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Lista de obras de Carlos López Otín

A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact.

artículo científico publicado en 2014

A Novel Family of Soluble Minimal Scaffolds Provides Structural Insight into the Catalytic Domains of Integral Membrane Metallopeptidases

artículo científico publicado en 2013

A barley flour inhibitor of insect α-amylase is a major allergen associated with baker's asthma disease

artículo científico publicado en 1989

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.

artículo científico publicado en 2015

A conserved splicing mechanism of the LMNA gene controls premature aging.

artículo científico publicado en 2011

A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction

article

A fruitful liaison of ZSCAN10 and ROS on the road to rejuvenation.

artículo científico publicado en 2017

A functional link between the tumour suppressors ARF and p33ING1.

artículo científico publicado en 2006

A gene homologous to topoisomerase II in African swine fever virus.

artículo científico publicado en 1992

A general method to cleave a known DNA sequence at any site

artículo científico publicado el 1 de octubre de 1991

A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features

artículo científico publicado en 2016

A genomic analysis of rat proteases and protease inhibitors

artículo científico publicado en 2004

A genomic view of the complexity of mammalian proteolytic systems.

artículo científico publicado en 2005

A major baker's asthma allergen from rye flour is considerably more active than its barley counterpart

scientific article published on 01 May 1995

A new distinct group of 2 S albumins from rapeseed. Amino acid sequence of two low molecular weight napins.

artículo científico publicado en 1991

A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formation

artículo científico publicado en 2001

A role of matrix metalloproteinase-8 in atherosclerosis

artículo científico publicado en 2009

A sequence variation in the human cystatin D gene resulting in an amino acid (Cys/Arg) polymorphism at the protein level

artículo científico publicado en 1993

A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes.

artículo científico publicado en 2017

ADAMTS proteases and cancer

artículo científico publicado en 2015

ADAMTS-12 metalloprotease is necessary for normal inflammatory response

artículo científico publicado en 2012

ADAMTS12

ATG4B/autophagin-1 regulates intestinal homeostasis and protects mice from experimental colitis

artículo científico publicado en 2013

ATG4D is the main ATG8 delipidating enzyme in mammalian cells and protects against cerebellar neurodegeneration

artículo científico publicado en 2021

ATP-Dependent Lon Protease Controls Tumor Bioenergetics by Reprogramming Mitochondrial Activity

Ablation of the stress protease OMA1 protects against heart failure in mice

scientific article published on 01 March 2018

Absence or Inhibition of Matrix Metalloproteinase–8 Decreases Ventilator-Induced Lung Injury

artículo científico publicado en 2009

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

artículo científico publicado en 2005

Accelerated ageing: from mechanism to therapy through animal models

artículo científico publicado en 2008

Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells

artículo científico

Activation of Progelatinase B (proMMP‐9) by Active Collagenase‐3 (MMP‐13) ⬇️

artículo científico publicado el 1 de septiembre de 1997

Activation of the mitogen activated protein kinase extracellular signal-regulated kinase 1 and 2 by the nitric oxide-cGMP-cGMP-dependent protein kinase axis regulates the expression of matrix metalloproteinase 13 in vascular endothelial cells

artículo científico publicado en 2002

Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity

scientific article published on 01 December 2019

Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity

artículo científico publicado en 2019

Age-driven developmental drift in the pathogenesis of idiopathic pulmonary fibrosis

artículo científico publicado en 2016

Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53.

artículo científico publicado en 2011

Altered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia

scientific article published on 04 September 2018

Alternative splicing gives rise to two novel long isoforms of Zn-alpha 2-glycoprotein, a member of the immunoglobulin superfamily

artículo científico publicado en 1996

Amino acid sequence homologies in alfa-sarcin, restrictocin and mitogillin

artículo científico publicado en 1982

Aminopeptidase O

An immunosurveillance mechanism controls cancer cell ploidy

artículo científico publicado en 2012

An overview of collagenase-3 expression in malignant tumors and analysis of its potential value as a target in antitumor therapies.

artículo científico publicado en 2000

Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma

artículo científico publicado en 2011

Arachidonic acid binds to apolipoprotein D: implications for the protein's function

artículo científico publicado en 1995

Arresten, a collagen-derived angiogenesis inhibitor, suppresses invasion of squamous cell carcinoma.

artículo científico publicado en 2012

Association of the POT1 Germline Missense Variant p.I78T With Familial Melanoma

AtFACE-2, a functional prenylated protein protease from Arabidopsis thaliana related to mammalian Ras-converting enzymes.

artículo científico publicado en 2003

Author Correction: Comparative and demographic analysis of orang-utan genomes

artículo científico publicado en 2022

Autophagy and aging: lessons from progeria models

artículo científico publicado en 2010

Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens.

artículo científico publicado en 2017

Autophagy is essential for mouse sense of balance

artículo científico publicado en 2010

Autophagy, proteases and the sense of balance.

artículo científico publicado en 2010

Biochemical characterization and crystalization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog

artículo científico publicado en 1997

Biochemical characterization of human collagenase-3

artículo científico publicado en 1996

Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme

artículo científico publicado en 2000

CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1- mantle cell lymphoma

scientific article published on 11 December 2018

Cancer Genomes

scientific article published on 03 September 2010

Carbohydrate- and conformation-dependent cargo capture for ER-exit

artículo científico publicado en 2005

Carbotoxicity-Noxious Effects of Carbohydrates

artículo científico publicado en 2018

Cathepsin O

Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location

artículo científico publicado en 1998

Cell autonomous and systemic factors in progeria development

artículo científico publicado en 2011

Cell-cell adhesion genes CTNNA2 and CTNNA3 are tumour suppressors frequently mutated in laryngeal carcinomas.

artículo científico publicado en 2013

Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver.

artículo científico publicado en 2018

Characterization of the African swine fever virus structural protein p14.5: a DNA binding protein

artículo científico publicado en 1997

Cholesterol and apolipoprotein D in gross cystic disease of the breast ⬇️

artículo científico publicado el 1 de mayo de 1992

Chronic Lymphocytic Leukemia withSF3B1Mutation

artículo científico publicado en 2012

Chronic lymphocytic leukemia: looking into the dark side of the genome

artículo científico publicado en 2015

Circulating tumor cells for comprehensive and multiregional non-invasive genetic characterization of multiple myeloma

artículo científico publicado en 2020

Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia.

artículo científico publicado en 2016

Clinical impact of the subclonal architecture and mutational complexity in chronic lymphocytic leukemia.

artículo científico publicado en 2017

Clonal evolution in leukemia

artículo científico publicado en 2017

Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members

artículo científico publicado en 1999

Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases

artículo científico publicado en 2004

Cloning and expression analysis of a novel human serine hydrolase with sequence similarity to prokaryotic enzymes involved in the degradation of aromatic compounds

artículo científico publicado en 1995

Cloning and expression analysis of the cDNA encoding rat Zn-alpha 2-glycoprotein

scientific journal article

Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains

artículo científico publicado en 2002

Collagenase 2 (MMP-8) expression in murine tissue-remodeling processes. Analysis of its potential role in postpartum involution of the uterus

artículo científico publicado en 1998

Collagenase-2 (MMP-8) and matrilysin-2 (MMP-26) expression in human wounds of different etiologies

artículo científico publicado en 2007

Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer

artículo científico publicado en 2008

Collagenase-2 Deficiency or Inhibition Impairs Experimental Autoimmune Encephalomyelitis in Mice

artículo científico publicado en 2008

Collagenase-3 (MMP-13) and its activators in rheumatoid arthritis: localization in the pannus-hard tissue junction and inhibition by alendronate

scientific article published on 01 August 1999

Collagenase-3 binds to a specific receptor and requires the low density lipoprotein receptor-related protein for internalization

artículo científico publicado en 1999

Collagenase-3 expression is associated with advanced local invasion in human squamous cell carcinomas of the larynx

artículo científico publicado en 1998

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

artículo científico publicado en 2008

Comparative analysis of cancer genes in the human and chimpanzee genomes

artículo científico publicado en 2006

Comparative and demographic analysis of orang-utan genomes

artículo científico publicado en 2011

Comparative genomic analysis of human and chimpanzee proteases

artículo científico publicado en 2005

Comparative genomic analysis of the zebra finch degradome provides new insights into evolution of proteases in birds and mammals

artículo científico publicado en 2010

Comprehensive characterization of complex structural variations in cancer by directly comparing genome sequence reads

artículo científico publicado en 2014

Conformational studies of the human complex-forming glycoprotein, heterogeneous in charge: protein HC ⬇️

artículo científico publicado el 13 de marzo de 1984

Conquering Cancer in Our Lifetime: New Diagnostic and Therapeutic Trends

artículo científico publicado en 2012

Control of allergen-induced inflammation and hyperresponsiveness by the metalloproteinase ADAMTS-12.

artículo científico publicado en 2012

Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification

scientific journal article

Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage

artículo científico publicado en 2020

Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells

artículo científico publicado en 2009

Decelerating ageing and biological clocks by autophagy

artículo científico publicado en 2019

Defective extracellular pyrophosphate metabolism promotes vascular calcification in a mouse model of Hutchinson-Gilford progeria syndrome that is ameliorated on pyrophosphate treatment

artículo científico publicado en 2013

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

artículo científico publicado en 2002

Detection, isolation and complete amino acid sequence of an aeroallergenic protein from rapeseed flour

scientific article published on 01 July 1997

Determination of polyprotein processing sites by amino terminal sequencing of nonstructural proteins encoded by plum pox potyvirus

scientific article published on 01 February 1990

Deubiquitinases in cancer: new functions and therapeutic options.

artículo científico

Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome

scientific article published on 18 February 2019

Diet-induced obesity and reduced skin cancer susceptibility in matrix metalloproteinase 19-deficient mice

artículo científico publicado en 2004

Differential effects of transforming growth factor-beta on the expression of collagenase-1 and collagenase-3 in human fibroblasts

artículo científico publicado en 1998

Differential expression of three matrix metalloproteinases, MMP-19, MMP-26, and MMP-28, in normal and inflamed intestine and colon cancer

artículo científico publicado en 2004

Differential mechanisms of tolerance to extreme environmental conditions in tardigrades

artículo científico publicado en 2019

Dm1-MMP, a matrix metalloproteinase from Drosophila with a potential role in extracellular matrix remodeling during neural development

artículo científico publicado en 2000

Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice

scientific journal article

Earlier Onset of Tumoral Angiogenesis in Matrix Metalloproteinase-19–Deficient Mice

artículo científico publicado en 2006

Emerging roles of proteases in tumour suppression

Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer

artículo científico publicado en 2010

Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia.

artículo científico publicado en 2012

Erratum: Corrigendum: Signatures of mutational processes in human cancer

artículo científico publicado en 2013

Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis

artículo científico publicado en 2015

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

artículo científico publicado en 2014

Estimation of copy number alterations from exome sequencing data

artículo científico publicado en 2012

Evaluation of some newer matrix metalloproteinases

artículo científico publicado en 1999

Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome

artículo científico publicado en 2011

Exome sequencing identifies a novel mutation in PIK3R1 as the cause of SHORT syndrome

artículo científico publicado en 2014

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

artículo científico publicado en 2011

Exosomes and autophagy: coordinated mechanisms for the maintenance of cellular fitness

artículo científico

Expanding the complexity of the human degradome: polyserases and their tandem serine protease domains.

artículo científico publicado en 2007

Extreme genomic erosion after recurrent demographic bottlenecks in the highly endangered Iberian lynx

artículo científico publicado en 2016

Factors affecting protein composition of breast secretions from nonlactating women

article

Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3

artículo científico publicado en 1996

Frequent somatic mutations in components of the RNA processing machinery in chronic lymphocytic leukemia

artículo científico publicado en 2012

Functional Relevance of Autophagins in Life and Disease

Functional analysis of a p21WAF1,CIP1,SDI1 mutant (Arg94 --> Trp) identified in a human breast carcinoma. Evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases.

artículo científico publicado en 1996

Functional analysis of sucrase-isomaltase mutations from chronic lymphocytic leukemia patients

artículo científico publicado en 2013

Functional interaction between acyl-CoA synthetase 4, lipooxygenases and cyclooxygenase-2 in the aggressive phenotype of breast cancer cells

artículo científico publicado en 2010

Functional relevance of miRNAs in premature ageing

artículo científico publicado en 2017

Gene characterization, promoter analysis, and chromosomal localization of human bleomycin hydrolase

artículo científico publicado en 1997

Genetic Predisposition to Chronic Lymphocytic Leukemia Is Mediated by a BMF Super-Enhancer Polymorphism.

artículo científico publicado en 2016

Genetic and epigenetic basis of chronic lymphocytic leukemia

artículo científico

Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer.

artículo científico publicado en 2009

Genome Sequencing and Analysis Methods in Chronic Lymphocytic Leukemia

artículo científico publicado en 2019

Genome analysis of the platypus reveals unique signatures of evolution

artículo científico publicado en 2008

Genome analysis of the platypus reveals unique signatures of evolution

artículo científico publicado en 2008

Genome sequence of the Brown Norway rat yields insights into mammalian evolution

artículo científico publicado en 2004

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

artículo científico publicado en 2013

Genomic instability in laminopathy-based premature aging

artículo científico publicado en 2005

Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO)

artículo científico publicado en 1998

Giant tortoise genomes provide insights into longevity and age-related disease

artículo científico publicado en 2018

Global Proteome of LonP1+/- Mouse Embryonal Fibroblasts Reveals Impact on Respiratory Chain, but No Interdependence between Eral1 and Mitoribosomes

scientific article published on 12 September 2019

Glucocorticoids and androgens up-regulate the Zn-?2-glycoprotein messenger RNA in human breast cancer cells

artículo científico publicado en 1994

Growth inhibition of human breast cancer cells by 1,25-dihydroxyvitamin D3 is accompanied by induction of apolipoprotein D expression ⬇️

artículo científico publicado el 15 de septiembre de 1997

Guidelines for the use and interpretation of assays for monitoring autophagy

artículo científico publicado en 2012

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

artículo científico publicado en 2008

Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells

artículo científico publicado en 2016

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

artículo científico publicado en 2019

High levels of expression of collagenase-3 (MMP-13) in pathological conditions associated with a foreign-body reaction

artículo científico publicado en 1998

High-level expression in Escherichia coli of the gene coding for the major structural protein (p72) of African swine fever virus.

artículo científico publicado en 1993

Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis.

artículo científico publicado en 2010

Hormonal Regulation of the Human Pepsinogen C Gene in Breast Cancer Cells

artículo científico publicado en 1996

Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues

artículo científico publicado en 1991

Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes

artículo científico publicado en 1993

Human and mouse proteases: a comparative genomic approach

artículo científico publicado en 2003

Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy

artículo científico publicado en 2003

Human polyserase-2, a novel enzyme with three tandem serine protease domains in a single polypeptide chain

artículo científico publicado en 2005

Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions

artículo científico publicado en 2007

Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain

scientific journal article

Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution

artículo científico publicado en 1997

Identification and characterization of human and mouse ovastacin: a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish

artículo científico publicado en 2004

Identification and characterization of human archaemetzincin-1 and -2, two novel members of a family of metalloproteases widely distributed in Archaea.

artículo científico publicado en 2005

Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain

artículo científico publicado en 2006

Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins

artículo científico publicado en 1999

Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation

scientific journal article

Identification and structural and functional characterization of human enamelysin (MMP-20)

artículo científico publicado en 1997

Identification of common cardiometabolic alterations and deregulated pathways in mouse and pig models of aging

artículo científico publicado en 2020

Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase

artículo científico publicado en 2005

Identification of mitochondrial dysfunction in Hutchinson-Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture

artículo científico publicado en 2013

Identification of novel tumor suppressor proteases by degradome profiling of colorectal carcinomas

artículo científico publicado en 2013

Identification of novel tumor suppressor proteases by degradome profiling of colorectal carcinomas.

artículo científico publicado en 2013

Identification of the major protein components in breast secretions from women with benign and malignant breast diseases ⬇️

artículo científico publicado el 1 de enero de 1992

Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats

artículo científico publicado en 2001

Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans.

artículo científico publicado en 2003

Immune and inflammatory responses to DNA damage in cancer and aging

artículo científico publicado en 2016

Immune-dependent and independent antitumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors.

artículo científico publicado en 2012

Immunofluorometric assay of pepsinogen C and preliminary clinical applications ⬇️

artículo científico publicado el 1 de agosto de 1997

Immunosuppression by Mutated Calreticulin Released from Malignant Cells

scientific article published on 27 November 2019

Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8).

artículo científico publicado en 2007

Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase

scientific journal article

Inhibitory effects of human cystatin C on plum pox potyvirus proteases

artículo científico publicado en 1993

Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics

scientific article published on 09 August 2019

Insights into the evolution of longevity from the bowhead whale genome ⬇️

artículo científico publicado en 2015

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function.

artículo científico publicado en 2010

Interruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype

artículo científico publicado en 2016

Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFNgamma-based cancer therapy in mice

artículo científico publicado en 2007

Iron-deficiency anemia from matriptase-2 inactivation is dependent on the presence of functional Bmp6

artículo científico publicado en 2010

Isolation and characterization of a pepsin C zymogen produced by human breast tissues ⬇️

artículo científico publicado el 5 de diciembre de 1992

Isolation of three allergenic fractions of the major allergen from Olea europea pollen and N-terminal amino acid sequence

artículo científico publicado en 1990

LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity

artículo científico publicado en 2007

Landscape of somatic mutations and clonal evolution in mantle cell lymphoma.

artículo científico publicado en 2013

Localization of the human membrane type 4-matrix metalloproteinase gene (MMP17) to chromosome 12q24.

artículo científico publicado en 1998

Lon protease: A key enzyme controlling mitochondrial bioenergetics in cancer

artículo científico publicado en 2014

Longevity-relevant regulation of autophagy at the level of the acetylproteome.

artículo científico publicado en 2011

Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid

artículo científico publicado en 2015

Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria

artículo científico publicado en 2016

Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors.

artículo científico publicado en 2005

Loss of collagenase-2 confers increased skin tumor susceptibility to male mice.

artículo científico publicado en 2003

Loss of genes implicated in gastric function during platypus evolution

artículo científico publicado en 2008

Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice

artículo científico publicado en 2012

Loss of the Deubiquitinase USP36 Destabilizes the RNA Helicase DHX33 and Causes Preimplantation Lethality in Mice

artículo científico publicado en 2017

Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.

artículo científico publicado en 2015

MMP-25 Metalloprotease Regulates Innate Immune Response through NF-κB Signaling.

artículo científico publicado en 2016

MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO)

artículo científico publicado en 2005

MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin

scientific journal article

Mapping and sequence of the gene coding for protein p72, the major capsid protein of African swine fever virus.

artículo científico publicado en 1990

Mapping and sequence of the gene encoding protein p17, a major African swine fever virus structural protein

artículo científico publicado en 1995

Mapping and sequence of the gene encoding protein p37, a major structural protein of African swine fever virus

artículo científico publicado en 1988

Matriptase-2

Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis

artículo científico publicado en 2009

Matriptase-2 is essential for hepcidin repression during fetal life and postnatal development in mice to maintain iron homeostasis

artículo científico publicado en 2014

Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms.

artículo científico publicado en 2009

Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins

artículo científico publicado en 2002

Matrix Metallopeptidase-19

Matrix Metalloproteinase-13 Is Highly Expressed in Destructive Periodontal Disease Activity

artículo científico publicado en 2006

Matrix Metalloproteinase-19 Expression in Dermal Wounds and by Fibroblasts in Culture

article

Matrix Proteases and the Degradome

Matrix metalloprotease 1a deficiency suppresses tumor growth and angiogenesis.

artículo científico publicado en 2013

Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases

artículo científico publicado en 2012

Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium

artículo científico publicado en 1997

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF.

scientific article published on 30 May 2013

Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses

artículo científico publicado en 2013

Matrix metalloproteinase-19 deficiency promotes tenascin-C accumulation and allergen-induced airway inflammation

artículo científico publicado en 2009

Matrix metalloproteinase-19 is a key regulator of lung fibrosis in mice and humans

artículo científico publicado en 2012

Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K/BxN serum-transfer arthritis model

artículo científico publicado en 2010

Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion

artículo científico publicado en 2008

Matrix metalloproteinase-8 is a regulator of the clinical aggressiveness of mammary tumours

artículo científico publicado en 2008

Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies.

artículo científico publicado en 2004

Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models.

artículo científico publicado en 2009

Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2.

artículo científico publicado en 2000

Membrane type-matrix metalloproteinases (MT-MMP)

artículo científico publicado el 1 de enero de 2003

Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis

artículo científico publicado en 2008

Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases

artículo científico publicado en 2006

Metabolic Control of Longevity.

artículo científico publicado en 2016

Metalloproteases and the Degradome

Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation

scientific journal article

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism

scientific article published on 01 August 2018

Microcephalia with mandibular and dental dysplasia in adult Zmpste24-deficient mice.

artículo científico publicado en 2008

Micromanaging aging with miRNAs: new messages from the nuclear envelope

artículo científico publicado en 2011

Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo

scientific article published on 06 January 2019

Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain

artículo científico publicado en 1999

Molecular definitions of autophagy and related processes.

artículo científico publicado en 2017

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

artículo científico publicado en 2018

Molecular mechanisms of normal and pathological aging.

artículo científico publicado en 2015

Molecular pathogenesis of CLL and its evolution

artículo científico publicado en 2015

Mouse Models to Disentangle the Hallmarks of Human Aging

artículo científico publicado en 2018

Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary

artículo científico publicado en 2019

Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma

artículo científico publicado en 2010

Mutations in CHD2 cause defective association with active chromatin in chronic lymphocytic leukemia

artículo científico publicado en 2015

Mutations in TLR/MYD88 pathway identify a subset of young chronic lymphocytic leukemia patients with favorable outcome

scientific article published on 29 April 2014

Mutations in filamin C cause a new form of familial hypertrophic cardiomyopathy

scientific journal article

Mutations in the RAS-BRAF-MAPK-ERK pathway define a specific subgroup of patients with adverse clinical features and provide new therapeutic options in chronic lymphocytic leukemia

artículo científico publicado en 2018

NF-kB in premature aging

artículo científico publicado en 2012

NF-κB activation impairs somatic cell reprogramming in ageing

artículo científico publicado en 2015

NF-κB signaling as a driver of ageing.

artículo científico publicado en 2016

NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome.

artículo científico publicado en 2012

Neutral microprotein, a novel human plasma and urinary protein associated with a yellow-brown chromophore. Isolation from protein HC preparations and partial characterization.

artículo científico publicado en 1983

New and paradoxical roles of matrix metalloproteinases in the tumor microenvironment.

artículo científico publicado en 2012

New roles for OMA1 metalloprotease: From mitochondrial proteostasis to metabolic homeostasis

artículo científico

New roles for mitochondrial proteases in health, ageing and disease

artículo científico

Next-generation sequencing in chronic lymphocytic leukemia

artículo científico

Nitric oxide elicits functional MMP-13 protein-tyrosine nitration during wound repair

artículo científico publicado en 2008

Nitric oxide regulates matrix metalloprotease-13 expression and activity in endothelium

Non-coding recurrent mutations in chronic lymphocytic leukaemia

artículo científico publicado en 2015

Nondegradative role of Atg5-Atg12/ Atg16L1 autophagy protein complex in antiviral activity of interferon gamma

artículo científico publicado en 2012

Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma

artículo científico publicado en 2014

Novel LMNA mutations cause an aggressive atypical neonatal progeria without progerin accumulation

artículo científico publicado en 2016

Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer ⬇️

artículo científico publicado en 2015

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

Nuclear envelope defects cause stem cell dysfunction in premature-aging mice

artículo científico publicado en 2008

Nuclear envelope lamin-A couples actin dynamics with immunological synapse architecture and T cell activation.

artículo científico publicado en 2014

Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response

artículo científico publicado en 2012

Nucleotide sequence of a nucleoside triphosphate phosphohydrolase gene from African swine fever virus

artículo científico

Néstor-Guillermo progeria syndrome: A novel premature aging condition with early onset and chronic development caused by BANF1 mutations

article

OMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury

artículo científico publicado en 2014

Overproduction and purification of biologically active native fungal alpha-sarcin in Escherichia coli.

artículo científico publicado en 1994

POT1 loss-of-function variants predispose to familial melanoma

artículo científico publicado en 2014

POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia

artículo científico publicado en 2013

Partial Loss of USP9X Function Leads to a Male Neurodevelopmental and Behavioral Disorder Converging on Transforming Growth Factor β Signaling

artículo científico publicado en 2019

Personalized Precision Medicine for Health Care Professionals: Development of a Competency Framework

artículo científico publicado en 2023

Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product

artículo científico publicado en 2003

Polyserases

Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction

artículo científico publicado en 2019

Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness

artículo científico publicado en 2018

Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion.

scientific article published on January 2013

Premature aging in mice activates a systemic metabolic response involving autophagy induction.

artículo científico publicado en 2008

Progeria: a paradigm for translational medicine.

artículo científico publicado en 2014

Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells

artículo científico publicado en 2019

Prostate specific antigen — a new constituent of breast cyst fluid

artículo científico publicado en 1996

Prostate-specific membrane antigen in breast carcinoma

scientific article published in The Lancet

Protease Genomics and the Cancer Degradome

article

Protease addiction and synthetic lethality in cancer

artículo científico publicado en 2011

Protease degradomics: a new challenge for proteomics

artículo científico publicado en 2002

Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors

artículo científico publicado en 2004

Proteases: multifunctional enzymes in life and disease

scientific article published on 23 July 2008

Protective roles of matrix metalloproteinases: from mouse models to human cancer

artículo científico publicado en 2009

Proteolytic systems: constructing degradomes

artículo científico publicado en 2009

Proteomic profiling of adipose tissue from Zmpste24-/- mice, a model of lipodystrophy and premature aging, reveals major changes in mitochondrial function and vimentin processing

artículo científico publicado en 2011

Proteostasis alterations in myeloproliferative neoplasms: Oncogenic relevance and therapeutic opportunities

artículo científico publicado en 2016

Quantification and molecular analysis of cathepsin D in breast cyst fluids

artículo científico publicado en 1992

Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions

artículo científico publicado en 2005

Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection

artículo científico publicado en 2012

Regulation of TMPRSS6 by BMP6 and iron in human cells and mice

artículo científico publicado en 2011

Regulation of autophagy by cytosolic acetyl-coenzyme A.

artículo científico publicado en 2014

Regulation of collagenase-3 expression in human breast carcinomas is mediated by stromal-epithelial cell interactions ⬇️

artículo científico publicado el 1 de noviembre de 1997

Regulatory Roles of miRNAs in Aging.

artículo científico publicado en 2015

Rejuvenating somatotropic signaling: a therapeutical opportunity for premature aging?

artículo científico publicado en 2010

Relationship between serum prolactin levels and protein composition of breast secretions in nonlactating women.

artículo científico publicado en 1994

Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging

artículo científico publicado en 2019

Reprogramming aging and progeria.

artículo científico

Reprogramming aging through DOT1L inhibition

artículo científico publicado en 2015

Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10

artículo científico publicado en 2010

Retinoic acid-induced expression of apolipoprotein D and concomitant growth arrest in human breast cancer cells are mediated through a retinoic acid receptor RARalpha-dependent signaling pathway

artículo científico publicado en 1996

Role of the carboxy terminal region of β tubulin on microtubule dynamics through its interaction with the GTP phosphate binding region

article

Rye chromosome arm 3RS encodes a homodimeric inhibitor of insect α-amylase

artículo científico publicado en 1994

Secretion of recombinant pro- and mature fungal alpha-sarcin ribotoxin by the methylotrophic yeast Pichia pastoris: the Lys-Arg motif is required for maturation.

artículo científico publicado en 1998

Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycle

artículo científico publicado en 2012

Sequence and evolutionary relationships of African swine fever virus thymidine kinase

artículo científico publicado en 1990

Sequence of the coding regions from the 3.0 kb and 3.9 kb mRNA. Subgenomic species from a virulent isolate of transmissible gastroenteritis virus

artículo científico publicado en 1989

Specific combinations of biallelic variants cause Wiedemann-Rautenstrauch syndrome

scientific article published on 15 October 2018

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome ⬇️

artículo científico publicado en 2011

Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging

article

Sporadic and reversible chromothripsis in chronic lymphocytic leukemia revealed by longitudinal genomic analysis.

artículo científico publicado en 2013

Sporadic and reversible chromothripsis in chronic lymphocytic leukemia revealed by longitudinal genomic analysis.

artículo científico publicado en 2015

Strategies for MMP inhibition in cancer: innovations for the post-trial era.

artículo científico publicado en 2002

Structural analysis and promoter characterization of the human collagenase-3 gene (MMP13)

artículo científico publicado en 1997

Structural analysis of the small chain of the 2S albumin, napin nIII, from rapeseed. Chemical and spectroscopic evidence of an intramolecular bond formation

artículo científico publicado en 1991

Structural and enzymatic characterization of Drosophila Dm2-MMP, a membrane-bound matrix metalloproteinase with tissue-specific expression.

artículo científico publicado en 2002

Structural characterization and chromosomal localization of the gene encoding human biphenyl hydrolase-related protein (BPHL).

artículo científico publicado en 1998

Structure and expression in E. coli of the gene coding for protein p10 of African swine fever virus

artículo científico publicado en 1993

Supercomplex assembly determines electron flux in the mitochondrial electron transport chain

artículo científico publicado en 2013

Tagged ATG8-Coding Constructs for the In Vitro and In Vivo Assessment of ATG4 Activity.

artículo científico publicado en 2016

Tau-related protein present in paired helical filaments has a decreased tubulin binding capacity as compared with microtubule-associated protein tau.

artículo científico publicado en 1991

The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer.

artículo científico publicado en 2009

The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway

artículo científico publicado en 2007

The Degradome database: mammalian proteases and diseases of proteolysis

artículo científico publicado en 2008

The Novel Evolution of the Sperm Whale Genome

artículo científico publicado en 2017

The U1 spliceosomal RNA is recurrently mutated in multiple cancers

scientific article published on 09 October 2019

The anti-metastatic activity of collagenase-2 in breast cancer cells is mediated by a signaling pathway involving decorin and miR-21.

artículo científico publicado en 2013

The complete amino acid sequence of human complex-forming glycoprotein heterogeneous in charge (protein HC) from one individual

artículo científico publicado en 1984

The evolutionary biography of chronic lymphocytic leukemia

artículo científico publicado en 2013

The functional and pathologic relevance of autophagy proteases

artículo científico publicado en 2015

The genome of a songbird

artículo científico publicado en 2010

The genomic landscape of chronic lymphocytic leukemia: clinical implications

artículo científico publicado en 2013

The hallmarks of aging

artículo científico publicado en 2013

The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain

artículo científico publicado en 1996

The human collagenase-3 (CLG3) gene is located on chromosome 11q22.3 clustered to other members of the matrix metalloproteinase gene family

artículo científico publicado en 1995

The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland.

artículo científico publicado en 2014

The microRNA-29/PGC1α regulatory axis is critical for metabolic control of cardiac function

scientific article published on 22 October 2018

The mutational landscape of small lymphocytic lymphoma compared to non-early stage chronic lymphocytic leukemia.

artículo científico publicado en 2017

The novel tumor suppressor AIRAPL regulates IGF1R proteostasis

artículo científico publicado en 2016

The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities

The prognostic impact of minimal residual disease in patients with chronic lymphocytic leukemia requiring first-line therapy

artículo científico publicado en 2014

The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome

artículo científico publicado en 2020

The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia

scientific article published on 21 May 2018

The regulatory crosstalk between kinases and proteases in cancer

artículo científico publicado en 2010

The role of matrix metalloproteinases in aging: Tissue remodeling and beyond.

artículo científico publicado en 2017

The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction

artículo científico publicado en 1997

The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia.

artículo científico publicado en 2015

The γ-secretase inhibitor PF-03084014 combined with fludarabine antagonizes migration, invasion and angiogenesis in NOTCH1-mutated CLL cells

artículo científico publicado en 2014

Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3

artículo científico publicado en 2007

Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia

artículo científico publicado en 2013

Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP

artículo científico publicado en 2004

USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer.

artículo científico publicado en 2017

Use of a multiple-enzyme/multiple-reagent assay system to quantify activity levels in samples containing mixtures of matrix metalloproteinases

artículo científico publicado en 2004

Vascular Smooth Muscle-Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome.

artículo científico publicado en 2018

Wheat and barley allergens associated with baker's asthma. Glycosylated subunits of the α-amylase-inhibitor family have enhanced IgE-binding capacity ⬇️

artículo científico publicado el 15 de enero de 1992

Zn-α2-glycoprotein levels in breast cancer cytosols and correlation with clinical, histological and biochemical parameters

artículo científico publicado en 1993

iPSCs: On the Road to Reprogramming Aging

artículo científico publicado en 2016

β-Turns as structural motifs for the proteolytic processing of seed proteins

artículo científico publicado en 1990

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

artículo científico publicado en 2016

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