Lista de obras - Alexandra Zhernakova - Dominio Público Uruguay

A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans.

artículo científico publicado en 2016

A genetic study on C5-TRAF1 and progression of joint damage in rheumatoid arthritis

artículo científico publicado en 2015

A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis

artículo científico publicado en 2013

A genetic variant in the region of MMP-9 is associated with serum levels and progression of joint damage in rheumatoid arthritis

artículo científico publicado en 2013

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

artículo científico publicado en 2007

ATG16L1andIL23RAre Associated With Inflammatory Bowel Diseases but Not With Celiac Disease in The Netherlands

article

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

artículo científico publicado en 2016

Analysis of 1135 gut metagenomes identifies sex-specific resistome profiles

artículo científico publicado en 2018

Analysis of HLA and non-HLA alleles can identify individuals at high risk for celiac disease

artículo científico publicado en 2009

Analysis of a functional BTNL2 polymorphism in type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus.

artículo científico publicado en 2005

Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes

artículo científico publicado en 2015

Association analysis of functional variants of the FcgRIIa and FcgRIIIa genes with type 1 diabetes, celiac disease and rheumatoid arthritis

artículo científico publicado en 2007

Association analysis of genetic variants in the myosin IXB gene in acute pancreatitis

artículo científico publicado en 2013

Association of DLG5 variants with gluten-sensitive enteropathy

article published in 2008

Association of Variants inIL2RAWith Progression of Joint Destruction in Rheumatoid Arthritis

artículo científico publicado en 2013

Association of genetic variants in the IL4 and IL4R genes with the severity of joint damage in rheumatoid arthritis: a study in seven cohorts

artículo científico publicado en 2013

Association of the TGF-beta receptor genes with abdominal aortic aneurysm.

artículo científico publicado en 2009

Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort

article by J. V. van Vliet-Ostaptchouk et al published 10 October 2006 in Diabetologia

Association study of functional genetic variants of innate immunity related genes in celiac disease

artículo científico publicado en 2005

Author Correction: Gut microbiome structure and metabolic activity in inflammatory bowel disease

scientific article published on 01 May 2019

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

scientific article published in Nature Communications

Blood lipids influence DNA methylation in circulating cells

artículo científico publicado en 2016

CTLA4 +49 A/G and CT60 polymorphisms in Dutch coeliac disease patients

artículo científico publicado en 2004

CTLA4 is differently associated with autoimmune diseases in the Dutch population

CTLA4/CT60 polymorphism is not relevant in susceptibility to autoimmune inflammatory intestinal disorders

Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

artículo científico publicado en 2019

Clinical implications of shared genetics and pathogenesis in autoimmune diseases

artículo científico publicado en 2013

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling

artículo científico publicado en 2009

Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics

artículo científico publicado en 2015

Common and different genetic background for rheumatoid arthritis and coeliac disease

artículo científico publicado en 2009

Convergent evolution in European and Rroma populations reveals pressure exerted by plague on Toll-like receptors

artículo científico publicado en 2014

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

artículo científico publicado en 2011

Detecting shared pathogenesis from the shared genetics of immune-related diseases

artículo científico publicado en 2009

Detection, imputation, and association analysis of small deletions and null alleles on oligonucleotide arrays

artículo científico publicado en 2008

Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch population

artículo científico publicado en 2005

Disease variants alter transcription factor levels and methylation of their binding sites

artículo científico publicado en 2016

Diversity and Ecology of Caudoviricetes Phages with Genome Terminal Repeats in Fecal Metagenomes from Four Dutch Cohorts

artículo científico publicado en 2022

Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms

artículo científico publicado en 2008

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

artículo científico publicado en 2016

Erratum: Corrigendum: Multiple common variants for celiac disease influencing immune gene expression

article

Evaluation of European coeliac disease risk variants in a north Indian population

artículo científico publicado en 2015

Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection

artículo científico publicado en 2010

Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease

artículo científico publicado en 2015

Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity.

artículo científico publicado en 2014

Functional implications of disease-specific variants in loci jointly associated with coeliac disease and rheumatoid arthritis

artículo científico publicado en 2015

Genetic Factors for the Severity of ACPA-negative Rheumatoid Arthritis in 2 Cohorts of Early Disease: A Genome-wide Study.

artículo científico publicado en 2015

Genetic Overlap Between Inflammatory Bowel Disease and Other Diseases

Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.

artículo científico publicado en 2008

Genetic and epigenetic regulation of gene expression in fetal and adult human livers

artículo científico publicado en 2014

Genetic risk scores and number of autoantibodies in patients with rheumatoid arthritis

artículo científico publicado en 2013

Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis

artículo científico publicado en 2012

Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis

artículo científico publicado en 2009

Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis.

artículo científico publicado en 2013

Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes

article

Genetic variation of the Fc gamma receptor 3B gene and association with rheumatoid arthritis.

artículo científico publicado en 2010

Genetic, parental and lifestyle factors influence telomere length

artículo científico publicado en 2022

Genetics of rheumatoid arthritis contributes to biology and drug discovery

artículo científico publicado en 2013

Genome-Wide Association Study Identifies Variants Associated With Autoimmune Hepatitis Type 1

article

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

artículo científico publicado en 2010

Global phylogeography and ancient evolution of the widespread human gut virus crAssphage

artículo científico publicado en 2019

Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome

scientific article published on 01 December 2018

Gut microbiota composition associated with stool consistency.

artículo científico publicado en 2015

HLA and Non-HLA Genes in Celiac Disease

article

HLA-DRB103:01 and HLA-DRB104:01 modify the presentation and outcome in autoimmune hepatitis type-1.

artículo científico publicado en 2015

Haplotype-based analysis of ulcerative colitis risk loci identifies both IL2 and IL21 as susceptibility genes in Han Chinese

artículo científico publicado en 2011

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

artículo científico publicado en 2012

Human disease-associated genetic variation impacts large intergenic non-coding RNA expression

artículo científico publicado en 2013

Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway

artículo científico publicado en 2013

Identification of TUB as a novel candidate gene influencing body weight in humans.

artículo científico publicado en 2006

Identification of context-dependent expression quantitative trait loci in whole blood

artículo científico publicado en 2016

Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis

scientific article published on January 2014

Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations

artículo científico publicado en 2015

Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas

scientific article published on 13 January 2020

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease

artículo científico publicado en 2016

Intestinal barrier gene variants may not explain the increased levels of antigliadin antibodies, suggesting other mechanisms than altered permeability

article

MICA marks additional risk factors for Type 1 diabetes on extended HLA haplotypes: An association and meta-analysis

article

Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci

scientific journal article

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.

artículo científico publicado en 2018

Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease

artículo científico publicado en 2020

Multiple common variants for celiac disease influencing immune gene expression

artículo científico publicado en 2010

Multiple independent variants in 6q21-22 associated with susceptibility to celiac disease in the Dutch, Finnish and Hungarian populations

artículo científico publicado en 2011

Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect

artículo científico publicado en 2005

Newly identified genetic risk variants for celiac disease related to the immune response

artículo científico publicado en 2008

Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases

artículo científico publicado en 2007

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

artículo científico publicado en 2016

Profile of volatile organic compounds in exhaled breath changes as a result of gluten-free diet

article

Proton pump inhibitors affect the gut microbiome

artículo científico publicado en 2015

Rapidly expanding knowledge on the role of the gut microbiome in health and disease

article

Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry

artículo científico publicado en 2011

Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis

artículo científico publicado en 2012

Six new coeliac disease loci replicated in an Italian population confirm association with coeliac disease.

artículo científico publicado en 2008

Studying associations between variants inTRAF1-C5andTNFAIP3-OLIG3and the progression of joint destruction in rheumatoid arthritis in multiple cohorts

scientific article published on 14 May 2012

Systematic annotation of celiac disease loci refines pathological pathways and suggests a genetic explanation for increased interferon-gamma levels

artículo científico publicado en 2014

Systematic identification of trans eQTLs as putative drivers of known disease associations

artículo científico publicado en 2013

TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits

artículo científico publicado en 2015

The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids

artículo científico publicado en 2015

The MYO9B Gene Is a Strong Risk Factor for Developing Refractory Celiac Disease

article

The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis

artículo científico publicado en 2003

The effect of host genetics on the gut microbiome

artículo científico

The genetics of East African populations: a Nilo-Saharan component in the African genetic landscape

artículo científico publicado en 2015

The importance of cohort studies in the post-GWAS era

artículo científico publicado en 2018

Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA

artículo científico publicado en 2011

Understanding human immune function using the resources from the Human Functional Genomics Project

artículo científico publicado en 2016

Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases

artículo científico publicado en 2015

Yoghurt consumption is associated with changes in the composition of the human gut microbiome and metabolome

artículo científico publicado en 2022

Lista de obras de Alexandra Zhernakova

A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans.

A genetic study on C5-TRAF1 and progression of joint damage in rheumatoid arthritis

A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis

A genetic variant in the region of MMP-9 is associated with serum levels and progression of joint damage in rheumatoid arthritis

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

ATG16L1andIL23RAre Associated With Inflammatory Bowel Diseases but Not With Celiac Disease in The Netherlands

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

Analysis of 1135 gut metagenomes identifies sex-specific resistome profiles

Analysis of HLA and non-HLA alleles can identify individuals at high risk for celiac disease

Analysis of a functional BTNL2 polymorphism in type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus.

Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes

Association analysis of functional variants of the FcgRIIa and FcgRIIIa genes with type 1 diabetes, celiac disease and rheumatoid arthritis

Association analysis of genetic variants in the myosin IXB gene in acute pancreatitis

Association of DLG5 variants with gluten-sensitive enteropathy

Association of Variants inIL2RAWith Progression of Joint Destruction in Rheumatoid Arthritis

Association of genetic variants in the IL4 and IL4R genes with the severity of joint damage in rheumatoid arthritis: a study in seven cohorts

Association of the TGF-beta receptor genes with abdominal aortic aneurysm.

Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort

Association study of functional genetic variants of innate immunity related genes in celiac disease

Author Correction: Gut microbiome structure and metabolic activity in inflammatory bowel disease

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

Blood lipids influence DNA methylation in circulating cells

CTLA4 +49 A/G and CT60 polymorphisms in Dutch coeliac disease patients

CTLA4 is differently associated with autoimmune diseases in the Dutch population

CTLA4/CT60 polymorphism is not relevant in susceptibility to autoimmune inflammatory intestinal disorders

Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

Clinical implications of shared genetics and pathogenesis in autoimmune diseases

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling

Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics

Common and different genetic background for rheumatoid arthritis and coeliac disease

Convergent evolution in European and Rroma populations reveals pressure exerted by plague on Toll-like receptors

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

Detecting shared pathogenesis from the shared genetics of immune-related diseases

Detection, imputation, and association analysis of small deletions and null alleles on oligonucleotide arrays

Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch population

Disease variants alter transcription factor levels and methylation of their binding sites

Diversity and Ecology of Caudoviricetes Phages with Genome Terminal Repeats in Fecal Metagenomes from Four Dutch Cohorts

Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

Erratum: Corrigendum: Multiple common variants for celiac disease influencing immune gene expression

Evaluation of European coeliac disease risk variants in a north Indian population

Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection

Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease

Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity.

Functional implications of disease-specific variants in loci jointly associated with coeliac disease and rheumatoid arthritis

Genetic Factors for the Severity of ACPA-negative Rheumatoid Arthritis in 2 Cohorts of Early Disease: A Genome-wide Study.

Genetic Overlap Between Inflammatory Bowel Disease and Other Diseases

Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.

Genetic and epigenetic regulation of gene expression in fetal and adult human livers

Genetic risk scores and number of autoantibodies in patients with rheumatoid arthritis

Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis

Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis

Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis.

Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes

Genetic variation of the Fc gamma receptor 3B gene and association with rheumatoid arthritis.

Genetic, parental and lifestyle factors influence telomere length

Genetics of rheumatoid arthritis contributes to biology and drug discovery

Genome-Wide Association Study Identifies Variants Associated With Autoimmune Hepatitis Type 1

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

Global phylogeography and ancient evolution of the widespread human gut virus crAssphage

Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome

Gut microbiota composition associated with stool consistency.

HLA and Non-HLA Genes in Celiac Disease

HLA-DRB1*03:01 and HLA-DRB1*04:01 modify the presentation and outcome in autoimmune hepatitis type-1.

Haplotype-based analysis of ulcerative colitis risk loci identifies both IL2 and IL21 as susceptibility genes in Han Chinese

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

Human disease-associated genetic variation impacts large intergenic non-coding RNA expression

Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway

Identification of TUB as a novel candidate gene influencing body weight in humans.

Identification of context-dependent expression quantitative trait loci in whole blood

Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis

Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations

Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease

Intestinal barrier gene variants may not explain the increased levels of antigliadin antibodies, suggesting other mechanisms than altered permeability

MICA marks additional risk factors for Type 1 diabetes on extended HLA haplotypes: An association and meta-analysis

Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.

Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease

HLA-DRB103:01 and HLA-DRB104:01 modify the presentation and outcome in autoimmune hepatitis type-1.