Lista de obras - Veerle Baekelandt - Dominio Público Uruguay

A Feasibility Study to Investigate Chemogenetic Modulation of the Locus Coeruleus by Means of Single Unit Activity

scientific article published on 06 March 2020

A PET brain reporter gene system based on type 2 cannabinoid receptors

artículo científico publicado en 2011

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation

artículo científico publicado en 2014

A lipid switch unlocks Parkinson's disease-associated ATP13A2

scientific journal article

ATP13A2 deficiency disrupts lysosomal polyamine export

scientific article published on 29 January 2020

ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress

artículo científico publicado en 2020

ATP13A3 is a major component of the enigmatic mammalian polyamine transport system

artículo científico publicado en 2020

Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice

artículo científico publicado en 2014

Altered mGluR5 binding potential and glutamine concentration in the 6-OHDA rat model of acute Parkinson's disease and levodopa-induced dyskinesia

artículo científico publicado en 2017

An integrated multi-electrode-optrode array for in vitro optogenetics.

artículo científico publicado en 2016

Automated quantitative gait analysis in animal models of movement disorders

artículo científico publicado en 2010

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

artículo científico publicado en 2012

Bioluminescence imaging of stroke-induced endogenous neural stem cell response

artículo científico publicado en 2014

Blockade of enzyme activity inhibits tissue transglutaminase-mediated transamidation of α-synuclein in a cellular model of Parkinson's disease ⬇️

artículo científico publicado el 31 de marzo de 2011

Brief wide-field photostimuli evoke and modulate oscillatory reverberating activity in cortical networks

artículo científico publicado en 2016

CNS-targeted LIF expression improves therapeutic efficacy and limits autoimmune-mediated demyelination in a model of multiple sclerosis

artículo científico publicado en 2010

Characterization of lentiviral vector-mediated gene transfer in adult mouse brain

artículo científico publicado en 2002

Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.

artículo científico publicado en 2015

Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an α-synuclein based rat model for Parkinson's disease

artículo científico publicado en 2019

Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain

artículo científico publicado en 2007

Comparative analysis of different peptidyl-prolyl isomerases reveals FK506-binding protein 12 as the most potent enhancer of alpha-synuclein aggregation

artículo científico publicado en 2011

Comparison of lentiviral vector titration methods

artículo científico publicado en 2006

Concise review: therapeutic strategies for Parkinson disease based on the modulation of adult neurogenesis

artículo científico publicado en 2006

Construction and evaluation of multitracer small-animal PET probabilistic atlases for voxel-based functional mapping of the rat brain.

artículo científico publicado en 2006

Construction and evaluation of quantitative small-animal PET probabilistic atlases for [¹⁸F]FDG and [¹⁸F]FECT functional mapping of the mouse brain

artículo científico publicado en 2013

Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes

artículo científico publicado en 2017

Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance

artículo científico publicado en 2011

Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector

artículo científico publicado en 2016

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

artículo científico publicado en 2014

Diffusion tensor imaging in a rat model of Parkinson's disease after lesioning of the nigrostriatal tract

artículo científico publicado en 2009

Distribution of PINK1 and LRRK2 in rat and mouse brain

artículo científico publicado en 2006

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues

artículo científico publicado en 2020

Dynamic changes in cell size and corresponding cell fate after optic nerve injury

artículo científico publicado en 2020

Editorial: The Role of Lipids in the Pathogenesis of Parkinson's Disease

scientific article published on 24 March 2020

Efficient gene transfer into the mouse lung by fetal intratracheal injection of rAAV2/6.2.

artículo científico publicado en 2010

Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease

artículo científico publicado en 2013

Evaluation of WGA-Cre-dependent topological transgene expression in the rodent brain

artículo científico publicado en 2016

Evaluation of the expression pattern of rAAV2/1, 2/5, 2/7, 2/8, and 2/9 serotypes with different promoters in the mouse visual cortex

artículo científico publicado en 2015

Evaluation of the specificity and sensitivity of ferritin as an MRI reporter gene in the mouse brain using lentiviral and adeno-associated viral vectors.

artículo científico publicado en 2011

Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2.

artículo científico publicado en 2012

FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T

artículo científico publicado en 2008

FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease

artículo científico publicado en 2015

High-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's disease

artículo científico publicado en 2015

Highly efficient multicistronic lentiviral vectors with peptide 2A sequences

artículo científico publicado en 2009

Human mesenchymal stem cells overexpressing the IL-33 antagonist soluble IL-1 receptor-like-1 attenuate endotoxin-induced acute lung injury

artículo científico publicado en 2013

IL-10 regulates adult neurogenesis by modulating ERK and STAT3 activity

artículo científico publicado en 2015

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle

artículo científico publicado en 2013

Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation.

artículo científico publicado en 2018

Identifying a glucose metabolic brain pattern in an adeno-associated viral vector based rat model for Parkinson's disease using 18F-FDG PET imaging

scientific article published on 26 August 2019

Immunohistochemical detection of transgene expression in the brain using small epitope tags

artículo científico publicado en 2010

Immunological ignorance allows long-term gene expression after perinatal recombinant adeno-associated virus-mediated gene transfer to murine airways

artículo científico publicado en 2014

Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin

artículo científico publicado en 2010

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.

artículo científico publicado en 2014

In vitro phosphorylation does not influence the aggregation kinetics of WT α-synuclein in contrast to its phosphorylation mutants

artículo científico publicado en 2014

In vivo type 1 cannabinoid receptor mapping in the 6-hydroxydopamine lesion rat model of Parkinson's disease

artículo científico publicado en 2009

Increased P2X7 Receptor Binding Is Associated With Neuroinflammation in Acute but Not Chronic Rodent Models for Parkinson's Disease

artículo científico publicado en 2019

Indolinone based LRRK2 kinase inhibitors with a key hydrogen bond

artículo científico publicado en 2014

Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology.

artículo científico publicado en 2010

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

artículo científico publicado en 2011

Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions

scientific article published on 08 June 2020

Kinases as targets for Parkinson's disease: from genetics to therapy

artículo científico publicado en 2011

Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

artículo científico publicado en 2009

LRRK2 Ablation Attenuates Αlpha-Synuclein-Induced Neuroinflammation Without Affecting Neurodegeneration or Neuropathology In Vivo

scientific article published on 16 February 2021

LRRK2 Phosphorylation: Behind the Scenes

artículo científico publicado en 2018

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

artículo científico publicado en 2011

Lentiviral vector-mediated delivery of short hairpin RNA results in persistent knockdown of gene expression in mouse brain

artículo científico publicado en 2003

Lentiviral vectors mediate efficient and stable gene transfer in adult neural stem cells in vivo

artículo científico publicado en 2006

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

artículo científico publicado en 2015

Leukemia inhibitory factor tips the immune balance towards regulatory T cells in multiple sclerosis.

artículo científico publicado en 2014

Local origin and activity-dependent generation of nestin-expressing protoplasmic astrocytes in CA1.

artículo científico publicado en 2007

Local overexpression of interleukin-11 in the central nervous system limits demyelination and enhances remyelination.

artículo científico publicado en 2013

Long-Term Fate Mapping Using Conditional Lentiviral Vectors Reveals a Continuous Contribution of Radial Glia-Like Cells to Adult Hippocampal Neurogenesis in Mice

artículo científico publicado en 2015

Long-term chemogenetic suppression of spontaneous seizures in a mouse model for temporal lobe epilepsy

scientific article published on 13 October 2019

Long-term overexpression of human wild-type and T240R mutant Parkin in rat substantia nigra induces progressive dopaminergic neurodegeneration

artículo científico publicado en 2014

Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors

artículo científico publicado en 2014

Loss-of-function rodent models for parkin and PINK1.

artículo científico publicado en 2011

MRI visualization of endogenous neural progenitor cell migration along the RMS in the adult mouse brain: validation of various MPIO labeling strategies.

artículo científico publicado en 2009

Metabolic labeling of leucine rich repeat kinases 1 and 2 with radioactive phosphate

scientific article published on 18 September 2013

Metabolic-dopaminergic mapping of the 6-hydroxydopamine rat model for Parkinson's disease

artículo científico publicado en 2007

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.

artículo científico publicado en 2012

Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate

scientific article published on 13 June 2016

Morphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinson's disease discerned with microSPECT and quantitative MRI.

artículo científico publicado en 2010

Multiple-Hit Hypothesis in Parkinson's Disease: LRRK2 and Inflammation

artículo científico publicado en 2020

Mutated ATP10B increases Parkinson's disease risk by compromising lysosomal glucosylceramide export

scientific article published on 14 March 2020

Neurogenesis as a new target for the development of antidepressant drugs

artículo científico

Neuronal hyperactivity accelerates depletion of neural stem cells and impairs hippocampal neurogenesis

artículo científico publicado en 2015

Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein

artículo científico publicado en 2003

Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration

artículo científico publicado en 2015

Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression

artículo científico publicado en 2006

Noninvasive Imaging Reveals Stable Transgene Expression in Mouse Airways After Delivery of a Nonintegrating Recombinant Adeno-Associated Viral Vector

artículo científico publicado en 2015

Noninvasive and quantitative monitoring of adult neuronal stem cell migration in mouse brain using bioluminescence imaging

artículo científico publicado en 2008

Noninvasive bioluminescence imaging of α-synuclein oligomerization in mouse brain using split firefly luciferase reporters.

artículo científico publicado en 2014

Noninvasive monitoring of long-term lentiviral vector-mediated gene expression in rodent brain with bioluminescence imaging

artículo científico publicado en 2006

Oncostatin M protects against demyelination by inducing a protective microglial phenotype

artículo científico publicado en 2015

Oncostatin M-induced astrocytic tissue inhibitor of metalloproteinases-1 drives remyelination

artículo científico publicado en 2020

Optogenetic Stimulation of the Superior Colliculus Confers Retinal Neuroprotection in a Mouse Glaucoma Model

scientific article published on 17 January 2019

P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy

artículo científico publicado en 2012

Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease

artículo científico publicado en 2006

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

artículo científico publicado en 2018

Pathogenic LRRK2 requires secondary factors to induce cellular toxicity

artículo científico publicado en 2020

Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration

Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism

artículo científico publicado en 2014

Phosphorylation of LRRK2: from kinase to substrate

artículo científico publicado en 2012

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

artículo científico publicado en 2009

Preclinical evaluation of [11C]NE40, a type 2 cannabinoid receptor PET tracer

artículo científico publicado en 2011

Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET.

artículo científico publicado en 2012

Probing the Mechanisms of Repetition Suppression in Inferior Temporal Cortex with Optogenetics

scientific article published on 06 June 2019

Prolyl oligopeptidase stimulates the aggregation of alpha-synuclein

artículo científico publicado en 2008

Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2.

artículo científico publicado en 2016

Proximal and distal modulation of neural activity by spatially confined optogenetic activation with an integrated high-density probe.

artículo científico publicado en 2018

Quantitative evaluation of MRI-based tracking of ferritin-labeled endogenous neural stem cell progeny in rodent brain

artículo científico publicado en 2012

RAB7L1-Mediated Relocalization of LRRK2 to the Golgi Complex Causes Centrosomal Deficits via RAB8A

artículo científico publicado en 2018

RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits

scientific article published on 01 November 2019

Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking

artículo científico publicado en 2019

Regional complexity in enteric neuron wiring reflects diversity of motility patterns in the mouse large intestine

artículo científico publicado en 2019

Regulation and targeting of enzymes mediating Parkinson's disease pathogenesis: focus on Parkinson's disease kinases, GTPases, and ATPases

artículo científico publicado en 2014

Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1

scientific journal article

Reporter gene-expressing bone marrow-derived stromal cells are immune-tolerated following implantation in the central nervous system of syngeneic immunocompetent mice

artículo científico publicado en 2009

Retinal α-synuclein deposits in Parkinson's disease patients and animal models

artículo científico publicado en 2019

Reversible neurochemical changes mediated by delayed intrastriatal glial cell line-derived neurotrophic factor gene delivery in a partial Parkinson's disease rat model

artículo científico publicado en 2009

Seeing genes at work in the living brain with non-invasive molecular imaging

artículo científico publicado en 2009

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis

Serotype-dependent transduction efficiencies of recombinant adeno-associated viral vectors in monkey neocortex

artículo científico publicado en 2015

Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging

artículo científico publicado en 2011

Tackling Glaucoma from within the Brain: An Unfortunate Interplay of BDNF and TrkB

artículo científico publicado en 2015

Temporal changes in neuroinflammation and brain glucose metabolism in a rat model of viral vector-induced α-synucleinopathy

artículo científico publicado en 2019

The Conformation and the Aggregation Kinetics of α-Synuclein Depend on the Proline Residues in Its C-Terminal Region ⬇️

artículo científico publicado el 2 de noviembre de 2010

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

artículo científico publicado en 2008

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

artículo científico publicado en 2009

The aggregation of alpha-synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy

artículo científico publicado en 2006

The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons

artículo científico publicado en 2009

The remarkable conformational plasticity of alpha-synuclein: blessing or curse?

artículo científico publicado en 2013

The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies

scientific article published on 30 April 2020

The α crystallin domain of small heat shock protein b8 (Hspb8) acts as survival and differentiation factor in adult hippocampal neurogenesis.

artículo científico publicado en 2013

Transient and localized optogenetic activation of somatostatin-interneurons in mouse visual cortex abolishes long-term cortical plasticity due to vision loss.

artículo científico publicado en 2018

Type 1 cannabinoid receptor mapping with [18F]MK-9470 PET in the rat brain after quinolinic acid lesion: a comparison to dopamine receptors and glucose metabolism

artículo científico publicado en 2010

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

artículo científico publicado en 2014

Unraveling the role of peptidyl-prolyl isomerases in neurodegeneration

scientific article published on 07 May 2011

Upscaling of lentiviral vector production by tangential flow filtration

artículo científico publicado en 2005

Viral vector-based models of Parkinson's disease

artículo científico

Viral vectors expressing a single microRNA-based short-hairpin RNA result in potent gene silencing in vitro and in vivo

artículo científico publicado en 2013

rAAV-CFTRΔR Rescues the Cystic Fibrosis Phenotype in Human Intestinal Organoids and Cystic Fibrosis Mice

artículo científico publicado en 2015

rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration

artículo científico publicado en 2013

ɑ-Synuclein strains and seeding in Parkinson's disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences

artículo científico publicado en 2018

ɑ-Synuclein strains and the variable pathologies of synucleinopathies

artículo científico publicado en 2016

Lista de obras de Veerle Baekelandt

A Feasibility Study to Investigate Chemogenetic Modulation of the Locus Coeruleus by Means of Single Unit Activity

A PET brain reporter gene system based on type 2 cannabinoid receptors

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation

A lipid switch unlocks Parkinson's disease-associated ATP13A2

ATP13A2 deficiency disrupts lysosomal polyamine export

ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress

ATP13A3 is a major component of the enigmatic mammalian polyamine transport system

Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice

Altered mGluR5 binding potential and glutamine concentration in the 6-OHDA rat model of acute Parkinson's disease and levodopa-induced dyskinesia

An integrated multi-electrode-optrode array for in vitro optogenetics.

Automated quantitative gait analysis in animal models of movement disorders

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

Bioluminescence imaging of stroke-induced endogenous neural stem cell response

Blockade of enzyme activity inhibits tissue transglutaminase-mediated transamidation of α-synuclein in a cellular model of Parkinson's disease ⬇️

Brief wide-field photostimuli evoke and modulate oscillatory reverberating activity in cortical networks

CNS-targeted LIF expression improves therapeutic efficacy and limits autoimmune-mediated demyelination in a model of multiple sclerosis

Characterization of lentiviral vector-mediated gene transfer in adult mouse brain

Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.

Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an α-synuclein based rat model for Parkinson's disease

Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain

Comparative analysis of different peptidyl-prolyl isomerases reveals FK506-binding protein 12 as the most potent enhancer of alpha-synuclein aggregation

Comparison of lentiviral vector titration methods

Concise review: therapeutic strategies for Parkinson disease based on the modulation of adult neurogenesis

Construction and evaluation of multitracer small-animal PET probabilistic atlases for voxel-based functional mapping of the rat brain.

Construction and evaluation of quantitative small-animal PET probabilistic atlases for [¹⁸F]FDG and [¹⁸F]FECT functional mapping of the mouse brain

Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes

Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance

Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

Diffusion tensor imaging in a rat model of Parkinson's disease after lesioning of the nigrostriatal tract

Distribution of PINK1 and LRRK2 in rat and mouse brain

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues

Dynamic changes in cell size and corresponding cell fate after optic nerve injury

Editorial: The Role of Lipids in the Pathogenesis of Parkinson's Disease

Efficient gene transfer into the mouse lung by fetal intratracheal injection of rAAV2/6.2.

Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease

Evaluation of WGA-Cre-dependent topological transgene expression in the rodent brain

Evaluation of the expression pattern of rAAV2/1, 2/5, 2/7, 2/8, and 2/9 serotypes with different promoters in the mouse visual cortex

Evaluation of the specificity and sensitivity of ferritin as an MRI reporter gene in the mouse brain using lentiviral and adeno-associated viral vectors.

Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2.

FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T

FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease

High-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's disease

Highly efficient multicistronic lentiviral vectors with peptide 2A sequences

Human mesenchymal stem cells overexpressing the IL-33 antagonist soluble IL-1 receptor-like-1 attenuate endotoxin-induced acute lung injury

IL-10 regulates adult neurogenesis by modulating ERK and STAT3 activity

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle

Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation.

Identifying a glucose metabolic brain pattern in an adeno-associated viral vector based rat model for Parkinson's disease using 18F-FDG PET imaging

Immunohistochemical detection of transgene expression in the brain using small epitope tags

Immunological ignorance allows long-term gene expression after perinatal recombinant adeno-associated virus-mediated gene transfer to murine airways

Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.

In vitro phosphorylation does not influence the aggregation kinetics of WT α-synuclein in contrast to its phosphorylation mutants

In vivo type 1 cannabinoid receptor mapping in the 6-hydroxydopamine lesion rat model of Parkinson's disease

Increased P2X7 Receptor Binding Is Associated With Neuroinflammation in Acute but Not Chronic Rodent Models for Parkinson's Disease

Indolinone based LRRK2 kinase inhibitors with a key hydrogen bond

Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology.

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions

Kinases as targets for Parkinson's disease: from genetics to therapy

Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

LRRK2 Ablation Attenuates Αlpha-Synuclein-Induced Neuroinflammation Without Affecting Neurodegeneration or Neuropathology In Vivo

LRRK2 Phosphorylation: Behind the Scenes

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

Lentiviral vector-mediated delivery of short hairpin RNA results in persistent knockdown of gene expression in mouse brain

Lentiviral vectors mediate efficient and stable gene transfer in adult neural stem cells in vivo

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

Leukemia inhibitory factor tips the immune balance towards regulatory T cells in multiple sclerosis.

Local origin and activity-dependent generation of nestin-expressing protoplasmic astrocytes in CA1.

Local overexpression of interleukin-11 in the central nervous system limits demyelination and enhances remyelination.

Long-Term Fate Mapping Using Conditional Lentiviral Vectors Reveals a Continuous Contribution of Radial Glia-Like Cells to Adult Hippocampal Neurogenesis in Mice

Long-term chemogenetic suppression of spontaneous seizures in a mouse model for temporal lobe epilepsy

Long-term overexpression of human wild-type and T240R mutant Parkin in rat substantia nigra induces progressive dopaminergic neurodegeneration

Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors

Loss-of-function rodent models for parkin and PINK1.

MRI visualization of endogenous neural progenitor cell migration along the RMS in the adult mouse brain: validation of various MPIO labeling strategies.

Metabolic labeling of leucine rich repeat kinases 1 and 2 with radioactive phosphate

Metabolic-dopaminergic mapping of the 6-hydroxydopamine rat model for Parkinson's disease