Lista de obras - Oluf Borbye Pedersen - Dominio Público Uruguay

'Omics'-driven discoveries in prevention and treatment of type 2 diabetes

artículo científico

1H-MRS Measured Ectopic Fat in Liver and Muscle in Danish Lean and Obese Children and Adolescents

artículo científico publicado en 2015

1H-MRS measured ectopic fat in liver and muscle is associated with the metabolic syndrome in Danish girls but not in boys with overweight and obesity.

scientific article published on 14 September 2016

35th Annual Meeting of the European Association for the Study of Diabetes

artículo científico

35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999

article

A -243A-->G polymorphism upstream of the gene encoding GAD65 associates with lower levels of body mass index and glycaemia in a population-based sample of 5857 middle-aged White subjects.

artículo científico publicado en 2007

A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites.

artículo científico publicado en 2005

A Bayesian multilocus association method: allowing for higher-order interaction in association studies

artículo científico publicado en 2007

A Comprehensive Reanalysis Of Publicly Available GWAS Datasets Reveals An X Chromosome Rare Regulatory Variant Associated With High Risk For Type 2 Diabetes

A Functional Amino Acid Substitution in the Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR) Gene Is Associated With Lower Bone Mineral Density and Increased Fracture Risk

article

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.

artículo científico publicado en 2018

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

artículo científico publicado en 2017

A Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young: Evidence for Further Genetic Heterogeneity

article

A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians

artículo científico publicado en 2003

A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production

artículo científico publicado en 2016

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

artículo científico publicado en 2017

A Mutation Map for Human Glycoside Hydrolase Genes

scientific article published on 10 February 2020

A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro

artículo científico publicado en 2002

A Splice Region Variant in LDLR Lowers Non-high Density Lipoprotein Cholesterol and Protects against Coronary Artery Disease

artículo científico publicado en 2015

A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study

artículo científico publicado en 2007

A combined analysis of 48 type 2 diabetes genetic risk variants shows no discriminative value to predict time to first prescription of a glucose lowering drug in Danish patients with screen detected type 2 diabetes

artículo científico publicado en 2014

A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

artículo científico publicado en 2014

A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis

artículo científico publicado en 2007

A common polymorphism in the promoter of the IGF-I gene associates with increased fasting serum triglyceride levels in glucose-tolerant subjects

artículo científico publicado en 2004

A computational framework to integrate high-throughput ‘-omics’ datasets for the identification of potential mechanistic links

A cost analysis of intensified vs conventional multifactorial therapy in individuals with type 2 diabetes: a post hoc analysis of the Steno-2 study

article

A diet-induced gut microbiota component and related plasma metabolites are associated with depressive-like behaviour in rats

scientific article published on 12 September 2020

A genome-wide association search for type 2 diabetes genes in African Americans

artículo científico publicado en 2012

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

artículo científico publicado en 2010

A genome-wide association study of thyroid stimulating hormone and free thyroxine in Danish children and adolescents

artículo científico publicado en 2017

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

artículo científico publicado en 2016

A germline variant in the TP53 polyadenylation signal confers cancer susceptibility

artículo científico publicado en 2011

A glycogene mutation map for discovery of diseases of glycosylation

artículo científico publicado en 2014

A human gut microbial gene catalogue established by metagenomic sequencing

artículo científico publicado en 2010

A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes.

artículo científico publicado en 2011

A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults

scientific article published in Nature Communications

A metagenome-wide association study of gut microbiota in type 2 diabetes

artículo científico publicado en 2012

A novel -192c/g mutation in the proximal P2 promoter of the hepatocyte nuclear factor-4 alpha gene (HNF4A) associates with late-onset diabetes.

artículo científico publicado en 2006

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria

article

A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene

artículo científico publicado en 2004

A possible association between a dysfunctional skin barrier (filaggrin null-mutation status) and diabetes: a cross-sectional study

artículo científico publicado en 2011

A prevalent amino acid polymorphism at codon 98 (Ala98Val) of the hepatocyte nuclear factor-1alpha is associated with maturity-onset diabetes of the young and younger age at onset of type 2 diabetes in Asian Indians.

artículo científico publicado en 2005

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

artículo científico publicado en 2016

A reference map of potential determinants for the human serum metabolome

artículo científico publicado en 2020

A role for coding functional variants in HNF4A in type 2 diabetes susceptibility

artículo científico publicado en 2011

A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes

artículo científico publicado en 2010

A statistical approach based on substitution of macronutrients provides additional information to models analyzing single dietary factors in relation to type 2 diabetes in danish adults: the Inter99 study

artículo científico publicado en 2005

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity

scientific article published on 01 October 2019

A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads

artículo científico publicado en 2009

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

artículo científico publicado en 2008

ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations

scientific article published on 09 January 2019

AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects

artículo científico publicado en 2008

AIRE variations in Addison's disease and autoimmune polyendocrine syndromes (APS): partial gene deletions contribute to APS I

article

Abdominal adiposity and cardiometabolic risk factors in children and adolescents: a Mendelian randomization analysis

scientific article published on 01 November 2019

Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents

scientific article published on 02 April 2020

Aberrant intestinal microbiota in individuals with prediabetes.

artículo científico publicado en 2018

Affective disorders and high familial risk of affective disorders associate with aberrant intestinal microbiota

Alcohol consumption and its interaction with adiposity-associated genetic variants in relation to subsequent changes in waist circumference and body weight

artículo científico publicado en 2017

Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets

artículo científico publicado en 2011

Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials

artículo científico publicado en 2016

Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus.

artículo científico publicado en 1993

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

artículo científico publicado en 2017

An Improved Method for High Quality Metagenomics DNA Extraction from Human and Environmental Samples

artículo científico publicado en 2016

An adult-based genetic risk score for hepatic fat associates with liver and lipid traits in Danish children and adolescents

artículo científico publicado en 2022

An adult-based insulin resistance genetic risk score associates with insulin resistance, metabolic traits and altered fat distribution in Danish children and adolescents who are overweight or obese

scholarly article by Anne-Sofie Graae et al published August 2018 in Diabetologia

An epigenome-wide association study meta-analysis of educational attainment.

artículo científico publicado en 2017

An integrated catalog of reference genes in the human gut microbiome

artículo científico publicado en 2014

Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes

artículo científico publicado en 2005

Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism

artículo científico publicado en 2012

Application of urinary proteomics as possible risk predictor of renal and cardiovascular complications in patients with type 2-diabetes and microalbuminuria

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

artículo científico publicado en 2010

Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion

artículo científico publicado en 2015

Association between Neuromedin U Gene Variants and Overweight and Obesity

article

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

scientific article published on 04 September 2019

Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis

scientific article published on 30 October 2018

Association of genetic variants previously implicated in coronary artery disease with age at onset of coronary artery disease requiring revascularizations

artículo científico publicado en 2019

Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults

artículo científico publicado en 2009

Association of the beta3-adrenergic receptor Trp64Arg polymorphism with common metabolic traits: studies of 7605 middle-aged white people

artículo científico publicado en 2008

Association of the calpain-10 gene with type 2 diabetes in Europeans: Results of pooled and meta-analyses

article

Association of variants in the sterol regulatory element-binding factor 1 (SREBF1) gene with type 2 diabetes, glycemia, and insulin resistance: a study of 15,734 Danish subjects

artículo científico publicado en 2008

Association studies of genetic scores of serum vitamin B12 and folate levels with symptoms of depression and anxiety in two danish population studies

artículo científico publicado en 2017

Association studies of novel obesity-related gene variants with quantitative metabolic phenotypes in a population-based sample of 6,039 Danish individuals

artículo científico publicado en 2011

Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged D

article by Niels Grarup et al published September 2008 in Diabetes

Associations between APOE variants and metabolic traits and the impact of psychological stress

artículo científico publicado en 2011

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

article

Associations of genetic determinants of serum vitamin B12 and folate concentrations with hay fever and asthma: a Mendelian randomization meta-analysis.

artículo científico publicado en 2017

Associations of the Inflammatory Marker YKL-40 with Measures of Obesity and Dyslipidaemia in Individuals at High Risk of Type 2 Diabetes

artículo científico publicado en 2015

Asthma in patients with psoriasis

artículo científico publicado en 2015

Author Correction: Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

artículo científico publicado en 2020

Authors' reply to Sert's comment on low-grade inflammation independently associates with cardiometabolic risk in children with overweight/obesity

scientific article published on 22 September 2020

Autosomal inheritance of diabetes in two families characterized by obesity and a novel H241Q mutation in NEUROD1.

artículo científico publicado en 2008

Availability and use of neighborhood resources by older people with osteoarthritis: Results from the European Project on OSteoArthritis.

artículo científico publicado en 2015

Beige adipocytes—will they beat obesity?

Beneficial impact of intensified multifactorial intervention on risk of stroke: outcome of 21 years of follow-up in the randomised Steno-2 Study

artículo científico publicado en 2019

Bioinformatics-driven identification and examination of candidate genes for non-alcoholic fatty liver disease ⬇️

artículo científico publicado en 2011

Blood pressure levels in male carriers of Arg82Cys in CD300LG

artículo científico publicado en 2014

Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes

artículo científico publicado en 2016

Bone turnover, calcium homeostasis, and vitamin D status in Danish vegans

artículo científico publicado en 2018

Brugada Syndrome-Associated Genetic Loci Are Associated With J-Point Elevation and an Increased Risk of Cardiac Arrest

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

scholarly article by Elahu G. Sustarsic published in July 2018

Cardiovascular and All-Cause Mortality Risk Associated With Urinary Excretion of 8-oxoGuo, a Biomarker for RNA Oxidation, in Patients With Type 2 Diabetes: A Prospective Cohort Study

artículo científico publicado en 2017

Carriers of a VEGFA enhancer polymorphism selectively binding CHOP/DDIT3 are predisposed to increased circulating levels of thyroid-stimulating hormone

artículo científico publicado en 2016

Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test

artículo científico publicado en 2010

Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis

artículo científico publicado en 2017

Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha

artículo científico publicado en 2002

Childhood obesity treatment; Effects on BMI SDS, body composition, and fasting plasma lipid concentrations

artículo científico publicado en 2018

Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness.

artículo científico publicado en 2013

Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples

artículo científico publicado en 2013

Cohort Profile: The Health2006 cohort, Research Centre for Prevention and Health

article

Cohort description: The Danish study of Functional Disorders

artículo científico publicado en 2017

Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut.

artículo científico publicado en 2016

Combined analyses of 20 common obesity susceptibility variants ⬇️

artículo científico publicado en 2010

Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene–gene interaction

article

Combining insulin with metformin or an insulin secretagogue in non-obese patients with type 2 diabetes: 12 month, randomised, double blind trial.

artículo científico publicado en 2009

Common Type 2 Diabetes Risk Gene Variants Associate with Gestational Diabetes

article

Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval

Common nonsynonymous variants in PCSK1 confer risk of obesity

article

Common variants in LEPR, IL6, AMD1, and NAMPT do not associate with risk of juvenile and childhood obesity in Danes: a case-control study

artículo científico publicado en 2015

Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses

artículo científico publicado en 2018

Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure

artículo científico publicado en 2009

Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites

artículo científico publicado en 2007

Common variation in oxidative phosphorylation genes is not a major cause of insulin resistance or type 2 diabetes

article

Comparative Analyses of QTLs Influencing Obesity and Metabolic Phenotypes in Pigs and Humans

artículo científico publicado en 2015

Comparative Studies of the Gut Microbiota in the Offspring of Mothers With and Without Gestational Diabetes

scientific article published on 23 October 2020

Comparison of accuracy of diabetes risk score and components of the metabolic syndrome in assessing risk of incident type 2 diabetes in Inter99 cohort

artículo científico publicado en 2011

Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study

artículo científico publicado en 2020

Correction: Does DNA Methylation of PPARGC1A Influence Insulin Action in First Degree Relatives of Patients with Type 2 Diabetes?

artículo científico publicado en 2013

Correction: Genetic Polymorphisms and Weight Loss in Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets.

artículo científico publicado en 2006

Correction: Genetic Variant SCL2A2 Is Associated with Risk of Cardiovascular Disease – Assessing the Individual and Cumulative Effect of 46 Type 2 Diabetes Related Genetic Variants

artículo científico publicado en 2013

Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

artículo científico publicado en 2017

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2016

Correction: The PNPLA3 rs738409 G-Allele Associates with Reduced Fasting Serum Triglyceride and Serum Cholesterol in Danes with Impaired Glucose Regulation

artículo científico publicado en 2012

Corrigendum: Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

artículo científico publicado en 2017

Corrigendum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

scholarly article published in Nature Genetics

Cost-effectiveness of intensified versus conventional multifactorial intervention in type 2 diabetes: results and projections from the Steno-2 study

artículo científico publicado en 2008

DNA methylation and gene expression of HIF3A: cross-tissue validation and associations with BMI and insulin resistance

artículo científico publicado en 2016

Data integration for prediction of weight loss in randomized controlled dietary trials

scientific article published on 18 November 2020

Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study

artículo científico publicado en 2011

Design of association studies with pooled or un-pooled next-generation sequencing data

artículo científico publicado en 2010

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

artículo científico publicado en 2020

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

Development of a type 2 diabetes risk model from a panel of serum biomarkers from the Inter99 cohort

artículo científico publicado en 2009

Diabetic cats have decreased gut microbial diversity and a lack of butyrate producing bacteria

artículo científico publicado en 2019

Dietary ascorbic acid and subsequent change in body weight and waist circumference: associations may depend on genetic predisposition to obesity--a prospective study of three independent cohorts.

artículo científico publicado en 2014

Dietary glycemic index, glycemic load, fiber, simple sugars, and insulin resistance: the Inter99 study.

artículo científico publicado en 2005

Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study

artículo científico publicado en 2020

Dietary modulation of the gut microbiota--a randomised controlled trial in obese postmenopausal women

artículo científico publicado en 2015

Dietary patterns predict changes in two-hour post-oral glucose tolerance test plasma glucose concentrations in middle-aged adults

artículo científico publicado en 2009

Digital questionnaire platform in the Danish Blood Donor Study.

artículo científico publicado en 2016

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

scientific article published on 15 June 2019

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium

artículo científico publicado en 2014

Discovery of coding genetic variants influencing diabetes-related serum biomarkers and their impact on risk of type 2 diabetes

artículo científico publicado en 2015

Discovery of novel heart rate-associated loci using the Exome Chip

artículo científico publicado en 2017

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

artículo científico publicado en 2020

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

artículo científico publicado en 2015

Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals

artículo científico publicado en 2010

Does DNA methylation of PPARGC1A influence insulin action in first degree relatives of patients with type 2 diabetes?

artículo científico publicado en 2013

Dyslipidemia and reference values for fasting plasma lipid concentrations in Danish/North-European White children and adolescents

artículo científico publicado en 2017

EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families

artículo científico publicado en 2006

Effect of Antibiotics on Gut Microbiota, Gut Hormones and Glucose Metabolism

artículo científico publicado en 2015

Effect of a multifactorial intervention on mortality in type 2 diabetes

artículo científico publicado en 2008

Effects of RYGB on energy expenditure, appetite and glycaemic control: a randomized controlled clinical trial.

artículo científico publicado en 2015

Effects of a Family-Based Childhood Obesity Treatment Program on Parental Weight Status

artículo científico publicado en 2016

Effects of biphasic, basal-bolus or basal insulin analogue treatments on carotid intima-media thickness in patients with type 2 diabetes mellitus: the randomised Copenhagen Insulin and Metformin Therapy (CIMT) trial

artículo científico publicado en 2016

Efficacy of dofetilide in the treatment of atrial fibrillation-flutter in patients with reduced left ventricular function: a Danish investigations of arrhythmia and mortality on dofetilide (diamond) substudy

artículo científico publicado en 2001

Elevation of serum insulin concentration during euglycemic hyperinsulinemic clamp studies leads to similar activation of insulin receptor kinase in skeletal muscle of subjects with and without NIDDM.

artículo científico publicado en 1995

Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations

artículo científico publicado en 2008

Enterotypes of the human gut microbiome

artículo científico publicado en 2011

Enterotypes of the human gut microbiome

artículo científico publicado en 2011

Environmental spread of microbes impacts the development of metabolic phenotypes in mice transplanted with microbial communities from humans

artículo científico publicado en 2016

Erratum to: 'Intake of Macro- and Micronutrients in Danish Vegans'

artículo científico publicado en 2016

Erratum: Addendum: Enterotypes of the human gut microbiome

artículo científico publicado en 2014

Erratum: Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

scholarly article by Johan Rung et al published October 2009 in Nature Genetics

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

artículo científico publicado en 2011

Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

artículo científico publicado en 2010

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

artículo científico publicado en 2018

Estimates of insulin sensitivity and β-cell function in children and adolescents with and without components of the metabolic syndrome

artículo científico publicado en 2017

Estimating the causal effect of body mass index on hay fever, asthma and lung function using Mendelian randomization

artículo científico publicado en 2017

Estimation of allele frequency and association mapping using next-generation sequencing data

artículo científico publicado en 2011

Evaluation of a target region capture sequencing platform using monogenic diabetes as a study-model

artículo científico publicado en 2014

Evidence for an association between the Leu162Val polymorphism of the PPARalpha gene and decreased fasting serum triglyceride levels in glucose tolerant subjects

artículo científico publicado en 2003

Evidence of a liver-alpha cell axis in humans: hepatic insulin resistance attenuates relationship between fasting plasma glucagon and glucagonotropic amino acids

artículo científico publicado en 2018

Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes.

artículo científico publicado en 2005

Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene

artículo científico publicado en 2005

Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits

artículo científico publicado en 2016

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

article by Jason Flannick et al published 22 May 2019 in Nature

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.

artículo científico publicado en 2012

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Exome-wide association study of plasma lipids in >300,000 individuals

artículo científico publicado en 2017

ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals

Expression of protein‐tyrosine phosphatases in the major insulin target tissues ⬇️

artículo científico publicado el 6 de octubre de 1997

Expression profiling of insulin action in human myotubes: induction of inflammatory and pro-angiogenic pathways in relationship with glycogen synthesis and type 2 diabetes

artículo científico publicado en 2004

Extracellular Vesicle Encapsulated MicroRNAs in Patients with Type 2 Diabetes Are Affected by Metformin Treatment

artículo científico publicado en 2019

FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans

artículo científico publicado en 2017

FTO gene associated fatness in relation to body fat distribution and metabolic traits throughout a broad range of fatness

artículo científico publicado en 2008

FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals.

artículo científico publicado en 2014

FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials

artículo científico publicado en 2016

FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

artículo científico publicado en 2020

Familial mild hyperglycemia associated with a novel ABCC8-V84I mutation within three generations

artículo científico publicado en 2011

Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity

artículo científico publicado en 2010

Fasting and oral glucose-stimulated levels of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are highly familial traits

artículo científico publicado en 2012

Fasting serum levels of ferritin are associated with impaired pancreatic beta cell function and decreased insulin sensitivity: a population-based study

artículo científico publicado en 2014

Fat mass measured by DXA varies with scan velocity

artículo científico

Fatness-associated FTO gene variant increases mortality independent of fatness--in cohorts of Danish men

artículo científico publicado en 2009

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

artículo científico publicado en 2018

First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

artículo científico publicado en 2018

Functional SOCS1 polymorphisms are associated with variation in obesity in whites.

artículo científico publicado en 2009

Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population

artículo científico publicado en 2016

Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY).

artículo científico publicado en 2010

G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans

artículo científico publicado en 2009

GLP-1 Receptor Agonist Treatment Increases Bone Formation and Prevents Bone Loss in Weight-Reduced Obese Women

artículo científico publicado en 2015

GLP-1 Receptor Agonist Treatment in Morbid Obesity and Type 2 Diabetes Due to Pathogenic Homozygous Melanocortin-4 Receptor Mutation: A Case Report

artículo científico publicado en 2020

GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study

article

Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry

artículo científico publicado en 2013

Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study

artículo científico publicado en 2014

Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology

artículo científico publicado en 2016

Genetic Determinants of Weight Loss After Bariatric Surgery

artículo científico publicado en 2019

Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention in Danish Children

artículo científico publicado en 2018

Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function

artículo científico publicado en 2016

Genetic analysis of Kruppel-like zinc finger 11 variants in 5864 Danish individuals: potential effect on insulin resistance and modified signal transducer and activator of transcription-3 binding by promoter variant -1659G>C.

artículo científico publicado en 2008

Genetic analysis of the estrogen-related receptor α and studies of association with obesity and type 2 diabetes

article

Genetic and phenotypic correlations between surrogate measures of insulin release obtained from OGTT data

artículo científico publicado en 2015

Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets

artículo científico publicado en 2013

Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study

artículo científico publicado en 2009

Genetic association analysis of LARS2 with type 2 diabetes

artículo científico publicado en 2010

Genetic determinants of blood pressure traits are associated with carotid arterial thickening and plaque formation in patients with type 2 diabetes

artículo científico publicado en 2019

Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians

artículo científico publicado en 2010

Genetic determinants of glycated hemoglobin levels in the Greenlandic Inuit population.

artículo científico publicado en 2018

Genetic determinants of serum vitamin B12 and their relation to body mass index

scientific article published on 19 December 2016

Genetic epidemiology of MODY in the Czech republic: new mutations in the MODY genes HNF-4alpha, GCK and HNF-1alpha

article

Genetic evidence of a causal effect of insulin resistance on branched-chain amino acid levels

artículo científico publicado en 2017

Genetic evidence of assortative mating in humans

article

Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function

artículo científico publicado en 2002

Genetic evidence that HNF-1α–dependent transcriptional control of HNF-4α is essential for human pancreatic β cell function

article

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

artículo científico publicado en 2009

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

artículo científico publicado en 2015

Genetic insights into fetal growth and measures of glycaemic regulation and adiposity in adulthood: a family-based study ⬇️

Genetic investigations of sudden unexpected deaths in infancy using next-generation sequencing of 100 genes associated with cardiac diseases

artículo científico publicado en 2015

Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets

artículo científico publicado en 2006

Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents

artículo científico publicado en 2019

Genetic risk score of 46 type 2 diabetes risk variants associates with changes in plasma glucose and estimates of pancreatic β-cell function over 5 years of follow-up

artículo científico publicado en 2013

Genetic risk scores link body fat distribution with specific cardiometabolic profiles

artículo científico publicado en 2016

Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond

artículo científico

Genetic variant SLC2A2 [corrected] Is associated with risk of cardiovascular disease – assessing the individual and cumulative effect of 46 type 2 diabetes related genetic variants

artículo científico publicado en 2012

Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits

artículo científico publicado en 2009

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

artículo científico publicado en 2009

Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes

artículo científico publicado en 2013

Genetic variants in promoters and coding regions of the muscle glycogen synthase and the insulin-responsive GLUT4 genes in NIDDM.

artículo científico publicado en 1994

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

scientific journal article

Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits

artículo científico publicado en 2003

Genetics in non-autoimmune diabetes. The Danish Society of Endocrinology

artículo científico publicado en 2008

Genetics of type 2 diabetes mellitus: status and perspectives

artículo científico publicado en 2005

Genome wide association study identifies KCNMA1 contributing to human obesity

artículo científico publicado en 2011

Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci

artículo científico publicado en 2016

Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent

artículo científico publicado en 2017

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

artículo científico publicado en 2018

Genome-wide analysis of genetic determinants of circulating factor VII-activating protease (FSAP) activity

artículo científico publicado en 2018

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention ⬇️

artículo científico publicado en 2022

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

artículo científico publicado en 2015

Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

artículo científico publicado en 2016

Genome-wide association studies of human adiposity: Zooming in on synapses

artículo científico

Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

scientific journal article

Genome-wide association study of circulating levels of glucagon during an oral glucose tolerance test

artículo científico publicado en 2021

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

artículo científico publicado en 2009

Genome-wide associations for birth weight and correlations with adult disease

artículo científico publicado en 2016

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

artículo científico publicado en 2017

Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium

artículo científico publicado en 2018

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

artículo científico publicado en 2016

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

artículo científico publicado en 2017

Genome-wide population-based association study of extremely overweight young adults--the GOYA study

artículo científico publicado en 2011

Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci

artículo científico publicado en 2013

Genotype-by-nutrient interactions assessed in European obese women

artículo científico publicado en 2006

Genotype-phenotype associations in obesity dependent on definition of the obesity phenotype.

artículo científico publicado en 2008

Gestational diabetes and the human salivary microbiota: a longitudinal study during pregnancy and postpartum

artículo científico publicado en 2020

Gestational diabetes is associated with change in the gut microbiota composition in third trimester of pregnancy and postpartum.

artículo científico publicado en 2018

Glucokinase diabetes in 103 families from a country-based study in the Czech Republic: geographically restricted distribution of two prevalent GCK mutations.

artículo científico publicado en 2010

Glucose ingestion causes cardiac repolarization disturbances in type 1 long QT syndrome patients and healthy subjects.

artículo científico publicado en 2017

Glucose metabolism in children and adolescents: Population-based reference values and comparisons to children and adolescents enrolled in obesity treatment

scientific article published on 09 May 2019

Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B.

artículo científico publicado en 2011

Glucose-Dependent Insulinotropic Polypeptide Is Associated With Lower Low-Density Lipoprotein But Unhealthy Fat Distribution, Independent of Insulin: The ADDITION-PRO Study

artículo científico publicado en 2015

Glucose-lowering effects and low risk of hypoglycemia in patients with maturity-onset diabetes of the young when treated with a GLP-1 receptor agonist: a double-blind, randomized, crossover trial

artículo científico publicado en 2014

Greater glucagon-like peptide-1 responses to oral glucose are associated with lower central and peripheral blood pressures

artículo científico publicado en 2019

Greenlandic Inuit show genetic signatures of diet and climate adaptation

artículo científico publicado en 2015

Grey-box modelling of pharmacokinetic/pharmacodynamic systems.

artículo científico publicado en 2004

Gut microbiota composition in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives

article

Gut microbiota in human metabolic health and disease

artículo científico publicado en 2020

Gut microbiota may have influence on glucose and lipid metabolism

artículo científico publicado en 2013

Gut microbiota may influence childhood and adolescent onset obesity ⬇️

artículo científico publicado en 2014

Gut microbiota profile and selected plasma metabolites in type 1 diabetes without and with stratification by albuminuria

artículo científico publicado en 2020

Habitual physical activity is associated with lower fasting and greater glucose-induced GLP-1 response in men

scientific article published on 01 December 2019

Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants

artículo científico publicado en 2014

Heterogeneity in glucose response curves during an oral glucose tolerance test and associated cardiometabolic risk

artículo científico publicado en 2016

High Prevalence of Diabetes-Predisposing Variants in MODY Genes Among Danish Women With Gestational Diabetes Mellitus.

artículo científico publicado en 2017

High heritability and genetic correlation of intravenous glucose- and tolbutamide-induced insulin secretion among non-diabetic family members of type 2 diabetic patients

artículo científico publicado en 2014

High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia

artículo científico publicado en 2007

Higher intake of fish and fat is associated with lower plasma s-adenosylhomocysteine: a cross-sectional study

artículo científico publicado en 2017

Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1.

artículo científico publicado en 2011

Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression

artículo científico publicado en 2017

Human gut microbes impact host serum metabolome and insulin sensitivity

artículo científico publicado en 2016

Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes

article

Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes

scientific article published on 28 June 2019

Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography

artículo científico publicado en 2018

IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies

artículo científico publicado en 2006

IRS1, KCNJ11, PPARgamma2 and HNF-1alpha: do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes?

artículo científico publicado en 2006

Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes

artículo científico publicado en 2014

Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus

artículo científico publicado en 2015

Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus

artículo científico publicado en 2010

Identification of Novel Genetic Determinants of Erythrocyte Membrane Fatty Acid Composition among Greenlanders

artículo científico publicado en 2016

Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity

artículo científico publicado en 1995

Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes

artículo científico publicado en 2014

Identification of novel LEPR mutations in Pakistani families with morbid childhood obesity

scholarly article by Robina Khan Niazi et al published 15 November 2018 in BMC Medical Genetics

Identification of novel high-impact recessively inherited type 2 diabetes risk variants in the Greenlandic population

Identification of novel variants in the hepatocyte nuclear factor-1alpha gene in South Indian patients with maturity onset diabetes of young

artículo científico publicado en 2009

Identification of peptides from foot-and-mouth disease virus structural proteins bound by class I swine leukocyte antigen (SLA) alleles, SLA-10401 and SLA-20401.

artículo científico publicado en 2012

Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics

artículo científico publicado en 2009

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

artículo científico publicado en 2020

Impact of PTBP1 rs11085226 on glucose-stimulated insulin release in adult Danes

artículo científico publicado en 2015

Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins

artículo científico publicado en 2008

Impact of a vegan diet on the human salivary microbiota.

artículo científico publicado en 2018

Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood

article published in 2015

Impact of clinical osteoarthritis of the hip, knee and hand on self-rated health in six European countries: the European Project on OSteoArthritis.

artículo científico publicado en 2015

Impact of low-dose acetylsalicylic acid on kidney function in type 2 diabetic patients with elevated urinary albumin excretion rate

artículo científico publicado en 2003

Impact of metformin versus repaglinide on non-glycaemic cardiovascular risk markers related to inflammation and endothelial dysfunction in non-obese patients with type 2 diabetes

artículo científico publicado en 2008

Impact of metformin versus the prandial insulin secretagogue, repaglinide, on fasting and postprandial glucose and lipid responses in non-obese patients with type 2 diabetes

artículo científico publicado en 2008

Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation

artículo científico publicado en 2008

Impact of rs361072 in the phosphoinositide 3-kinase p110beta gene on whole-body glucose metabolism and subunit protein expression in skeletal muscle

artículo científico publicado en 2010

Impact of size at birth and prematurity on adult anthropometry in 4744 middle-aged Danes - The Inter99 study

artículo científico publicado en 2010

Impact of the peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) Ala203Pro polymorphism on in vivo metabolism, PGC-1beta expression and fibre type composition in human skeletal muscle

scientific article published on 20 June 2007

Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both?

artículo científico publicado en 2003

Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity

artículo científico publicado en 2013

Impact on weight dynamics and general growth of the common FTO rs9939609: a longitudinal Danish cohort study

artículo científico publicado en 2008

Impaired Insulin-Stimulated Nonoxidative Glucose Metabolism in Pancreas-Kidney Transplant Recipients: Dose-Response Effects of Insulin on Glucose Turnover

article

Impaired expression of glycogen synthase mRNA in skeletal muscle of NIDDM patients.

artículo científico publicado en 1991

Impaired fasting glucose and the metabolic profile in Danish children and adolescents with normal weight, overweight, or obesity.

artículo científico publicado en 2017

Impaired fasting glycaemia vs impaired glucose tolerance: similar impairment of pancreatic alpha and beta cell function but differential roles of incretin hormones and insulin action

artículo científico publicado en 2008

Impaired insulin-stimulated nonoxidative glucose metabolism in glucose-tolerant women with previous gestational diabetes

artículo científico publicado en 1996

Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism

Implications of central obesity-related variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on quantitative metabolic traits in adult Danes

artículo científico publicado en 2011

Importance of congestive heart failure and interaction of congestive heart failure and left ventricular systolic function on prognosis in patients with acute myocardial infarction

artículo científico publicado en 1996

Improved glycemic control induced by both metformin and repaglinide is associated with a reduction in blood levels of 3-deoxyglucosone in nonobese patients with type 2 diabetes

artículo científico publicado en 2011

In Vivo and Ex Vivo Inflammatory Markers of Common Metabolic Phenotypes in Humans

artículo científico publicado en 2018

Increase in clinically recorded type 2 diabetes after colectomy

artículo científico publicado en 2018

Increased frequency of rare missense PPP1R3B variants among Danish patients with type 2 diabetes

artículo científico publicado en 2019

Increased recovery rates of phosphocreatine and inorganic phosphate after isometric contraction in oxidative muscle fibers and elevated hepatic insulin resistance in homozygous carriers of the A-allele of FTO rs9939609.

artículo científico publicado en 2008

Increasing incidence of diabetes after gestational diabetes: a long-term follow-up in a Danish population

artículo científico publicado en 2004

Increasing insulin resistance accentuates the effect of triglyceride-associated loci on serum triglycerides during 5 years

artículo científico publicado en 2016

Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele

artículo científico publicado en 2012

Incretin effect and glucagon responses to oral and intravenous glucose in patients with maturity-onset diabetes of the young--type 2 and type 3.

artículo científico publicado en 2014

Indicator of RNA oxidation in urine for the prediction of mortality in patients with type 2 diabetes and microalbuminuria: A post-hoc analysis of the Steno-2 trial

scientific article published on 21 September 2018

Influences of the common FTO rs9939609 variant on inflammatory markers throughout a broad range of body mass index

artículo científico publicado en 2011

Insulin Resistance Is Accompanied by Increased Fasting Glucagon and Delayed Glucagon Suppression in Individuals With Normal and Impaired Glucose Regulation

artículo científico publicado en 2016

Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention

artículo científico publicado en 2009

Insulin resistance and impaired pancreatic β-cell function in adult offspring of women with diabetes in pregnancy

artículo científico publicado en 2013

Insulin resistance and maximal oxygen uptake.

artículo científico publicado en 2003

Insulin resistance as a physiological defense against metabolic stress: implications for the management of subsets of type 2 diabetes

artículo científico publicado en 2015

Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study

artículo científico publicado en 2007

Intake of macro- and micronutrients in Danish vegans

artículo científico publicado en 2015

Intensified multifactorial intervention and cardiovascular outcome in type 2 diabetes: the Steno-2 study

artículo científico publicado en 2003

Intensified multifactorial intervention in type 2 diabetics with microalbuminuria leads to long-term renal benefits

artículo científico publicado en 2017

Intensified multifactorial treatment of patients with Type 2 diabetes: What can be achieved and does it pay off? ⬇️

artículo científico publicado el 1 de junio de 2009

Intensive integrated therapy of type 2 diabetes: implications for long-term prognosis

artículo científico publicado en 2004

Interaction between genetic predisposition to adiposity and dietary protein in relation to subsequent change in body weight and waist circumference

artículo científico publicado en 2014

Interaction between genetic predisposition to obesity and dietary calcium in relation to subsequent change in body weight and waist circumference

artículo científico publicado en 2014

Interactions between genetic variants associated with adiposity traits and soft drinks in relation to longitudinal changes in body weight and waist circumference

artículo científico publicado en 2016

Interactions of Lipid Genetic Risk Scores With Estimates of Metabolic Health in a Danish Population

artículo científico publicado en 2015

Intrafamilial Variability of Early-Onset Diabetes due to an INS Mutation

artículo científico publicado en 2011

Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium

artículo científico publicado en 2017

Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index

artículo científico publicado en 2009

KCNQ1 long QT syndrome patients have hyperinsulinemia and symptomatic hypoglycemia

artículo científico publicado en 2013

LMNA rs4641 and the muscle lamin A and C isoforms in twins--metabolic implications and transcriptional regulation

artículo científico publicado en 2010

Lack of Association of Fatness-Related FTO Gene Variants with Energy Expenditure or Physical Activity

article

Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits

artículo científico publicado en 2008

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.

artículo científico publicado en 2017

Large-scale study of the ?232C�>�G polymorphism of PCK1 in Type�2 diabetes

Lens fluorescence in relation to glucose tolerance and genetic predisposition to type 2 diabetes mellitus in a population-based study

artículo científico publicado en 2006

Leptin and bone mineral density: a cross-sectional study in obese and nonobese men.

artículo científico publicado en 2003

Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesity

scientific article published on 26 December 2019

Lessons from whole-exome sequencing in MODYX families

scholarly article by Petra Dusatkova et al published June 2014 in Diabetes Research and Clinical Practice

Linking glycemic dysregulation in diabetes to symptoms, comorbidities, and genetics through EHR data mining

artículo científico publicado en 2019

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

artículo científico publicado en 2021

Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome

artículo científico publicado en 2002

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

artículo científico publicado en 2014

Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes

artículo científico publicado en 2018

Low birthweight and premature birth are both associated with type 2 diabetes in a random sample of middle-aged Danes.

artículo científico publicado en 2010

Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation

artículo científico publicado en 2007

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

artículo científico publicado en 2015

Low-grade inflammation independently associates with cardiometabolic risk in children with overweight/obesity

artículo científico publicado en 2020

MR-proANP Associated with Body Mass Index in Patients with Anorexia Nervosa

scientific article published on 22 January 2019

MTHFR C677T genotype and cardiovascular risk in a general population without mandatory folic acid fortification

artículo científico publicado en 2014

MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans

artículo científico publicado en 2010

Many sequence variants affecting diversity of adult human height

artículo científico publicado en 2008

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

artículo científico publicado en 2019

Maturity-onset diabetes of the young with end-stage nephropathy: a new indication for simultaneous pancreas and kidney transplantation?

artículo científico publicado en 2004

Mechanism-based population modelling for assessment of L-cell function based on total GLP-1 response following an oral glucose tolerance test

artículo científico publicado en 2011

Mechanisms in endocrinology: Gut microbiota in patients with type 2 diabetes mellitus

artículo científico publicado en 2014

Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis

artículo científico publicado en 2007

Mendelian randomisation study of the associations of vitamin B12 and folate genetic risk scores with blood pressure and fasting serum lipid levels in three Danish population-based studies.

artículo científico publicado en 2016

Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes

artículo científico publicado en 2013

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

artículo científico publicado en 2010

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

artículo científico publicado en 2008

Metagenomic species profiling using universal phylogenetic marker genes

artículo científico publicado en 2013

Metformin versus placebo in combination with insulin analogues in patients with type 2 diabetes mellitus-the randomised, blinded Copenhagen Insulin and Metformin Therapy (CIMT) trial

artículo científico publicado en 2016

Metformin-induced changes of the gut microbiota in healthy young men: results of a non-blinded, one-armed intervention study

artículo científico publicado en 2019

Microbiome and metabolome features of the cardiometabolic disease spectrum

artículo científico publicado en 2022

Monitoring kidney function in type 2 diabetic patients with incipient and overt diabetic nephropathy.

artículo científico publicado en 2006

Multidisciplinary care of obese children and adolescents for one year reduces ectopic fat content in liver and skeletal muscle

artículo científico publicado en 2015

Multifactorial Intervention in Type 2 Diabetes

Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes

artículo científico publicado en 2003

Mutation analysis of NR0B2 among 1545 Danish men identifies a novel c.278G>A (p.G93D) variant with reduced functional activity

artículo científico publicado en 2004

Mutation analysis of the MCHR1 gene in human obesity

artículo científico publicado en 2005

Mutation analysis of the preproghrelin gene: no association with obesity and type 2 diabetes

artículo científico publicado en 2005

Mutational analysis of the UCP2 core promoter and relationships of variants with obesity

artículo científico publicado en 2003

Mutations in HNF1A result in marked alterations of plasma glycan profile

artículo científico publicado en 2012

Mutations in the VNTR of the carboxyl-ester lipase gene (CEL) are a rare cause of monogenic diabetes

artículo científico publicado en 2009

Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome.

artículo científico publicado en 2011

New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals

artículo científico publicado en 2017

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

artículo científico publicado en 2010

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

artículo científico publicado en 2012

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ⬇️

artículo científico publicado en 2016

No consistent effect of ADRB2 haplotypes on obesity, hypertension and quantitative traits of body fatness and blood pressure among 6,514 adult Danes

artículo científico publicado en 2009

No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels

artículo científico publicado en 2012

Non-melanoma skin cancer may be a marker of poor prognosis in patients with non-Hodgkin's lymphoma

artículo científico publicado en 2000

Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes

artículo científico publicado en 2008

Novel Variants in the Putative Peroxisome Proliferator-activated Receptor γ Promoter and Relationships with Obesity in Men

articulo cientifico

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

artículo científico publicado en 2012

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

artículo científico publicado en 2020

Novel variation and de novo mutation rates in population-wide de novo assembled Danish trios ⬇️

artículo científico publicado en 2015

Numerous Brugada syndrome-associated genetic variants have no effect on J-point elevation, syncope susceptibility, malignant cardiac arrhythmia, and all-cause mortality

artículo científico publicado en 2016

Obesity is associated with vitamin D deficiency in Danish children and adolescents

artículo científico publicado en 2017

Obesity treatment effect in Danish children and adolescents carrying Melanocortin-4 Receptor mutations

scientific article published on 13 September 2020

Obesity, unfavourable lifestyle and genetic risk of type 2 diabetes: a case-cohort study

scientific article published on 15 April 2020

Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study

artículo científico publicado en 2010

Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial

artículo científico publicado en 2017

One-carbon metabolism markers are associated with cardiometabolic risk factors.

artículo científico publicado en 2018

Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes.

artículo científico publicado en 2009

PC-1 amino acid variant (K121Q) has no impact on progression of diabetic nephropathy in type 1 diabetic patients

artículo científico publicado en 2002

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

artículo científico publicado en 2016

PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites

artículo científico publicado en 2005

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

article

PROactive study

artículo científico publicado en 2006

Pancreatic endocrine function in recipients of segmental and whole pancreas transplantation

artículo científico publicado en 1996

Past and current body size affect validity of reported energy intake among middle-aged Danish men.

artículo científico publicado en 2009

Patients With Long-QT Syndrome Caused by Impaired hERG-Encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated With Reactive Hypoglycemia

artículo científico publicado en 2017

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

scientific article published on 29 October 2019

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children

artículo científico publicado en 2011

Plasma Alkylresorcinols Reflect Gluten Intake and Distinguish between Gluten-Rich and Gluten-Poor Diets in a Population at Risk of Metabolic Syndrome

artículo científico publicado en 2016

Pleiotropic genes for metabolic syndrome and inflammation

artículo científico publicado en 2014

Polygenic predisposition to breast cancer and the risk of coronary artery disease

artículo científico publicado en 2019

Polymorphisms in AHI1 are not associated with type 2 diabetes or related phenotypes in Danes: non-replication of a genome-wide association result

article by J. Holmkvist et al published 29 January 2008 in Diabetologia

Polymorphisms in the 3' UTR in the neurocalcin delta gene affect mRNA stability, and confer susceptibility to diabetic nephropathy

artículo científico

Polymorphisms of serotonin receptor 2A and 2C genes and COMT in relation to obesity and type 2 diabetes

artículo científico publicado en 2009

Ponderal index at birth associates with later risk of gestational diabetes mellitus.

artículo científico publicado en 2017

Population-based studies of relationships between dietary acidity load, insulin resistance and incident diabetes in Danes

artículo científico publicado en 2018

Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study

artículo científico publicado en 2020

Postprandial incretin and islet hormone responses and dipeptidyl-peptidase 4 enzymatic activity in patients with maturity onset diabetes of the young

artículo científico publicado en 2015

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

scientific article published on 19 June 2020

Predicting glycated hemoglobin levels in the non-diabetic general population: Development and validation of the DIRECT-DETECT prediction model - a DIRECT study

artículo científico publicado en 2017

Predictive performance for population models using stochastic differential equations applied on data from an oral glucose tolerance test

artículo científico publicado en 2009

Predictors of future fasting and 2-h post-OGTT plasma glucose levels in middle-aged men and women-the Inter99 study.

artículo científico publicado en 2009

Prenatal exposure to systemic antibacterials and overweight and obesity in Danish schoolchildren: a prevalence study

artículo científico publicado en 2015

Prevalence of Mutations and Functional Analyses of Melanocortin 4 Receptor Variants Identified among 750 Men with Juvenile-Onset Obesity

article by Lesli H. Larsen et al published January 2005 in The Journal of Clinical Endocrinology and Metabolism

Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study

scientific article published on 15 December 2020

Prognosis of late versus early ventricular fibrillation in acute myocardial infarction

artículo científico publicado en 1990

Prognostic impact of carboxylesterase 1 gene variants in patients with congestive heart failure treated with angiotensin-converting enzyme inhibitors

artículo científico publicado en 2016

Progression to impaired glucose regulation and diabetes in the population-based Inter99 study

scientific article published on 29 December 2008

Prospective studies exploring the possible impact of an ID3 polymorphism on changes in obesity measures

artículo científico publicado en 2018

Protein Intake, Metabolic Status and the Gut Microbiota in Different Ethnicities: Results from Two Independent Cohorts

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

artículo científico publicado en 2017

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

article

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

artículo científico publicado en 2019

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

artículo científico publicado en 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

artículo científico publicado en 2018

Publisher Correction: Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.

artículo científico publicado en 2018

Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis

artículo científico publicado en 2019

Rare and low-frequency coding variants alter human adult height

artículo científico publicado en 2017

Rare genetic variants previously associated with congenital forms of long QT syndrome have little or no effect on the QT interval

artículo científico publicado en 2015

Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

artículo científico publicado en 2018

Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes.

artículo científico publicado en 2012

Recessive Genome-Wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes

artículo científico publicado en 2022

Recovery of gut microbiota of healthy adults following antibiotic exposure

scientific article published on 22 October 2018

Reduced CD300LG mRNA tissue expression, increased intramyocellular lipid content and impaired glucose metabolism in healthy male carriers of Arg82Cys in CD300LG: a novel genometabolic cross-link between CD300LG and common metabolic phenotypes

artículo científico publicado en 2015

Reduced risk of heart failure with intensified multifactorial intervention in individuals with type 2 diabetes and microalbuminuria: 21 years of follow-up in the randomised Steno-2 study

article published in 2018

Reference values for fasting serum concentrations of thyroid-stimulating hormone and thyroid hormones in healthy Danish/North-European white children and adolescents

scientific article published on 01 February 2019

Reference values for fasting serum resistin in healthy children and adolescents.

artículo científico publicado en 2017

Reference values for leptin/adiponectin ratio in healthy children and adolescents

artículo científico publicado en 2019

Reference values for serum leptin in healthy non-obese children and adolescents

artículo científico publicado en 2016

Reference values for serum total adiponectin in healthy non-obese children and adolescents

artículo científico publicado en 2015

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

article

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.

artículo científico publicado en 2018

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

article

Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue

artículo científico publicado en 2009

Relationships between the functional PPARalpha Leu162Val polymorphism and obesity, type 2 diabetes, dyslipidaemia, and related quantitative traits in studies of 5799 middle-aged white people

artículo científico publicado en 2006

Remission to normoalbuminuria during multifactorial treatment preserves kidney function in patients with type 2 diabetes and microalbuminuria

artículo científico publicado en 2004

Remitted affective disorders and high familial risk of affective disorders associate with aberrant intestinal microbiota

Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants

Response to Comment on Færch et al. GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study. Diabetes 2015;64:2513–2525

Response to Comments on Nolan et al. Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes. Diabetes 2015;64:673-686.

artículo científico publicado en 2015

Richness of human gut microbiome correlates with metabolic markers

artículo científico publicado en 2013

Risk of schizophrenia in relation to parental origin and genome-wide divergence

artículo científico publicado en 2011

Role of fasting duration and weekday in incretin and glucose regulation

scientific article published on 01 March 2020

Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function

artículo científico publicado en 2005

Rosiglitazone monotherapy for type 2 diabetes mellitus—too soon to ADOPT?

Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota

artículo científico publicado en 2016

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

article

SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function

artículo científico publicado en 2016

Sagittal abdominal diameter and waist circumference appear to be equally good as identifiers of cardiometabolic risk

artículo científico publicado en 2020

Screening of 31 genes involved in monogenic forms of obesity in 23 Pakistani probands with early-onset childhood obesity: a case report

scientific article published on 05 September 2019

Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity.

artículo científico publicado en 1999

Selection in Europeans on Fatty Acid Desaturases Associated with Dietary Changes

artículo científico publicado en 2017

Selection on the FADS region in Europeans

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

artículo científico publicado en 2017

Sequence of the human glycogen-associated regulatory subunit of type 1 protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with NIDDM.

artículo científico publicado en 1994

Sequencing and de novo assembly of 150 genomes from Denmark as a population reference

artículo científico publicado en 2017

Sequencing reveals protective and pathogenic effects on development of diabetes of rare GLIS3 variants

scientific article published on 15 August 2019

Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity.

artículo científico publicado en 2016

Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus

artículo científico publicado en 2008

Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility.

artículo científico publicado en 2014

Short telomere length is associated with impaired cognitive performance in European ancestry cohorts.

artículo científico publicado en 2017

Short- and long-term metabolic effects of recombinant human IGF-I treatment in patients with severe insulin resistance and diabetes mellitus.

artículo científico publicado en 1997

Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance

artículo científico publicado en 2008

Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

scientific article published on 01 June 2020

Slimming down via the microbiota

artículo científico publicado en 2013

Solute carrier family 2 member 1 is involved in the development of nonalcoholic fatty liver disease

artículo científico publicado en 2012

Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies

artículo científico publicado en 2016

Specific gut microbiota features and metabolic markers in postmenopausal women with obesity

artículo científico publicado en 2015

Specificity and sensitivity of commercially available assays for glucagon-like peptide-1 (GLP-1): implications for GLP-1 measurements in clinical studies

artículo científico publicado en 2014

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

scientific article published on 06 May 2020

Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes

artículo científico publicado en 2009

Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes

artículo científico publicado en 2011

Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes

artículo científico publicado en 2010

Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes

artículo científico publicado en 2013

Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites

artículo científico publicado en 2007

Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies

artículo científico publicado en 2007

Studies of associations between the Arg389Gly polymorphism of the beta1-adrenergic receptor gene (ADRB1) and hypertension and obesity in 7677 Danish white subjects.

artículo científico publicado en 2007

Studies of metabolic phenotypic correlates of 15 obesity associated gene variants

artículo científico publicado en 2011

Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a combined analysis of 55,521 Europeans

artículo científico publicado en 2011

Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes.

artículo científico publicado en 2005

Studies of the associations between functional beta2-adrenergic receptor variants and obesity, hypertension and type 2 diabetes in 7,808 white subjects.

artículo científico publicado en 2007

Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects

artículo científico publicado en 2006

Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects

artículo científico publicado en 2006

Studies of the variability of the genes encoding the insulin-like growth factor I receptor and its ligand in relation to type 2 diabetes mellitus

scientific article published on 01 April 2000

Studies of variability in the PTEN gene among Danish caucasian patients with Type II diabetes mellitus

artículo científico publicado en 2001

Studies of variations of the cyclin-dependent kinase inhibitor 1C and the cyclin-dependent kinase 4 genes in relation to type 2 diabetes mellitus and related quantitative traits

artículo científico publicado en 2005

Study rationale and design of the CIMT trial: the Copenhagen Insulin and Metformin Therapy trial

artículo científico publicado en 2009

Subclinical Hypothyroidism in Danish Lean and Obese Children and Adolescents.

artículo científico publicado en 2016

Sulfonylurea therapy improves glucose disposal without changing skeletal muscle GLUT4 levels in noninsulin-dependent diabetes mellitus subjects: a longitudinal study

artículo científico publicado en 1995

TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet

artículo científico publicado en 2009

TFAP2B influences the effect of dietary fat on weight loss under energy restriction

artículo científico publicado en 2012

Target intervention against multiple-risk markers to reduce cardiovascular disease in patients with type 2 diabetes.

artículo científico publicado en 2004

The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects.

artículo científico publicado en 2008

The Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene contributes to the interindividual variation in serum C-peptide response during an oral glucose tolerance test: evidence from studies of 231 glucose-tolerant first degree relativ

article

The BIGTT test: a novel test for simultaneous measurement of pancreatic beta-cell function, insulin sensitivity, and glucose tolerance

artículo científico publicado en 2007

The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins

artículo científico publicado en 2019

The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway

artículo científico publicado en 2013

The Danish Centre for Strategic Research in Type 2 Diabetes (DD2) Project: rationale and planned nationwide studies of genetic predictors, physical exercise, and individualized pharmacological treatment

artículo científico publicado en 2012

The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes

artículo científico publicado en 2003

The Effect of Overweight and Obesity on Liver Biochemical Markers in Children and Adolescents

scientific article published on 01 February 2020

The FOXO3A rs2802292 G-allele associates with improved peripheral and hepatic insulin sensitivity and increased skeletal muscle-FOXO3A mRNA expression in twins

artículo científico publicado en 2010

The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes

The Gly482Ser genotype at the PPARGC1A gene and elevated blood pressure: a meta-analysis involving 13,949 individuals

artículo científico publicado en 2008

The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study

artículo científico publicado en 2006

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2015

The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians.

artículo científico publicado en 2000

The KCNMB1 Glu65Lys polymorphism associates with reduced systolic and diastolic blood pressure in the Inter99 study of 5729 Danes

artículo científico publicado en 2008

The N363S polymorphism of the glucocorticoid receptor and metabolic syndrome factors in men.

artículo científico publicado en 2005

The PNPLA3 rs738409 G-allele associates with reduced fasting serum triglyceride and serum cholesterol in Danes with impaired glucose regulation

artículo científico publicado en 2012

The PPARγ2 Pro12Ala variant predicts ESRD and mortality in patients with type 1 diabetes and diabetic nephropathy

The Polygenic and Monogenic Basis of Blood Traits and Diseases

artículo científico publicado en 2020

The Role of the Gut Microbiome in Obesity

The Role of the Gut Microbiota in Childhood Obesity

artículo científico publicado en 2016

The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men.

artículo científico publicado en 2009

The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest

artículo científico publicado en 2010

The antidepressant-like effect of probiotics and their faecal abundance may be modulated by the cohabiting gut microbiota in rats

artículo científico publicado en 2018

The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample

artículo científico publicado en 2015

The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population

artículo científico publicado en 2010

The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge

artículo científico publicado en 2011

The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study

artículo científico publicado en 2008

The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders

scientific article published on 24 January 2020

The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals

artículo científico publicado en 2011

The effect of FOXA2 rs1209523 on glucose-related phenotypes and risk of type 2 diabetes in Danish individuals

artículo científico publicado en 2012

The effect of GWAS identified BMI loci on changes in body weight among middle-aged Danes during a five-year period.

artículo científico publicado en 2013

The effect of PCSK1 variants on waist, waist-hip ratio and glucose metabolism is modified by sex and glucose tolerance status

artículo científico publicado en 2011

The effect of drinking water pH on the human gut microbiota and glucose regulation: results of a randomized controlled cross-over intervention

scientific article published in Scientific Reports

The effect of impaired glucose metabolism on weight loss in multidisciplinary childhood obesity treatment.

artículo científico publicado en 2017

The effect of intensive insulin therapy on the insulin-regulatable glucose transporter (GLUT4) expression in skeletal muscle in type 1 diabetes.

artículo científico publicado en 1993

The effect of smoking on the urinary excretion of 8-oxodG and 8-oxoGuo in patients with type 2 diabetes

The effect of two frequent amino acid variants of the hepatocyte nuclear factor-1alpha gene on estimates of the pancreatic beta-cell function in Caucasian glucose-tolerant first-degree relatives of type 2 diabetic patients

article

The effects of adding group-based lifestyle counselling to individual counselling on changes in plasma glucose levels in a randomized controlled trial: the Inter99 study.

artículo científico publicado en 2011

The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes.

artículo científico publicado en 2012

The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites

article

The functional Thr130Ile and Val255Met polymorphisms of the hepatocyte nuclear factor-4alpha (HNF4A): gene associations with type 2 diabetes or altered beta-cell function among Danes

artículo científico publicado en 2005

The genetic abnormality in the beta cell determines the response to an oral glucose load

artículo científico publicado en 2002

The genetic architecture of type 2 diabetes

artículo científico publicado en 2016

The gut microbiome in cardio-metabolic health.

artículo científico publicado en 2015

The iPSYCH2012 case-cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders.

artículo científico publicado en 2017

The influence of parental history of diabetes and offspring birthweight on offspring glucose metabolism in adulthood

The intestinal microbiome is a co-determinant of the postprandial plasma glucose response

scientific article published on 18 September 2020

The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load

artículo científico publicado en 2011

The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype

artículo científico publicado en 2003

The prevalence of the metabolic syndrome in a danish population of women with previous gestational diabetes mellitus is three-fold higher than in the general population

artículo científico publicado en 2005

The role of genetic liability in the association of urbanicity at birth and during upbringing with schizophrenia in Denmark.

artículo científico publicado en 2017

The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study

artículo científico publicado en 2020

The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm

article

The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load

artículo científico publicado en 2009

The type 2 diabetes risk allele of TMEM154-rs6813195 associates with decreased beta cell function in a study of 6,486 Danes

artículo científico publicado en 2015

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

artículo científico publicado en 2015

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

artículo científico publicado en 2016

Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

artículo científico publicado en 2020

Trans-ethnic gut microbiota signatures of type 2 diabetes in Denmark and India

artículo científico publicado en 2021

Transcriptional interactions suggest niche segregation among microorganisms in the human gut.

artículo científico publicado en 2016

Treatment with a GLP-1 receptor agonist diminishes the decrease in free plasma leptin during maintenance of weight loss.

artículo científico publicado en 2014

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

artículo científico publicado en 2010

Two variants on chromosome 17 confer prostate cancer risk and the one in TCF2 protects against type 2 diabetes

article

Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release

artículo científico publicado en 2011

Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.

artículo científico publicado en 2010

Type 2 diabetes risk alleles near BCAR1 and in ANK1 associate with decreased β-cell function whereas risk alleles near ANKRD55 and GRB14 associate with decreased insulin sensitivity in the Danish Inter99 cohort

artículo científico publicado en 2013

Ultraviolet Radiation Exposure and Risk of Malignant Lymphomas

Uncovering the genetic history of the present-day Greenlandic population. ⬇️

artículo científico publicado en 2014

Urinary metabolomics reveals glycemic and coffee associated signatures of thyroid function in two population-based cohorts

artículo científico publicado en 2017

Urinary nucleic acid oxidation product levels show differential associations with pharmacological treatment in patients with type 2 diabetes

scientific article published on 04 June 2019

Utility of Plasma Concentration of Trimethylamine N-Oxide in Predicting Cardiovascular and Renal Complications in Individuals With Type 1 Diabetes

artículo científico publicado en 2019

Validation of a multi-marker model for the prediction of incident type 2 diabetes mellitus: combined results of the Inter99 and Botnia studies

artículo científico publicado en 2011

Validation of a multimarker model for assessing risk of type 2 diabetes from a five-year prospective study of 6784 Danish people (Inter99).

scientific article published on July 2009

Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies

artículo científico publicado en 2008

Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease

artículo científico publicado en 2016

Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study

artículo científico publicado en 2009

Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people

artículo científico publicado en 2010

Variants in the 5′ region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects

article

Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes

artículo científico publicado en 2008

Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians

artículo científico publicado en 2002

Variation and association to diabetes in 2000 full mtDNA sequences mined from an exome study in a Danish population

artículo científico publicado en 2014

Variation in CAPN10 in relation to type 2 diabetes, obesity and quantitative metabolic traits: Studies in 6018 whites

article

Variation in CHI3LI in relation to type 2 diabetes and related quantitative traits

artículo científico publicado en 2009

Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus

artículo científico publicado en 2004

Variation in the gene encoding Krüppel-like factor 7 influences body fat: studies of 14 818 Danes

article

Variation in the interleukin-6 receptor gene associates with type 2 diabetes in Danish whites.

artículo científico publicado en 2004

Variation in the peroxisome proliferator-activated receptor delta gene in relation to common metabolic traits in 7,495 middle-aged white people

artículo científico publicado en 2007

Variation of the McKusick-Kaufman Gene and Studies of Relationships with Common Forms of Obesity

article

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels

artículo científico publicado en 2008

Vejle Diabetes Biobank - a resource for studies of the etiologies of diabetes and its comorbidities

artículo científico publicado en 2016

What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications?

artículo científico publicado en 2013

Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study

artículo científico publicado en 2020

Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial.

artículo científico publicado en 2017

Whole-Exome Sequencing of 2,000 Danish Individuals and the Role of Rare Coding Variants in Type 2 Diabetes

Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes

artículo científico publicado en 2013

Years of life gained by multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: 21 years follow-up on the Steno-2 randomised trial.

artículo científico publicado en 2016

[Chasing the genetic determinants of the presumed polygenic forms of type 2 diabetes. Status and perspectives]

artículo científico publicado en 2002

[Diabetes in infants may be treated with sulfonylurea as a replacement for insulin].

artículo científico publicado en 2009

[Management plan for diabetes]

artículo científico publicado en 2004

[Maturity-onset diabetes of the young--MODY. Molecular-genetic, pathophysiological and clinical characteristics]

artículo científico publicado en 2002

[Molecular pathogenesis in monogenic and polygenic obesity]

scientific article published on 01 January 2006

[The Steno-2 study. Intensive multifactorial intervention reduces the occurrence of cardiovascular disease in patients with type 2 diabetes]

artículo científico publicado en 2003

[The genetics of obesity]

scientific article published on 01 January 2006

[The genome and diabetes] ⬇️

artículo científico publicado en 2014

Lista de obras de Oluf Borbye Pedersen

'Omics'-driven discoveries in prevention and treatment of type 2 diabetes

1H-MRS Measured Ectopic Fat in Liver and Muscle in Danish Lean and Obese Children and Adolescents

1H-MRS measured ectopic fat in liver and muscle is associated with the metabolic syndrome in Danish girls but not in boys with overweight and obesity.

35th Annual Meeting of the European Association for the Study of Diabetes

35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999

A -243A-->G polymorphism upstream of the gene encoding GAD65 associates with lower levels of body mass index and glycaemia in a population-based sample of 5857 middle-aged White subjects.

A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites.

A Bayesian multilocus association method: allowing for higher-order interaction in association studies

A Comprehensive Reanalysis Of Publicly Available GWAS Datasets Reveals An X Chromosome Rare Regulatory Variant Associated With High Risk For Type 2 Diabetes

A Functional Amino Acid Substitution in the Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR) Gene Is Associated With Lower Bone Mineral Density and Increased Fracture Risk

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

A Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young: Evidence for Further Genetic Heterogeneity

A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians

A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

A Mutation Map for Human Glycoside Hydrolase Genes

A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro

A Splice Region Variant in LDLR Lowers Non-high Density Lipoprotein Cholesterol and Protects against Coronary Artery Disease

A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study

A combined analysis of 48 type 2 diabetes genetic risk variants shows no discriminative value to predict time to first prescription of a glucose lowering drug in Danish patients with screen detected type 2 diabetes

A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis

A common polymorphism in the promoter of the IGF-I gene associates with increased fasting serum triglyceride levels in glucose-tolerant subjects

A computational framework to integrate high-throughput ‘-omics’ datasets for the identification of potential mechanistic links

A cost analysis of intensified vs conventional multifactorial therapy in individuals with type 2 diabetes: a post hoc analysis of the Steno-2 study

A diet-induced gut microbiota component and related plasma metabolites are associated with depressive-like behaviour in rats

A genome-wide association search for type 2 diabetes genes in African Americans

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

A genome-wide association study of thyroid stimulating hormone and free thyroxine in Danish children and adolescents

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

A germline variant in the TP53 polyadenylation signal confers cancer susceptibility

A glycogene mutation map for discovery of diseases of glycosylation

A human gut microbial gene catalogue established by metagenomic sequencing

A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes.

A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults

A metagenome-wide association study of gut microbiota in type 2 diabetes

A novel -192c/g mutation in the proximal P2 promoter of the hepatocyte nuclear factor-4 alpha gene (HNF4A) associates with late-onset diabetes.

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria

A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene

A possible association between a dysfunctional skin barrier (filaggrin null-mutation status) and diabetes: a cross-sectional study

A prevalent amino acid polymorphism at codon 98 (Ala98Val) of the hepatocyte nuclear factor-1alpha is associated with maturity-onset diabetes of the young and younger age at onset of type 2 diabetes in Asian Indians.

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

A reference map of potential determinants for the human serum metabolome

A role for coding functional variants in HNF4A in type 2 diabetes susceptibility

A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes

A statistical approach based on substitution of macronutrients provides additional information to models analyzing single dietary factors in relation to type 2 diabetes in danish adults: the Inter99 study

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity

A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations

AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects

AIRE variations in Addison's disease and autoimmune polyendocrine syndromes (APS): partial gene deletions contribute to APS I

Abdominal adiposity and cardiometabolic risk factors in children and adolescents: a Mendelian randomization analysis

Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents

Aberrant intestinal microbiota in individuals with prediabetes.

Affective disorders and high familial risk of affective disorders associate with aberrant intestinal microbiota

Alcohol consumption and its interaction with adiposity-associated genetic variants in relation to subsequent changes in waist circumference and body weight

Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets

Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials

Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus.

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

An Improved Method for High Quality Metagenomics DNA Extraction from Human and Environmental Samples

An adult-based genetic risk score for hepatic fat associates with liver and lipid traits in Danish children and adolescents

An adult-based insulin resistance genetic risk score associates with insulin resistance, metabolic traits and altered fat distribution in Danish children and adolescents who are overweight or obese

An epigenome-wide association study meta-analysis of educational attainment.

An integrated catalog of reference genes in the human gut microbiome

Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes

Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism

Application of urinary proteomics as possible risk predictor of renal and cardiovascular complications in patients with type 2-diabetes and microalbuminuria

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion

Association between Neuromedin U Gene Variants and Overweight and Obesity

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis

Association of genetic variants previously implicated in coronary artery disease with age at onset of coronary artery disease requiring revascularizations

Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults

Association of the beta3-adrenergic receptor Trp64Arg polymorphism with common metabolic traits: studies of 7605 middle-aged white people

Association of the calpain-10 gene with type 2 diabetes in Europeans: Results of pooled and meta-analyses