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Lista de obras de Yuan-Ping Pang

A potent and selective tacrine analog--biomembrane permeation and physicochemical characterization

scientific article published on 01 January 2005

A single amino acid of the human and rat neurotensin receptors (subtype 1) determining the pharmacological profile of a species-selective neurotensin agonist

artículo científico publicado en 2000

ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating

artículo científico publicado en 2004

Accurate reproduction of 161 small-molecule complex crystal structures using the EUDOC program: expanding the use of EUDOC to supramolecular chemistry

artículo científico publicado en 2007

Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity

artículo científico publicado en 2003

Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects.

artículo científico publicado en 2012

Alkylene tether-length dependent gamma-aminobutyric acid type A receptor competitive antagonism by tacrine dimers

artículo científico publicado en 2006

At least 10% shorter C-H bonds in cryogenic protein crystal structures than in current AMBER forcefields

artículo científico publicado en 2015

Atomic levers control pyranose ring conformations.

artículo científico publicado en 1999

Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization

artículo científico publicado en 2012

Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels

artículo científico publicado en 2006

Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptors.

artículo científico publicado en 2008

Bis(7)-tacrine, a novel acetylcholinesterase inhibitor, reverses AF64A-induced deficits in navigational memory in rats

artículo científico publicado en 2000

Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine

artículo científico publicado en 2000

Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia

artículo científico publicado en 2008

Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3β pathways

artículo científico publicado en 2013

Bis-imidazoles as molecular probes for peripheral sites of the zinc endopeptidase of botulinum neurotoxin serotype A.

artículo científico publicado en 2006

CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module

scientific article published on 02 November 2020

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

artículo científico publicado en 2014

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation.

artículo científico publicado en 2014

Characterization of an alternative BAK-binding site for BH3 peptides

artículo científico publicado en 2020

Chemical structure of Retro-2, a compound that protects cells against ribosome-inactivating proteins

artículo científico publicado en 2012

Chimeric rat/human neurotensin receptors localize a region of the receptor sensitive to binding of a novel, species-specific, picomolar affinity peptide

artículo científico publicado en 1996

Cholinergic and non-cholinergic functions of two acetylcholinesterase genes revealed by gene-silencing in Tribolium castaneum.

artículo científico publicado en 2012

Cholinesterase reactivation in vivo with a novel bis-oxime optimized by computer-aided design

artículo científico publicado en 2003

Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase

artículo científico publicado en 2002

Common pharmacophore of structurally distinct small-molecule inhibitors of intracellular retrograde trafficking of ribosome inactivating proteins

artículo científico publicado en 2013

Complexes of Alkylene-Linked Tacrine Dimers withTorpedo californicaAcetylcholinesterase: Binding of Bis(5)-tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge

artículo científico publicado en 2006

Computer-aided lead optimization: improved small-molecule inhibitor of the zinc endopeptidase of botulinum neurotoxin serotype A

artículo científico publicado en 2007

Configurational entropy in protein-peptide binding: computational study of Tsg101 ubiquitin E2 variant domain with an HIV-derived PTAP nonapeptide

artículo científico publicado en 2009

Convenient Synthesis of a Library of Discrete Hydroxamic Acids Using the Hydroxythiophenol (Marshall) Resin

artículo científico publicado en 2008

Corrigendum to 'Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor' [Neurosci. Lett. 288 (2000) 95–98]

artículo científico publicado en 2000

Critical role of the FERM domain in Pyk2 stimulated glioma cell migration

artículo científico publicado en 2006

Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase

scientific article published on 01 August 2005

Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates

scientific article published on 31 July 2006

Crystal structures of oxime-bound fenamiphos-acetylcholinesterases: reactivation involving flipping of the His447 ring to form a reactive Glu334-His447-oxime triad

artículo científico publicado en 2010

Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer's dimer, in rat blood

article

Differential binding of Sin3 interacting repressor domains to the PAH2 domain of Sin3A

artículo científico publicado en 2003

Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's β-Amyloid Neurotoxicity Via the Inhibition of Aβ Fibrils Formation and Disaggregation of Preformed Fibrils

artículo científico publicado en 2015

Discovery of a new inhibitor lead of adenovirus proteinase: steps toward selective, irreversible inhibitors of cysteine proteinases.

artículo científico publicado en 2001

Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities

artículo científico publicado en 1999

EUDOC: a computer program for identification of drug interaction sites in macromolecules and drug leads from chemical databases

scientific article published on 01 November 2001

East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A.

artículo científico publicado en 2007

Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect

artículo científico publicado en 2021

Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis

artículo científico publicado en 1999

Evaluation of the BH3-only protein Puma as a direct Bak activator

artículo científico publicado en 2013

FF12MC: A revised AMBER forcefield and new protein simulation protocol

artículo científico publicado en 2016

From genome to drug lead: identification of a small-molecule inhibitor of the SARS virus

artículo científico publicado en 2005

Genome organization, phylogenies, expression patterns, and three-dimensional protein models of two acetylcholinesterase genes from the red flour beetle

artículo científico publicado en 2012

Heterodimeric Tacrine-Based Acetylcholinesterase Inhibitors: Investigating Ligand−Peripheral Site Interactions

scientific article published on 01 October 1999

Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease

artículo científico publicado en 1996

How fast fast-folding proteins fold in silico

artículo científico publicado en 2017

Improved loading and cleavage methods for solid-phase synthesis using chlorotrityl resins: synthesis and testing of a library of 144 discrete chemicals as potential farnesyltransferase inhibitors

artículo científico publicado en 2004

In silico drug discovery: solving the "target-rich and lead-poor" imbalance using the genome-to-drug-lead paradigm

artículo científico publicado en 2007

In vitro binding and CNS effects of novel neurotensin agonists that cross the blood-brain barrier

artículo científico publicado en 1999

Inhibition by bis(7)-tacrine of native delayed rectifier and KV1.2 encoded potassium channels

artículo científico publicado en 2006

Inhibition of NMDA-gated ion channels by bis(7)-tacrine: whole-cell and single-channel studies

artículo científico publicado en 2008

Inhibition of mitochondrial respiration as a source of adaphostin-induced reactive oxygen species and cytotoxicity.

artículo científico publicado en 2007

Insect-specific irreversible inhibitors of acetylcholinesterase in pests including the bed bug, the eastern yellowjacket, German and American cockroaches, and the confused flour beetle

artículo científico publicado en 2010

Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds

artículo científico publicado en 2010

Low-mass molecular dynamics simulation for configurational sampling enhancement: More evidence and theoretical explanation

artículo científico publicado en 2015

Low-mass molecular dynamics simulation: a simple and generic technique to enhance configurational sampling

artículo científico publicado en 2014

Mechanism of bis(7)-tacrine inhibition of GABA-activated current in cultured rat hippocampal neurons.

artículo científico publicado en 2009

Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons.

artículo científico publicado en 2007

Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's Disease

artículo científico publicado en 2015

Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine

artículo científico publicado en 2006

Nonbonded bivalence approach to cell-permeable molecules that target DNA sequences

scientific article published on 01 June 2004

Normal-mode-analysis-monitored energy minimization procedure for generating small-molecule bound conformations

artículo científico publicado en 2007

Novel acetylcholinesterase target site for malaria mosquito control

artículo científico publicado en 2006

Novel and viable acetylcholinesterase target site for developing effective and environmentally safe insecticides

artículo científico publicado en 2012

Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets

artículo científico publicado en 2009

Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors

artículo científico publicado en 2005

Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents

scientific article published on 20 July 2007

Novel selective and irreversible mosquito acetylcholinesterase inhibitors for controlling malaria and other mosquito-borne diseases

artículo científico publicado en 2013

On the use of the experimentally determined enzyme inhibition constant as a measure of absolute binding affinity

artículo científico publicado en 2017

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1. ⬇️

artículo científico publicado en 2015

Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin

artículo científico publicado en 2010

Peptide-Binding Groove Contraction Linked to the Lack of T Cell Response: Using Complex Structure and Energy To Identify Neoantigens

scientific article published on 10 August 2018

Pharmacological and biochemical profiles of unique neurotensin 8-13 analogs exhibiting species selectivity, stereoselectivity, and superagonism

artículo científico publicado en 1995

Physiological roles for butyrylcholinesterase: A BChE-ghrelin axis

artículo científico publicado en 2016

Plasma butyrylcholinesterase regulates ghrelin to control aggression

artículo científico publicado en 2015

Polysaccharide elasticity governed by chair–boat transitions of the glucopyranose ring

artículo científico publicado en 1998

Potent new small-molecule inhibitor of botulinum neurotoxin serotype A endopeptidase developed by synthesis-based computer-aided molecular design

artículo científico publicado en 2009

Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors

artículo científico publicado en 1999

Preclinical characterization of intestinal absorption and metabolism of promising anti-Alzheimer's dimer bis(7)-tacrine

artículo científico publicado en 2008

Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication

artículo científico publicado en 2000

Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program

artículo científico publicado en 1994

Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies

artículo científico publicado en 1994

Preference of small molecules for local minimum conformations when binding to proteins

artículo científico publicado en 2007

Prime, Shock, and Kill: Priming CD4 T Cells from HIV Patients with a BCL-2 Antagonist before HIV Reactivation Reduces HIV Reservoir Size

artículo científico publicado en 2016

Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity

artículo científico publicado en 2007

Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently

artículo científico publicado en 2009

Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin

artículo científico publicado en 2015

Proteomics shows Hsp70 does not bind peptide sequences indiscriminately in vivo

artículo científico publicado en 2004

Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators

artículo científico publicado en 2003

Rational design of novel neurotensin mimetics: discovery of a pharmacologically unprecedented agent exhibiting concentration-dependent dual effects as antagonist and full agonist

scientific article published on 01 August 1994

Re-engineering butyrylcholinesterase as a cocaine hydrolase

artículo científico publicado en 2002

Regulation of error-prone translesion synthesis by Spartan/C1orf124.

artículo científico publicado en 2012

Robust Neuritogenesis-Promoting Activity by Bis(heptyl)-Cognitin Through the Activation of alpha7-Nicotinic Acetylcholine Receptor/ERK Pathway.

artículo científico publicado en 2015

Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice.

artículo científico publicado en 2002

Selective and Irreversible Inhibitors of Mosquito Acetylcholinesterases for Controlling Malaria and Other Mosquito-Borne Diseases

artículo científico publicado en 2009

Serotype-selective, small-molecule inhibitors of the zinc endopeptidase of botulinum neurotoxin serotype A

artículo científico publicado en 2005

Small molecules showing significant protection of mice against botulinum neurotoxin serotype A

artículo científico publicado en 2010

Small-Molecule Inhibitor Leads of Ribosome-Inactivating Proteins Developed Using the Doorstop Approach ⬇️

artículo científico publicado el 24 de marzo de 2011

Species marker for developing novel and safe pesticides

artículo científico publicado en 2006

Structure of HI-6*sarin-acetylcholinesterase determined by X-ray crystallography and molecular dynamics simulation: reactivator mechanism and design

artículo científico publicado en 2009

Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer's Dimer

artículo científico publicado en 2015

Substantial neuroprotection against K+ deprivation-induced apoptosis in primary cerebellar granule neurons by novel dimer bis(propyl)-cognitin via the activation of VEGFR-2 signaling pathway

artículo científico publicado en 2013

Successful Virtual Screening of a Chemical Database for Farnesyltransferase Inhibitor Leads

artículo científico publicado en 2000

Successful molecular dynamics simulation of two zinc complexes bridged by a hydroxide in phosphotriesterase using the cationic dummy atom method

artículo científico publicado en 2001

Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase.

artículo científico publicado en 2007

The antiangiogenic activity of cleaved high molecular weight kininogen is mediated through binding to endothelial cell tropomyosin

artículo científico publicado en 2002

The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine

artículo científico publicado en 2007

Theoretical 3D model of histamine N-methyltransferase: insights into the effects of a genetic polymorphism on enzymatic activity and thermal stability

artículo científico publicado en 2001

Three-dimensional model of a substrate-bound SARS chymotrypsin-like cysteine proteinase predicted by multiple molecular dynamics simulations: catalytic efficiency regulated by substrate binding

artículo científico publicado en 2004

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

artículo científico publicado en 2011

Use of 1-4 interaction scaling factors to control the conformational equilibrium between α-helix and β-strand

artículo científico publicado en 2014

Use of multiple picosecond high-mass molecular dynamics simulations to predict crystallographic B-factors of folded globular proteins

scientific article published on 20 September 2016

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