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Lista de obras de Johannes Kettunen

A blood pressure genetic risk score is a significant predictor of incident cardiovascular events in 32,669 individuals

artículo científico publicado en 2013

A cross-omics integrative study of metabolic signatures of chronic obstructive pulmonary disease

scientific article published on 16 July 2020

A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation

artículo científico publicado en 2012

A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study

artículo científico publicado en 2012

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

scientific article published on 20 August 2019

A metabolic view on menopause and ageing

artículo científico publicado en 2014

Age at adiposity rebound in childhood is associated with PCOS diagnosis and obesity in adulthood-longitudinal analysis of BMI data from birth to age 46 in cases of PCOS

scientific article published on 04 February 2019

An epigenome-wide association study of metabolic syndrome and its components

artículo científico publicado en 2020

An interaction map of circulating metabolites, immune gene networks, and their genetic regulation

artículo científico publicado en 2017

Apolipoprotein A-I concentrations and risk of coronary artery disease: A Mendelian randomization study

artículo científico publicado en 2020

Assessing multivariate gene-metabolome associations with rare variants using Bayesian reduced rank regression

artículo científico publicado en 2014

Association of LIN28B with adult adiposity-related traits in females

artículo científico publicado en 2012

Association of circulating metabolites in plasma or serum and risk of stroke: Meta-analysis from seven prospective cohorts

scientific article published on 02 December 2020

Associations of increased physical performance and change in body composition with molecular pathways of heart disease and diabetes risk

artículo científico publicado en 2018

Biomarker Glycoprotein Acetyls Is Associated With the Risk of a Wide Spectrum of Incident Diseases and Stratifies Mortality Risk in Angiography Patients

scientific article published on 01 November 2018

Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons

artículo científico publicado en 2014

Cell Specific eQTL Analysis without Sorting Cells

artículo científico publicado en 2015

Cell specific eQTL analysis without sorting cells

Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D: a cross-sectional analysis in population-based data

artículo científico publicado en 2016

Chromosome X-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation

artículo científico publicado en 2014

Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts

Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts

scientific article published on 04 October 2019

Common genetic variants associated with sudden cardiac death: the FinSCDgen study

artículo científico publicado en 2012

Common variants associated with plasma triglycerides and risk for coronary artery disease

artículo científico publicado en 2013

Conventional and Mendelian randomization analyses suggest no association between lipoprotein(a) and early atherosclerosis: the Young Finns Study

artículo científico publicado en 2010

Coronary artery disease, genetic risk and the metabolome in young individuals

scholarly article by Thomas Battram et al published 12 September 2018 in Wellcome Open Research

Coronary artery disease, genetic risk and the metabolome in young individuals

artículo científico publicado en 2018

Correction: Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1

Correction: Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition

artículo científico publicado en 2020

DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures

artículo científico publicado en 2021

Data-driven multivariate population subgrouping via lipoprotein phenotypes versus apolipoprotein B in the risk assessment of coronary heart disease

artículo científico publicado en 2019

Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci

artículo científico publicado en 2011

Direct Estimation of HDL-Mediated Cholesterol Efflux Capacity from Serum

scientific article published on 17 April 2019

Discovery and refinement of loci associated with lipid levels

artículo científico publicado en 2013

Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence

artículo científico publicado en 2016

Elevated serum alpha-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality

scientific article published on 23 October 2019

EpiMetal: an open-source graphical web browser tool for easy statistical analyses in epidemiology and metabolomics

scientific article published on 16 January 2020

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

artículo científico publicado en 2011

European lactase persistence genotype shows evidence of association with increase in body mass index

artículo científico publicado en 2009

Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure

artículo científico publicado en 2017

Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease

scientific article published on 01 May 2019

Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential

artículo científico publicado en 2016

Genetic Variants on Chromosome 1p13.3 Are Associated with Non-ST Elevation Myocardial Infarction and the Expression of DRAM2 in the Finnish Population

artículo científico publicado en 2015

Genetic determinants of circulating interleukin-1 receptor antagonist levels and their association with glycemic traits

artículo científico publicado en 2014

Genetic evidence of assortative mating in humans

article

Genetic profiling using genome-wide significant coronary artery disease risk variants does not improve the prediction of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns Study, the Bogalusa Heart Study and the Health 2000 Survey--

artículo científico publicado en 2012

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

artículo científico publicado en 2011

Genome-Wide Association Study Implicates Atrial Natriuretic Peptide Rather Than B-Type Natriuretic Peptide in the Regulation of Blood Pressure in the General Population

artículo científico publicado en 2017

Genome-Wide Association Study Pinpoints a New Functional Apolipoprotein B Variant Influencing Oxidized Low-Density Lipoprotein Levels But Not Cardiovascular Events

scholarly article by Kari-Matti Mäkelä et al published February 2013 in Circulation: Cardiovascular Genetics

Genome-Wide Meta-Analysis of Sciatica in Finnish Population

artículo científico publicado en 2016

Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors

artículo científico publicado en 2016

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity

artículo científico publicado en 2013

Genome-wide association study identifies multiple loci influencing human serum metabolite levels

artículo científico publicado en 2012

Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1

scientific journal article

Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns

artículo científico publicado en 2019

Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns:

Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.

artículo científico publicado en 2014

Genome-wide association study of sleep duration in the Finnish population

artículo científico publicado en 2014

Genome-wide meta-analysis identifies genetic locus on chromosome 9 associated with Modic changes

scientific article published on 26 February 2019

Genome-wide scan of job-related exhaustion with three replication studies implicate a susceptibility variant at the UST gene locus

scientific article published on 24 April 2013

Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits

scientific journal article

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.

artículo científico publicado en 2016

Genomic, Transcriptomic, and Lipidomic Profiling Highlights the Role of Inflammation in Individuals With Low High-density Lipoprotein Cholesterol

High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms

artículo científico publicado en 2014

Hundreds of variants clustered in genomic loci and biological pathways affect human height

artículo científico publicado en 2010

Identification of seven loci affecting mean telomere length and their association with disease

artículo científico publicado en 2013

Insomnia does not mediate or modify the association between MTNR1B risk variant rs10830963 and glucose levels

artículo científico publicado en 2016

Insulin resistance and systemic metabolic changes in oral glucose tolerance test in 5340 individuals: an interventional study

artículo científico publicado en 2019

Interactions between genetic variants and dietary lipid composition: effects on circulating LDL cholesterol in children

artículo científico publicado en 2014

Intracranial aneurysm risk locus 5q23.2 is associated with elevated systolic blood pressure

artículo científico publicado en 2012

Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition

artículo científico publicado en 2019

Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study

scientific journal article

Low-expression variant of fatty acid-binding protein 4 favors reduced manifestations of atherosclerotic disease and increased plaque stability

artículo científico publicado en 2014

Mergeomics: integration of diverse genomics resources to identify pathogenic perturbations to biological systems

Mergeomics: multidimensional data integration to identify pathogenic perturbations to biological systems

artículo científico publicado en 2016

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

artículo científico publicado en 2010

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels

artículo científico publicado en 2011

Metabolic Characterization of a Rare Genetic Variation Within APOC3 and Its Lipoprotein Lipase-Independent Effects

artículo científico publicado en 2016

Metabolic Effects Of Risk Alleles In PNPLA3, TM6SF2, GCKR, And LYPLAL1 Inform About Heterogeneity Of Non-Alcoholic Fatty Liver Disease

artículo científico publicado en 2017

Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition: a drug-target Mendelian randomization analysis

artículo científico publicado en 2020

Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence

artículo científico publicado en 2016

Metabolic signatures of insulin resistance in 7,098 young adults

artículo científico publicado en 2012

Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts

artículo científico publicado en 2015

Metabolomic Consequences of Genetic Inhibition of PCSK9 Compared With Statin Treatment

artículo científico publicado en 2018

Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase

artículo científico publicado en 2016

Metabonomic, transcriptomic, and genomic variation of a population cohort

artículo científico publicado en 2010

Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy

scientific article published on 31 October 2019

NAFLD risk alleles in PNPLA3, TM6SF2, GCKR, and LYPLAL1 show divergent metabolic effects.

artículo científico publicado en 2018

Neolithic dairy farming at the extreme of agriculture in northern Europe

article

No association of nineteen COX-2 gene variants to preclinical markers of atherosclerosis The Cardiovascular Risk in Young Finns Study

artículo científico publicado en 2012

Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis

artículo científico publicado en 2012

Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses

artículo científico publicado en 2016

Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and genetics

article

Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior

artículo científico publicado en 2010

Sex hormone-binding globulin associations with circulating lipids and metabolites and the risk for type 2 diabetes: observational and causal effect estimates

artículo científico publicado en 2015

Systematic identification of trans eQTLs as putative drivers of known disease associations

artículo científico publicado en 2013

Systems medicine links microbial inflammatory response with glycoprotein-associated mortality risk

artículo científico publicado en 2015

The Biomarker GlycA Is Associated with Chronic Inflammation and Predicts Long-Term Risk of Severe Infection

artículo científico publicado en 2015

The impact of low-frequency and rare variants on lipid levels

artículo científico publicado en 2015

The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis

artículo científico publicado en 2013

The transcriptional landscape of age in human peripheral blood

artículo científico publicado en 2015

USF1 deficiency activates brown adipose tissue and improves cardiometabolic health

artículo científico publicado en 2016

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

scholarly article published 19 October 2018

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