Lista de obras - Pieter Leyssen - Dominio Público Uruguay

3',5'Di-O-trityluridine inhibits in vitro flavivirus replication

artículo científico publicado en 2013

3'-Deoxy phosphoramidate dinucleosides as improved inhibitors of hepatitis C virus subgenomic replicon and NS5B polymerase activity

artículo científico publicado en 2010

3-(imidazo[1,2-a:5,4-b']dipyridin-2-yl)aniline inhibits pestivirus replication by targeting a hot spot drug binding pocket in the RNA-dependent RNA polymerase

artículo científico publicado en 2016

3-Biphenylimidazo[1,2-a]pyridines or [1,2-b]pyridazines and analogues, novel Flaviviridae inhibitors

artículo científico publicado en 2013

3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses

artículo científico publicado en 2013

A Dengue type 2 reporter virus assay amenable to high-throughput screening

artículo científico publicado en 2020

A novel benzonitrile analogue inhibits rhinovirus replication

artículo científico publicado en 2014

A novel class of chikungunya virus small molecule inhibitors that targets the viral capping machinery

scientific article published on 27 April 2020

A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses

scientific article published on 11 June 2019

A novel method for high-throughput screening to quantify antiviral activity against viruses that induce limited CPE

scientific article published on 28 April 2012

A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.

artículo científico publicado en 2013

A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase

artículo científico publicado en 2006

A rapid and convenient variant of fusion-PCR to construct chimeric flaviviruses

artículo científico publicado en 2003

A reassessment of mycophenolic acid as a lead compound for the development of inhibitors of chikungunya virus replication

article

Acute Encephalitis, a Poliomyelitis-like Syndrome and Neurological Sequelae in a Hamster Model for Flavivirus Infections

artículo científico publicado en 2006

Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication

artículo científico publicado en 2020

Anti-enterovirus activity and structure–activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles

scientific article published in 2007

Antibacterial, Antifungal, Antiviral, and Anthelmintic Activities of Medicinal Plants of Nepal Selected Based on Ethnobotanical Evidence

artículo científico publicado en 2020

Antimicrobial, Anthelmintic, and Antiviral Activity of Plants Traditionally Used for Treating Infectious Disease in the Similipal Biosphere Reserve, Odisha, India

artículo científico publicado en 2017

Antiplasmodial, Anti-chikungunya virus and Antioxidant Activities of 64 endemic Plants from the Mascarene Islands

article

Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.

artículo científico publicado en 2015

Antiviral Activity of Diterpene Esters on Chikungunya Virus and HIV Replication

artículo científico publicado en 2015

Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata ⬇️

artículo científico publicado en 2015

Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones against chikungunya virus targeting the viral capping nsP1.

artículo científico publicado en 2017

Antiviral and Cytotoxic Activity of Different Plant Parts of Banana (Musa spp.).

scientific article published on 15 May 2020

Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri

artículo científico publicado en 2012

Assessing medicinal plants traditionally used in the Chirang Reserve Forest, Northeast India for antimicrobial activity

article

Benzouracil-coumarin-arene conjugates as inhibiting agents for chikungunya virus

artículo científico publicado en 2015

Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation.

artículo científico publicado en 2018

Biodiversity as a Source of Potent and Selective Inhibitors of Chikungunya Virus Replication

Bioengineering and semisynthesis of an optimized cyclophilin inhibitor for treatment of chronic viral infection

artículo científico publicado en 2015

Chemical constituents of Anacolosa pervilleana and their antiviral activities

artículo científico publicado en 2012

Chemical modification of the plant isoprenoid cytokinin N(6)-isopentenyladenosine yields a selective inhibitor of human enterovirus 71 replication

artículo científico publicado en 2014

Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors

artículo científico publicado en 2008

Comparative analysis of the anti-chikungunya virus activity of novel bryostatin analogs confirms the existence of a PKC-independent mechanism

artículo científico publicado en 2016

Complete genome sequence of Montana Myotis leukoencephalitis virus, phylogenetic analysis and comparative study of the 3' untranslated region of flaviviruses with no known vector

artículo científico publicado en 2002

Complete genome sequence, taxonomic assignment, and comparative analysis of the untranslated regions of the Modoc virus, a flavivirus with no known vector

artículo científico publicado en 2002

Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus

artículo científico publicado en 2013

Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication

artículo científico publicado en 2016

Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxonorbornane and their antiviral properties

Correction to 3′-Deoxy Phosphoramidate Dinucleosides as Improved Inhibitors of Hepatitis C Virus Subgenomic Replicon and NS5B Polymerase Activity

scholarly article published in Journal of Medicinal Chemistry

Coumarin-purine ribofuranoside conjugates as new agents against hepatitis C virus

artículo científico publicado en 2011

Design, synthesis and evaluation against Chikungunya virus of novel small-molecule antiviral agents

artículo científico publicado en 2018

Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors

artículo científico publicado en 2010

Design, synthesis, optimization and antiviral activity of a class of hybrid dengue virus E protein inhibitors

artículo científico publicado en 2015

Development of New Sulfur-Containing Conjugated Compounds as Anti-HCV Agents

article

Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases

artículo científico publicado en 2017

Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases

artículo científico publicado en 2015

Discovery of a novel HCV helicase inhibitor by a de novo drug design approach

artículo científico publicado en 2009

Discovery of novel multi-target indole-based derivatives as potent and selective inhibitors of chikungunya virus replication

artículo científico publicado en 2016

Efficacy of cidofovir in a murine model of disseminated progressive vaccinia

artículo científico publicado en 2004

Efficient synthesis and anti-enteroviral activity of 9-arylpurines

artículo científico publicado en 2012

Enterovirus Inhibition by Hinged Aromatic Compounds with Polynuclei

scientific article published on 22 August 2020

Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata.

artículo científico publicado en 2017

Euphorbia dendroides Latex as a Source of Jatrophane Esters: Isolation, Structural Analysis, Conformational Study, and Anti-CHIKV Activity

artículo científico publicado en 2016

Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry

artículo científico publicado en 2020

Exchanging the yellow fever virus envelope proteins with Modoc virus prM and E proteins results in a chimeric virus that is neuroinvasive in SCID mice

artículo científico publicado en 2004

Exploration of the anti-enterovirus activity of a series of pleconaril/pirodavir-like compounds

artículo científico publicado en 2015

Exploration of the in vitro antiviral activity of a series of new pyrimidine analogues on the replication of HIV and HCV.

artículo científico publicado en 2012

Exploring the importance of zinc binding and steric/hydrophobic factors in novel HCV replication inhibitors

artículo científico publicado en 2016

Fitness and virulence of a coxsackievirus mutant that can circumnavigate the need for phosphatidylinositol 4-kinase class III beta

artículo científico publicado en 2013

Flacourtosides A-F, phenolic glycosides isolated from Flacourtia ramontchi

artículo científico publicado en 2012

Fluorination of Naturally Occurring N⁶-Benzyladenosine Remarkably Increased Its Antiviral Activity and Selectivity.

artículo científico publicado en 2017

From norbornane-based nucleotide analogs locked in South conformation to novel inhibitors of feline herpes virus

artículo científico publicado en 2014

H1PVAT is a novel and potent early-stage inhibitor of poliovirus replication that targets VP1.

artículo científico publicado en 2014

Identification and Analysis of Antiviral Compounds Against Poliovirus

artículo científico publicado en 2016

Identification of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones as novel inhibitors of Chikungunya virus replication

artículo científico publicado en 2014

Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections

artículo científico publicado en 2013

Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step

artículo científico publicado en 2009

Impact of Direct Virus-Induced Neuronal Dysfunction and Immunological Damage on the Progression of Flavivirus (Modoc) Encephalitis in a Murine Model

scholarly article by Pieter Leyssen et al published January 2003 in Journal of NeuroVirology

Impact of direct virus-induced neuronal dysfunction and immunological damage on the progression of flavivirus (Modoc) encephalitis in a murine model

artículo científico publicado en 2003

In Vitro Selection and Characterization of Hepatitis C Virus Replicons Double or Triple Resistant to Various Non-nucleoside HCV Polymerase Inhibitors

artículo científico publicado en 2010

In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase

artículo científico publicado en 2016

In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses.

artículo científico publicado en 2015

In vitro selection and characterization of HCV replicons resistant to multiple non-nucleoside polymerase inhibitors

artículo científico publicado en 2011

In vivo monitoring of acute flavivirus (Modoc) encephalitis with regional and whole-brain quantitative diffusion magnetic resonance imaging

artículo científico publicado en 2004

Infection of SCID mice with Montana Myotis leukoencephalitis virus as a model for flavivirus encephalitis

artículo científico publicado en 2002

Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway

artículo científico publicado en 2016

Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones.

artículo científico publicado en 2018

Interferons, Interferon Inducers, and Interferon-Ribavirin in Treatment of Flavivirus-Induced Encephalitis in Mice

artículo científico publicado en 2003

Intra-host emergence of an enterovirus A71 variant with enhanced PSGL1 usage and neurovirulence

scientific article published on 01 January 2019

Investigation of Premyrsinane and Myrsinane Esters in Euphorbia cupanii and Euphobia pithyusa with MS2LDA and Combinatorial Molecular Network Annotation Propagation

scientific article published on 05 June 2019

Isolation of Premyrsinane, Myrsinane, and Tigliane Diterpenoids from Euphorbia pithyusa Using a Chikungunya Virus Cell-Based Assay and Analogue Annotation by Molecular Networking

artículo científico publicado en 2017

Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein

artículo científico publicado en 2015

Jatrophane diterpenes as inhibitors of chikungunya virus replication: structure-activity relationship and discovery of a potent lead

artículo científico publicado en 2014

LC-MS²-Based dereplication of Euphorbia extracts with anti-Chikungunya virus activity

artículo científico publicado en 2015

Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.

artículo científico publicado en 2015

Modification of the length and structure of the linker of N(6)-benzyladenosine modulates its selective antiviral activity against enterovirus 71.

artículo científico publicado en 2016

Molecular strategies to inhibit the replication of RNA viruses

artículo científico publicado en 2008

Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral

artículo científico publicado en 2014

NMR-based conformational analysis of 2',6-disubstituted uridines and antiviral evaluation of new phosphoramidate prodrugs

artículo científico publicado en 2015

New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2.

artículo científico publicado en 2014

New pyrazolobenzothiazine derivatives as hepatitis C virus NS5B polymerase palm site I inhibitors

artículo científico publicado en 2014

Norbornane-based nucleoside and nucleotide analogues locked in North conformation

artículo científico publicado en 2014

Novel 1,2,4-triazole and imidazole derivatives of L-ascorbic and imino-ascorbic acid: synthesis, anti-HCV and antitumor activity evaluations

artículo científico publicado en 2012

Novel substituted 9-norbornylpurines and their activities against RNA viruses

artículo científico publicado en 2012

Novel symmetrical phenylenediamines as potential anti-hepatitis C virus agents.

artículo científico publicado en 2016

Optimization of a Class of Tryptophan Dendrimers That Inhibit HIV Replication Leads to a Selective, Specific, and Low-Nanomolar Inhibitor of Clinical Isolates of Enterovirus A71.

artículo científico publicado en 2016

PHYTOCHIK: Biodiversity As A Source of Selective Inhibitors of CHIKV Replication

article published in 2011

PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases

scholarly article by Leen Delang et al published 14 September 2018 in Journal of Antimicrobial Chemotherapy

Phosphatidylinositol 4-kinase III beta is essential for replication of human rhinovirus and its inhibition causes a lethal phenotype in vivo

artículo científico publicado en 2013

Preclinical characterization of naturally occurring polyketide cyclophilin inhibitors from the sanglifehrin family

artículo científico publicado en 2011

Prostratin and 12-O-tetradecanoylphorbol 13-acetate are potent and selective inhibitors of Chikungunya virus replication

artículo científico publicado en 2012

Protein kinases C as potential host targets for the inhibition of chikungunya virus replication

artículo científico publicado en 2016

Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase

artículo científico publicado en 2011

Quinolinecarboxamides Inhibit the Replication of the Bovine Viral Diarrhea Virus by Targeting a Hot Spot for the Inhibition of Pestivirus Replication in the RNA-Dependent RNA Polymerase

artículo científico publicado en 2020

Rational modifications on a benzylidene-acrylohydrazide antiviral scaffold, synthesis and evaluation of bioactivity against Chikungunya virus

artículo científico publicado en 2018

Reaching beyond HIV/HCV: nelfinavir as a potential starting point for broad-spectrum protease inhibitors against dengue and chikungunya virus

article

Rodent models for the study of therapy against flavivirus infections

artículo científico publicado en 2004

S-aryltriazole acyclonucleosides: synthesis and biological evaluation against hepatitis C virus

artículo científico publicado en 2010

SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors

artículo científico publicado en 2011

STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters

artículo científico publicado en 2020

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

artículo científico publicado en 2020

Sangamides, a new class of cyclophilin-inhibiting host-targeted antivirals for treatment of HCV infection

Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enteroviruses B and D by targeting viral protein 2C.

artículo científico publicado en 2013

Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV.

artículo científico publicado en 2017

Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death

artículo científico publicado en 2016

Statins potentiate the in vitro anti-hepatitis C virus activity of selective hepatitis C virus inhibitors and delay or prevent resistance development

artículo científico publicado en 2009

Straightforward synthesis of triazoloacyclonucleotide phosphonates as potential HCV inhibitors

artículo científico publicado en 2010

Structurally Diverse Diterpenoids from Sandwithia guyanensis

artículo científico publicado en 2018

Structure Elucidation of Coxsackievirus A16 in Complex with GPP3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses

artículo científico publicado en 2015

Structure-activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid.

artículo científico publicado en 2016

Structure-activity relationship study of arbidol derivatives as inhibitors of chikungunya virus replication

artículo científico publicado en 2014

Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication

artículo científico publicado en 2013

Substituted 2,6-bis(benzimidazol-2-yl)pyridines: a novel chemical class of pestivirus inhibitors that targets a hot spot for inhibition of pestivirus replication in the RNA-dependent RNA polymerase

artículo científico publicado en 2014

Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C.

artículo científico publicado en 2014

Synthesis and Structure-Activity Relationships of Imidazole-Coumarin Conjugates against Hepatitis C Virus

artículo científico publicado en 2016

Synthesis of novel azanorbornylpurine derivatives

Synthesis of novel purine-based coxsackievirus inhibitors bearing polycylic substituents at the N-9 position

artículo científico publicado en 2014

Synthesis of novel thienonorbornylpurine derivatives

Synthesis, biological activity and structure-activity relationship of 4,5-dimethoxybenzene derivatives inhibitor of rhinovirus 14 infection

artículo científico publicado en 2014

The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication

artículo científico publicado en 2007

The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family

artículo científico publicado en 2015

The anti-yellow fever virus activity of ribavirin is independent of error-prone replication

artículo científico publicado en 2006

The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication

artículo científico publicado en 2014

The enterovirus 3C protease inhibitor SG85 efficiently blocks rhinovirus replication and is not cross-resistant with rupintrivir

artículo científico publicado en 2015

The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase

artículo científico publicado en 2005

The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors

artículo científico publicado en 2013

Tigliane diterpenes from Croton mauritianus as inhibitors of chikungunya virus replication

artículo científico publicado en 2014

Tiyoüreler, açiltiyoüreler ve 4-tiyazolidinonların sentezi, karakterizasyonu ve antikanser ve antiviral etkilerinin değerlendirilmesi

Towards the design of combination therapy for the treatment of enterovirus infections

artículo científico publicado en 2011

Trigocherrierin A, a potent inhibitor of chikungunya virus replication.

artículo científico publicado en 2014

Trigocherrin A, the first natural chlorinated daphnane diterpene orthoester from Trigonostemon cherrieri ⬇️

artículo científico publicado en 2011

Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase

artículo científico publicado en 2017

VP1 crystal structure-guided exploration and optimization of 4,5-dimethoxybenzene-based inhibitors of rhinovirus 14 infection

artículo científico publicado en 2016

Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus-A71 capsid

artículo científico publicado en 2019

α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

artículo científico publicado en 2020

Lista de obras de Pieter Leyssen

3',5'Di-O-trityluridine inhibits in vitro flavivirus replication

3'-Deoxy phosphoramidate dinucleosides as improved inhibitors of hepatitis C virus subgenomic replicon and NS5B polymerase activity

3-(imidazo[1,2-a:5,4-b']dipyridin-2-yl)aniline inhibits pestivirus replication by targeting a hot spot drug binding pocket in the RNA-dependent RNA polymerase

3-Biphenylimidazo[1,2-a]pyridines or [1,2-b]pyridazines and analogues, novel Flaviviridae inhibitors

3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses

A Dengue type 2 reporter virus assay amenable to high-throughput screening

A novel benzonitrile analogue inhibits rhinovirus replication

A novel class of chikungunya virus small molecule inhibitors that targets the viral capping machinery

A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses

A novel method for high-throughput screening to quantify antiviral activity against viruses that induce limited CPE

A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.

A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase

A rapid and convenient variant of fusion-PCR to construct chimeric flaviviruses

A reassessment of mycophenolic acid as a lead compound for the development of inhibitors of chikungunya virus replication

Acute Encephalitis, a Poliomyelitis-like Syndrome and Neurological Sequelae in a Hamster Model for Flavivirus Infections

Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication

Anti-enterovirus activity and structure–activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles

Antibacterial, Antifungal, Antiviral, and Anthelmintic Activities of Medicinal Plants of Nepal Selected Based on Ethnobotanical Evidence

Antimicrobial, Anthelmintic, and Antiviral Activity of Plants Traditionally Used for Treating Infectious Disease in the Similipal Biosphere Reserve, Odisha, India

Antiplasmodial, Anti-chikungunya virus and Antioxidant Activities of 64 endemic Plants from the Mascarene Islands

Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.

Antiviral Activity of Diterpene Esters on Chikungunya Virus and HIV Replication

Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata ⬇️

Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones against chikungunya virus targeting the viral capping nsP1.

Antiviral and Cytotoxic Activity of Different Plant Parts of Banana (Musa spp.).

Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri

Assessing medicinal plants traditionally used in the Chirang Reserve Forest, Northeast India for antimicrobial activity

Benzouracil-coumarin-arene conjugates as inhibiting agents for chikungunya virus

Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation.

Biodiversity as a Source of Potent and Selective Inhibitors of Chikungunya Virus Replication

Bioengineering and semisynthesis of an optimized cyclophilin inhibitor for treatment of chronic viral infection

Chemical constituents of Anacolosa pervilleana and their antiviral activities

Chemical modification of the plant isoprenoid cytokinin N(6)-isopentenyladenosine yields a selective inhibitor of human enterovirus 71 replication

Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors

Comparative analysis of the anti-chikungunya virus activity of novel bryostatin analogs confirms the existence of a PKC-independent mechanism

Complete genome sequence of Montana Myotis leukoencephalitis virus, phylogenetic analysis and comparative study of the 3' untranslated region of flaviviruses with no known vector

Complete genome sequence, taxonomic assignment, and comparative analysis of the untranslated regions of the Modoc virus, a flavivirus with no known vector

Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus

Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication

Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxonorbornane and their antiviral properties

Correction to 3′-Deoxy Phosphoramidate Dinucleosides as Improved Inhibitors of Hepatitis C Virus Subgenomic Replicon and NS5B Polymerase Activity

Coumarin-purine ribofuranoside conjugates as new agents against hepatitis C virus

Design, synthesis and evaluation against Chikungunya virus of novel small-molecule antiviral agents

Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors

Design, synthesis, optimization and antiviral activity of a class of hybrid dengue virus E protein inhibitors

Development of New Sulfur-Containing Conjugated Compounds as Anti-HCV Agents

Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases

Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases

Discovery of a novel HCV helicase inhibitor by a de novo drug design approach

Discovery of novel multi-target indole-based derivatives as potent and selective inhibitors of chikungunya virus replication

Efficacy of cidofovir in a murine model of disseminated progressive vaccinia

Efficient synthesis and anti-enteroviral activity of 9-arylpurines

Enterovirus Inhibition by Hinged Aromatic Compounds with Polynuclei

Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata.

Euphorbia dendroides Latex as a Source of Jatrophane Esters: Isolation, Structural Analysis, Conformational Study, and Anti-CHIKV Activity

Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry

Exchanging the yellow fever virus envelope proteins with Modoc virus prM and E proteins results in a chimeric virus that is neuroinvasive in SCID mice

Exploration of the anti-enterovirus activity of a series of pleconaril/pirodavir-like compounds

Exploration of the in vitro antiviral activity of a series of new pyrimidine analogues on the replication of HIV and HCV.

Exploring the importance of zinc binding and steric/hydrophobic factors in novel HCV replication inhibitors

Fitness and virulence of a coxsackievirus mutant that can circumnavigate the need for phosphatidylinositol 4-kinase class III beta

Flacourtosides A-F, phenolic glycosides isolated from Flacourtia ramontchi

Fluorination of Naturally Occurring N⁶-Benzyladenosine Remarkably Increased Its Antiviral Activity and Selectivity.

From norbornane-based nucleotide analogs locked in South conformation to novel inhibitors of feline herpes virus

H1PVAT is a novel and potent early-stage inhibitor of poliovirus replication that targets VP1.

Identification and Analysis of Antiviral Compounds Against Poliovirus

Identification of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones as novel inhibitors of Chikungunya virus replication

Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections

Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step

Impact of Direct Virus-Induced Neuronal Dysfunction and Immunological Damage on the Progression of Flavivirus (Modoc) Encephalitis in a Murine Model

Impact of direct virus-induced neuronal dysfunction and immunological damage on the progression of flavivirus (Modoc) encephalitis in a murine model

In Vitro Selection and Characterization of Hepatitis C Virus Replicons Double or Triple Resistant to Various Non-nucleoside HCV Polymerase Inhibitors

In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase

In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses.

In vitro selection and characterization of HCV replicons resistant to multiple non-nucleoside polymerase inhibitors

In vivo monitoring of acute flavivirus (Modoc) encephalitis with regional and whole-brain quantitative diffusion magnetic resonance imaging

Infection of SCID mice with Montana Myotis leukoencephalitis virus as a model for flavivirus encephalitis

Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway

Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones.