Lista de obras - Nils Blüthgen - Dominio Público Uruguay

A 3D gene expression atlas of the floral meristem based on spatial reconstruction of single nucleus RNA sequencing data

artículo científico publicado en 2022

A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology

artículo científico publicado en 2008

A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts

artículo científico

A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors

artículo científico publicado en 2015

An immediate-late gene expression module decodes ERK signal duration

artículo científico publicado en 2017

An immediate-late gene expression module decodes ERK signal duration

artículo científico publicado en 2017

Analysis of impedance-based cellular growth assays

artículo científico publicado en 2015

Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A. ⬇️

artículo científico publicado en 2015

Assessment of stem cell differentiation based on genome-wide expression profiles

artículo científico publicado en 2018

Bacterial computing with engineered populations

artículo científico

Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium

artículo científico publicado en 2019

Competing docking interactions can bring about bistability in the MAPK cascade

artículo científico publicado en 2007

Computer-assisted curation of a human regulatory core network from the biological literature.

artículo científico publicado en 2014

DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas and pancreatic neuroendocrine tumors

artículo científico publicado en 2022

Discovering causal signaling pathways through gene-expression patterns

artículo científico publicado en 2010

Dissecting the action of an evolutionary conserved non-coding region on renin promoter activity

artículo científico publicado en 2007

Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis

artículo científico publicado en 2016

Effects of sequestration on signal transduction cascades

artículo científico publicado en 2006

Efficient translation initiation dictates codon usage at gene start

artículo científico

From Reaction Networks to Information Flow—Using Modular Response Analysis to Track Information in Signaling Networks ⬇️

artículo científico publicado el 1 de enero de 2011

Gene expression. MicroRNA control of protein expression noise

artículo científico publicado en 2015

Genome-wide profiling of the activity-dependent hippocampal transcriptome

artículo científico publicado en 2013

Global analysis of host tissue gene expression in the invasive front of colorectal liver metastases

artículo científico

Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling

artículo científico publicado en 2015

HOMGL-comparing genelists across species and with different accession numbers

artículo científico

Handling and Interpreting Gene Groups

article

How robust are switches in intracellular signaling cascades?

artículo científico publicado en 2003

Hypoxia-induced gene expression results from selective mRNA partitioning to the endoplasmic reticulum.

artículo científico publicado en 2015

Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells

artículo científico publicado en 2010

Inferring combinatorial regulation of transcription in silico

artículo científico publicado en 2005

Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability

artículo científico publicado en 2006

Mathematical models in mammalian cell biology

artículo científico publicado en 2008

Measuring specialization in species interaction networks

artículo científico publicado en 2006

Mechanisms Generating Ultrasensitivity, Bistability, and Oscillations in Signal Transduction

Multilevel regulation of HIF-1 signaling by TTP.

artículo científico publicado en 2012

Natural Cubic Spline Regression Modeling Followed by Dynamic Network Reconstruction for the Identification of Radiation-Sensitivity Gene Association Networks from Time-Course Transcriptome Data

artículo científico publicado en 2016

Network quantification of EGFR signaling unveils potential for targeted combination therapy.

artículo científico publicado en 2013

Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance

artículo científico publicado en 2021

Noise management by molecular networks

artículo científico publicado en 2009

Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids.

artículo científico publicado en 2017

Personalized signaling models for personalized treatments

artículo científico publicado en 2020

Perturbation-response genes reveal signaling footprints in cancer gene expression

artículo científico publicado en 2018

Quantitative analysis of ultrasensitive responses

artículo científico publicado en 2005

RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway

artículo científico publicado en 2015

RORγt⁺ innate lymphoid cells acquire a proinflammatory program upon engagement of the activating receptor NKp44.

artículo científico publicado en 2013

Recurrent design patterns in the feedback regulation of the mammalian signalling network

artículo científico publicado en 2008

Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe

artículo científico publicado en 2020

Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS.

artículo científico publicado en 2012

Robustness of signal transduction pathways ⬇️

artículo científico publicado el 25 de septiembre de 2012

Seed-based systematic discovery of specific transcription factor target genes.

artículo científico publicado en 2008

Sequestration shapes the response of signal transduction cascades

artículo científico publicado en 2006

Signal integration by the CYP1A1 promoter--a quantitative study

artículo científico publicado en 2015

Signaling output: it's all about timing and feedbacks

artículo científico publicado en 2015

Silence on the relevant literature and errors in implementation

artículo científico publicado en 2015

Spatial partitioning of the regulatory landscape of the X-inactivation centre ⬇️

artículo científico publicado el 11 de abril de 2012

Specialization, constraints, and conflicting interests in mutualistic networks

artículo científico publicado en 2007

Stem Cell-Derived Immature Human Dorsal Root Ganglia Neurons to Identify Peripheral Neurotoxicants

artículo científico publicado en 2016

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.

artículo científico publicado en 2011

SysBioMed report: advancing systems biology for medical applications.

artículo científico

Systems biologists seek fuller integration of systems biology approaches in new cancer research programs

artículo científico publicado en 2009

Targetfinder.org: a resource for systematic discovery of transcription factor target genes

artículo científico publicado en 2010

The cancer cell proteome and transcriptome predicts sensitivity to targeted and cytotoxic drugs

scientific article published on 28 June 2019

The gene regulatory network of mESC differentiation: a benchmark for reverse engineering methods

article

The two active X chromosomes in female ESCs block exit from the pluripotent state by modulating the ESC signaling network

artículo científico publicado en 2014

Tracking in vivo dynamics of NK cells transferred in patients undergoing stem cell transplantation

artículo científico publicado en 2014

TransFind--predicting transcriptional regulators for gene sets

artículo científico publicado en 2010

Transcriptional feedbacks in mammalian signal transduction pathways facilitate rapid and reliable protein induction

artículo científico publicado en 2010

Transcriptional profiling of Saccharomyces cerevisiae cells under adhesion-inducing conditions

artículo científico publicado en 2005

Ultrasensitization: switch-like regulation of cellular signaling by transcriptional induction

artículo científico publicado en 2005

Lista de obras de Nils Blüthgen

A 3D gene expression atlas of the floral meristem based on spatial reconstruction of single nucleus RNA sequencing data

A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology

A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts

A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors

An immediate-late gene expression module decodes ERK signal duration

An immediate-late gene expression module decodes ERK signal duration

Analysis of impedance-based cellular growth assays

Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A. ⬇️

Assessment of stem cell differentiation based on genome-wide expression profiles

Bacterial computing with engineered populations

Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium

Competing docking interactions can bring about bistability in the MAPK cascade

Computer-assisted curation of a human regulatory core network from the biological literature.

DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas and pancreatic neuroendocrine tumors

Discovering causal signaling pathways through gene-expression patterns

Dissecting the action of an evolutionary conserved non-coding region on renin promoter activity

Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis

Effects of sequestration on signal transduction cascades

Efficient translation initiation dictates codon usage at gene start

From Reaction Networks to Information Flow—Using Modular Response Analysis to Track Information in Signaling Networks ⬇️

Gene expression. MicroRNA control of protein expression noise

Genome-wide profiling of the activity-dependent hippocampal transcriptome

Global analysis of host tissue gene expression in the invasive front of colorectal liver metastases

Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling

HOMGL-comparing genelists across species and with different accession numbers

Handling and Interpreting Gene Groups

How robust are switches in intracellular signaling cascades?

Hypoxia-induced gene expression results from selective mRNA partitioning to the endoplasmic reticulum.

Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells

Inferring combinatorial regulation of transcription in silico

Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability

Mathematical models in mammalian cell biology

Measuring specialization in species interaction networks

Mechanisms Generating Ultrasensitivity, Bistability, and Oscillations in Signal Transduction

Multilevel regulation of HIF-1 signaling by TTP.

Natural Cubic Spline Regression Modeling Followed by Dynamic Network Reconstruction for the Identification of Radiation-Sensitivity Gene Association Networks from Time-Course Transcriptome Data

Network quantification of EGFR signaling unveils potential for targeted combination therapy.

Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance

Noise management by molecular networks

Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids.

Personalized signaling models for personalized treatments

Perturbation-response genes reveal signaling footprints in cancer gene expression

Quantitative analysis of ultrasensitive responses

RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway

RORγt⁺ innate lymphoid cells acquire a proinflammatory program upon engagement of the activating receptor NKp44.

Recurrent design patterns in the feedback regulation of the mammalian signalling network

Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe

Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS.

Robustness of signal transduction pathways ⬇️

Seed-based systematic discovery of specific transcription factor target genes.

Sequestration shapes the response of signal transduction cascades

Signal integration by the CYP1A1 promoter--a quantitative study

Signaling output: it's all about timing and feedbacks

Silence on the relevant literature and errors in implementation

Spatial partitioning of the regulatory landscape of the X-inactivation centre ⬇️

Specialization, constraints, and conflicting interests in mutualistic networks

Stem Cell-Derived Immature Human Dorsal Root Ganglia Neurons to Identify Peripheral Neurotoxicants

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.

SysBioMed report: advancing systems biology for medical applications.

Systems biologists seek fuller integration of systems biology approaches in new cancer research programs

Targetfinder.org: a resource for systematic discovery of transcription factor target genes

The cancer cell proteome and transcriptome predicts sensitivity to targeted and cytotoxic drugs

The gene regulatory network of mESC differentiation: a benchmark for reverse engineering methods

The two active X chromosomes in female ESCs block exit from the pluripotent state by modulating the ESC signaling network

Tracking in vivo dynamics of NK cells transferred in patients undergoing stem cell transplantation

TransFind--predicting transcriptional regulators for gene sets

Transcriptional feedbacks in mammalian signal transduction pathways facilitate rapid and reliable protein induction

Transcriptional profiling of Saccharomyces cerevisiae cells under adhesion-inducing conditions

Ultrasensitization: switch-like regulation of cellular signaling by transcriptional induction