Lista de obras - Ewgenij Proschak - Dominio Público Uruguay

2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization

artículo científico publicado en 2009

A Diverse Benchmark Based on 3D Matched Molecular Pairs for Validating Scoring Functions

artículo científico publicado en 2018

A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity

artículo científico publicado en 2018

Allosteric modulation of the farnesoid X receptor by a small molecule

artículo científico publicado en 2018

Anthranilic acid derivatives as nuclear receptor modulators--development of novel PPAR selective and dual PPAR/FXR ligands.

artículo científico publicado en 2014

Antidiabetic sulfonylureas modulate farnesoid X receptor activation and target gene transcription

artículo científico publicado en 2010

Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria

artículo científico publicado en 2015

Argyreia nervosa (Burm. f.): receptor profiling of lysergic acid amide and other potential psychedelic LSD-like compounds by computational and binding assay approaches

artículo científico publicado en 2013

Bacterial Expression and HTS Assessment of Soluble Epoxide Hydrolase Phosphatase

artículo científico publicado en 2016

Bacterial zincophore [S,S]-ethylenediamine-N,N'-disuccinic acid is an effective inhibitor of MBLs

artículo científico publicado en 2017

Biological impact of freezing Plk1 in its inactive conformation in cancer cells

artículo científico publicado en 2010

Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE.

artículo científico publicado en 2017

Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-β-Lactamases

artículo científico publicado en 2017

Complementary Screening Techniques Yielded Fragments that Inhibit the Phosphatase Activity of Soluble Epoxide Hydrolase

Computational tools for polypharmacology and repurposing

artículo científico publicado el 1 de junio de 2011

Concept of combinatorial de novo design of drug-like molecules by particle swarm optimization

artículo científico publicado en 2008

Correction to Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria

artículo científico publicado en 2015

DOGS: reaction-driven de novo design of bioactive compounds

artículo científico publicado en 2012

Design of dual ligands using excessive pharmacophore query alignment.

artículo científico publicado en 2012

Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase.

artículo científico publicado en 2016

Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors.

artículo científico publicado en 2014

Drug-mediated intracellular donation of nitric oxide potently inhibits 5-lipoxygenase: a possible key to future anti-leukotriene therapy

artículo científico publicado en 2017

Dual-target virtual screening by pharmacophore elucidation and molecular shape filtering

artículo científico publicado en 2012

Exploring the chemical space of multitarget ligands using aligned self-organizing maps

artículo científico publicado en 2013

Fate of primary cells at the G₁/S boundary after polo-like kinase 1 inhibition by SBE13.

artículo científico publicado en 2011

Form follows function: shape analysis of protein cavities for receptor-based drug design

artículo científico publicado en 2009

Fragment-based identification of multi-target ligands by self-organizing map alignment.

artículo científico publicado en 2012

From a multipotent stilbene to soluble epoxide hydrolase inhibitors with antiproliferative properties

artículo científico publicado en 2013

From machine learning to natural product derivatives that selectively activate transcription factor PPARgamma

artículo científico publicado en 2010

Homology model adjustment and ligand screening with a pseudoreceptor of the human histamine H4 receptor

artículo científico publicado en 2009

Identification and validation of a potent type II inhibitor of inactive polo-like kinase 1.

artículo científico publicado en 2009

Impact of X-Ray Structure on Predictivity of Scoring Functions: PPARγ Case Study

scholarly article by Julia Weber et al published 23 August 2012 in Molecular Informatics

In silico characterization of ligand binding modes in the human histamine H4 receptor and their impact on receptor activation

artículo científico publicado en 2010

In silico polypharmacology: retrospective recognition vs. rational design

artículo científico publicado en 2014

Inhibitors of the arachidonic acid cascade: interfering with multiple pathways

artículo científico

Investigation of imatinib and other approved drugs as starting points for antidiabetic drug discovery with FXR modulating activity

artículo científico publicado en 2012

Kernel approach to molecular similarity based on iterative graph similarity

artículo científico publicado en 2007

Kernel learning for ligand-based virtual screening: discovery of a new PPARγ agonist.

artículo científico publicado en 2010

Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein

artículo científico publicado en 2015

Molecular query language (MQL)--a context-free grammar for substructure matching

artículo científico publicado en 2007

Multipotente Liganden mit kombinierter Cholinesterase- und Monoaminooxidase-Inhibition sowie Histamin-H3 R-Antagonismus bei neurodegenerativen Erkrankungen

Multistep virtual screening for rapid and efficient identification of non-nucleoside bacterial thymidine kinase inhibitors

artículo científico publicado en 2010

N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators

artículo científico publicado en 2015

Nonacidic inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1) identified by a multistep virtual screening protocol

artículo científico publicado en 2010

Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain.

artículo científico publicado en 2018

PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation

artículo científico publicado en 2014

PENG: a neural gas-based approach for pharmacophore elucidation. method design, validation, and virtual screening for novel ligands of LTA4H

artículo científico publicado en 2015

PhAST: pharmacophore alignment search tool

artículo científico publicado en 2009

Phosphatase activity of soluble epoxide hydrolase

artículo científico publicado en 2017

PocketPicker: analysis of ligand binding-sites with shape descriptors.

artículo científico publicado en 2007

Potent inhibitors of 5-lipoxygenase identified using pseudoreceptors

artículo científico publicado en 2011

Probing metallo-β-lactamases with molecular fragments identified by consensus docking

artículo científico publicado en 2015

Protein-protein docking by shape-complementarity and property matching

artículo científico publicado en 2010

Pyrazolo[1,5a]pyrimidines as a new class of FUSE binding protein 1 (FUBP1) inhibitors

artículo científico publicado en 2016

Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator

artículo científico publicado en 2010

Reaction-MQL: line notation for functional transformation

artículo científico publicado en 2009

Reconsidering the drug discovery pipeline for designed multitarget drugs

artículo científico publicado en 2013

SBE13, a newly identified inhibitor of inactive polo-like kinase 1.

artículo científico publicado en 2010

SOMMER: self-organising maps for education and research

artículo científico publicado en 2006

Scaffold hopping by "fuzzy" pharmacophores and its application to RNA targets

artículo científico publicado en 2007

Shapelets: Possibilities and limitations of shape-based virtual screening

Structure-Based Pharmacophores for Virtual Screening

artículo científico publicado en 2011

Structure-activity relationship and in vitro pharmacological evaluation of imidazo[1,2-a]pyridine-based inhibitors of 5-LO.

artículo científico publicado en 2013

Structure-activity relationship of nonacidic quinazolinone inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1).

artículo científico publicado en 2012

Synthesis and pharmacological characterization of benzenesulfonamides as dual species inhibitors of human and murine mPGES-1.

artículo científico publicado en 2013

Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase

artículo científico publicado en 2013

Synthetic cannabinoids: In silico prediction of the cannabinoid receptor 1 affinity by a quantitative structure-activity relationship model

artículo científico publicado en 2016

The holistic integration of virtual screening in drug discovery

artículo científico publicado en 2013

Thermodynamic properties of leukotriene A4 hydrolase inhibitors

artículo científico publicado en 2016

Truxillic acid derivatives act as peroxisome proliferator-activated receptor gamma activators

artículo científico publicado en 2010

VAMMPIRE-LORD: a web server for straightforward lead optimization using matched molecular pairs

artículo científico publicado en 2015

VAMMPIRE: a matched molecular pairs database for structure-based drug design and optimization

artículo científico publicado en 2013

Vanillin-derived antiproliferative compounds influence Plk1 activity

artículo científico publicado en 2014

Voyages to the (un)known: adaptive design of bioactive compounds

artículo científico publicado en 2008

Lista de obras de Ewgenij Proschak

2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization

A Diverse Benchmark Based on 3D Matched Molecular Pairs for Validating Scoring Functions

A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity

Allosteric modulation of the farnesoid X receptor by a small molecule

Anthranilic acid derivatives as nuclear receptor modulators--development of novel PPAR selective and dual PPAR/FXR ligands.

Antidiabetic sulfonylureas modulate farnesoid X receptor activation and target gene transcription

Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria

Argyreia nervosa (Burm. f.): receptor profiling of lysergic acid amide and other potential psychedelic LSD-like compounds by computational and binding assay approaches

Bacterial Expression and HTS Assessment of Soluble Epoxide Hydrolase Phosphatase

Bacterial zincophore [S,S]-ethylenediamine-N,N'-disuccinic acid is an effective inhibitor of MBLs

Biological impact of freezing Plk1 in its inactive conformation in cancer cells

Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE.

Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-β-Lactamases

Complementary Screening Techniques Yielded Fragments that Inhibit the Phosphatase Activity of Soluble Epoxide Hydrolase

Computational tools for polypharmacology and repurposing

Concept of combinatorial de novo design of drug-like molecules by particle swarm optimization

Correction to Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria

DOGS: reaction-driven de novo design of bioactive compounds

Design of dual ligands using excessive pharmacophore query alignment.

Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase.

Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors.

Drug-mediated intracellular donation of nitric oxide potently inhibits 5-lipoxygenase: a possible key to future anti-leukotriene therapy

Dual-target virtual screening by pharmacophore elucidation and molecular shape filtering

Exploring the chemical space of multitarget ligands using aligned self-organizing maps

Fate of primary cells at the G₁/S boundary after polo-like kinase 1 inhibition by SBE13.

Form follows function: shape analysis of protein cavities for receptor-based drug design

Fragment-based identification of multi-target ligands by self-organizing map alignment.

From a multipotent stilbene to soluble epoxide hydrolase inhibitors with antiproliferative properties

From machine learning to natural product derivatives that selectively activate transcription factor PPARgamma

Homology model adjustment and ligand screening with a pseudoreceptor of the human histamine H4 receptor

Identification and validation of a potent type II inhibitor of inactive polo-like kinase 1.

Impact of X-Ray Structure on Predictivity of Scoring Functions: PPARγ Case Study

In silico characterization of ligand binding modes in the human histamine H4 receptor and their impact on receptor activation

In silico polypharmacology: retrospective recognition vs. rational design

Inhibitors of the arachidonic acid cascade: interfering with multiple pathways

Investigation of imatinib and other approved drugs as starting points for antidiabetic drug discovery with FXR modulating activity

Kernel approach to molecular similarity based on iterative graph similarity

Kernel learning for ligand-based virtual screening: discovery of a new PPARγ agonist.

Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein

Molecular query language (MQL)--a context-free grammar for substructure matching

Multipotente Liganden mit kombinierter Cholinesterase- und Monoaminooxidase-Inhibition sowie Histamin-H3 R-Antagonismus bei neurodegenerativen Erkrankungen

Multistep virtual screening for rapid and efficient identification of non-nucleoside bacterial thymidine kinase inhibitors

N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators

Nonacidic inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1) identified by a multistep virtual screening protocol

Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain.

PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation

PENG: a neural gas-based approach for pharmacophore elucidation. method design, validation, and virtual screening for novel ligands of LTA4H

PhAST: pharmacophore alignment search tool

Phosphatase activity of soluble epoxide hydrolase

PocketPicker: analysis of ligand binding-sites with shape descriptors.

Potent inhibitors of 5-lipoxygenase identified using pseudoreceptors

Probing metallo-β-lactamases with molecular fragments identified by consensus docking

Protein-protein docking by shape-complementarity and property matching

Pyrazolo[1,5a]pyrimidines as a new class of FUSE binding protein 1 (FUBP1) inhibitors

Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator

Reaction-MQL: line notation for functional transformation

Reconsidering the drug discovery pipeline for designed multitarget drugs

SBE13, a newly identified inhibitor of inactive polo-like kinase 1.

SOMMER: self-organising maps for education and research

Scaffold hopping by "fuzzy" pharmacophores and its application to RNA targets

Shapelets: Possibilities and limitations of shape-based virtual screening

Structure-Based Pharmacophores for Virtual Screening

Structure-activity relationship and in vitro pharmacological evaluation of imidazo[1,2-a]pyridine-based inhibitors of 5-LO.

Structure-activity relationship of nonacidic quinazolinone inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1).

Synthesis and pharmacological characterization of benzenesulfonamides as dual species inhibitors of human and murine mPGES-1.

Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase

Synthetic cannabinoids: In silico prediction of the cannabinoid receptor 1 affinity by a quantitative structure-activity relationship model

The holistic integration of virtual screening in drug discovery

Thermodynamic properties of leukotriene A4 hydrolase inhibitors

Truxillic acid derivatives act as peroxisome proliferator-activated receptor gamma activators

VAMMPIRE-LORD: a web server for straightforward lead optimization using matched molecular pairs

VAMMPIRE: a matched molecular pairs database for structure-based drug design and optimization

Vanillin-derived antiproliferative compounds influence Plk1 activity

Voyages to the (un)known: adaptive design of bioactive compounds

Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ