Lista de obras - Stefan Gerhardt - Dominio Público Uruguay

4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1)

artículo científico publicado en 2016

4-Acyl pyrroles: mimicking acetylated lysines in histone code reading

artículo científico publicado en 2013

A Conformational Switch Triggers Nitrogenase Protection from Oxygen Damage by Shethna Protein II (FeSII)

artículo científico publicado en 2016

A combined spectroscopic and crystallographic approach to probing drug–human serum albumin interactions ⬇️

artículo científico publicado el 24 de septiembre de 2010

A mechanism to prevent production of reactive oxygen species by Escherichia coli respiratory complex I.

artículo científico publicado en 2019

Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study

artículo científico publicado en 2016

Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation

artículo científico publicado en 2016

Biocatalytic Properties and Structural Analysis of Phloroglucinol Reductases.

artículo científico publicado en 2016

Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe

artículo científico publicado en 2002

Crystal structure of Cdc11, a septin subunit from Saccharomyces cerevisiae

artículo científico publicado en 2016

Crystal structure of an archaeal pentameric riboflavin synthase in complex with a substrate analog inhibitor: stereochemical implications

artículo científico publicado en 2005

Crystal structure of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Bacillus subtilis

artículo científico publicado en 2003

Design, synthesis, and evaluation of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase

artículo científico publicado en 2002

Deterministic generation of bright single resonance fluorescence photons from a Purcell-enhanced quantum dot-micropillar system ⬇️

artículo científico publicado en 2015

Dipeptidyl nitrile inhibitors of Cathepsin L

artículo científico publicado en 2009

Discovery of a Potent, Selective, and Orally Bioavailable Acidic 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitor: Discovery of 2-[(3S)-1-[5-(Cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic Acid (AZD4017) ⬇️

artículo científico publicado el 19 de junio de 2012

Engineering a High-Affinity Anti-IL-15 Antibody: Crystal Structure Reveals an α-Helix in VH CDR3 as Key Component of Paratope ⬇️

artículo científico publicado el 16 de diciembre de 2010

Highly indistinguishable on-demand resonance fluorescence photons from a deterministic quantum dot micropillar device with 74% extraction efficiency ⬇️

artículo científico publicado en 2016

Improving coiled coil stability while maintaining specificity by a bacterial hitchhiker selection system

artículo científico publicado en 2014

Incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs lumazine synthase

artículo científico publicado en 2002

Lead optimisation of selective non-zinc binding inhibitors of MMP13. Part 2

artículo científico publicado en 2012

MacA is a Second Cytochrome c Peroxidase of Geobacter sulfurreducens

artículo científico publicado en 2012

Novel Acidic 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitor with Reduced Acyl Glucuronide Liability: The Discovery of 4-[4-(2-Adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic Acid (AZD8329) ⬇️

artículo científico publicado el 7 de noviembre de 2012

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes.

artículo científico publicado en 2016

Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase

artículo científico publicado en 2005

Quantum dot-micropillars: A bright source of coherent single photons

Riboflavin synthase of Schizosaccharomyces pombe. Protein dynamics revealed by 19F NMR protein perturbation experiments

artículo científico publicado en 2003

Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking

artículo científico publicado en 2015

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.

artículo científico publicado en 2015

Selective non zinc binding inhibitors of MMP13

artículo científico publicado en 2011

Structural and functional characterisation of the methionine adenosyltransferase from Thermococcus kodakarensis

artículo científico publicado en 2013

Structural and functional characterization of 4-hydroxyphenylpyruvate dioxygenase from the thermoacidophilic archaeon Picrophilus torridus.

artículo científico publicado en 2014

Structural basis of the action of glucosyltransferase Lgt1 from Legionella pneumophila

artículo científico publicado en 2010

Structural characterization of O- and C-glycosylating variants of the landomycin glycosyltransferase LanGT2

artículo científico publicado en 2015

Structure and Properties of an Engineered Transketolase from Maize

artículo científico publicado en 2003

Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids

artículo científico publicado en 2002

Structure of GlnK1, a signalling protein fromArchaeoglobus fulgidus ⬇️

artículo científico publicado el 21 de enero de 2011

Structure-Based Development of an Affinity Probe for Sirtuin 2

artículo científico publicado en 2016

Studies on the reaction mechanism of riboflavin synthase: X-ray crystal structure of a complex with 6-carboxyethyl-7-oxo-8-ribityllumazine

artículo científico publicado en 2002

The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis

artículo científico publicado en 2011

The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases

artículo científico publicado en 2012

Lista de obras de Stefan Gerhardt

4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1)

4-Acyl pyrroles: mimicking acetylated lysines in histone code reading

A Conformational Switch Triggers Nitrogenase Protection from Oxygen Damage by Shethna Protein II (FeSII)

A combined spectroscopic and crystallographic approach to probing drug–human serum albumin interactions ⬇️

A mechanism to prevent production of reactive oxygen species by Escherichia coli respiratory complex I.

Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study

Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation

Biocatalytic Properties and Structural Analysis of Phloroglucinol Reductases.

Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe

Crystal structure of Cdc11, a septin subunit from Saccharomyces cerevisiae

Crystal structure of an archaeal pentameric riboflavin synthase in complex with a substrate analog inhibitor: stereochemical implications

Crystal structure of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Bacillus subtilis

Design, synthesis, and evaluation of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase

Deterministic generation of bright single resonance fluorescence photons from a Purcell-enhanced quantum dot-micropillar system ⬇️

Dipeptidyl nitrile inhibitors of Cathepsin L

Discovery of a Potent, Selective, and Orally Bioavailable Acidic 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitor: Discovery of 2-[(3S)-1-[5-(Cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic Acid (AZD4017) ⬇️

Engineering a High-Affinity Anti-IL-15 Antibody: Crystal Structure Reveals an α-Helix in VH CDR3 as Key Component of Paratope ⬇️

Highly indistinguishable on-demand resonance fluorescence photons from a deterministic quantum dot micropillar device with 74% extraction efficiency ⬇️

Improving coiled coil stability while maintaining specificity by a bacterial hitchhiker selection system

Incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs lumazine synthase

Lead optimisation of selective non-zinc binding inhibitors of MMP13. Part 2

MacA is a Second Cytochrome c Peroxidase of Geobacter sulfurreducens

Novel Acidic 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitor with Reduced Acyl Glucuronide Liability: The Discovery of 4-[4-(2-Adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic Acid (AZD8329) ⬇️

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes.

Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase

Quantum dot-micropillars: A bright source of coherent single photons

Riboflavin synthase of Schizosaccharomyces pombe. Protein dynamics revealed by 19F NMR protein perturbation experiments

Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.

Selective non zinc binding inhibitors of MMP13

Structural and functional characterisation of the methionine adenosyltransferase from Thermococcus kodakarensis

Structural and functional characterization of 4-hydroxyphenylpyruvate dioxygenase from the thermoacidophilic archaeon Picrophilus torridus.

Structural basis of the action of glucosyltransferase Lgt1 from Legionella pneumophila

Structural characterization of O- and C-glycosylating variants of the landomycin glycosyltransferase LanGT2

Structure and Properties of an Engineered Transketolase from Maize

Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids

Structure of GlnK1, a signalling protein fromArchaeoglobus fulgidus ⬇️

Structure-Based Development of an Affinity Probe for Sirtuin 2

Studies on the reaction mechanism of riboflavin synthase: X-ray crystal structure of a complex with 6-carboxyethyl-7-oxo-8-ribityllumazine

The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis

The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases