Lista de obras - Jean-Marc Taymans - Dominio Público Uruguay

A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively

scientific article published on 17 March 2022

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation

artículo científico publicado en 2014

A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells

artículo científico publicado en 2024

Activator of G protein signaling type 3 mRNA is widely distributed in the rat brain and is particularly abundant in the subventricular zone-olfactory bulb system of neural precursor cell proliferation, migration and differentiation

artículo científico publicado en 2005

Automated quantitative gait analysis in animal models of movement disorders

artículo científico publicado en 2010

Bilateral control of brain activity by dopamine D1 receptors: evidence from induction patterns of regulator of G protein signaling 2 and c-fos mRNA in D1-challenged hemiparkinsonian rats

artículo científico publicado en 2005

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

artículo científico publicado en 2012

Can the increasing number of newly developed leucine-rich repeat kinase 2 inhibitors validate or invalidate a potential disease-modifying therapeutic approach for Parkinson's disease?

artículo científico publicado en 2014

Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients

artículo científico publicado en 2019

Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.

artículo científico publicado en 2015

Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain

artículo científico publicado en 2007

Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes

artículo científico publicado en 2017

Deregulation of protein translation control, a potential game-changing hypothesis for Parkinson's disease pathogenesis.

artículo científico

Detailed localization of regulator of G protein signaling 2 messenger ribonucleic acid and protein in the rat brain.

artículo científico publicado en 2002

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

artículo científico publicado en 2014

Distribution of PINK1 and LRRK2 in rat and mouse brain

artículo científico publicado en 2006

Dopamine receptor-mediated regulation of RGS2 and RGS4 mRNA differentially depends on ascending dopamine projections and time

artículo científico publicado en 2004

Evidence for the Involvement of the Small Subunit of HIV-1 Reverse Transcriptase (RT) in the TSAO-Resistance

article

Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2.

artículo científico publicado en 2012

GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.

artículo científico publicado en 2017

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle

artículo científico publicado en 2013

Immunohistochemical detection of transgene expression in the brain using small epitope tags

artículo científico publicado en 2010

In silico and Wet Bench Interactomics Sheds Light on the Similitudes and Differences between Human ROCO Proteins

scientific article published on 13 June 2018

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.

artículo científico publicado en 2014

Indolinone based LRRK2 kinase inhibitors with a key hydrogen bond

artículo científico publicado en 2014

Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology.

artículo científico publicado en 2010

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

artículo científico publicado en 2011

Kinases as targets for Parkinson's disease: from genetics to therapy

artículo científico publicado en 2011

LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?

artículo científico publicado en 2015

LRRK2 detection in human biofluids: potential use as a Parkinson's disease biomarker?

artículo científico publicado en 2017

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

artículo científico publicado en 2011

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

artículo científico publicado en 2015

MK-801 alters RGS2 levels and adenylyl cyclase sensitivity in the rat striatum

artículo científico publicado en 2005

Metabolic labeling of leucine rich repeat kinases 1 and 2 with radioactive phosphate

scientific article published on 18 September 2013

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.

artículo científico publicado en 2012

On the road to leucine-rich repeat kinase 2 signalling: evidence from cellular and in vivo studies

artículo científico publicado en 2011

PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.

artículo científico publicado en 2017

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

artículo científico publicado en 2018

Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation

artículo científico publicado en 2016

Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism

artículo científico publicado en 2014

Phosphorylation of LRRK2: from kinase to substrate

artículo científico publicado en 2012

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

artículo científico publicado en 2009

Regulation of LRRK2 by Phosphatases

artículo científico publicado en 2017

Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit.

artículo científico publicado en 1994

Role of LRRK2 in the regulation of dopamine receptor trafficking

artículo científico publicado en 2017

Striatal gene expression of RGS2 and RGS4 is specifically mediated by dopamine D1 and D2 receptors: clues for RGS2 and RGS4 functions

artículo científico publicado en 2003

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

artículo científico publicado en 2008

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation

artículo científico publicado en 2010

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

artículo científico publicado en 2009

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

artículo científico publicado en 2014

Lista de obras de Jean-Marc Taymans

A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation

A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells

Activator of G protein signaling type 3 mRNA is widely distributed in the rat brain and is particularly abundant in the subventricular zone-olfactory bulb system of neural precursor cell proliferation, migration and differentiation

Automated quantitative gait analysis in animal models of movement disorders

Bilateral control of brain activity by dopamine D1 receptors: evidence from induction patterns of regulator of G protein signaling 2 and c-fos mRNA in D1-challenged hemiparkinsonian rats

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

Can the increasing number of newly developed leucine-rich repeat kinase 2 inhibitors validate or invalidate a potential disease-modifying therapeutic approach for Parkinson's disease?

Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients

Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.

Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain

Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes

Deregulation of protein translation control, a potential game-changing hypothesis for Parkinson's disease pathogenesis.

Detailed localization of regulator of G protein signaling 2 messenger ribonucleic acid and protein in the rat brain.

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

Distribution of PINK1 and LRRK2 in rat and mouse brain

Dopamine receptor-mediated regulation of RGS2 and RGS4 mRNA differentially depends on ascending dopamine projections and time

Evidence for the Involvement of the Small Subunit of HIV-1 Reverse Transcriptase (RT) in the TSAO-Resistance

Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2.

GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle

Immunohistochemical detection of transgene expression in the brain using small epitope tags

In silico and Wet Bench Interactomics Sheds Light on the Similitudes and Differences between Human ROCO Proteins

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.

Indolinone based LRRK2 kinase inhibitors with a key hydrogen bond

Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology.

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

Kinases as targets for Parkinson's disease: from genetics to therapy

LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?

LRRK2 detection in human biofluids: potential use as a Parkinson's disease biomarker?

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

MK-801 alters RGS2 levels and adenylyl cyclase sensitivity in the rat striatum

Metabolic labeling of leucine rich repeat kinases 1 and 2 with radioactive phosphate

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.

On the road to leucine-rich repeat kinase 2 signalling: evidence from cellular and in vivo studies

PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation

Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism

Phosphorylation of LRRK2: from kinase to substrate

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

Regulation of LRRK2 by Phosphatases

Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit.

Role of LRRK2 in the regulation of dopamine receptor trafficking

Striatal gene expression of RGS2 and RGS4 is specifically mediated by dopamine D1 and D2 receptors: clues for RGS2 and RGS4 functions

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease