Lista de obras -

2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors

artículo científico publicado en 2016

A Multicomponent Carba-Betti Strategy to Alkylidene Heterodimers - Total Synthesis and Structure-Activity Relationships of Arzanol

Acetyl-CoA carboxylase 1 regulates endothelial cell migration by shifting the phospholipid composition

artículo científico publicado en 2017

Analgesic potential of standardized methanol stem bark extract of Ficus platyphylla in mice: Mechanisms of action

artículo científico publicado en 2016

Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males

artículo científico publicado en 2017

Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor

scientific article published on 28 October 2019

Anti-inflammatory and analgesic activity of carnosol and carnosic acid in vivo and in vitro and in silico analysis of their target interactions.

artículo científico publicado en 2016

Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding

artículo científico publicado en 2013

Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo

artículo científico publicado en 2010

Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors.

artículo científico publicado en 2015

Carnosol and carnosic acids from Salvia officinalis inhibit microsomal prostaglandin E2 synthase-1.

artículo científico publicado en 2012

Connecting lysosomes and mitochondria - a novel role for lipid metabolism in cancer cell death

artículo científico publicado en 2019

Corrigendum to “Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors” [Eur. J. Med. Chem. 101 (2015) 573–583]

scholarly article by Daniela de Lucia et al published October 2015 in European Journal of Medicinal Chemistry

Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1.

artículo científico publicado en 2009

Defined Structure-Activity Relationships of Boswellic Acids Determine Modulation of Ca2+ Mobilization and Aggregation of Human Platelets by Boswellia serrata Extracts.

artículo científico publicado en 2017

Design and Development of Microsomal Prostaglandin E2 Synthase-1 Inhibitors: Challenges and Future Directions

artículo científico publicado en 2016

Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors

artículo científico publicado en 2015

Developmental stage-dependent regulation of spine formation by calcium-calmodulin-dependent protein kinase IIα and Rap1.

artículo científico publicado en 2017

Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1.

artículo científico publicado en 2009

Discovery of new potent molecular entities able to inhibit mPGES-1.

artículo científico publicado en 2017

Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol

artículo científico publicado en 2015

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase

artículo científico publicado en 2018

Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation

artículo científico publicado en 2021

Ginkgolic Acid is a Multi-Target Inhibitor of Key Enzymes in Pro-Inflammatory Lipid Mediator Biosynthesis

scientific article published on 17 July 2019

Green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin E(2) synthase-1.

artículo científico publicado en 2009

Hit-to-lead optimization of phenylsulfonyl hydrazides for a potent suppressor of PGE2 production: Synthesis, biological activity, and molecular docking study

artículo científico publicado en 2015

Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo.

artículo científico publicado en 2009

Hyperforin, an Anti-Inflammatory Constituent from St. John's Wort, Inhibits Microsomal Prostaglandin E(2) Synthase-1 and Suppresses Prostaglandin E(2) Formation in vivo ⬇️

artículo científico publicado en 2011

Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1.

artículo científico publicado en 2011

Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol

artículo científico publicado en 2009

Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase-1 Inhibitors by Automated De Novo Design

artículo científico publicado en 2021

Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1.

artículo científico publicado en 2008

Lipid Mediator Profiles Predict Response to Therapy with an Oral Frankincense Extract in Relapsing-Remitting Multiple Sclerosis

artículo científico publicado en 2020

Lipophilic extracts of Leucas zeylanica, a multi-purpose medicinal plant in the tropics, inhibit key enzymes involved in inflammation and gout.

artículo científico publicado en 2018

Lysophosphatidylcholine acyltransferase 3 is the key enzyme for incorporating arachidonic acid into glycerophospholipids during adipocyte differentiation

artículo científico publicado en 2012

MK-886, an inhibitor of the 5-lipoxygenase-activating protein, inhibits cyclooxygenase-1 activity and suppresses platelet aggregation

artículo científico publicado en 2009

Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor

scientific article published on 17 July 2018

Matrix-based Molecular Descriptors for Prospective Virtual Compound Screening

artículo científico publicado en 2016

Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy

artículo científico publicado en 2017

Multi-target approach for natural products in inflammation

artículo científico publicado en 2014

Munronia pinnata (Wall.) Theob.: unveiling phytochemistry and dual inhibition of 5-lipoxygenase and microsomal prostaglandin E2 synthase (mPGES)-1.

artículo científico publicado en 2013

Myrtucommulone from Myrtus communis exhibits potent anti-inflammatory effectiveness in vivo

artículo científico publicado en 2008

Myxochelins target human 5-lipoxygenase

artículo científico publicado en 2015

Natural products as inhibitors of prostaglandin E2 and pro-inflammatory 5-lipoxygenase-derived lipid mediator biosynthesis

artículo científico publicado en 2018

Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid

artículo científico publicado en 2008

PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling

artículo científico publicado en 2022

Palmitoleate is a mitogen, formed upon stimulation with growth factors, and converted to palmitoleoyl-phosphatidylinositol

artículo científico publicado en 2012

Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders

artículo científico

Pharmacological targeting of membrane rigidity: implications on cancer cell migration and invasion

scholarly article by Simone Braig et al published 5 August 2015 in New Journal of Physics

Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase

artículo científico publicado en 2008

Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3 ⬇️

artículo científico publicado el 3 de octubre de 2011

Predictive Bioinformatic Assignment of Methyl-Bearing Stereocenters, Total Synthesis, and an Additional Molecular Target of Ajudazol B.

artículo científico publicado en 2016

Protective Effect of Casperome®, an Orally Bioavailable Frankincense Extract, on Lipopolysaccharide- Induced Systemic Inflammation in Mice.

artículo científico publicado en 2018

Regeneration in starved planarians depends on TRiC/CCT subunits modulating the unfolded protein response

artículo científico publicado en 2021

Revealing the macromolecular targets of complex natural products

artículo científico publicado en 2014

Role of lysophosphatidic acid acyltransferase 3 for the supply of highly polyunsaturated fatty acids in TM4 Sertoli cells

artículo científico publicado en 2010

Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with endoplasmic reticulum homeostasis

artículo científico publicado en 2015

Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor ⬇️

artículo científico publicado el 25 de diciembre de 2011

Stearoyl-CoA desaturase-1 and adaptive stress signaling

artículo científico publicado en 2016

Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme

artículo científico publicado en 2016

Structure-Function Relationship Studies In Vitro Reveal Distinct and Specific Effects of Long-Chain Metabolites of Vitamin E.

artículo científico publicado en 2017

Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents

artículo científico publicado en 2016

Target identification and lead discovery by functional lipidomics

artículo científico publicado en 2016

Targeting de novo lipogenesis as a novel approach in anti-cancer therapy

artículo científico publicado en 2017

The 5‐lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages ⬇️

artículo científico publicado el 1 de octubre de 2010

The Anti-Inflammatory and Antimicrobial Potential of Selected Ethnomedicinal Plants from Sri Lanka

scientific article published on 20 April 2020

The Bibenzyl Canniprene Inhibits the Production of Pro-Inflammatory Eicosanoids and Selectively Accumulates in Some Cannabis sativa Strains

artículo científico publicado en 2017

The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase

artículo científico publicado en 2009

The role of diacylglyceride generation by phospholipase D and phosphatidic acid phosphatase in the activation of 5-lipoxygenase in polymorphonuclear leukocytes

artículo científico publicado en 2008

The standardized herbal combination BNO 2103 contained in Canephron® N alleviates inflammatory pain in experimental cystitis and prostatitis

scientific article published on 10 June 2019

The vitamin E derivative garcinoic acid from Garcinia kola nut seeds attenuates the inflammatory response

artículo científico publicado en 2019

Tnfaip2/exoc3-driven lipid metabolism is essential for stem cell differentiation and organ homeostasis

scientific article published on 10 December 2020

Total synthesis of myrtucommulone A.

artículo científico publicado en 2010

Triterpene Acids from Frankincense and Semi-Synthetic Derivatives That Inhibit 5-Lipoxygenase and Cathepsin G.

artículo científico publicado en 2018

V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - a new option for HCC therapy

scientific article published on 28 December 2016

Vitamin A regulates Akt signaling through the phospholipid fatty acid composition

artículo científico publicado en 2017

α-Tocopherol long-chain metabolite α-13'-COOH affects the inflammatory response of lipopolysaccharide-activated murine RAW264.7 macrophages

artículo científico publicado en 2015

Lista de obras de

2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors

A Multicomponent Carba-Betti Strategy to Alkylidene Heterodimers - Total Synthesis and Structure-Activity Relationships of Arzanol

Acetyl-CoA carboxylase 1 regulates endothelial cell migration by shifting the phospholipid composition

Analgesic potential of standardized methanol stem bark extract of Ficus platyphylla in mice: Mechanisms of action

Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males

Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor

Anti-inflammatory and analgesic activity of carnosol and carnosic acid in vivo and in vitro and in silico analysis of their target interactions.

Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding

Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo

Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors.

Carnosol and carnosic acids from Salvia officinalis inhibit microsomal prostaglandin E2 synthase-1.

Connecting lysosomes and mitochondria - a novel role for lipid metabolism in cancer cell death

Corrigendum to “Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors” [Eur. J. Med. Chem. 101 (2015) 573–583]

Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1.

Defined Structure-Activity Relationships of Boswellic Acids Determine Modulation of Ca2+ Mobilization and Aggregation of Human Platelets by Boswellia serrata Extracts.

Design and Development of Microsomal Prostaglandin E2 Synthase-1 Inhibitors: Challenges and Future Directions

Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors

Developmental stage-dependent regulation of spine formation by calcium-calmodulin-dependent protein kinase IIα and Rap1.

Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1.

Discovery of new potent molecular entities able to inhibit mPGES-1.

Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase

Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation

Ginkgolic Acid is a Multi-Target Inhibitor of Key Enzymes in Pro-Inflammatory Lipid Mediator Biosynthesis

Green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin E(2) synthase-1.

Hit-to-lead optimization of phenylsulfonyl hydrazides for a potent suppressor of PGE2 production: Synthesis, biological activity, and molecular docking study

Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo.

Hyperforin, an Anti-Inflammatory Constituent from St. John's Wort, Inhibits Microsomal Prostaglandin E(2) Synthase-1 and Suppresses Prostaglandin E(2) Formation in vivo ⬇️

Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1.

Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol

Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase-1 Inhibitors by Automated De Novo Design

Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1.

Lipid Mediator Profiles Predict Response to Therapy with an Oral Frankincense Extract in Relapsing-Remitting Multiple Sclerosis

Lipophilic extracts of Leucas zeylanica, a multi-purpose medicinal plant in the tropics, inhibit key enzymes involved in inflammation and gout.

Lysophosphatidylcholine acyltransferase 3 is the key enzyme for incorporating arachidonic acid into glycerophospholipids during adipocyte differentiation

MK-886, an inhibitor of the 5-lipoxygenase-activating protein, inhibits cyclooxygenase-1 activity and suppresses platelet aggregation

Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor

Matrix-based Molecular Descriptors for Prospective Virtual Compound Screening

Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy

Multi-target approach for natural products in inflammation

Munronia pinnata (Wall.) Theob.: unveiling phytochemistry and dual inhibition of 5-lipoxygenase and microsomal prostaglandin E2 synthase (mPGES)-1.

Myrtucommulone from Myrtus communis exhibits potent anti-inflammatory effectiveness in vivo

Myxochelins target human 5-lipoxygenase

Natural products as inhibitors of prostaglandin E2 and pro-inflammatory 5-lipoxygenase-derived lipid mediator biosynthesis

Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid

PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling

Palmitoleate is a mitogen, formed upon stimulation with growth factors, and converted to palmitoleoyl-phosphatidylinositol

Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders

Pharmacological targeting of membrane rigidity: implications on cancer cell migration and invasion

Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase

Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3 ⬇️

Predictive Bioinformatic Assignment of Methyl-Bearing Stereocenters, Total Synthesis, and an Additional Molecular Target of Ajudazol B.

Protective Effect of Casperome®, an Orally Bioavailable Frankincense Extract, on Lipopolysaccharide- Induced Systemic Inflammation in Mice.

Regeneration in starved planarians depends on TRiC/CCT subunits modulating the unfolded protein response

Revealing the macromolecular targets of complex natural products

Role of lysophosphatidic acid acyltransferase 3 for the supply of highly polyunsaturated fatty acids in TM4 Sertoli cells

Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with endoplasmic reticulum homeostasis

Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor ⬇️

Stearoyl-CoA desaturase-1 and adaptive stress signaling

Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme

Structure-Function Relationship Studies In Vitro Reveal Distinct and Specific Effects of Long-Chain Metabolites of Vitamin E.

Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents

Target identification and lead discovery by functional lipidomics

Targeting de novo lipogenesis as a novel approach in anti-cancer therapy

The 5‐lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages ⬇️

The Anti-Inflammatory and Antimicrobial Potential of Selected Ethnomedicinal Plants from Sri Lanka

The Bibenzyl Canniprene Inhibits the Production of Pro-Inflammatory Eicosanoids and Selectively Accumulates in Some Cannabis sativa Strains

The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase

The role of diacylglyceride generation by phospholipase D and phosphatidic acid phosphatase in the activation of 5-lipoxygenase in polymorphonuclear leukocytes

The standardized herbal combination BNO 2103 contained in Canephron® N alleviates inflammatory pain in experimental cystitis and prostatitis

The vitamin E derivative garcinoic acid from Garcinia kola nut seeds attenuates the inflammatory response

Tnfaip2/exoc3-driven lipid metabolism is essential for stem cell differentiation and organ homeostasis

Total synthesis of myrtucommulone A.

Triterpene Acids from Frankincense and Semi-Synthetic Derivatives That Inhibit 5-Lipoxygenase and Cathepsin G.

V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - a new option for HCC therapy

Vitamin A regulates Akt signaling through the phospholipid fatty acid composition

α-Tocopherol long-chain metabolite α-13'-COOH affects the inflammatory response of lipopolysaccharide-activated murine RAW264.7 macrophages