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Lista de obras de Alan R. Shuldiner

A Common Variant in the SETD7 Gene Predicts Serum Lycopene Concentrations

artículo científico publicado en 2016

A Genome-Wide Scan for Autoimmune Thyroiditis in the Old Order Amish: Replication of Genetic Linkage on Chromosome 5q11.2-q14.3

artículo científico publicado en 2003

A case of congenital generalized lipodystrophy: metabolic effects of four dietary regimens. Lack of association of CGL with polymorphism in the lamin A/C Gene

artículo científico publicado en 2001

A common variant in fibroblast growth factor binding protein 1 (FGFBP1) is associated with bone mineral density and influences gene expression in vitro

artículo científico publicado en 2010

A common variant in the telomerase RNA component is associated with short telomere length

artículo científico publicado en 2010

A functional haplotype in EIF2AK3, an ER stress sensor, is associated with lower bone mineral density

artículo científico publicado en 2012

A functional variant in the peroxisome proliferator-activated receptor gamma2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians

artículo científico publicado en 2003

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

artículo científico publicado en 2012

A genome-wide association search for type 2 diabetes genes in African Americans

artículo científico publicado en 2012

A genome-wide linkage scan of insulin level derived traits: the Amish Family Diabetes Study

artículo científico publicado en 2007

A genome-wide scan of serum lipid levels in the Old Order Amish

artículo científico publicado en 2004

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function

artículo científico publicado en 2013

A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference

artículo científico publicado en 2002

A mutation of the b3-adrenergic receptor is associated with visceral obesity but decreased serum triglyceride

artículo científico publicado en 1997

A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection

artículo científico publicado en 2008

A rapid and versatile method to synthesize internal standards for competitive PCR

artículo científico publicado en 1993

A recombinant rat regenerating protein is mitogenic to pancreatic derived cells

artículo científico publicado en 2000

Accounting for relatedness in family based genetic association studies

artículo científico publicado en 2007

Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits

artículo científico publicado en 2007

Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications

artículo científico publicado en 2006

American Diabetes Association and JDRF Research Symposium: Diabetes and the Microbiome

artículo científico publicado en 2015

Analysis of the bereavement effect after the death of a spouse in the Amish: a population-based retrospective cohort study

artículo científico publicado en 2014

Analysis of the gut microbiota in the old order Amish and its relation to the metabolic syndrome.

artículo científico publicado en 2012

Analysis of the peroxisome proliferator activated receptor gamma (PPARgamma) gene in HAIRAN syndrome with obesity

article

Anti-inflammatory effects of simvastatin on adipokines in type 2 diabetic patients with carotid atherosclerosis

artículo científico publicado en 2009

Aspirin Resistance in healthy drug-naive men versus women (from the Heredity and Phenotype Intervention Heart Study).

artículo científico publicado en 2009

Assessment of sex-specific genetic and environmental effects on bone mineral density

artículo científico publicado en 2004

Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits

artículo científico publicado en 2016

Assignment of the human pancreatic regenerating (REG) gene to chromosome 2p12

artículo científico publicado en 1994

Association between bilirubin and cardiovascular disease risk factors: using Mendelian randomization to assess causal inference

artículo científico publicado en 2012

Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies

artículo científico publicado en 2011

Association between obesity and a polymorphism in the β1-adrenoceptor gene (Gly389Arg ADRB1) in Caucasian women

article

Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians.

artículo científico publicado en 1998

Association of APOE polymorphism with chronic kidney disease in a nationally representative sample: a Third National Health and Nutrition Examination Survey (NHANES III) Genetic Study

artículo científico publicado en 2009

Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish

artículo científico publicado en 2008

Association of a polymorphism in the beta 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns.

artículo científico publicado en 1995

Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy

artículo científico publicado en 2009

Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease

artículo científico publicado en 2010

Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations

article

Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification

artículo científico publicado en 2010

Associations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the old order Amish

artículo científico publicado en 2007

Associations of autozygosity with a broad range of human phenotypes

scientific article published on 31 October 2019

Autoantibodies in Type 1 and Type 2 diabetes in the Old Order Amish of Lancaster County, Pennsylvania.

artículo científico publicado en 2003

Autosome-wide linkage analysis of hip structural phenotypes in the Old Order Amish

artículo científico publicado en 2008

BMI in the Old Order Amish

artículo científico publicado en 2004

COL4A1 is associated with arterial stiffness by genome-wide association scan

artículo científico publicado en 2009

CPT1A methylation is associated with plasma adiponectin

artículo científico publicado en 2016

CUBN is a gene locus for albuminuria

artículo científico publicado en 2011

CYP2C19 Genotype and Cardiovascular Events

artículo científico publicado en 2012

CYP2C19 and clopidogrel response: more than validation in the real world

artículo científico publicado en 2012

CYP2C19 metabolizer status and clopidogrel efficacy in the Secondary Prevention of Small Subcortical Strokes (SPS3) study

artículo científico publicado en 2015

Calcified granulomatous disease: occupational associations and lack of familial aggregation

artículo científico publicado en 2014

Candidate gene association study of coronary artery calcification in chronic kidney disease: findings from the CRIC study (Chronic Renal Insufficiency Cohort).

artículo científico publicado en 2013

Cardiovascular pharmacogenomics

artículo científico publicado en 2011

Carrying one or two reduced-function CYP2C19 alleles is associated with an increased risk of major adverse cardiovascular events in people undergoing percutaneous coronary intervention and treated with clopidogrel

artículo científico publicado en 2011

Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common, functional Pro12Ala peroxisome proliferator-activated receptor-gamma2 gene variant: results from the Troglitazone in Prevention of

artículo científico publicado en 2004

Chromosomal Localization and Partial Genomic Structure of the Human Peroxisome Proliferator Activated Receptor-Gamma (hPPARγ) Gene

article

Chronotype and seasonality: morningness is associated with lower seasonal mood and behavior changes in the Old Order Amish

artículo científico publicado en 2014

Clinical Pharmacogenetics Implementation Consortium guidelines for CYP2C19 genotype and clopidogrel therapy: 2013 update.

artículo científico publicado en 2013

Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy

artículo científico publicado en 2011

Clopidogrel Improves Skin Microcirculatory Endothelial Function in Persons With Heightened Platelet Aggregation

artículo científico publicado en 2016

Clopidogrel pharmacogenetics: Beyond candidate genes and genome-wide association studies

artículo científico publicado en 2016

Clopidogrel: a case for indication-specific pharmacogenetics

artículo científico publicado en 2012

Cognitive profiles and heritability estimates in the Old Order Amish

artículo científico publicado en 2016

Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium

artículo científico publicado en 2011

Common variants associated with plasma triglycerides and risk for coronary artery disease

artículo científico publicado en 2013

Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program

artículo científico publicado en 2010

Common variants in Mendelian kidney disease genes and their association with renal function

artículo científico publicado en 2013

Common variants in the GDF5-UQCC region are associated with variation in human height

artículo científico publicado en 2008

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia

artículo científico publicado en 2009

Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects

artículo científico publicado en 2007

Comparative studies of resistin expression and phylogenomics in human and mouse

artículo científico publicado en 2003

Comparison of BMI and physical activity between old order Amish children and non-Amish children

artículo científico publicado en 2012

Competitive Reverse-Transcriptase Polymerase Chain Reaction without an Artificial Internal Standard

artículo científico publicado en 1995

Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

artículo científico publicado en 2017

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2016

Correlation of circulating MMP-9 with white blood cell count in humans: effect of smoking

artículo científico publicado en 2013

DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation

artículo científico publicado en 2017

Decreased bone mineral density in subjects carrying familial defective apolipoprotein B-100.

artículo científico publicado en 2013

Defining the role of common variation in the genomic and biological architecture of adult human height

artículo científico publicado en 2014

Determinants of blood pressure response to low-salt intake in a healthy adult population

artículo científico publicado en 2011

Determinants of coronary artery and aortic calcification in the Old Order Amish

artículo científico publicado en 2007

Determination of Gene Dosage by a Quantitative Adaptation of the Polymerase Chain Reaction (gd-PCR): Rapid Detection of Deletions and Duplications of Gene Sequences

article

Determination of the genomic structures of two nonallelic preproinsulin genes in Xenopus laevis using the polymerase chain reaction

artículo científico publicado en 1995

Development of a physiology-directed population pharmacokinetic and pharmacodynamic model for characterizing the impact of genetic and demographic factors on clopidogrel response in healthy adults

artículo científico publicado en 2015

Differences in prevalence and severity of coronary artery calcification between two non-Hispanic white populations with diverse lifestyles

artículo científico publicado en 2007

Directional dominance on stature and cognition in diverse human populations

artículo científico publicado en 2015

Discovery and refinement of loci associated with lipid levels

artículo científico publicado en 2013

Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study

artículo científico publicado en 2016

Does having children extend life span? A genealogical study of parity and longevity in the Amish

scientific article published on 01 February 2006

ERRATUM: Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

article by Matthew B. Lanktree et al published June 2012 in American Journal of Human Genetics

Educational innovations in clinical pharmacogenomics

artículo científico publicado en 2016

Effect of the Pro12Ala variant of the human peroxisome proliferator-activated receptor gamma 2 gene on adiposity, fat distribution, and insulin sensitivity in Japanese men.

artículo científico publicado en 1998

Effect of zinc supplementation on insulin secretion: interaction between zinc and SLC30A8 genotype in Old Order Amish

artículo científico publicado en 2014

Effectiveness of clopidogrel dose escalation to normalize active metabolite exposure and antiplatelet effects in CYP2C19 poor metabolizers

artículo científico publicado en 2014

Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program

artículo científico publicado en 2012

Elabela-apelin receptor signaling pathway is functional in mammalian systems

artículo científico publicado en 2015

Endurance training-induced changes in the insulin response to oral glucose are associated with the peroxisome proliferator-activated receptor-gamma2 Pro12Ala genotype in men but not in women

artículo científico publicado en 2005

Erratum to “Comparative studies of resistin expression and phylogenomics in human and mouse” [Biochem. Biophys. Res. Commun. 310 (2003) 927–935]

scholarly article published in Biochemical and Biophysical Research Communications

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

artículo científico publicado en 2011

Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

artículo científico publicado en 2010

Ethical and practical guidelines for reporting genetic research results to study participants: updated guidelines from a National Heart, Lung, and Blood Institute working group

artículo científico publicado en 2010

Evaluation of A2BP1 as an obesity gene ⬇️

artículo científico publicado en 2010

Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels.

artículo científico publicado en 2015

Evidence that Rho guanine nucleotide exchange factor 11 (ARHGEF11) on 1q21 is a type 2 diabetes susceptibility gene in the Old Order Amish.

artículo científico publicado en 2007

Evidence that Xenopus laevis contains two different nonallelic insulin-like growth factor-I genes

article

Exploring the genetics of longevity in the Old Order Amish

artículo científico publicado en 2005

Expression, purification, and initial characterization of human alanine aminotransferase (ALT) isoenzyme 1 and 2 in High-five insect cells

artículo científico publicado en 2008

Extension of GWAS results for lipid-related phenotypes to extreme obesity using electronic health record (EHR) data and the Metabochip

artículo científico publicado en 2014

Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program

artículo científico publicado en 2008

Extent and distribution of linkage disequilibrium in the Old Order Amish

artículo científico publicado en 2010

FABP2 genotype is associated with insulin sensitivity in older women

artículo científico publicado en 2001

FTO genotype is associated with phenotypic variability of body mass index

artículo científico publicado en 2012

Familial aggregation of tobacco use behaviors among Amish men.

artículo científico publicado en 2014

Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the old order amish

artículo científico publicado en 2010

From Genotype to Phenotype: Nonsense Variants in SLC13A1 Are Associated with Decreased Serum Sulfate and Increased Serum Aminotransferases

artículo científico publicado en 2016

From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.

artículo científico publicado en 2008

Functional variants in MBL2 are associated with type 2 diabetes and pre-diabetes traits in Pima Indians and the old order Amish

artículo científico publicado en 2010

Gender differences in first and secondhand smoke exposure, spirometric lung function and cardiometabolic health in the old order Amish: A novel population without female smoking

artículo científico publicado en 2017

Gene Expression Differences Between Offspring of Long-Lived Individuals and Controls in Candidate Longevity Regions: Evidence for PAPSS2 as a Longevity Gene

artículo científico publicado en 2016

Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations

artículo científico publicado en 2013

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

artículo científico publicado en 2017

Genetic and environmental influences on bone mineral density in pre- and post-menopausal women

artículo científico publicado en 2005

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

artículo científico publicado en 2014

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

artículo científico publicado en 2016

Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium

artículo científico publicado en 2012

Genetic effects on postprandial variations of inflammatory markers in healthy individuals

artículo científico publicado en 2009

Genetic evidence of assortative mating in humans

article

Genetic identification of familial hypercholesterolemia within a single U.S. health care system

artículo científico publicado en 2016

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

artículo científico publicado en 2018

Genetic influences on blood pressure response to the cold pressor test: results from the Heredity and Phenotype Intervention Heart Study

artículo científico publicado en 2008

Genetic loci influencing kidney function and chronic kidney disease

artículo científico publicado en 2010

Genetic modulation of lipid profiles following lifestyle modification or metformin treatment: the Diabetes Prevention Program

artículo científico publicado en 2012

Genetic nondiscrimination legislation: a critical prerequisite for pharmacogenomics data sharing

artículo científico publicado en 2007

Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program

artículo científico publicado en 2011

Genetic studies of body mass index yield new insights for obesity biology

artículo científico publicado en 2015

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

artículo científico publicado en 2011

Genetic variation at NCAN locus is associated with inflammation and fibrosis in non-alcoholic fatty liver disease in morbid obesity

artículo científico publicado en 2013

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

scientific journal article

Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes

scientific article published on 07 February 2013

Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish

artículo científico publicado en 2005

Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity

artículo científico publicado en 1995

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

artículo científico publicado en 2011

Genetic variation of glucose transporter-1 (GLUT1) and albuminuria in 10,278 European Americans and African Americans: a case-control study in the Atherosclerosis Risk in Communities (ARIC) study

artículo científico publicado en 2011

Genetics of diabetes

artículo científico publicado en 2004

Genetics of obesity: More complicated than initially thought ⬇️

artículo científico publicado el 1 de febrero de 2003

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

artículo científico publicado en 2018

Genome-wide analysis of clopidogrel active metabolite levels identifies novel variants that influence antiplatelet response

artículo científico publicado en 2017

Genome-wide and fine-mapping linkage studies of type 2 diabetes and glucose traits in the Old Order Amish: evidence for a new diabetes locus on chromosome 14q11 and confirmation of a locus on chromosome 1q21-q24.

artículo científico publicado en 2003

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

artículo científico publicado en 2013

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits

artículo científico publicado en 2011

Genome-wide association and functional follow-up reveals new loci for kidney function

artículo científico publicado en 2012

Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum MMP-1 levels

artículo científico publicado en 2009

Genome-wide association studies identified novel loci for non-high-density lipoprotein cholesterol and its postprandial lipemic response.

artículo científico publicado en 2014

Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction

artículo científico publicado en 2011

Genome-wide association study of kidney function decline in individuals of European descent

artículo científico publicado en 2014

Genome-wide association study of triglyceride response to a high-fat meal among participants of the NHLBI Genetics of Lipid Lowering Drugs and Diet Network (GOLDN)

artículo científico publicado en 2015

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

artículo científico publicado en 2012

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

artículo científico publicado en 2017

Genome-wide scan of obesity in the Old Order Amish

artículo científico publicado en 2001

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

artículo científico publicado en 2014

Genomic characterization of the coding region of the human type II 5'-deiodinase gene.

artículo científico publicado en 1998

Genomics: Variations in blood lipids

artículo científico publicado en 2010

Genotype-based changes in serum uric acid affect blood pressure

artículo científico publicado en 2011

Genotyping: one piece of the puzzle to personalize antiplatelet therapy

artículo científico publicado en 2010

Global implementation of genomic medicine: We are not alone

artículo científico publicado en 2015

Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study

artículo científico publicado en 2009

Hepatic Lipase Genotype, Diabetes Risk, and Implications for Preventative Medicine

artículo científico publicado en 2004

Heritability of complex white matter diffusion traits assessed in a population isolate

artículo científico publicado en 2015

Heritability of life span in the Old Order Amish.

artículo científico publicado en 2001

Heritability of plasma neopterin levels in the Old Order Amish

artículo científico publicado en 2017

Heritability of serum sodium concentration: evidence for sex- and ethnic-specific effects

artículo científico publicado en 2011

Homozygosity by descent mapping of blood pressure in the Old Order Amish: evidence for sex specific genetic architecture

artículo científico publicado en 2007

Hundreds of variants clustered in genomic loci and biological pathways affect human height

artículo científico publicado en 2010

Hybrid DNA artifact from PCR of closely related target sequences.

artículo científico publicado en 1989

Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality

artículo científico publicado en 2011

Identification of a variant in KDR associated with serum VEGFR2 and pharmacodynamics of Pazopanib

artículo científico publicado en 2014

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

artículo científico publicado en 2013

Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations

artículo científico publicado en 2007

Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action

artículo científico publicado en 2006

Identifying clinically relevant sources of variability: The clopidogrel challenge

artículo científico publicado en 2016

Impact of common variation in bone-related genes on type 2 diabetes and related traits

artículo científico publicado en 2012

Implementation of pharmacogenetics: the University of Maryland Personalized Anti-platelet Pharmacogenetics Program

artículo científico publicado en 2014

Implementing Genomic Medicine in the Clinic

Implementing genomic medicine in the clinic: the future is here

artículo científico publicado en 2013

Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease

artículo científico publicado en 2016

Insulin response to glucose is lower in individuals homozygous for the Arg 64 variant of the beta-3-adrenergic receptor

artículo científico publicado en 2000

Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function

artículo científico publicado en 2012

Investigations of the Y chromosome, male founder structure and YSTR mutation rates in the Old Order Amish

artículo científico publicado en 2007

Isolation and characterization of two different insulins from an amphibian, Xenopus laevis

artículo científico publicado en 1989

KCNQ1 and Long QT Syndrome in 1/45 Amish: The Road from Identification to Implementation of Culturally Appropriate Precision Medicine

artículo científico publicado en 2020

Lack of IRS-1 codon 513 and 972 polymorphism in Pima Indians

artículo científico publicado en 1995

Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci.

artículo científico publicado en 2012

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

artículo científico publicado en 2012

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

artículo científico publicado en 2012

Letter by Gurbel et al regarding article, "Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement".

artículo científico publicado en 2010

Ligase-free subcloning: a versatile method to subclone polymerase chain reaction (PCR) products in a single day.

artículo científico publicado en 1991

Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q

artículo científico publicado en 2009

Linkage of Plasma Adiponectin Levels to 3q27 Explained by Association With Variation in the APM1 Gene

article

Lipoprotein genotype and conserved pathway for exceptional longevity in humans

artículo científico publicado en 2006

Living the good life? Mortality and hospital utilization patterns in the Old Order Amish

artículo científico publicado en 2012

Loci influencing blood pressure identified using a cardiovascular gene-centric array

artículo científico publicado en 2013

Loci influencing blood pressure identified using a cardiovascular gene-centric array.

artículo científico publicado en 2013

Mammographic breast density--evidence for genetic correlations with established breast cancer risk factors

artículo científico publicado en 2008

Mapping Genes in Isolated Populations: Lessons from the Old Order Amish

article

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

artículo científico publicado en 2010

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

artículo científico publicado en 2010

Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

artículo científico publicado en 2009

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque

artículo científico publicado en 2011

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels

artículo científico publicado en 2011

Metformin pharmacogenomics: current status and future directions

artículo científico publicado en 2014

Modeled nitrate levels in well water supplies and prevalence of abnormal thyroid conditions among the Old Order Amish in Pennsylvania

artículo científico publicado en 2012

Molecular scanning for mutations in the beta 3-adrenergic receptor gene in Nauruans with obesity and noninsulin-dependent diabetes mellitus

artículo científico publicado en 1996

Molecular scanning of beta-3-adrenergic receptor gene in total congenital lipoatrophic diabetes mellitus

artículo científico publicado en 1997

Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutation

artículo científico publicado en 1997

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

scientific article published on 21 May 2020

Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation

artículo científico publicado en 2016

Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver

artículo científico publicado en 2004

Mutations in Gng3lg and AGPAT2 in Berardinelli-Seip congenital lipodystrophy and Brunzell syndrome: phenotype variability suggests important modifier effects

artículo científico publicado en 2004

N-cyclo-[Leu5]enkephalin: A rational approach for the synthesis of conformationally restricted cyclic pentapeptides

artículo científico publicado en 1985

NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality

artículo científico

NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium

artículo científico publicado en 2009

New gene functions in megakaryopoiesis and platelet formation

artículo científico publicado en 2011

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

artículo científico publicado en 2010

New genetic loci link adipose and insulin biology to body fat distribution

artículo científico publicado en 2015

New loci associated with kidney function and chronic kidney disease

artículo científico publicado en 2010

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ⬇️

artículo científico publicado en 2016

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

artículo científico publicado en 2008

No effect of the Trp64Arg beta 3-adrenoceptor variant on in vivo lipolysis in subcutaneous adipose tissue

artículo científico publicado en 1997

No effect of the Trp64Arg beta(3)-adrenoceptor gene variant on weight loss, body composition, or energy expenditure in obese, caucasian postmenopausal women

artículo científico publicado en 2002

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

artículo científico publicado en 2012

Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes

artículo científico publicado en 2014

Obesity gene variant and elite endurance performance

article

Obesity genes and gene-environment-behavior interactions: recommendations for a way forward

artículo científico publicado en 2008

Obesity-related phenotypes and the beta3-adrenoceptor gene variant in postmenopausal women

artículo científico publicado en 1999

Omentin plasma levels and gene expression are decreased in obesity.

artículo científico publicado en 2007

Oxylipid Profile of Low-Dose Aspirin Exposure: A Pharmacometabolomics Study

artículo científico publicado en 2015

PCR-induced (ligase-free) subcloning: a rapid reliable method to subclone polymerase chain reaction (PCR) products

artículo científico publicado en 1990

Pancreatic reg gene expression is inhibited during cellular differentiation

artículo científico publicado en 1997

Pancreatic regeneration (reg) gene expression in a rat model of islet hyperplasia

article

Pancreatic thread protein is mitogenic to pancreatic-derived cells in culture

article

Paraoxonase 1 (PON1) gene variants are not associated with clopidogrel response

artículo científico publicado en 2011

Paraoxonase 1 Q192R variant and clopidogrel efficacy: fact or fiction?

artículo científico publicado en 2012

Persistent Staphylococcus aureus colonization is not a strongly heritable trait in Amish families

artículo científico publicado en 2011

PharmGKB summary: very important pharmacogene information for cytochrome P450, family 2, subfamily C, polypeptide 19.

artículo científico publicado en 2012

Pharmacogenetic Associations of β1-Adrenergic Receptor Polymorphisms With Cardiovascular Outcomes in the SPS3 Trial (Secondary Prevention of Small Subcortical Strokes).

artículo científico

Pharmacogenetics and clopidogrel response in patients undergoing percutaneous coronary interventions.

artículo científico publicado en 2011

Pharmacogenomics of anti-platelet and anti-coagulation therapy

artículo científico

Pharmacogenomics of anti-platelet therapy: how much evidence is enough for clinical implementation?

artículo científico publicado en 2013

Pharmacogenomics: application to the management of cardiovascular disease

artículo científico publicado en 2011

Pharmacogenomics: challenges and opportunities

artículo científico publicado en 2006

Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability

artículo científico publicado en 2014

Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function

artículo científico publicado en 2008

Physical activity and the association of common FTO gene variants with body mass index and obesity

artículo científico publicado en 2008

Platelet aggregation pathway

artículo científico publicado en 2011

Polymorphism in the calsequestrin 1 (CASQ1) gene on chromosome 1q21 is associated with type 2 diabetes in the old order Amish

artículo científico publicado en 2004

Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish

artículo científico publicado en 2004

Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes

artículo científico publicado en 2006

Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.

artículo científico publicado en 2006

Predictive Accuracy of a Clinical and Genetic Risk Model for Atrial Fibrillation

artículo científico publicado en 2021

Preparation and properties of poly(2,2-dialkyltrimethylene sulphones)

article

Prevalence, control, and treatment of diabetes, hypertension, and high cholesterol in the Amish

artículo científico publicado en 2020

Pro12Ala of the peroxisome proliferator-activated receptor-gamma2 gene is associated with lower serum insulin levels in nonobese African Americans: the Atherosclerosis Risk in Communities Study

artículo científico publicado en 2003

Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics

artículo científico publicado en 2013

Quantitative trait loci for BMD identified by autosome-wide linkage scan to chromosomes 7q and 21q in men from the Amish Family Osteoporosis Study.

artículo científico publicado en 2006

RNA template-specific polymerase chain reaction (RS-PCR): a novel strategy to reduce dramatically false positives ⬇️

artículo científico publicado el 2 de julio de 1990

Rapid synthesis of standards or allele-specific oligonucleotide hybridization

scientific article published on 01 June 1994

Reduced incidence of hip fracture in the Old Order Amish

artículo científico publicado en 2003

Relationship between Vascular Calcification and Bone Mineral Density in the Old-Order Amish

artículo científico publicado en 2007

Resistin, obesity, and insulin resistance--the emerging role of the adipocyte as an endocrine organ

artículo científico publicado en 2001

Responding to the clopidogrel warning by the US food and drug administration: real life is complicated

artículo científico publicado en 2010

Rethinking the genetic basis for comorbidity of schizophrenia and type 2 diabetes.

artículo científico publicado en 2010

Role of a proline insertion in the insulin promoter factor 1 (IPF1) gene in African Americans with type 2 diabetes

artículo científico publicado en 2006

Role of the beta 3-adrenergic receptor locus in obesity and noninsulin-dependent diabetes among members of Caucasian families with a diabetic sibling pair

artículo científico publicado en 1996

Seasonality of mood and behavior in the Old Order Amish

artículo científico publicado en 2012

Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder

artículo científico publicado en 2015

Serum 25-hydroxyvitamin d levels are not associated with subclinical vascular disease or C-reactive protein in the old order amish

artículo científico publicado en 2009

Serum alanine aminotransferase is correlated with hematocrit in healthy human subjects

artículo científico publicado en 2012

Seventy-five genetic loci influencing the human red blood cell

artículo científico publicado en 2012

Sex-specific effects of serum sulfate level and SLC13A1 nonsense variants on DHEA homeostasis.

artículo científico publicado en 2017

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

artículo científico publicado en 2013

Single nucleotide polymorphism upstream of interleukin 28B associated with phase 1 and phase 2 of early viral kinetics in patients infected with HCV genotype 1.

artículo científico publicado en 2011

Spaced administration of PA32540 and clopidogrel results in greater platelet inhibition than synchronous administration of enteric-coated aspirin and enteric-coated omeprazole and clopidogrel

Stroke Genetics Network (SiGN) study: design and rationale for a genome-wide association study of ischemic stroke subtypes

artículo científico publicado en 2013

TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program

artículo científico publicado en 2011

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

artículo científico publicado en 2006

TCF7L2 variants associate with CKD progression and renal function in population-based cohorts

artículo científico publicado en 2008

TM6SF2 rs58542926 impacts lipid processing in liver and small intestine.

artículo científico publicado en 2016

TRP64ARG β3-adrenergic receptor and obesity in Mexican Americans

scientific article published on 01 December 1997

Telomere length is paternally inherited and is associated with parental lifespan

artículo científico publicado en 2007

The ABCG8 G574R variant, serum plant sterol levels, and cardiovascular disease risk in the Old Order Amish

artículo científico publicado en 2012

The C allele of ATM rs11212617 does not associate with metformin response in the Diabetes Prevention Program

artículo científico publicado en 2012

The CAPN2/CAPN8 Locus on Chromosome 1q Is Associated with Variation in Serum Alpha-Carotene Concentrations

artículo científico publicado en 2016

The CFTR Met 470 allele is associated with lower birth rates in fertile men from a population isolate

artículo científico publicado en 2010

The CYP2C19*17 variant is not independently associated with clopidogrel response

artículo científico publicado en 2013

The IGNITE network: a model for genomic medicine implementation and research

artículo científico publicado en 2016

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2015

The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation

artículo científico publicado en 2013

The Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study: Variation in Platelet Response to Clopidogrel and Aspirin

artículo científico publicado en 2015

The Relationship between Parity and Bone Mineral Density in Women Characterized by a Homogeneous Lifestyle and High Parity

artículo científico publicado en 2005

The Thr92Ala deiodinase type 2 (DIO2) variant is not associated with type 2 diabetes or indices of insulin resistance in the old order of Amish

artículo científico publicado en 2005

The association of coronary artery calcification and carotid artery intima-media thickness with distinct, traditional coronary artery disease risk factors in asymptomatic adults

artículo científico publicado en 2008

The association of podocin R229Q polymorphism with increased albuminuria or reduced estimated GFR in a large population-based sample of US adults

artículo científico publicado en 2008

The beta3-adrenergic receptor in the obesity and diabetes prone rhesus monkey is very similar to human and contains arginine at codon 64.

artículo científico publicado en 1997

The common genetic influence over processing speed and white matter microstructure: Evidence from the Old Order Amish and Human Connectome Projects

artículo científico publicado en 2015

The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to CYP2C19*2 genotype: first experience in patients

artículo científico publicado en 2009

The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response

artículo científico publicado en 2013

The genetic interface between gestational diabetes and type 2 diabetes

artículo científico

The genetic response to short-term interventions affecting cardiovascular function: rationale and design of the Heredity and Phenotype Intervention (HAPI) Heart Study

artículo científico publicado en 2008

The genetics of obesity.

artículo científico publicado en 2003

The influence of rare genetic variation in SLC30A8 on diabetes incidence and β-cell function

artículo científico publicado en 2014

The insulin-like growth factor I (IGF-I) gene is expressed in chick embryos during early organogenesis

artículo científico publicado en 1990

The pharmacogenetics research network: from SNP discovery to clinical drug response.

artículo científico publicado en 2007

The relation between CYP2C19 genotype and phenotype in stented patients on maintenance dual antiplatelet therapy

artículo científico publicado en 2011

The role of cigarette smoking and statins in the development of postmenopausal osteoporosis: a pilot study utilizing the Marshfield Clinic Personalized Medicine Cohort

artículo científico publicado en 2009

The two nonallelic insulin-like growth factor-I genes in Xenopus laevis are differentially regulated during development

artículo científico publicado en 1994

The worry about clopidogrel "nonresponsiveness": identification and treatment in the post-percutaneous coronary intervention patient

artículo científico publicado en 2009

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

artículo científico publicado en 2010

Thrombin-induced platelet-fibrin clot strength: Relation to high on-clopidogrel platelet reactivity, genotype, and post-percutaneous coronary intervention outcomes

Time of Onset of Non-Insulin-Dependent Diabetes Mellitus and Genetic Variation in the β3-Adrenergic–Receptor Gene ⬇️

artículo científico publicado el 10 de agosto de 1995

Transgenic Animals

scientific article published on 01 March 1996

Unique lipoprotein phenotype and genotype associated with exceptional longevity

artículo científico publicado en 2003

User-centered design of multi-gene sequencing panel reports for clinicians

artículo científico publicado en 2016

Variable bone fragility associated with an Amish COL1A2 variant and a knock-in mouse model

artículo científico publicado en 2010

Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians

artículo científico publicado en 2007

Variants in scavenger receptor class B type I gene are associated with HDL cholesterol levels in younger women

artículo científico publicado en 2007

Variants in the ghrelin gene are associated with metabolic syndrome in the Old Order Amish

artículo científico publicado en 2005

Variants of the insulin receptor substrate-1 and fatty acid binding protein 2 genes and the risk of type 2 diabetes, obesity, and hyperinsulinemia in African-Americans: the Atherosclerosis Risk in Communities Study

article

Variation Within the Gene Encoding the Upstream Stimulatory Factor 1 Does Not Influence Susceptibility to Type 2 Diabetes in Samples From Populations With Replicated Evidence of Linkage to Chromosome 1q

article

Variation in the lamin A/C gene: associations with metabolic syndrome

artículo científico publicado en 2004

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels

artículo científico publicado en 2008

Vesicle-associated membrane protein 4, a positional candidate gene on 1q24-q25, is not associated with type 2 diabetes in the Old Order Amish

artículo científico publicado en 2005

Vitamin and supplement use among old order amish: sex-specific prevalence and associations with use

artículo científico publicado en 2014

cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase

artículo científico publicado en 2002

β2- and β3-Adrenergic receptor polymorphisms and exercise hemodynamics in postmenopausal women

article

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