Lista de obras - Gerard Manning - Dominio Público Uruguay

A comprehensive transcriptional portrait of human cancer cell lines

artículo científico publicado en 2014

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

artículo científico publicado en 2014

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

artículo científico publicado en 2016

Amphioxus encodes the largest known family of green fluorescent proteins, which have diversified into distinct functional classes

artículo científico publicado en 2009

Assessment of computational methods for predicting the effects of missense mutations in human cancers

artículo científico publicado en 2013

Bioinformatics analysis of thousands of TCGA tumors to determine the involvement of epigenetic regulators in human cancer

artículo científico publicado en 2015

Comparative analysis of Histophilus somni immunoglobulin-binding protein A (IbpA) with other fic domain-containing enzymes reveals differences in substrate and nucleotide specificities

artículo científico publicado en 2011

Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat

artículo científico publicado en 2015

Cyclin-dependent kinases: a family portrait.

artículo científico publicado en 2009

Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events

artículo científico publicado en 1996

Discovery of a metabolic alternative to the classical mevalonate pathway

artículo científico publicado en 2013

Distinct structural and functional roles of conserved residues in the first extracellular domain of receptors for corticotropin-releasing factor and related G-protein-coupled receptors

artículo científico publicado en 2007

Evolution of protein kinase signaling from yeast to man

artículo científico publicado en 2002

Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis

artículo científico publicado en 2012

From Plk1 to Plk5: functional evolution of polo-like kinases

artículo científico publicado en 2011

Genetic control of epithelial tube fusion during Drosophila tracheal development

artículo científico publicado en 1996

Genomic Minimalism in the Early Diverging Intestinal Parasite Giardia lamblia

artículo científico publicado en 2007

Genomic overview of protein kinases

artículo científico publicado en 2005

Genomic survey of premetazoans shows deep conservation of cytoplasmic tyrosine kinases and multiple radiations of receptor tyrosine kinases.

artículo científico publicado en 2012

Genomics and evolution of protein phosphatases

artículo científico publicado en 2017

Genomics, evolution, and crystal structure of a new family of bacterial spore kinases

artículo científico publicado en 2010

HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors.

artículo científico publicado en 2018

HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span

artículo científico publicado en 2014

How the vertebrates were made: selective pruning of a double-duplicated genome

artículo científico publicado en 2010

Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the Eubacterium Rhodopirellula baltica

artículo científico publicado en 2013

Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus)

artículo científico publicado en 2010

Insulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool release

scientific journal article

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer

artículo científico publicado en 2014

Key challenges for the creation and maintenance of specialist protein resources

artículo científico publicado en 2015

Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series

artículo científico publicado en 2015

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

artículo científico publicado en 2011

Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote

artículo científico publicado en 2006

Members of the NIMA-related kinase family promote disassembly of cilia by multiple mechanisms

artículo científico publicado en 2006

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

artículo científico publicado en 2015

Mutational alteration of human immunodeficiency virus type 1 Vif allows for functional interaction with nonhuman primate APOBEC3G.

artículo científico publicado en 2006

Necroptosis and Inflammation

artículo científico publicado en 2016

Nitrosopumilus maritimus genome reveals unique mechanisms for nitrification and autotrophy in globally distributed marine crenarchaea

artículo científico publicado en 2010

Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression

artículo científico publicado en 2011

Premetazoan genome evolution and the regulation of cell differentiation in the choanoflagellate Salpingoeca rosetta

artículo científico publicado en 2013

Programmed ribosomal frameshifting in the expression of the regulator of intestinal stem cell proliferation, adenomatous polyposis coli (APC).

artículo científico publicado en 2011

Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases

artículo científico publicado en 2008

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

artículo científico publicado en 2012

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

artículo científico publicado en 2010

Short Promoters in Viral Vectors Drive Selective Expression in Mammalian Inhibitory Neurons, but do not Restrict Activity to Specific Inhibitory Cell-Types

artículo científico publicado en 2009

Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis

artículo científico publicado en 2011

Structural and functional diversity of the microbial kinome

artículo científico publicado en 2007

Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site

artículo científico publicado en 2009

TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.

artículo científico publicado en 2009

The Amphimedon queenslandica genome and the evolution of animal complexity ⬇️

artículo científico publicado en 2010

The Capsaspora genome reveals a complex unicellular prehistory of animals

artículo científico publicado en 2013

The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress

artículo científico publicado en 2009

The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins

artículo científico publicado en 2012

The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion

artículo científico publicado en 2003

The Selaginella genome identifies genetic changes associated with the evolution of vascular plants

artículo científico publicado en 2011

The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families

artículo científico publicado en 2007

The dictyostelium kinome--analysis of the protein kinases from a simple model organism.

artículo científico publicado en 2006

The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima ⬇️

artículo científico publicado en 2014

The fold of alpha-synuclein fibrils

artículo científico publicado en 2008

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

artículo científico publicado en 2008

The genome of the sea urchin Strongylocentrotus purpuratus

artículo científico publicado en 2006

The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology.

artículo científico publicado en 2011

The mouse kinome: discovery and comparative genomics of all mouse protein kinases

scientific journal article

The protein kinase complement of the human genome

artículo científico publicado en 2002

The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan

artículo científico publicado en 2008

The sea urchin kinome: a first look

artículo científico publicado en 2006

Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3

scientific article published on 01 September 2019

Whole animal cell sorting of Drosophila embryos

artículo científico publicado en 1991

Lista de obras de Gerard Manning

A comprehensive transcriptional portrait of human cancer cell lines

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

Amphioxus encodes the largest known family of green fluorescent proteins, which have diversified into distinct functional classes

Assessment of computational methods for predicting the effects of missense mutations in human cancers

Bioinformatics analysis of thousands of TCGA tumors to determine the involvement of epigenetic regulators in human cancer

Comparative analysis of Histophilus somni immunoglobulin-binding protein A (IbpA) with other fic domain-containing enzymes reveals differences in substrate and nucleotide specificities

Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat

Cyclin-dependent kinases: a family portrait.

Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events

Discovery of a metabolic alternative to the classical mevalonate pathway

Distinct structural and functional roles of conserved residues in the first extracellular domain of receptors for corticotropin-releasing factor and related G-protein-coupled receptors

Evolution of protein kinase signaling from yeast to man

Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis

From Plk1 to Plk5: functional evolution of polo-like kinases

Genetic control of epithelial tube fusion during Drosophila tracheal development

Genomic Minimalism in the Early Diverging Intestinal Parasite Giardia lamblia

Genomic overview of protein kinases

Genomic survey of premetazoans shows deep conservation of cytoplasmic tyrosine kinases and multiple radiations of receptor tyrosine kinases.

Genomics and evolution of protein phosphatases

Genomics, evolution, and crystal structure of a new family of bacterial spore kinases

HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors.

HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span

How the vertebrates were made: selective pruning of a double-duplicated genome

Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the Eubacterium Rhodopirellula baltica

Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus)

Insulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool release

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer

Key challenges for the creation and maintenance of specialist protein resources

Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote

Members of the NIMA-related kinase family promote disassembly of cilia by multiple mechanisms

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

Mutational alteration of human immunodeficiency virus type 1 Vif allows for functional interaction with nonhuman primate APOBEC3G.

Necroptosis and Inflammation

Nitrosopumilus maritimus genome reveals unique mechanisms for nitrification and autotrophy in globally distributed marine crenarchaea

Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression

Premetazoan genome evolution and the regulation of cell differentiation in the choanoflagellate Salpingoeca rosetta

Programmed ribosomal frameshifting in the expression of the regulator of intestinal stem cell proliferation, adenomatous polyposis coli (APC).

Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

Short Promoters in Viral Vectors Drive Selective Expression in Mammalian Inhibitory Neurons, but do not Restrict Activity to Specific Inhibitory Cell-Types

Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis

Structural and functional diversity of the microbial kinome

Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site

TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.

The Amphimedon queenslandica genome and the evolution of animal complexity ⬇️

The Capsaspora genome reveals a complex unicellular prehistory of animals

The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress

The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins

The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion

The Selaginella genome identifies genetic changes associated with the evolution of vascular plants

The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families

The dictyostelium kinome--analysis of the protein kinases from a simple model organism.

The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima ⬇️

The fold of alpha-synuclein fibrils

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

The genome of the sea urchin Strongylocentrotus purpuratus

The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology.

The mouse kinome: discovery and comparative genomics of all mouse protein kinases

The protein kinase complement of the human genome

The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan

The sea urchin kinome: a first look

Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3

Whole animal cell sorting of Drosophila embryos