Lista de obras - Zachary A Knight - Dominio Público Uruguay

A Spotlight on Appetite

A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.

artículo científico publicado en 2008

A critical role for mTORC1 in erythropoiesis and anemia

artículo científico publicado en 2014

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

artículo científico publicado en 2006

A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma

artículo científico publicado en 2007

A membrane capture assay for lipid kinase activity

artículo científico publicado en 2007

A novel pseudoknot element is essential for the action of a yeast telomerase

artículo científico publicado en 2003

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

artículo científico publicado en 2006

A remodelled protease that cleaves phosphotyrosine substrates

artículo científico publicado en 2007

Ablation of AgRP neurons impairs adaption to restricted feeding

artículo científico publicado en 2014

Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells

artículo científico publicado en 2008

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

artículo científico publicado en 2009

Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport

artículo científico publicado en 2008

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

artículo científico publicado en 2009

Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma

artículo científico publicado en 2008

Chemical genetics: where genetics and pharmacology meet

artículo científico publicado en 2007

Design of drug-resistant alleles of type-III phosphatidylinositol 4-kinases using mutagenesis and molecular modeling

artículo científico publicado en 2008

Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha

artículo científico publicado en 2008

Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs

artículo científico publicado en 2010

Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer

artículo científico publicado en 2015

Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma

artículo científico publicado en 2008

Dynamics of Gut-Brain Communication Underlying Hunger

artículo científico publicado en 2017

EGFR signals to mTOR through PKC and independently of Akt in glioma

artículo científico publicado en 2009

Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage

artículo científico publicado en 2006

Features of selective kinase inhibitors

artículo científico publicado en 2005

For a PDK1 inhibitor, the substrate matters ⬇️

artículo científico publicado el 15 de enero de 2011

Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production

artículo científico publicado en 2008

HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.

artículo científico publicado en 2007

Hunger neurons drive feeding through a sustained, positive reinforcement signal

artículo científico publicado en 2016

Hyperleptinemia is required for the development of leptin resistance

artículo científico publicado en 2010

Identification of preoptic sleep neurons using retrograde labelling and gene profiling

artículo científico publicado en 2017

Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach

artículo científico publicado en 2009

Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold

artículo científico publicado en 2004

Linking smell to metabolism and aging

artículo científico publicado en 2017

Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha

artículo científico publicado en 2007

Making sense of the sensory regulation of hunger neurons

artículo científico publicado en 2016

Molecular profiling of activated neurons by phosphorylated ribosome capture

artículo científico publicado en 2012

Molecular profiling of neurons based on connectivity

artículo científico publicado en 2014

Neural circuits underlying thirst and fluid homeostasis

artículo científico publicado en 2017

Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat

artículo científico publicado en 2020

PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML.

artículo científico publicado en 2008

PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation

artículo científico publicado en 2008

Phosphospecific proteolysis for mapping sites of protein phosphorylation

artículo científico publicado en 2003

Rapid Sensing of Dietary Amino Acid Deficiency Does Not Require GCN2

artículo científico publicado en 2016

Re-examination of Dietary Amino Acid Sensing Reveals a GCN2-Independent Mechanism

artículo científico publicado en 2015

Regulation of Body Temperature by the Nervous System.

artículo científico publicado en 2018

Sensory detection of food rapidly modulates arcuate feeding circuits

artículo científico publicado en 2015

Small molecule inhibitors of the PI3-kinase family

scientific article published on January 2010

Sustained NPY signaling enables AgRP neurons to drive feeding

artículo científico publicado en 2019

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

artículo científico publicado en 2008

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

artículo científico publicado en 2008

Targeting the cancer kinome through polypharmacology

artículo científico publicado en 2010

Targeting the gatekeeper residue in phosphoinositide 3-kinases

artículo científico publicado en 2005

The Forebrain Thirst Circuit Drives Drinking through Negative Reinforcement

artículo científico publicado en 2017

Thirst

Thirst neurons anticipate the homeostatic consequences of eating and drinking

artículo científico publicado en 2016

To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front

artículo científico publicado en 2006

Warm-Sensitive Neurons that Control Body Temperature

artículo científico publicado en 2016

Lista de obras de Zachary A Knight

A Spotlight on Appetite

A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.

A critical role for mTORC1 in erythropoiesis and anemia

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma

A membrane capture assay for lipid kinase activity

A novel pseudoknot element is essential for the action of a yeast telomerase

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

A remodelled protease that cleaves phosphotyrosine substrates

Ablation of AgRP neurons impairs adaption to restricted feeding

Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma

Chemical genetics: where genetics and pharmacology meet

Design of drug-resistant alleles of type-III phosphatidylinositol 4-kinases using mutagenesis and molecular modeling

Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha

Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs

Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer

Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma

Dynamics of Gut-Brain Communication Underlying Hunger

EGFR signals to mTOR through PKC and independently of Akt in glioma

Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage

Features of selective kinase inhibitors

For a PDK1 inhibitor, the substrate matters ⬇️

Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production

HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.

Hunger neurons drive feeding through a sustained, positive reinforcement signal

Hyperleptinemia is required for the development of leptin resistance

Identification of preoptic sleep neurons using retrograde labelling and gene profiling

Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach

Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold

Linking smell to metabolism and aging

Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha

Making sense of the sensory regulation of hunger neurons

Molecular profiling of activated neurons by phosphorylated ribosome capture

Molecular profiling of neurons based on connectivity

Neural circuits underlying thirst and fluid homeostasis

Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat

PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML.

PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation

Phosphospecific proteolysis for mapping sites of protein phosphorylation

Rapid Sensing of Dietary Amino Acid Deficiency Does Not Require GCN2

Re-examination of Dietary Amino Acid Sensing Reveals a GCN2-Independent Mechanism

Regulation of Body Temperature by the Nervous System.

Sensory detection of food rapidly modulates arcuate feeding circuits

Small molecule inhibitors of the PI3-kinase family

Sustained NPY signaling enables AgRP neurons to drive feeding

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

Targeting the cancer kinome through polypharmacology

Targeting the gatekeeper residue in phosphoinositide 3-kinases

The Forebrain Thirst Circuit Drives Drinking through Negative Reinforcement

Thirst

Thirst neurons anticipate the homeostatic consequences of eating and drinking

To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front

Warm-Sensitive Neurons that Control Body Temperature