Lista de obras - Lothar Gremer - Dominio Público Uruguay

A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family

artículo científico publicado en 2009

A D-enantiomeric peptide interferes with hetero-association of amyloid-β oligomers and prion protein

artículo científico publicado en 2018

A near atomic-scale view at the composition of amyloid-beta fibrils by atom probe tomography

artículo científico publicado en 2018

A novel binuclear [CuSMo] cluster at the active site of carbon monoxide dehydrogenase: characterization by X-ray absorption spectroscopy

artículo científico publicado en 2003

A restricted spectrum of NRAS mutations causes Noonan syndrome

artículo científico publicado en 2010

Analysis of the Bin1 SH3 interaction with peptides derived from the hepatitis C virus protein NS5A and c-Myc reveals that NS5A can competitively displace c-Myc in vitro.

artículo científico publicado en 2014

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

artículo científico publicado en 2011

Arl3 regulates a transport system for farnesylated cargo

Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy

scientific article published on 21 August 2019

Binding modes of thioflavin T and Congo red to the fibril structure of amyloid-β(1-42)

artículo científico publicado en 2020

Binding of Flavin Adenine Dinucleotide to Molybdenum-containing Carbon Monoxide Dehydrogenase fromOligotropha carboxidovorans

artículo científico publicado en 2000

Biochemical Assays to Characterize Rho GTPases ⬇️

artículo científico publicado el 1 de enero de 2012

Catalysis at a dinuclear [CuSMo(==O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution

artículo científico publicado en 2002

Characterization of xanthine dehydrogenase from the anaerobic bacterium Veillonella atypica and identification of a molybdopterin-cytosine-dinucleotide-containing molybdenum cofactor

artículo científico publicado en 1996

Clustering of human prion protein and α-synuclein oligomers requires the prion protein N-terminus

artículo científico publicado en 2020

Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity

artículo científico publicado en 2016

Correction: Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity

artículo científico publicado en 2016

Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils

artículo científico publicado en 2020

Crystal structure of a carbon monoxide dehydrogenase reveals a [Ni-4Fe-5S] cluster

artículo científico publicado en 2001

Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and cardio-facio-cutaneous syndromes

artículo científico publicado en 2012

Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation

artículo científico publicado en 2009

Engineered aggregation inhibitor fusion for production of highly amyloidogenic human islet amyloid polypeptide

artículo científico publicado en 2014

Fibril structure of amyloid-β(1-42) by cryo-electron microscopy

artículo científico publicado en 2017

Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGap interaction

artículo científico publicado en 2008

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders

artículo científico publicado en 2010

High-Affinity Binding of Monomeric but Not Oligomeric Amyloid-β to Ganglioside GM1 Containing Nanodiscs

artículo científico publicado en 2016

IQGAP1 Interaction with RHO Family Proteins Revisited: KINETIC AND EQUILIBRIUM EVIDENCE FOR MULTIPLE DISTINCT BINDING SITES.

artículo científico publicado en 2016

Impact of subunit linkages in an engineered homodimeric binding protein to α-synuclein

artículo científico publicado en 2014

Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d-Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ Species.

artículo científico publicado en 2016

Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1.

artículo científico publicado en 2014

Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).

artículo científico publicado en 2011

Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth

artículo científico publicado en 2017

Optimization of d-Peptides for Aβ Monomer Binding Specificity Enhances Their Potential to Eliminate Toxic Aβ Oligomers.

artículo científico publicado en 2017

Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination

artículo científico publicado en 2016

Origin of metastable oligomers and their effects on amyloid fibril self-assembly

scientific article published on 13 June 2018

Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication

artículo científico publicado en 2019

Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release

artículo científico publicado en 2016

Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s Disease

artículo científico publicado en 2015

Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR Spectroscopy

artículo científico publicado en 2015

Pyroglutamate-Modified Amyloid-β(3-42) Shows α-Helical Intermediates before Amyloid Formation

artículo científico publicado en 2017

QIAD assay for quantitating a compound's efficacy in elimination of toxic Aβ oligomers

artículo científico publicado en 2015

Relevance of N-terminal residues for amyloid-β binding to platelet integrin α IIb β 3 , integrin outside-in signaling and amyloid-β fibril formation

Rho-kinase: regulation, (dys)function, and inhibition

artículo científico publicado en 2013

Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division

artículo científico publicado en 2013

Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes

artículo científico publicado en 2010

Structural Analysis and Aggregation Propensity of Pyroglutamate Aβ(3-40) in Aqueous Trifluoroethanol

artículo científico publicado en 2015

Structural Characterization of Fibrils from Recombinant Human Islet Amyloid Polypeptide by Solid-State NMR: The Central FGAILS Segment Is Part of the β-Sheet Core

artículo científico publicado en 2016

Structural analysis of the pyroglutamate-modified isoform of the Alzheimer's disease-related amyloid-β using NMR spectroscopy

artículo científico publicado en 2012

Surprisingly high stability of the Aβ oligomer eliminating all-d-enantiomeric peptide D3 in media simulating the route of orally administered drugs

artículo científico publicado en 2017

Synthesis of the Rheb and K-Ras4B GTPases

The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology

artículo científico publicado en 2017

The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction

artículo científico publicado en 2008

The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.

artículo científico publicado en 2013

The effect of intracellular molybdenum in Hydrogenophaga pseudoflava on the crystallographic structure of the seleno-molybdo-iron-sulfur flavoenzyme carbon monoxide dehydrogenase

artículo científico publicado en 2000

The role of Se, Mo and Fe in the structure and function of carbon monoxide dehydrogenase

artículo científico publicado en 2000

Two novel germline KRAS mutations: expanding the molecular and clinical phenotype

artículo científico publicado en 2011

β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor

artículo científico publicado en 2016

Lista de obras de Lothar Gremer

A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family

A D-enantiomeric peptide interferes with hetero-association of amyloid-β oligomers and prion protein

A near atomic-scale view at the composition of amyloid-beta fibrils by atom probe tomography

A novel binuclear [CuSMo] cluster at the active site of carbon monoxide dehydrogenase: characterization by X-ray absorption spectroscopy

A restricted spectrum of NRAS mutations causes Noonan syndrome

Analysis of the Bin1 SH3 interaction with peptides derived from the hepatitis C virus protein NS5A and c-Myc reveals that NS5A can competitively displace c-Myc in vitro.

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

Arl3 regulates a transport system for farnesylated cargo

Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy

Binding modes of thioflavin T and Congo red to the fibril structure of amyloid-β(1-42)

Binding of Flavin Adenine Dinucleotide to Molybdenum-containing Carbon Monoxide Dehydrogenase fromOligotropha carboxidovorans

Biochemical Assays to Characterize Rho GTPases ⬇️

Catalysis at a dinuclear [CuSMo(==O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution

Characterization of xanthine dehydrogenase from the anaerobic bacterium Veillonella atypica and identification of a molybdopterin-cytosine-dinucleotide-containing molybdenum cofactor

Clustering of human prion protein and α-synuclein oligomers requires the prion protein N-terminus

Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity

Correction: Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity

Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils

Crystal structure of a carbon monoxide dehydrogenase reveals a [Ni-4Fe-5S] cluster

Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and cardio-facio-cutaneous syndromes

Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation

Engineered aggregation inhibitor fusion for production of highly amyloidogenic human islet amyloid polypeptide

Fibril structure of amyloid-β(1-42) by cryo-electron microscopy

Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGap interaction

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders

High-Affinity Binding of Monomeric but Not Oligomeric Amyloid-β to Ganglioside GM1 Containing Nanodiscs

IQGAP1 Interaction with RHO Family Proteins Revisited: KINETIC AND EQUILIBRIUM EVIDENCE FOR MULTIPLE DISTINCT BINDING SITES.

Impact of subunit linkages in an engineered homodimeric binding protein to α-synuclein

Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d-Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ Species.

Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1.

Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).

Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth

Optimization of d-Peptides for Aβ Monomer Binding Specificity Enhances Their Potential to Eliminate Toxic Aβ Oligomers.

Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination

Origin of metastable oligomers and their effects on amyloid fibril self-assembly

Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication

Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release

Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s Disease

Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR Spectroscopy

Pyroglutamate-Modified Amyloid-β(3-42) Shows α-Helical Intermediates before Amyloid Formation

QIAD assay for quantitating a compound's efficacy in elimination of toxic Aβ oligomers

Relevance of N-terminal residues for amyloid-β binding to platelet integrin α IIb β 3 , integrin outside-in signaling and amyloid-β fibril formation

Rho-kinase: regulation, (dys)function, and inhibition

Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division

Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes

Structural Analysis and Aggregation Propensity of Pyroglutamate Aβ(3-40) in Aqueous Trifluoroethanol

Structural Characterization of Fibrils from Recombinant Human Islet Amyloid Polypeptide by Solid-State NMR: The Central FGAILS Segment Is Part of the β-Sheet Core

Structural analysis of the pyroglutamate-modified isoform of the Alzheimer's disease-related amyloid-β using NMR spectroscopy

Surprisingly high stability of the Aβ oligomer eliminating all-d-enantiomeric peptide D3 in media simulating the route of orally administered drugs

Synthesis of the Rheb and K-Ras4B GTPases

The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology

The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction

The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.

The effect of intracellular molybdenum in Hydrogenophaga pseudoflava on the crystallographic structure of the seleno-molybdo-iron-sulfur flavoenzyme carbon monoxide dehydrogenase

The role of Se, Mo and Fe in the structure and function of carbon monoxide dehydrogenase

Two novel germline KRAS mutations: expanding the molecular and clinical phenotype

β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor