Lista de obras - Søren Brøgger Christensen

19alpha-Hydroxy-3-oxo-ursa-1,12-dien-28-oic acid, an antiplasmodial triterpenoid isolated from Canthium multiflorum

artículo científico publicado en 2009

6-O-Methylkrigeine, a new Amaryllidaceae alkaloid fromNerine huttoniaeSchönland

A Trojan horse in drug development: targeting of thapsigargins towards prostate cancer cells

artículo científico publicado en 2009

A new flavonol glycoside and other flavonoids from the aerial parts of Taverniera aegyptiaca

artículo científico publicado en 2018

A new oxygenated ursane derivative from Canthium multiflorum

artículo científico publicado en 2008

A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca2+-ATPase inhibitors from Thapsia villosa

artículo científico publicado en 2009

A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases ⬇️

artículo científico publicado el 1 de abril de 1998

Absolute configuration and antiprotozoal activity of minquartynoic acid

artículo científico publicado en 2000

Accelerating the Domestication of New Crops: Feasibility and Approaches

artículo científico publicado en 2017

Alkaloid analysis by high-performance liquid chromatography-solid phase extraction-nuclear magnetic resonance: new strategies going beyond the standard

artículo científico publicado en 2012

Amaryllidaceae alkaloids from the Australasian tribe Calostemmateae with acetylcholinesterase inhibitory activity

artículo científico publicado en 2011

Amino acid containing thapsigargin analogues deplete androgen receptor protein via synthesis inhibition and induce the death of prostate cancer cells

artículo científico publicado en 2009

Ancistrotanzanine A, the first 5,3'-coupled naphthylisoquinoline alkaloid, and two further, 5,8'-linked related compounds from the newly described species Ancistrocladus tanzaniensis.

artículo científico publicado en 2003

Ancistrotanzanine C and related 5,1'- and 7,3'-coupled naphthylisoquinoline alkaloids from Ancistrocladus tanzaniensis.

artículo científico publicado en 2004

Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani

artículo científico publicado en 1994

Are we ready for back-to-nature crop breeding?

artículo científico

Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy

artículo científico publicado en 2018

Ca2+ influx in human T lymphocytes is induced independently of inositol phosphate production by mobilization of intracellular Ca2+ stores. A study with the Ca2+ endoplasmic reticulum-ATPase inhibitor thapsigargin ⬇️

artículo científico publicado el 1 de octubre de 1990

Can phylogeny predict chemical diversity and potential medicinal activity of plants? A case study of Amaryllidaceae

artículo científico publicado en 2012

Carroll rearrangement to construct the norneolignan skeleton

artículo científico publicado en 2008

Chalcone inhibitors of the NorA efflux pump in Staphylococcus aureus whole cells and enriched everted membrane vesicles

artículo científico publicado en 2012

Chemo- and Regioselective Functionalization of Nortrilobolide: Application for Semisynthesis of the Natural Product 2-Acetoxytrilobolide

artículo científico publicado en 2015

Comparison of the effects of thapsigargin and BAY K 8644 on spontaneous mechanical activity in rat portal vein and contractile responses of rat cardiac muscle

artículo científico publicado el 1 de febrero de 1992

Cover Feature: Difluoroacetic Acid as a New Reagent for Direct C−H Difluoromethylation of Heteroaromatic Compounds (Chem. Eur. J. 72/2017)

Cover Feature: LEGO-Inspired Drug Design: Unveiling a Class of Benzo[d ]thiazoles Containing a 3,4-Dihydroxyphenyl Moiety as Plasma Membrane H+ -ATPase Inhibitors (ChemMedChem 1/2018)

scholarly article by Truong-Thanh Tung et al published 8 January 2018 in ChemMedChem

Cranberry Juice and Combinations of Its Organic Acids Are Effective against Experimental Urinary Tract Infection

scientific article published on 04 April 2017

Critical Roles of Hydrophobicity and Orientation of Side Chains for Inactivation of Sarcoplasmic Reticulum Ca2+-ATPase with Thapsigargin and Thapsigargin Analogs

artículo científico publicado en 2010

Cyclic AMP- and inositol phosphate-independent inhibition of Ca2+ influx by cholera toxin in CD3-stimulated Jurkat T cells. A study with a cholera toxin-resistant cell variant and the Ca2+ endoplasmic reticulum-ATPase inhibitor thapsigargin ⬇️

artículo científico publicado el 1 de agosto de 1991

Cytotoxic kurubasch aldehyde from Trichilia emetica

artículo científico publicado en 2007

Cytotoxic phenylpropanoids and an additional thapsigargin analogue isolated from Thapsia garganica.

artículo científico publicado en 2006

Demethoxycurcumin Is A Potent Inhibitor of P-Type ATPases from Diverse Kingdoms of Life

artículo científico publicado en 2016

Design, Synthesis, and Pharmacological Evaluation of Thapsigargin Analogues for Targeting Apoptosis to Prostatic Cancer Cells ⬇️

artículo científico publicado el 20 de diciembre de 2001

Differential effects of thapsigargin analogues on apoptosis of prostate cancer cells: complex regulation by intracellular calcium.

artículo científico publicado en 2013

Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds

artículo científico publicado en 2017

Effect of thapsigargin on cytoplasmic Ca2+ and proliferation of human lymphocytes in relation to AIDS

scientific article published on 01 December 1988

Effects of thapsigargin in isolated rat thoracic aorta

scientific article published on 01 January 1988

Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase.

artículo científico publicado en 2010

Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy

artículo científico publicado en 2012

Fusaric acid and analogues as Gram-negative bacterial quorum sensing inhibitors

artículo científico publicado en 2016

Hydrophilic carboxylic acids and iridoid glycosides in the juice of American and European cranberries (Vaccinium macrocarpon and V. oxycoccos), lingonberries (V. vitis-idaea), and blueberries (V. myrtillus).

artículo científico publicado en 2002

Identification of Natural Products Using HPLC-SPE Combined with CapNMR

artículo científico publicado en 2007

Iminolactones as tools for inversion of the absolute configuration of α-amino acids and as inhibitors of cancer cell proliferation

artículo científico publicado en 2016

Iminolactones from Schizophyllum commune.

artículo científico publicado en 2015

Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones.

artículo científico publicado en 2001

Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+ depletion and the unfolded protein response.

artículo científico publicado en 2017

Inositol trisphosphate and thapsigargin discriminate endoplasmic reticulum stores of calcium in rat brain

artículo científico publicado en 1990

Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.).

artículo científico publicado en 2011

Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip.

artículo científico publicado en 2008

Isolation of the MAO-inhibitor naringenin from Mentha aquatica L.

artículo científico publicado en 2008

LEGO-Inspired Drug Design: Unveiling a Class of Benzo[d]thiazoles Containing a 3,4-Dihydroxyphenyl Moiety as Plasma Membrane H+ -ATPase Inhibitors.

artículo científico publicado en 2017

Large Scale Conversion of Trilobolide into the Payload of Mipsagargin: 8-<i>O</i>-(12-Aminododecanoyl)-8-<i>O</i>-Debutanoylthapsigargin

scientific article published on 05 December 2020

Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection

artículo científico publicado en 1994

Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania

artículo científico publicado en 1993

Localization and in-Vivo Characterization of Thapsia garganica CYP76AE2 Indicates a Role in Thapsigargin Biosynthesis

artículo científico publicado en 2017

Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

artículo científico publicado en 2017

Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities

artículo científico publicado en 1998

New proazulene guaianolides from Thapsia villosa

artículo científico publicado en 1990

Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death

scientific article published on 17 September 2018

Novel inhibitory activity of the Staphylococcus aureus NorA efflux pump by a kaempferol rhamnoside isolated from Persea lingue Nees

artículo científico publicado en 2012

Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E(2)P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump

artículo científico publicado en 2011

Organic Hydroxylamine Derivatives. VII. Isoxazolin-5-ones. An Investigation of a Reaction Sequence Previously Stated to Give 3-Hydroxyisoxazoles

artículo científico publicado el 1 de enero de 1973

Phorbol Rearrangements

artículo científico publicado en 2018

Prenylated acetophenones from Melicope obscura and Melicope obtusifolia ssp. obtusifolia var. arborea and their distribution in Rutaceae

scientific article published in 2007

Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis

artículo científico publicado en 2018

Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer

artículo científico publicado en 2003

Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida

artículo científico publicado en 2006

Structure-Activity Relationships of Analogs of Thapsigargin Modified at O-11 and O-12

artículo científico publicado en 1995

Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1

artículo científico publicado en 2010

Structure/activity relationship of thapsigargin inhibition on the purified Golgi/secretory pathway Ca2+/Mn2+-transport ATPase (SPCA1a).

artículo científico publicado en 2017

Targeting thapsigargin towards tumors

artículo científico publicado en 2014

Thapsigargin affinity purification of intracellular P(2A)-type Ca(2+) ATPases

artículo científico publicado en 2011

Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage. 1989.

artículo científico publicado en 1994

The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response

artículo científico publicado en 1985

The antileishmanial activity of novel oxygenated chalcones and their mechanism of action

artículo científico publicado en 1999

The antileishmanial agent licochalcone A interferes with the function of parasite mitochondria

artículo científico publicado en 1995

The antiparasitic compound licochalcone a is a potent echinocytogenic agent that modifies the erythrocyte membrane in the concentration range where antiplasmodial activity is observed.

artículo científico publicado en 2004

The inflammatory and tumor-promoting sesquiterpene lactone, thapsigargin, activates platelets by selective mobilization of calcium as shown by protein phosphorylations

scientific article published on 01 January 1987

The molluscicidal activity of coumarins from Ethulia conyzoides and of dicumarol

artículo científico publicado en 1992

Toxicodynamics of tumour promoters of mouse skin. III. Specific binding of the tumour promoter thapsigargin as measured by the cold-acetone filter assay

artículo científico publicado el 1 de enero de 1992

Two new antiprotozoal 5-methylcoumarins from Vernonia brachycalyx

artículo científico publicado en 1997

Lista de obras de Søren Brøgger Christensen

19alpha-Hydroxy-3-oxo-ursa-1,12-dien-28-oic acid, an antiplasmodial triterpenoid isolated from Canthium multiflorum

6-O-Methylkrigeine, a new Amaryllidaceae alkaloid fromNerine huttoniaeSchönland

A Trojan horse in drug development: targeting of thapsigargins towards prostate cancer cells

A new flavonol glycoside and other flavonoids from the aerial parts of Taverniera aegyptiaca

A new oxygenated ursane derivative from Canthium multiflorum

A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca2+-ATPase inhibitors from Thapsia villosa

A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases ⬇️

Absolute configuration and antiprotozoal activity of minquartynoic acid

Accelerating the Domestication of New Crops: Feasibility and Approaches

Alkaloid analysis by high-performance liquid chromatography-solid phase extraction-nuclear magnetic resonance: new strategies going beyond the standard

Amaryllidaceae alkaloids from the Australasian tribe Calostemmateae with acetylcholinesterase inhibitory activity

Amino acid containing thapsigargin analogues deplete androgen receptor protein via synthesis inhibition and induce the death of prostate cancer cells

Ancistrotanzanine A, the first 5,3'-coupled naphthylisoquinoline alkaloid, and two further, 5,8'-linked related compounds from the newly described species Ancistrocladus tanzaniensis.

Ancistrotanzanine C and related 5,1'- and 7,3'-coupled naphthylisoquinoline alkaloids from Ancistrocladus tanzaniensis.

Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani

Are we ready for back-to-nature crop breeding?

Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy

Ca2+ influx in human T lymphocytes is induced independently of inositol phosphate production by mobilization of intracellular Ca2+ stores. A study with the Ca2+ endoplasmic reticulum-ATPase inhibitor thapsigargin ⬇️

Can phylogeny predict chemical diversity and potential medicinal activity of plants? A case study of Amaryllidaceae

Carroll rearrangement to construct the norneolignan skeleton

Chalcone inhibitors of the NorA efflux pump in Staphylococcus aureus whole cells and enriched everted membrane vesicles

Chemo- and Regioselective Functionalization of Nortrilobolide: Application for Semisynthesis of the Natural Product 2-Acetoxytrilobolide

Comparison of the effects of thapsigargin and BAY K 8644 on spontaneous mechanical activity in rat portal vein and contractile responses of rat cardiac muscle

Cover Feature: Difluoroacetic Acid as a New Reagent for Direct C−H Difluoromethylation of Heteroaromatic Compounds (Chem. Eur. J. 72/2017)

Cover Feature: LEGO-Inspired Drug Design: Unveiling a Class of Benzo[d ]thiazoles Containing a 3,4-Dihydroxyphenyl Moiety as Plasma Membrane H+ -ATPase Inhibitors (ChemMedChem 1/2018)

Cranberry Juice and Combinations of Its Organic Acids Are Effective against Experimental Urinary Tract Infection

Critical Roles of Hydrophobicity and Orientation of Side Chains for Inactivation of Sarcoplasmic Reticulum Ca2+-ATPase with Thapsigargin and Thapsigargin Analogs

Cyclic AMP- and inositol phosphate-independent inhibition of Ca2+ influx by cholera toxin in CD3-stimulated Jurkat T cells. A study with a cholera toxin-resistant cell variant and the Ca2+ endoplasmic reticulum-ATPase inhibitor thapsigargin ⬇️

Cytotoxic kurubasch aldehyde from Trichilia emetica

Cytotoxic phenylpropanoids and an additional thapsigargin analogue isolated from Thapsia garganica.

Demethoxycurcumin Is A Potent Inhibitor of P-Type ATPases from Diverse Kingdoms of Life

Design, Synthesis, and Pharmacological Evaluation of Thapsigargin Analogues for Targeting Apoptosis to Prostatic Cancer Cells ⬇️

Differential effects of thapsigargin analogues on apoptosis of prostate cancer cells: complex regulation by intracellular calcium.

Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds

Effect of thapsigargin on cytoplasmic Ca2+ and proliferation of human lymphocytes in relation to AIDS

Effects of thapsigargin in isolated rat thoracic aorta

Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase.

Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy

Fusaric acid and analogues as Gram-negative bacterial quorum sensing inhibitors

Hydrophilic carboxylic acids and iridoid glycosides in the juice of American and European cranberries (Vaccinium macrocarpon and V. oxycoccos), lingonberries (V. vitis-idaea), and blueberries (V. myrtillus).

Identification of Natural Products Using HPLC-SPE Combined with CapNMR

Iminolactones as tools for inversion of the absolute configuration of α-amino acids and as inhibitors of cancer cell proliferation

Iminolactones from Schizophyllum commune.

Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones.

Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+ depletion and the unfolded protein response.

Inositol trisphosphate and thapsigargin discriminate endoplasmic reticulum stores of calcium in rat brain

Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.).

Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip.

Isolation of the MAO-inhibitor naringenin from Mentha aquatica L.

LEGO-Inspired Drug Design: Unveiling a Class of Benzo[d]thiazoles Containing a 3,4-Dihydroxyphenyl Moiety as Plasma Membrane H+ -ATPase Inhibitors.

Large Scale Conversion of Trilobolide into the Payload of Mipsagargin: 8-<i>O</i>-(12-Aminododecanoyl)-8-<i>O</i>-Debutanoylthapsigargin

Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection

Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania

Localization and in-Vivo Characterization of Thapsia garganica CYP76AE2 Indicates a Role in Thapsigargin Biosynthesis

Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities

New proazulene guaianolides from Thapsia villosa

Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death

Novel inhibitory activity of the Staphylococcus aureus NorA efflux pump by a kaempferol rhamnoside isolated from Persea lingue Nees

Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E(2)P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump

Organic Hydroxylamine Derivatives. VII. Isoxazolin-5-ones. An Investigation of a Reaction Sequence Previously Stated to Give 3-Hydroxyisoxazoles

Phorbol Rearrangements

Prenylated acetophenones from Melicope obscura and Melicope obtusifolia ssp. obtusifolia var. arborea and their distribution in Rutaceae

Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis

Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer

Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida

Structure-Activity Relationships of Analogs of Thapsigargin Modified at O-11 and O-12

Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1

Structure/activity relationship of thapsigargin inhibition on the purified Golgi/secretory pathway Ca2+/Mn2+-transport ATPase (SPCA1a).

Targeting thapsigargin towards tumors

Thapsigargin affinity purification of intracellular P(2A)-type Ca(2+) ATPases

Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage. 1989.

The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response

The antileishmanial activity of novel oxygenated chalcones and their mechanism of action

The antileishmanial agent licochalcone A interferes with the function of parasite mitochondria

The antiparasitic compound licochalcone a is a potent echinocytogenic agent that modifies the erythrocyte membrane in the concentration range where antiplasmodial activity is observed.

The inflammatory and tumor-promoting sesquiterpene lactone, thapsigargin, activates platelets by selective mobilization of calcium as shown by protein phosphorylations

The molluscicidal activity of coumarins from Ethulia conyzoides and of dicumarol

Toxicodynamics of tumour promoters of mouse skin. III. Specific binding of the tumour promoter thapsigargin as measured by the cold-acetone filter assay