Lista de obras - Leopold Eckhart - Dominio Público Uruguay

'Don't be so over-protective!'

artículo científico publicado en 2012

2,3,7,8-tetrachlorodibenzo-p-dioxin impairs differentiation of normal human epidermal keratinocytes in a skin equivalent model

artículo científico publicado en 2005

A Stress Response Program at the Origin of Evolutionary Innovation in the Skin

scientific article published on 03 July 2019

A basement membrane-like matrix formed by cell-released proteins at the medium/air interface supports growth of keratinocytes

artículo científico publicado en 2003

ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging

artículo científico publicado en 2020

Against the rules: human keratin K80: two functional alternative splice variants, K80 and K80.1, with special cellular localization in a wide range of epithelia

artículo científico publicado en 2010

Aldehyde dehydrogenase 1A3 is transcriptionally activated by all-trans-retinoic acid in human epidermal keratinocytes

artículo científico publicado en 2010

Alternative splicing of caspase-8 mRNA during differentiation of human leukocytes

artículo científico publicado en 2001

Author Correction: Dense sampling of bird diversity increases power of comparative genomics

Autophagy - how to control your intracellular diet

article by E. Tschachler & Leopold Eckhart published June 2017 in British Journal of Dermatology

Autophagy in epithelial homeostasis and defense.

artículo científico publicado en 2013

Autophagy in the thymic epithelium is dispensable for the development of self-tolerance in a novel mouse model

artículo científico publicado en 2012

Autophagy is induced by UVA and promotes removal of oxidized phospholipids and protein aggregates in epidermal keratinocytes

artículo científico publicado en 2013

Caspase-14 but not caspase-3 is processed during the development of fetal mouse epidermis

article

Caspase-14 expression by epidermal keratinocytes is regulated by retinoids in a differentiation-associated manner

artículo científico publicado en 2002

Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation

artículo científico publicado en 2000

Caspase-15 is autoprocessed at two sites that contain an aspartate residue in the P1' position

artículo científico publicado en 2006

Cell death by cornification

artículo científico publicado en 2013

Comparative Genomics Identifies Epidermal Proteins Associated with the Evolution of the Turtle Shell

artículo científico publicado en 2015

Comparative analysis of epidermal differentiation genes of crocodilians suggests new models for the evolutionary origin of avian feather proteins

artículo científico publicado en 2018

Comparative genomics reveals conservation of filaggrin and loss of caspase-14 in dolphins

artículo científico publicado en 2015

Comparative genomics suggests loss of keratin K24 in three evolutionary lineages of mammals

artículo científico publicado en 2019

Control of cell death-associated danger signals during cornification prevents autoinflammation of the skin

artículo científico publicado en 2018

Convergent evolution of cysteine-rich proteins in feathers and hair

artículo científico publicado en 2015

Cornification of nail keratinocytes requires autophagy for bulk degradation of intracellular proteins while sparing components of the cytoskeleton

scientific article published on 01 February 2019

Cuts by caspase-14 control the proteolysis of filaggrin ⬇️

artículo científico publicado el 1 de noviembre de 2011

Cytosolic DNA sensing through cGAS and STING is inactivated by gene mutations in pangolins

artículo científico publicado en 2020

DNase 2 is the main DNA-degrading enzyme of the stratum corneum

artículo científico publicado en 2011

DNase1L2 degrades nuclear DNA during corneocyte formation

artículo científico publicado en 2006

DNase1L2 suppresses biofilm formation by Pseudomonas aeruginosa and Staphylococcus aureus

Degradation by stratum corneum proteases prevents endogenous RNase inhibitor from blocking antimicrobial activities of RNase 5 and RNase 7.

artículo científico publicado en 2009

Deleterious mutations of a claw keratin in multiple taxa of reptiles

artículo científico publicado en 2010

Dense sampling of bird diversity increases power of comparative genomics

artículo científico publicado en 2020

Differential Evolution of the Epidermal Keratin Cytoskeleton in Terrestrial and Aquatic Mammals.

artículo científico publicado en 2019

Distribution of caspase-14 in epidermis and hair follicles is evolutionarily conserved among mammals

scientific journal article

Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses

artículo científico publicado en 2017

Duplication of the caspase-12 prodomain and inactivation of NLRC4/IPAF in the dog.

artículo científico publicado en 2009

Epidermal cornification is preceded by the expression of a keratinocyte-specific set of pyroptosis-related genes

artículo científico publicado en 2017

Epidermal keratinocytes form a functional skin barrier in the absence of Atg7 dependent autophagy

artículo científico publicado en 2013

Essential role of the keratinocyte-specific endonuclease DNase1L2 in the removal of nuclear DNA from hair and nails

scientific journal article

Evidence that caspase-13 is not a human but a bovine gene

artículo científico publicado en 2001

Evolution of Trichocyte Keratins

Evolutionary origin and diversification of epidermal barrier proteins in amniotes

artículo científico publicado en 2014

Filaggrin has evolved from an "S100 fused-type protein" (SFTP) gene present in a common ancestor of amphibians and mammals

artículo científico publicado en 2017

Filamentous Aggregation of Sequestosome-1/p62 in Brain Neurons and Neuroepithelial Cells upon Tyr-Cre-Mediated Deletion of the Autophagy Gene Atg7.

artículo científico publicado en 2018

Flagellin is the principal inducer of the antimicrobial peptide S100A7c (psoriasin) in human epidermal keratinocytes exposed to Escherichia coli

artículo científico publicado en 2008

Genome sequence comparison reveals independent inactivation of the caspase-15 gene in different evolutionary lineages of mammals

artículo científico publicado en 2006

Hepatocyte growth factor/scatter factor inhibits UVB induced apoptosis of human keratinocytes via the PI-3-kinase pathway

artículo científico publicado en 1999

Hepatocyte growth factor/scatter factor inhibits UVB-induced apoptosis of human keratinocytes but not of keratinocyte-derived cell lines via the phosphatidylinositol 3-kinase/AKT pathway

artículo científico publicado en 2002

Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model

artículo científico publicado en 2012

Histidase expression in human epidermal keratinocytes: regulation by differentiation status and all-trans retinoic acid

artículo científico publicado en 2008

Holocrine Secretion of Sebum Is a Unique DNase2-Dependent Mode of Programmed Cell Death

artículo científico publicado en 2016

Human caspase 12 has acquired deleterious mutations

artículo científico publicado en 2002

Identification and characterization of a novel mammalian caspase with proapoptotic activity

artículo científico publicado en 2005

Identification and comparative analysis of the epidermal differentiation complex in snakes

artículo científico publicado en 2017

Identification of Novel Mammalian Caspases Reveals an Important Role of Gene Loss in Shaping the Human Caspase Repertoire

article

Identification of a homozygous PSTPIP1 mutation in a patient with a PAPA-like syndrome responding to canakinumab treatment

artículo científico publicado en 2013

Identification of a human cDNA encoding a novel Bcl-x isoform.

artículo científico publicado en 1998

Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants

artículo científico publicado en 2006

Identification of reptilian genes encoding hair keratin-like proteins suggests a new scenario for the evolutionary origin of hair

artículo científico publicado en 2008

Immunogenic presentation of a conserved gp41 epitope of human immunodeficiency virus type 1 on recombinant surface antigen of hepatitis B virus.

artículo científico publicado en 1996

Immunolocalization and phylogenetic profiling of the feather protein with the highest cysteine content

scientific article published on 29 April 2019

Immunolocalization of a Histidine-Rich Epidermal Differentiation Protein in the Chicken Supports the Hypothesis of an Evolutionary Developmental Link between the Embryonic Subperiderm and Feather Barbs and Barbules

artículo científico publicado en 2016

Immunolocalization of loricrin in the maturing α-layer of normal and regenerating epidermis of the lizard Anolis carolinensis

artículo científico publicado en 2015

Immunolocalization of scaffoldin, a trichohyalin-like protein, in the epidermis of the chicken embryo

article published in 2015

Impact of filaggrin mutations on Raman spectra and biophysical properties of the stratum corneum in mild to moderate atopic dermatitis

In situ labeling of DNA reveals interindividual variation in nuclear DNA breakdown in hair and may be useful to predict success of forensic genotyping of hair

artículo científico publicado en 2011

Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA degradation during epidermal cornification and results in constitutive parakeratosis

artículo científico publicado en 2017

Inactivation of autophagy leads to changes in sebaceous gland morphology and function

artículo científico publicado en 2018

Increased Sensitivity of Histidinemic Mice to UVB Radiation Suggests a Crucial Role of Endogenous Urocanic Acid in Photoprotection

Infection with human immunodeficiency virus-1 increases expression of vascular endothelial cell growth factor in T cells: implications for acquired immunodeficiency syndrome-associated vasculopathy.

artículo científico publicado en 1999

Is the filaggrin-histidine-urocanic acid pathway essential for stratum corneum acidification?

artículo científico publicado en 2010

Keratins K2 and K10 are essential for the epidermal integrity of plantar skin

artículo científico publicado en 2015

Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model

artículo científico publicado en 2010

Localisation of keratin K78 in the basal layer and first suprabasal layers of stratified epithelia completes expression catalogue of type II keratins and provides new insights into sequential keratin expression

artículo científico publicado en 2015

Loss of keratin K2 expression causes aberrant aggregation of K10, hyperkeratosis, and inflammation

scientific journal article

MCPIP1 contributes to the inflammatory response of UVB-treated keratinocytes.

artículo científico publicado en 2017

Mechanisms and emerging functions of DNA degradation in the epidermis

artículo científico

Melanin Binds Reversibly to Thermostable DNA Polymerase and Inhibits Its Activity

scientific article published in 2000

Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis

artículo científico publicado en 2015

New facets of keratin K77: interspecies variations of expression and different intracellular location in embryonic and adult skin of humans and mice

artículo científico publicado en 2013

Phylogenetic profiling and gene expression studies implicate a primary role of PSORS1C2 in terminal differentiation of keratinocytes

artículo científico publicado en 2016

Phylogenomics of caspase-activated DNA fragmentation factor

artículo científico publicado en 2007

Psoriasin (S100A7) is a major Escherichia coli-cidal factor of the female genital tract

artículo científico publicado en 2010

Retinoic acid increases the expression of p53 and proapoptotic caspases and sensitizes keratinocytes to apoptosis: a possible explanation for tumor preventive action of retinoids

artículo científico publicado en 2004

Reverse transcription-polymerase chain reaction products of alternatively spliced mRNAs form DNA heteroduplexes and heteroduplex complexes

artículo científico publicado en 1999

Review: Evolution and diversification of corneous beta-proteins, the characteristic epidermal proteins of reptiles and birds

scientific article published on 01 December 2018

Stratum corneum-derived caspase-14 is catalytically active

artículo científico publicado en 2004

Suppression of autophagy dysregulates the antioxidant response and causes premature senescence of melanocytes

artículo científico publicado en 2014

Suppression of autophagy perturbs turnover of sequestosome-1/p62 in Merkel cells but not in keratinocytes

artículo científico publicado en 2018

Suppression of epithelial autophagy compromises the homeostasis of sweat glands during aging

artículo científico publicado en 2018

TINCR is not a non-coding RNA but encodes a protein component of cornified epidermal keratinocytes

artículo científico publicado en 2020

Targeted deletion of Atg5 reveals differential roles of autophagy in keratin K5-expressing epithelia

artículo científico publicado en 2012

Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation

artículo científico publicado en 2000

Terminal differentiation of nail matrix keratinocytes involves up-regulation of DNase1L2 but is independent of caspase-14 expression

artículo científico publicado en 2007

The Differentiation-Associated Keratinocyte Protein Cornifelin Contributes to Cell-Cell Adhesion of Epidermal and Mucosal Keratinocytes

scientific article published on 24 May 2019

The Expression of the Endogenous mTORC1 Inhibitor Sestrin 2 Is Induced by UVB and Balanced with the Expression Level of Sestrin 1.

artículo científico publicado en 2016

The anatomy and development of the claws of Xenopus laevis (Lissamphibia: Anura) reveal alternate pathways of structural evolution in the integument of tetrapods

artículo científico publicado en 2009

The antimicrobial heterodimer S100A8/S100A9 (calprotectin) is upregulated by bacterial flagellin in human epidermal keratinocytes

artículo científico publicado en 2010

The caspase-1 inhibitor CARD18 is specifically expressed during late differentiation of keratinocytes and its expression is lost in lichen planus

artículo científico publicado en 2017

The molecular organization of the beta-sheet region in Corneous beta-proteins (beta-keratins) of sauropsids explains its stability and polymerization into filaments

artículo científico publicado en 2016

The skin barrier: Epidermis vs environment

scientific article published on 01 August 2018

The tail domains of keratins contain conserved amino acid sequence motifs

artículo científico publicado en 2009

Transcription of the caspase-14 gene in human epidermal keratinocytes requires AP-1 and NFkappaB.

artículo científico publicado en 2008

Trichohyalin-like proteins have evolutionarily conserved roles in the morphogenesis of skin appendages

artículo científico publicado en 2014

Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice

artículo científico publicado en 2016

Ultrastructural characterization of an artificial basement membrane produced by cultured keratinocytes

artículo científico publicado en 2005

Ultrastructural localization of caspase-14 in human epidermis

artículo científico publicado en 2004

Ultrastructural localization of hair keratin homologs in the claw of the lizard Anolis carolinensis

artículo científico publicado en 2010

Urocanic Acid: An Endogenous Regulator of Langerhans Cells

artículo científico publicado en 2016

miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging

artículo científico publicado en 2010

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

artículo científico publicado en 2016

Lista de obras de Leopold Eckhart

'Don't be so over-protective!'

2,3,7,8-tetrachlorodibenzo-p-dioxin impairs differentiation of normal human epidermal keratinocytes in a skin equivalent model

A Stress Response Program at the Origin of Evolutionary Innovation in the Skin

A basement membrane-like matrix formed by cell-released proteins at the medium/air interface supports growth of keratinocytes

ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging

Against the rules: human keratin K80: two functional alternative splice variants, K80 and K80.1, with special cellular localization in a wide range of epithelia

Aldehyde dehydrogenase 1A3 is transcriptionally activated by all-trans-retinoic acid in human epidermal keratinocytes

Alternative splicing of caspase-8 mRNA during differentiation of human leukocytes

Author Correction: Dense sampling of bird diversity increases power of comparative genomics

Autophagy - how to control your intracellular diet

Autophagy in epithelial homeostasis and defense.

Autophagy in the thymic epithelium is dispensable for the development of self-tolerance in a novel mouse model

Autophagy is induced by UVA and promotes removal of oxidized phospholipids and protein aggregates in epidermal keratinocytes

Caspase-14 but not caspase-3 is processed during the development of fetal mouse epidermis

Caspase-14 expression by epidermal keratinocytes is regulated by retinoids in a differentiation-associated manner

Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation

Caspase-15 is autoprocessed at two sites that contain an aspartate residue in the P1' position

Cell death by cornification

Comparative Genomics Identifies Epidermal Proteins Associated with the Evolution of the Turtle Shell

Comparative analysis of epidermal differentiation genes of crocodilians suggests new models for the evolutionary origin of avian feather proteins

Comparative genomics reveals conservation of filaggrin and loss of caspase-14 in dolphins

Comparative genomics suggests loss of keratin K24 in three evolutionary lineages of mammals

Control of cell death-associated danger signals during cornification prevents autoinflammation of the skin

Convergent evolution of cysteine-rich proteins in feathers and hair

Cornification of nail keratinocytes requires autophagy for bulk degradation of intracellular proteins while sparing components of the cytoskeleton

Cuts by caspase-14 control the proteolysis of filaggrin ⬇️

Cytosolic DNA sensing through cGAS and STING is inactivated by gene mutations in pangolins

DNase 2 is the main DNA-degrading enzyme of the stratum corneum

DNase1L2 degrades nuclear DNA during corneocyte formation

DNase1L2 suppresses biofilm formation by Pseudomonas aeruginosa and Staphylococcus aureus

Degradation by stratum corneum proteases prevents endogenous RNase inhibitor from blocking antimicrobial activities of RNase 5 and RNase 7.

Deleterious mutations of a claw keratin in multiple taxa of reptiles

Dense sampling of bird diversity increases power of comparative genomics

Differential Evolution of the Epidermal Keratin Cytoskeleton in Terrestrial and Aquatic Mammals.

Distribution of caspase-14 in epidermis and hair follicles is evolutionarily conserved among mammals

Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses

Duplication of the caspase-12 prodomain and inactivation of NLRC4/IPAF in the dog.

Epidermal cornification is preceded by the expression of a keratinocyte-specific set of pyroptosis-related genes

Epidermal keratinocytes form a functional skin barrier in the absence of Atg7 dependent autophagy

Essential role of the keratinocyte-specific endonuclease DNase1L2 in the removal of nuclear DNA from hair and nails

Evidence that caspase-13 is not a human but a bovine gene

Evolution of Trichocyte Keratins

Evolutionary origin and diversification of epidermal barrier proteins in amniotes

Filaggrin has evolved from an "S100 fused-type protein" (SFTP) gene present in a common ancestor of amphibians and mammals

Filamentous Aggregation of Sequestosome-1/p62 in Brain Neurons and Neuroepithelial Cells upon Tyr-Cre-Mediated Deletion of the Autophagy Gene Atg7.

Flagellin is the principal inducer of the antimicrobial peptide S100A7c (psoriasin) in human epidermal keratinocytes exposed to Escherichia coli

Genome sequence comparison reveals independent inactivation of the caspase-15 gene in different evolutionary lineages of mammals

Hepatocyte growth factor/scatter factor inhibits UVB induced apoptosis of human keratinocytes via the PI-3-kinase pathway

Hepatocyte growth factor/scatter factor inhibits UVB-induced apoptosis of human keratinocytes but not of keratinocyte-derived cell lines via the phosphatidylinositol 3-kinase/AKT pathway

Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model

Histidase expression in human epidermal keratinocytes: regulation by differentiation status and all-trans retinoic acid

Holocrine Secretion of Sebum Is a Unique DNase2-Dependent Mode of Programmed Cell Death

Human caspase 12 has acquired deleterious mutations

Identification and characterization of a novel mammalian caspase with proapoptotic activity

Identification and comparative analysis of the epidermal differentiation complex in snakes

Identification of Novel Mammalian Caspases Reveals an Important Role of Gene Loss in Shaping the Human Caspase Repertoire

Identification of a homozygous PSTPIP1 mutation in a patient with a PAPA-like syndrome responding to canakinumab treatment

Identification of a human cDNA encoding a novel Bcl-x isoform.

Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants

Identification of reptilian genes encoding hair keratin-like proteins suggests a new scenario for the evolutionary origin of hair

Immunogenic presentation of a conserved gp41 epitope of human immunodeficiency virus type 1 on recombinant surface antigen of hepatitis B virus.

Immunolocalization and phylogenetic profiling of the feather protein with the highest cysteine content

Immunolocalization of a Histidine-Rich Epidermal Differentiation Protein in the Chicken Supports the Hypothesis of an Evolutionary Developmental Link between the Embryonic Subperiderm and Feather Barbs and Barbules

Immunolocalization of loricrin in the maturing α-layer of normal and regenerating epidermis of the lizard Anolis carolinensis

Immunolocalization of scaffoldin, a trichohyalin-like protein, in the epidermis of the chicken embryo

Impact of filaggrin mutations on Raman spectra and biophysical properties of the stratum corneum in mild to moderate atopic dermatitis

In situ labeling of DNA reveals interindividual variation in nuclear DNA breakdown in hair and may be useful to predict success of forensic genotyping of hair

Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA degradation during epidermal cornification and results in constitutive parakeratosis

Inactivation of autophagy leads to changes in sebaceous gland morphology and function

Increased Sensitivity of Histidinemic Mice to UVB Radiation Suggests a Crucial Role of Endogenous Urocanic Acid in Photoprotection

Infection with human immunodeficiency virus-1 increases expression of vascular endothelial cell growth factor in T cells: implications for acquired immunodeficiency syndrome-associated vasculopathy.

Is the filaggrin-histidine-urocanic acid pathway essential for stratum corneum acidification?

Keratins K2 and K10 are essential for the epidermal integrity of plantar skin

Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model

Localisation of keratin K78 in the basal layer and first suprabasal layers of stratified epithelia completes expression catalogue of type II keratins and provides new insights into sequential keratin expression

Loss of keratin K2 expression causes aberrant aggregation of K10, hyperkeratosis, and inflammation

MCPIP1 contributes to the inflammatory response of UVB-treated keratinocytes.

Mechanisms and emerging functions of DNA degradation in the epidermis

Melanin Binds Reversibly to Thermostable DNA Polymerase and Inhibits Its Activity