Lista de obras - Alexandra Beilina - Dominio Público Uruguay

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation

artículo científico publicado en 2014

Age-associated changes in gene expression in human brain and isolated neurons

artículo científico publicado en 2012

Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution

artículo científico publicado en 2014

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

artículo científico publicado en 2012

Cell population-specific expression analysis of human cerebellum

artículo científico publicado en 2012

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.

artículo científico publicado en 2018

Correction to: Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC

scientific article published on 09 January 2020

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

artículo científico publicado en 2010

Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity.

artículo científico publicado en 2018

Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2

artículo científico publicado en 2018

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

artículo científico publicado en 2014

Elevated FMR1 mRNA in premutation carriers is due to increased transcription.

artículo científico publicado en 2007

Expression of PINK1 mRNA in human and rodent brain and in Parkinson's disease

scholarly article by Jeff G. Blackinton et al published December 2007 in Brain Research

Genes associated with Parkinson's disease: regulation of autophagy and beyond

artículo científico

Hexokinases link DJ-1 to the PINK1/parkin pathway

artículo científico publicado en 2017

Induction of inclusion formation and disruption of lamin A/C structure by premutation CGG-repeat RNA in human cultured neural cells

artículo científico publicado en 2005

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

artículo científico publicado en 2011

LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies

artículo científico publicado en 2020

LRRK2 mediates tubulation and vesicle sorting from lysosomes

artículo científico publicado en 2020

LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network

artículo científico publicado en 2017

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

artículo científico publicado en 2015

Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.

artículo científico publicado en 2009

Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC

artículo científico publicado en 2019

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

artículo científico publicado en 2007

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

artículo científico publicado en 2005

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

artículo científico publicado en 2014

Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice

RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways

artículo científico publicado en 2008

Redistribution of transcription start sites within the FMR1 promoter region with expansion of the downstream CGG-repeat element

artículo científico publicado en 2004

Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis

scientific article published on 17 May 2020

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

artículo científico publicado en 2008

The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2.

artículo científico publicado en 2017

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

artículo científico publicado en 2008

The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network

artículo científico publicado en 2020

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation

artículo científico publicado en 2010

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

artículo científico publicado en 2009

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

artículo científico publicado en 2007

Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease

artículo científico publicado en 2005

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

artículo científico publicado en 2014

Lista de obras de Alexandra Beilina

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation

Age-associated changes in gene expression in human brain and isolated neurons

Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

Cell population-specific expression analysis of human cerebellum

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.

Correction to: Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity.

Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

Elevated FMR1 mRNA in premutation carriers is due to increased transcription.

Expression of PINK1 mRNA in human and rodent brain and in Parkinson's disease

Genes associated with Parkinson's disease: regulation of autophagy and beyond

Hexokinases link DJ-1 to the PINK1/parkin pathway

Induction of inclusion formation and disruption of lamin A/C structure by premutation CGG-repeat RNA in human cultured neural cells

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies

LRRK2 mediates tubulation and vesicle sorting from lysosomes

LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.

Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice

RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways

Redistribution of transcription start sites within the FMR1 promoter region with expansion of the downstream CGG-repeat element

Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2.

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease