Lista de obras - Roger L. Williams - Dominio Público Uruguay

A Role for the ESCRT System in Cell Division in Archaea

artículo científico publicado en 2008

A computer method for scanning and analysis of dot blots

artículo científico publicado en 1985

Ab initio self-consistent field and potential-dependent partial equalization of orbital electronegativity calculations of hydration properties of N-acetyl-N'-methyl-alanineamide

artículo científico publicado en 1990

Activation of GCN2 by the ribosomal P-stalk

artículo científico publicado en 2019

Allosteric activation of PI3Kα by oncogenic mutations.

artículo científico publicado en 2013

Architecture of human Rag GTPase heterodimers and their complex with mTORC1

artículo científico publicado en 2019

Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction

artículo científico publicado en 2002

C2 domain conformational changes in phospholipase C-delta 1

artículo científico publicado en 1996

Calcium-dependent membrane penetration is a hallmark of the C2 domain of cytosolic phospholipase A2 whereas the C2A domain of synaptotagmin binds membranes electrostatically.

artículo científico publicado en 1998

Connecting with an old partner in a new way.

artículo científico publicado en 2013

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

artículo científico publicado en 2000

Crystal structure of Myxococcus xanthus nucleoside diphosphate kinase and its interaction with a nucleotide substrate at 2.0 A resolution

artículo científico publicado en 1993

Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2

artículo científico publicado en 1998

Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta

artículo científico publicado en 1996

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA ⬇️

artículo científico publicado el 1 de julio de 1993

Crystal structure of the two N-terminal domains of g3p from filamentous phage fd at 1.9 A: evidence for conformational lability

artículo científico publicado en 1999

Crystallization and preliminary X-ray diffraction analysis of oucleoside diphosphate kinase from Myxococcus xanthus

artículo científico publicado en 1991

Crystals of a ternary complex of human immunodeficiency virus type 1 reverse transcriptase with a monoclonal antibody Fab fragment and double-stranded DNA diffract x-rays to 3.5-A resolution

artículo científico publicado en 1991

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity

artículo científico publicado en 2015

Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS) ⬇️

artículo científico publicado el 13 de septiembre de 2012

Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α

artículo científico publicado en 2011

ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes.

artículo científico publicado en 2004

ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes

artículo científico publicado en 2012

Empirical solvation models can be used to differentiate native from near-native conformations of bovine pancreatic trypsin inhibitor

artículo científico publicado en 1991

Empirical solvation models in the context of conformational energy searches: application to bovine pancreatic trypsin inhibitor

artículo científico publicado en 1992

Evolution and assembly of ESCRTs.

artículo científico publicado en 2009

Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor

artículo científico publicado en 2010

Form and flexibility in phosphoinositide 3-kinases

artículo científico publicado en 2009

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness

artículo científico publicado en 2012

Guidelines for the use and interpretation of assays for monitoring autophagy

artículo científico publicado en 2012

Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils

artículo científico publicado en 2020

Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology

artículo científico publicado en 2019

Kinases charging to the membrane

scientific article published on 01 December 2010

Mammalian phosphoinositide-specific phospholipase C.

artículo científico publicado en 1999

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

artículo científico publicado en 2007

Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes

scientific article published on 30 June 2020

Membrane trafficking: Arls squeeze the fat out

artículo científico publicado en 2011

Methods in the Study of PTEN Structure: X-Ray Crystallography and Hydrogen Deuterium Exchange Mass Spectrometry

artículo científico publicado en 2016

Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division

artículo científico publicado en 2011

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)

artículo científico publicado en 2013

Nm23/nucleoside diphosphate kinase: toward a structural and biochemical understanding of its biological functions

artículo científico publicado en 1995

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).

artículo científico publicado en 2012

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation

artículo científico publicado en 2021

PI3Kβ downstream of GPCRs - crucial partners in oncogenesis.

artículo científico publicado en 2012

PIKKs--the solenoid nest where partners and kinases meet

artículo científico publicado en 2014

PTEN regulates cilia through Dishevelled ⬇️

artículo científico publicado en 2015

Phosphoinositide 3-kinases as drug targets in cancer

artículo científico publicado en 2005

Phosphoinositide-Specific Phospholipase C δ1 Activity toward Micellar Substrates, Inositol 1,2-Cyclic Phosphate, and Other Water-Soluble Substrates: A Sequential Mechanism and Allosteric Activation ⬇️

artículo científico publicado el 16 de septiembre de 1997

Phospholipase C delta 1 requires a pleckstrin homology domain for interaction with the plasma membrane

artículo científico publicado en 1995

Propidium binding to a ribonuclease-DNA complex: X-ray and fluorescence studies.

artículo científico publicado en 1987

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors

article published in the Proceedings of the National Academy of Sciences of the United States of America

Ragtime Regulation: Mechanism of TORC1 Activation in Nutrient Sensing

artículo científico publicado en 2017

Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway

artículo científico publicado en 2016

Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases

artículo científico publicado en 2012

Replacements of single basic amino acids in the pleckstrin homology domain of phospholipase C-delta1 alter the ligand binding, phospholipase activity, and interaction with the plasma membrane

artículo científico publicado en 1998

Specific killing of lymphoma cells by cytotoxic T-cells mediated by a bispecific diabody

artículo científico publicado en 1996

Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi

artículo científico publicado en 2016

Structural Mechanisms of PTEN Regulation

artículo científico publicado en 2020

Structural and mechanistic comparison of prokaryotic and eukaryotic phosphoinositide-specific phospholipases C

artículo científico publicado en 1998

Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha.

artículo científico publicado en 2006

Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α

artículo científico publicado en 2014

Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus

artículo científico publicado en 2003

Structural basis for activation and inhibition of class I phosphoinositide 3-kinases

artículo científico publicado en 2011

Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4

artículo científico publicado en 2007

Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta

artículo científico publicado en 2000

Structural insight into the ESCRT-I/-II link and its role in MVB trafficking

artículo científico publicado en 2007

Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins.

artículo científico publicado en 2004

Structural mapping of the catalytic mechanism for a mammalian phosphoinositide-specific phospholipase C

artículo científico publicado en 1997

Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication.

artículo científico publicado en 2006

Structural studies of phosphoinositide 3-kinase-dependent traffic to multivesicular bodies.

artículo científico publicado en 2007

Structural views of phosphoinositide-specific phospholipase C: signalling the way ahead

artículo científico publicado en 1996

Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24.

artículo científico publicado en 2008

Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

artículo científico publicado en 2015

Structure of HIV-1 reverse transcriptase/DNA complex at 7 A resolution showing active site locations

artículo científico publicado en 1992

Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase

artículo científico publicado en 2004

Structure of a ribonuclease B+d(pA)4 complex

artículo científico publicado en 1996

Structures of PI4KIII complexes show simultaneous recruitment of Rab11 and its effectors

artículo científico publicado en 2014

Structures of closed and open conformations of dimeric human ATM

artículo científico publicado en 2017

Synergy in activating class I PI3Ks

artículo científico

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

artículo científico publicado en 2008

The 2.0-A resolution crystal structure of a trimeric antibody fragment with noncognate VH-VL domain pairs shows a rearrangement of VH CDR3

artículo científico publicado en 1997

The Crystal Structure of Human Nucleoside Diphosphate Kinase, NM23-H2 ⬇️

artículo científico publicado el 25 de agosto de 1995

The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain

artículo científico publicado en 2012

The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate

artículo científico publicado en 2001

The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site

scientific journal article

The intrinsic helix-forming tendency of L-alanine

artículo científico publicado en 1992

The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity

artículo científico publicado en 2016

The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

artículo científico publicado en 2019

The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase

artículo científico publicado en 2004

The structural basis for mTOR function

artículo científico

The structure of a tunicate C-type lectin from Polyandrocarpa misakiensis complexed with D -galactose

artículo científico publicado en 1999

Tor forms a dimer through an N-terminal helical solenoid with a complex topology.

artículo científico publicado en 2016

Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS

artículo científico publicado en 2007

Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11

artículo científico publicado en 2016

Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi

artículo científico publicado en 2013

[Roles of ESCRT complexes in the MVB pathway]

artículo científico publicado en 2008

Lista de obras de Roger L. Williams

A Role for the ESCRT System in Cell Division in Archaea

A computer method for scanning and analysis of dot blots

Ab initio self-consistent field and potential-dependent partial equalization of orbital electronegativity calculations of hydration properties of N-acetyl-N'-methyl-alanineamide

Activation of GCN2 by the ribosomal P-stalk

Allosteric activation of PI3Kα by oncogenic mutations.

Architecture of human Rag GTPase heterodimers and their complex with mTORC1

Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction

C2 domain conformational changes in phospholipase C-delta 1

Calcium-dependent membrane penetration is a hallmark of the C2 domain of cytosolic phospholipase A2 whereas the C2A domain of synaptotagmin binds membranes electrostatically.

Connecting with an old partner in a new way.

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

Crystal structure of Myxococcus xanthus nucleoside diphosphate kinase and its interaction with a nucleotide substrate at 2.0 A resolution

Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2

Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA ⬇️

Crystal structure of the two N-terminal domains of g3p from filamentous phage fd at 1.9 A: evidence for conformational lability

Crystallization and preliminary X-ray diffraction analysis of oucleoside diphosphate kinase from Myxococcus xanthus

Crystals of a ternary complex of human immunodeficiency virus type 1 reverse transcriptase with a monoclonal antibody Fab fragment and double-stranded DNA diffract x-rays to 3.5-A resolution

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity

Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS) ⬇️

Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α

ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes.

ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes

Empirical solvation models can be used to differentiate native from near-native conformations of bovine pancreatic trypsin inhibitor

Empirical solvation models in the context of conformational energy searches: application to bovine pancreatic trypsin inhibitor

Evolution and assembly of ESCRTs.

Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor

Form and flexibility in phosphoinositide 3-kinases

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness

Guidelines for the use and interpretation of assays for monitoring autophagy

Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils

Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology

Kinases charging to the membrane

Mammalian phosphoinositide-specific phospholipase C.

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes

Membrane trafficking: Arls squeeze the fat out

Methods in the Study of PTEN Structure: X-Ray Crystallography and Hydrogen Deuterium Exchange Mass Spectrometry

Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)

Nm23/nucleoside diphosphate kinase: toward a structural and biochemical understanding of its biological functions

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation

PI3Kβ downstream of GPCRs - crucial partners in oncogenesis.

PIKKs--the solenoid nest where partners and kinases meet

PTEN regulates cilia through Dishevelled ⬇️

Phosphoinositide 3-kinases as drug targets in cancer

Phosphoinositide-Specific Phospholipase C δ1 Activity toward Micellar Substrates, Inositol 1,2-Cyclic Phosphate, and Other Water-Soluble Substrates: A Sequential Mechanism and Allosteric Activation ⬇️

Phospholipase C delta 1 requires a pleckstrin homology domain for interaction with the plasma membrane

Propidium binding to a ribonuclease-DNA complex: X-ray and fluorescence studies.

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors

Ragtime Regulation: Mechanism of TORC1 Activation in Nutrient Sensing

Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway

Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases

Replacements of single basic amino acids in the pleckstrin homology domain of phospholipase C-delta1 alter the ligand binding, phospholipase activity, and interaction with the plasma membrane

Specific killing of lymphoma cells by cytotoxic T-cells mediated by a bispecific diabody

Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi

Structural Mechanisms of PTEN Regulation

Structural and mechanistic comparison of prokaryotic and eukaryotic phosphoinositide-specific phospholipases C

Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha.

Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α

Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus

Structural basis for activation and inhibition of class I phosphoinositide 3-kinases

Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4

Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta

Structural insight into the ESCRT-I/-II link and its role in MVB trafficking

Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins.

Structural mapping of the catalytic mechanism for a mammalian phosphoinositide-specific phospholipase C

Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication.

Structural studies of phosphoinositide 3-kinase-dependent traffic to multivesicular bodies.

Structural views of phosphoinositide-specific phospholipase C: signalling the way ahead

Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24.

Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

Structure of HIV-1 reverse transcriptase/DNA complex at 7 A resolution showing active site locations

Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase

Structure of a ribonuclease B+d(pA)4 complex

Structures of PI4KIII complexes show simultaneous recruitment of Rab11 and its effectors

Structures of closed and open conformations of dimeric human ATM

Synergy in activating class I PI3Ks