Lista de obras - Kalle Saksela - Dominio Público Uruguay

A crucial role in cell spreading for the interaction of Abl PxxP motifs with Crk and Nck adaptors

artículo científico publicado en 2008

A single-chain antibody/epitope system for functional analysis of protein-protein interactions

artículo científico publicado en 2002

ANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library

artículo científico publicado en 2017

Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice

artículo científico publicado en 2005

Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins

artículo científico publicado en 2009

Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue

artículo científico publicado en 2007

Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex

artículo científico publicado en 2015

Attenuation of Semliki Forest virus neurovirulence by microRNA-mediated detargeting

artículo científico publicado en 2012

Autoimmune regulator induced changes in the gene expression profile of human monocyte-dendritic cell-lineage

artículo científico publicado en 2004

Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling.

artículo científico publicado en 2007

Capacity of simian immunodeficiency virus strain mac Nef for high-affinity Src homology 3 (SH3) binding revealed by ligand-tailored SH3 domains

artículo científico publicado en 2002

Cdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation

artículo científico publicado en 2002

Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome

artículo científico publicado en 2012

Conformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assembly

artículo científico publicado en 2011

Dystroglycan, Tks5 and Src mediated assembly of podosomes in myoblasts

artículo científico publicado en 2008

Enterohaemorrhagic Escherichia Coli Exploits a Tryptophan Switch to Hijack Host F-Actin Assembly

artículo científico publicado en 2012

Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling

artículo científico publicado en 2005

Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific MicroRNA.

artículo científico publicado en 2008

HIV Activates the Tyrosine Kinase Hck to Secrete ADAM Protease-Containing Extracellular Vesicles.

artículo científico publicado en 2018

HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases

artículo científico publicado en 2013

HIV-Nef and ADAM17-Containing Plasma Extracellular Vesicles Induce and Correlate with Immune Pathogenesis in Chronic HIV Infection

artículo científico publicado en 2016

Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines

artículo científico publicado en 2008

Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis ⬇️

artículo científico publicado en 2013

Hepatitis C virus NS5A protein blocks epidermal growth factor receptor degradation via a proline motif- dependent interaction ⬇️

artículo científico publicado en 2015

High-affinity target binding engineered via fusion of a single-domain antibody fragment with a ligand-tailored SH3 domain

artículo científico publicado en 2012

High-throughput phosphotyrosine profiling using SH2 domains

artículo científico publicado en 2007

Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity

artículo científico publicado en 2007

Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function

artículo científico publicado en 2012

Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome

artículo científico publicado en 2006

Identification of specific residues in avian influenza A virus NS1 that enhance viral replication and pathogenicity in mammalian systems

artículo científico publicado en 2016

Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation

artículo científico publicado en 2009

Interactions of the HIV/SIV Pathogenicity Factor Nef with SH3 Domain-Containing Host Cell Proteins ⬇️

artículo científico publicado el 1 de octubre de 2011

Large-Scale Screening of Preferred Interactions of Human Src Homology-3 (SH3) Domains Using Native Target Proteins as Affinity Ligands

artículo científico publicado en 2016

MC159 of Molluscum Contagiosum Virus Suppresses Autophagy by Recruiting Cellular SH3BP4 via an SH3 Domain-Mediated Interaction

scientific article published on 01 May 2019

Macrophage metalloelastase (MME) as adjuvant for intra-tumoral injection of oncolytic adenovirus and its influence on metastases development

article

MicroRNA-Attenuated Clone of Virulent Semliki Forest Virus Overcomes Antiviral Type I Interferon in Resistant Mouse CT-2A Glioma

artículo científico publicado en 2015

MicroRNA-mediated suppression of oncolytic adenovirus replication in human liver

artículo científico publicado en 2013

Modulation of cell spreading and cell-substrate adhesion dynamics by dystroglycan.

artículo científico publicado en 2010

Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role

artículo científico publicado en 2009

Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts.

artículo científico publicado en 2004

Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors

artículo científico publicado en 2004

Nuclear Translocation of Crk Adaptor Proteins by the Influenza A Virus NS1 Protein

artículo científico publicado en 2016

Optimized mouse model for the imaging of tumor metastasis upon experimental therapy

artículo científico publicado en 2011

Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription

artículo científico publicado en 2011

Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions

artículo científico publicado en 2015

Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms

artículo científico publicado en 2013

Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon

artículo científico publicado en 2007

Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly

artículo científico publicado en 2010

Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB

artículo científico publicado en 2003

Reorganization of the host cell Crk(L)-PI3 kinase signaling complex by the influenza A virus NS1 protein

artículo científico publicado en 2015

Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation

artículo científico publicado en 2010

SH3 domain ligand binding: What's the consensus and where's the specificity?

artículo científico publicado en 2012

SH3 domain-mediated recruitment of host cell amphiphysins by alphavirus nsP3 promotes viral RNA replication

artículo científico publicado en 2011

Single-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functions

artículo científico publicado en 2012

Structural Basis of the High Affinity Interaction between the Alphavirus Nonstructural Protein-3 (nsP3) and the SH3 Domain of Amphiphysin-2

artículo científico publicado en 2016

Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody

artículo científico publicado en 2014

Structural basis of PxxDY motif recognition in SH3 binding

artículo científico publicado en 2008

The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice.

artículo científico publicado en 2015

The mechanism of tissue-restricted antigen gene expression by AIRE.

artículo científico

Therapeutic targeting of interactions between Nef and host cell proteins

artículo científico publicado en 2004

Tyrosine phosphorylation directs TACE into extracellular vesicles via unconventional secretion

artículo científico publicado en 2019

Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes

artículo científico publicado en 2012

Versatile retargeting of SH3 domain binding by modification of non-conserved loop residues

artículo científico publicado en 2007

Lista de obras de Kalle Saksela

A crucial role in cell spreading for the interaction of Abl PxxP motifs with Crk and Nck adaptors

A single-chain antibody/epitope system for functional analysis of protein-protein interactions

ANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library

Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice

Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins

Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue

Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex

Attenuation of Semliki Forest virus neurovirulence by microRNA-mediated detargeting

Autoimmune regulator induced changes in the gene expression profile of human monocyte-dendritic cell-lineage

Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling.

Capacity of simian immunodeficiency virus strain mac Nef for high-affinity Src homology 3 (SH3) binding revealed by ligand-tailored SH3 domains

Cdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation

Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome

Conformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assembly

Dystroglycan, Tks5 and Src mediated assembly of podosomes in myoblasts

Enterohaemorrhagic Escherichia Coli Exploits a Tryptophan Switch to Hijack Host F-Actin Assembly

Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling

Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific MicroRNA.

HIV Activates the Tyrosine Kinase Hck to Secrete ADAM Protease-Containing Extracellular Vesicles.

HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases

HIV-Nef and ADAM17-Containing Plasma Extracellular Vesicles Induce and Correlate with Immune Pathogenesis in Chronic HIV Infection

Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines

Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis ⬇️

Hepatitis C virus NS5A protein blocks epidermal growth factor receptor degradation via a proline motif- dependent interaction ⬇️

High-affinity target binding engineered via fusion of a single-domain antibody fragment with a ligand-tailored SH3 domain

High-throughput phosphotyrosine profiling using SH2 domains

Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity

Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function

Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome

Identification of specific residues in avian influenza A virus NS1 that enhance viral replication and pathogenicity in mammalian systems

Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation

Interactions of the HIV/SIV Pathogenicity Factor Nef with SH3 Domain-Containing Host Cell Proteins ⬇️

Large-Scale Screening of Preferred Interactions of Human Src Homology-3 (SH3) Domains Using Native Target Proteins as Affinity Ligands

MC159 of Molluscum Contagiosum Virus Suppresses Autophagy by Recruiting Cellular SH3BP4 via an SH3 Domain-Mediated Interaction

Macrophage metalloelastase (MME) as adjuvant for intra-tumoral injection of oncolytic adenovirus and its influence on metastases development

MicroRNA-Attenuated Clone of Virulent Semliki Forest Virus Overcomes Antiviral Type I Interferon in Resistant Mouse CT-2A Glioma

MicroRNA-mediated suppression of oncolytic adenovirus replication in human liver

Modulation of cell spreading and cell-substrate adhesion dynamics by dystroglycan.

Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role

Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts.

Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors

Nuclear Translocation of Crk Adaptor Proteins by the Influenza A Virus NS1 Protein

Optimized mouse model for the imaging of tumor metastasis upon experimental therapy

Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription

Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions

Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms

Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon

Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly

Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB

Reorganization of the host cell Crk(L)-PI3 kinase signaling complex by the influenza A virus NS1 protein

Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation

SH3 domain ligand binding: What's the consensus and where's the specificity?

SH3 domain-mediated recruitment of host cell amphiphysins by alphavirus nsP3 promotes viral RNA replication

Single-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functions

Structural Basis of the High Affinity Interaction between the Alphavirus Nonstructural Protein-3 (nsP3) and the SH3 Domain of Amphiphysin-2

Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody

Structural basis of PxxDY motif recognition in SH3 binding

The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice.

The mechanism of tissue-restricted antigen gene expression by AIRE.

Therapeutic targeting of interactions between Nef and host cell proteins

Tyrosine phosphorylation directs TACE into extracellular vesicles via unconventional secretion

Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes

Versatile retargeting of SH3 domain binding by modification of non-conserved loop residues