycin on protein synthesis

artículo científico publicado en 2012

Staurosporine inhibits phosphorylation of translational regulators linked to mTOR.

artículo científico publicado en 2001

Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398

artículo científico publicado en 2004

Stoichiometry of the eIF2B complex is maintained by mutual stabilization of subunits

artículo científico publicado en 2015

Structure and phosphorylation of eukaryotic initiation factor 2. Casein kinase 2 and protein kinase C phosphorylate distinct but adjacent sites in the beta-subunit

artículo científico publicado en 1988

Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors

artículo científico publicado en 2006

Synthesis of human initiation factor-2 alpha in Saccharomyces cerevisiae

artículo científico publicado en 1991

Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1

artículo científico publicado en 2003

The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation

artículo científico publicado en 2003

The C-terminal domain of Mnk1a plays a dual role in tightly regulating its activity

artículo científico publicado en 2009

The Drosophila cell shape regulator c-Jun N-terminal kinase also functions as a stress-activated protein kinase

artículo científico publicado en 2001

The Drosophila protein kinase LK6 is regulated by ERK and phosphorylates the eukaryotic initiation factor eIF4E in vivo

artículo científico publicado en 2005

The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding

artículo científico publicado en 2015

The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1

artículo científico publicado en 2005

The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases).

artículo científico publicado en 2008

The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization

artículo científico publicado en 2003

The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2

artículo científico publicado en 2008

The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor alpha

artículo científico publicado en 2007

The RNA-binding properties of protein synthesis initiation factor eIF-2

artículo científico publicado en 1994

The activation of eukaryotic initiation factor (eIF)2B by growth factors in PC12 cells requires MEK/ERK signalling

scientific article published on 01 July 2000

The alpha-subunit of the mammalian guanine nucleotide-exchange factor eIF-2B is essential for catalytic activity in vitro

artículo científico publicado en 1996

The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK.

artículo científico publicado en 2008

The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation

artículo científico publicado en 2013

The effect of ethanol on polypeptide chain initiation in reticulocyte lysates. Inhibition of recycling of initiation factor eIF-2

artículo científico publicado en 1988

The eukaryotic initiation factor 4E-binding proteins and apoptosis

scientific article published on 01 June 2005

The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites

artículo científico publicado en 2002

The guanine nucleotide-exchange factor, eIF-2B

artículo científico publicado en 1994

The highly acidic C-terminal region of the yeast initiation factor subunit 2 alpha (eIF-2 alpha) contains casein kinase phosphorylation sites and is essential for maintaining normal regulation of GCN4.

artículo científico publicado en 1995

The mTOR pathway in the control of protein synthesis

artículo científico publicado en 2006

The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells

artículo científico publicado en 2001

The multifaceted role of mTOR in cellular stress responses

artículo científico publicado en 2004

The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways

artículo científico publicado en 1998

The rapid activation of protein synthesis by growth hormone requires signaling through mTOR.

artículo científico publicado en 2007

The role of the beta-subunit of initiation factor eIF-2 in initiation complex formation

artículo científico publicado en 1993

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

artículo científico publicado en 2005

The two forms of the beta-subunit of initiation factor-2 from reticulocyte lysates arise from proteolytic degradation

scientific article published on 01 July 1989

The worm profits from undercharging

artículo científico publicado en 2009

Translation factors: in sickness and in health

artículo científico publicado en 2004

Translation matters: protein synthesis defects in inherited disease

artículo científico publicado en 2007

Translational regulation of terminal oligopyrimidine mRNAs induced by serum and amino acids involves distinct signaling events

artículo científico publicado en 2004

Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK

scientific journal article

Vanishing white matter: Eukaryotic initiation factor 2B model and the impact of missense mutations

artículo científico publicado en 2021

When translation meets transformation: the mTOR story

artículo científico publicado en 2006

beta-Adrenergic agonists increase phosphorylation of elongation factor 2 in cardiomyocytes without eliciting calcium-independent eEF2 kinase activity

artículo científico publicado en 2001

cAMP inhibits translation by inducing Ca2+/calmodulin-independent elongation factor 2 kinase activity in IPC-81 cells

artículo científico publicado en 1999

cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner

artículo científico publicado en 2008

eEF2K enhances expression of PD-L1 by promoting the translation of its mRNA

artículo científico publicado en 2020

eEF2K/eEF2 Pathway Controls the Excitation/Inhibition Balance and Susceptibility to Epileptic Seizures.

artículo científico publicado en 2016

eIF2 and the control of cell physiology

artículo científico publicado en 2004

eIF2B-related disorders: antenatal onset and involvement of multiple organs

artículo científico publicado en 2003

eIF2B: recent structural and functional insights into a key regulator of translation

artículo científico publicado en 2015

mTOR Signalling in Health and Disease ⬇️

artículo científico publicado el 1 de abril de 2011

mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging

artículo científico publicado en 2013

mTOR inhibitors in cancer therapy

artículo científico publicado en 2016

mTOR signaling regulates the processing of pre-rRNA in human cells

artículo científico publicado en 2011

mTOR-mediated regulation of translation factors by amino acids

artículo científico publicado en 2004

mTORC1 regulates the efficiency and cellular capacity for protein synthesis

artículo científico publicado en 2013

mTORC1 signaling controls multiple steps in ribosome biogenesis

artículo científico publicado en 2014

mTORC1 signaling: what we still don't know

artículo científico publicado en 2010

mTORC1 signalling and eIF4E/4E-BP1 translation initiation factor stoichiometry influence recombinant protein productivity from GS-CHOK1 cells.

artículo científico publicado en 2016

mTORC1 signalling and mRNA translation

scientific article published on February 2009

mTORC2 is a tyrosine kinase

artículo científico publicado en 2015

mTORC2 is a tyrosine kinase

artículo científico publicado en 2016

p70 S6 kinase is activated by sodium arsenite in adult rat cardiomyocytes: roles for phosphatidylinositol 3-kinase and p38 MAP kinase

scientific article published on 01 September 1997

p70 S6 kinase: an enigma with variations

artículo científico publicado en 1996

p90(RSK)s mediate the activation of ribosomal RNA synthesis by the hypertrophic agonist phenylephrine in adult cardiomyocytes

artículo científico publicado en 2013

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