Lista de obras - Mitsuhiko Ikura - Dominio Público Uruguay

A Ca2+-dependent mechanism of neuronal survival mediated by the microtubule-associated protein p600

artículo científico publicado en 2013

A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1).

artículo científico publicado en 2014

A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues

artículo científico publicado en 2013

A fluorescent cassette-based strategy for engineering multiple domain fusion proteins

artículo científico publicado en 2003

A monomeric histidine kinase derived from EnvZ, an Escherichia coli osmosensor

artículo científico publicado en 2000

Alternate routes to conformational specificity in a Greek key beta barrel protein

artículo científico publicado en 2001

An Autoinhibited Structure of -Catenin and Its Implications for Vinculin Recruitment to Adherens Junctions

artículo científico publicado en 2013

An Optical Method for Evaluating Ion Selectivity for Calcium Signaling Pathways in the Cell

artículo científico publicado en 1997

An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis

artículo científico publicado en 2012

An efficient 3D NMR technique for correlating the proton and 15N backbone amide resonances with the alpha-carbon of the preceding residue in uniformly 15N/13C enriched proteins

artículo científico publicado en 1991

An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function

artículo científico publicado en 2016

Application of two-dimensional NMR spectroscopy to the complete analysis of the1H and13C NMR spectra ofd-biotin in aqueous solution

article published in 1982

Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry

artículo científico publicado en 2011

Backbone dynamics of calmodulin studied by 15N relaxation using inverse detected two-dimensional NMR spectroscopy: the central helix is flexible.

artículo científico publicado en 1992

Backbone resonance assignments of the F-actin binding domain of mouse αN-catenin.

artículo científico publicado en 2016

Bacterial histidine kinase as signal sensor and transducer.

artículo científico publicado en 2005

Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2

artículo científico publicado en 2008

CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1

artículo científico publicado en 2007

CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions.

artículo científico publicado en 2013

Calcium Binding and Conformation of Regulatory Light Chains of Smooth Muscle Myosin of Scallop1

scientific article published in 1985

Calcium-induced conformational transition revealed by the solution structure of apo calmodulin

artículo científico publicado en 1995

Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3

artículo científico publicado en 2001

Calexcitin B is a new member of the sarcoplasmic calcium-binding protein family.

artículo científico publicado en 2001

Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety

scientific article published on 31 March 2020

Calmodulin in action: diversity in target recognition and activation mechanisms.

artículo científico publicado en 2002

Calmodulin target database

artículo científico publicado en 2000

Characterization of a conserved "threonine clasp" in CAP-Gly domains: role of a functionally critical OH/pi interaction in protein recognition.

artículo científico publicado en 2008

Characterization of novel calmodulin-binding peptides with distinct inhibitory effects on calmodulin-dependent enzymes

artículo científico publicado en 1997

Characterization of the ATP-binding domain of the sarco(endo)plasmic reticulum Ca(2+)-ATPase: probing nucleotide binding by multidimensional NMR.

artículo científico publicado en 2002

Characterization of the intrinsic and TSC2-GAP-regulated GTPase activity of Rheb by real-time NMR.

artículo científico publicado en 2009

Cholesterol modulates Orai1 channel function

scientific article published on 26 January 2016

Complete structural analysis of globoseries glycolipids by two-dimensional nuclear magnetic resonance

article

Conformational coupling of Mg2+ and Ca2+ on the three-state folding of calexcitin B.

artículo científico publicado en 2003

Conformational states of syntaxin-1 govern the necessity of N-peptide binding in exocytosis of PC12 cells and Caenorhabditis elegans

artículo científico publicado en 2015

Crystal structure of the amino-terminal microtubule-binding domain of end-binding protein 1 (EB1)

artículo científico publicado en 2003

Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor.

artículo científico publicado en 2005

Crystal structure of type I ryanodine receptor amino-terminal -trefoil domain reveals a disease-associated mutation"hot spot"loop

artículo científico publicado en 2009

Crystal structure of venus, a yellow fluorescent protein with improved maturation and reduced environmental sensitivity

artículo científico publicado en 2002

Crystallographic evidence for water-assisted photo-induced peptide cleavage in the stony coral fluorescent protein Kaede

artículo científico publicado en 2007

DREAM is a critical transcriptional repressor for pain modulation

artículo científico publicado en 2002

Detecting protein kinase recognition modes of calmodulin by residual dipolar couplings in solution NMR.

artículo científico publicado en 2002

Detection of nuclear Overhauser effects between degenerate amide proton resonances by heteronuclear three-dimensional NMR spectroscopy

scientific article published in 1990

Domain fusion analysis by applying relational algebra to protein sequence and domain databases

artículo científico publicado en 2003

Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion

artículo científico publicado en 2010

Equilibrium folding intermediates of a Greek key beta-barrel protein.

artículo científico publicado en 1998

Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.

artículo científico publicado en 2017

FRET evidence for a conformational change in TFIIB upon TBP-DNA binding.

artículo científico publicado en 2004

Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin

artículo científico publicado en 1997

Four-dimensional heteronuclear triple-resonance NMR of isotopically enriched proteins for sequential assignment of backbone atoms

Functional silencing of TATA-binding protein (TBP) by a covalent linkage of the N-terminal domain of TBP-associated factor 1.

artículo científico publicado en 2007

High-resolution structure of TBP with TAF1 reveals anchoring patterns in transcriptional regulation

artículo científico publicado en 2013

How calpain is activated by calcium

artículo científico publicado en 2002

Human general transcription factor TFIIB: conformational variability and interaction with VP16 activation domain

artículo científico publicado en 1998

Identification and characterization of subfamily-specific signatures in a large protein superfamily by a hidden Markov model approach

artículo científico publicado en 2002

Improved three-dimensional1H−13C−1H correlation spectroscopy of a13C-labeled protein using constant-time evolution ⬇️

artículo científico publicado el 1 de septiembre de 1991

Inhibition of RAS function through targeting an allosteric regulatory site.

artículo científico publicado en 2016

Inhibitory Mechanism of Escherichia coli RelE-RelB Toxin-Antitoxin Module Involves a Helix Displacement Near an mRNA Interferase Active Site

artículo científico publicado en 2009

Initial activation of STIM1, the regulator of store-operated calcium entry

artículo científico publicado en 2013

Insights into a Single Rod-like Helix in Activated Radixin Required for Membrane−Cytoskeletal Cross-Linking ⬇️

artículo científico publicado el 14 de octubre de 2003

Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate

scientific journal article

Largen: a molecular regulator of mammalian cell size control

artículo científico publicado en 2014

Lateral self-assembly of E-cadherin directed by cooperative calcium binding

artículo científico publicado en 1997

Ligand-induced conformational changes via flexible linkers in the amino-terminal region of the inositol 1,4,5-trisphosphate receptor.

artículo científico publicado en 2007

Light-dependent regulation of structural flexibility in a photochromic fluorescent protein

artículo científico publicado en 2008

MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.

artículo científico publicado en 2017

Measurement of the exchange rates of rapidly exchanging amide protons: Application to the study of calmodulin and its complex with a myosin light chain kinase fragment ⬇️

artículo científico publicado el 1 de julio de 1991

Mechanistic Insight into the Microtubule and Actin Cytoskeleton Coupling through Dynein-Dependent RhoGEF Inhibition

article published in 2012

Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc

artículo científico publicado en 2013

Mg2+ and Ca2+ differentially regulate DNA binding and dimerization of DREAM

scientific journal article

Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation

artículo científico publicado en 2015

Molecular and structural basis of target recognition by calmodulin.

artículo científico publicado en 1995

Molecular basis for E-cadherin recognition by killer cell lectin-like receptor G1 (KLRG1).

artículo científico publicado en 2009

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors

scientific journal article

Molecular mechanics of calcium-myristoyl switches

artículo científico publicado en 1997

Molecular structure and target recognition of neuronal calcium sensor proteins.

artículo científico publicado en 2012

Multiple Calmodulin-Binding Sites Positively and Negatively Regulate Arabidopsis CYCLIC NUCLEOTIDE-GATED CHANNEL12.

artículo científico publicado en 2016

Multiplexed Real-Time NMR GTPase Assay for Simultaneous Monitoring of Multiple Guanine Nucleotide Exchange Factor Activities from Human Cancer Cells and Organoids

artículo científico publicado en 2018

Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane

scientific article published on 15 May 2020

N-terminal region (domain 1) of calmodulin is the low affinity site for Ca2+. A 13C NMR study of S-cyanocalmodulin.

artículo científico publicado en 1984

NMR in integrated biophysical drug discovery for RAS: past, present, and future

artículo científico publicado en 2020

NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ

artículo científico publicado en 1998

NMR-based functional profiling of RASopathies and oncogenic RAS mutations.

artículo científico publicado en 2013

Nuclear magnetic resonance evidence for Ca(2+)-induced extrusion of the myristoyl group of recoverin.

artículo científico publicado en 1995

Nuclear magnetic resonance studies on calmodulin: calcium-induced conformational change

article

Nuclear magnetic resonance studies on calmodulin: spectral assignments in the calcium-free state

artículo científico publicado en 1983

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

artículo científico publicado en 2015

Point mutations of the mTOR-RHEB pathway in renal cell carcinoma

artículo científico publicado en 2015

Practical aspects of proton-carbon-carbon-proton three-dimensional correlation spectroscopy of 13C-labeled proteins

Probing Zn2+-binding effects on the zinc-ribbon domain of human general transcription factor TFIIB

artículo científico publicado en 2004

Probing catalytically essential domain orientation in histidine kinase EnvZ by targeted disulfide crosslinking.

artículo científico publicado en 2003

Probing nucleotide-binding effects on backbone dynamics and folding of the nucleotide-binding domain of the sarcoplasmic/endoplasmic-reticulum Ca2+-ATPase.

artículo científico publicado en 2004

Proton-proton correlation via carbon-carbon couplings: a three-dimensional NMR approach for the assignment of aliphatic resonances in proteins labeled with carbon-13

artículo científico publicado en 1990

Purification and spectroscopic characterization of a recombinant amino-terminal polypeptide fragment of mouse epithelial cadherin

artículo científico publicado en 1994

Radixin: cytoskeletal adopter and signaling protein

artículo científico publicado en 2004

Real-time NMR study of guanine nucleotide exchange and activation of RhoA by PDZ-RhoGEF.

artículo científico publicado en 2009

Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.

artículo científico publicado en 2009

Resonance Assignments of 30 kDa Complexes of TFIID Subunit TAF1 with TATA-binding Protein

artículo científico publicado en 2005

Ryanodine receptor calcium release channels: lessons from structure-function studies.

artículo científico publicado en 2013

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

artículo científico publicado en 2011

Secretion of human superoxide dismutase in Escherichia coli using the condensed single-protein-production system

artículo científico publicado en 2010

Sequestration of the membrane-targeting myristoyl group of recoverin in the calcium-free state

artículo científico publicado en 1995

Solution structure of a calmodulin-target peptide complex by multidimensional NMR

artículo científico publicado el 1 de mayo de 1992

Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein

scientific journal article

Solution structure of the epithelial cadherin domain responsible for selective cell adhesion.

artículo científico publicado en 1995

Spectroscopic Characterization of a High-Affinity Calmodulin−Target Peptide Hybrid Molecule†

artículo científico publicado en 1996

Stored Ca2+ depletion-induced oligomerization of stromal interaction molecule 1 (STIM1) via the EF-SAM region: An initiation mechanism for capacitive Ca2+ entry

artículo científico publicado en 2006

Stromal interaction molecule (STIM) 1 and STIM2 calcium sensing regions exhibit distinct unfolding and oligomerization kinetics

artículo científico publicado en 2009

Structural Determinants of the Mechanical Stability of α-Catenin

artículo científico publicado en 2015

Structural and functional conservation of key domains in InsP3 and ryanodine receptors

artículo científico publicado en 2012

Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry

artículo científico publicado en 2008

Structural aspects of calcium-release activated calcium channel function

artículo científico publicado en 2013

Structural basis for simultaneous binding of two carboxy-terminal peptides of plant glutamate decarboxylase to calmodulin

artículo científico publicado en 2003

Structural basis for the activation of microtubule assembly by the EB1 and p150Glued complex.

artículo científico publicado en 2005

Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX1.

artículo científico publicado en 2012

Structural basis of calcium-induced E-cadherin rigidification and dimerization

artículo científico publicado en 1996

Structural characterization of Escherichia coli sensor histidine kinase EnvZ: the periplasmic C-terminal core domain is critical for homodimerization.

artículo científico publicado en 2005

Structural characterization of a blue chromoprotein and its yellow mutant from the sea anemone Cnidopus japonicus.

artículo científico publicado en 2006

Structural determination of the phosphorylation domain of the ryanodine receptor

artículo científico publicado en 2012

Structural insights into the regulatory mechanism of IP3 receptor.

artículo científico publicado en 2004

Structural mechanism of transcriptional autorepression of the Escherichia coli RelB/RelE antitoxin/toxin module

artículo científico publicado en 2008

Structural similarity of a developmentally regulated bacterial spore coat protein to beta gamma-crystallins of the vertebrate eye lens.

artículo científico publicado en 1994

Structurally delineating stromal interaction molecules as the endoplasmic reticulum calcium sensors and regulators of calcium release-activated calcium entry.

artículo científico publicado en 2009

Structure of calmodulin-target peptide complexes

Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand

artículo científico publicado en 2002

Structure-guided Mutation of the Conserved G3-box Glycine in Rheb Generates a Constitutively Activated Regulator of Mammalian Target of Rapamycin (mTOR)

artículo científico publicado en 2014

Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment

artículo científico publicado en 2012

TFIIA-TAF regulatory interplay: NMR evidence for overlapping binding sites on TBP.

artículo científico publicado en 2000

The ATCUN Domain as a Probe of Intermolecular Interactions: Application to Calmodulin−Peptide Complexes

artículo científico publicado en 2002

The Histone Folds in Transcription Factor TFIID

artículo científico publicado en 1996

The LxxLL motif: a multifunctional binding sequence in transcriptional regulation

artículo científico publicado en 2005

The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1

scientific journal article

The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1

artículo científico publicado en 2014

The acute myeloid leukemia fusion protein AML1-ETO targets E proteins via a paired amphipathic helix-like TBP-associated factor homology domain

artículo científico publicado en 2006

The cadherin-catenin complex as a focal point of cell adhesion and signalling: new insights from three-dimensional structures.

artículo científico publicado en 2004

The design and optimization of complex NMR experiments. Application to a triple-resonance pulse scheme correlating Hα, NH, and 15N chemical shifts in 15N13C-labeled proteins

The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold.

artículo científico publicado en 2012

Themes and Variations in ER/SR Calcium Release Channels: Structure and Function ⬇️

artículo científico publicado el 1 de diciembre de 2012

Three-dimensional NOESY-HMQC spectroscopy of a 13C-labeled protein

Three-dimensional structure of guanylyl cyclase activating protein-2, a calcium-sensitive modulator of photoreceptor guanylyl cyclases

artículo científico publicado en 1999

Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.

artículo científico publicado en 2013

Type 2 ryanodine receptor domain A contains a unique and dynamic α-helix that transitions to a β-strand in a mutant linked with a heritable cardiomyopathy

artículo científico publicado en 2013

Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening

scientific journal article

Unusual helix-containing greek keys in development-specific Ca(2+)-binding protein S. 1H, 15N, and 13C assignments and secondary structure determined with the use of multidimensional double and triple resonance heteronuclear NMR spectroscopy.

artículo científico publicado en 1994

Where cancer meets calcium--p53 crosstalk with EF-hands

artículo científico publicado en 2000

p120-catenin binding masks an endocytic signal conserved in classical cadherins.

artículo científico publicado en 2012

p120RasGAP is a mediator of rho pathway activation and tumorigenicity in the DLD1 colorectal cancer cell line

artículo científico publicado en 2014

α-Catenin homodimers are recruited to phosphoinositide-activated membranes to promote adhesion.

artículo científico publicado en 2017

α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism.

artículo científico publicado en 2015

Lista de obras de Mitsuhiko Ikura

A Ca2+-dependent mechanism of neuronal survival mediated by the microtubule-associated protein p600

A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1).

A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues

A fluorescent cassette-based strategy for engineering multiple domain fusion proteins

A monomeric histidine kinase derived from EnvZ, an Escherichia coli osmosensor

Alternate routes to conformational specificity in a Greek key beta barrel protein

An Autoinhibited Structure of -Catenin and Its Implications for Vinculin Recruitment to Adherens Junctions

An Optical Method for Evaluating Ion Selectivity for Calcium Signaling Pathways in the Cell

An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis

An efficient 3D NMR technique for correlating the proton and 15N backbone amide resonances with the alpha-carbon of the preceding residue in uniformly 15N/13C enriched proteins

An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function

Application of two-dimensional NMR spectroscopy to the complete analysis of the1H and13C NMR spectra ofd-biotin in aqueous solution

Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry

Backbone dynamics of calmodulin studied by 15N relaxation using inverse detected two-dimensional NMR spectroscopy: the central helix is flexible.

Backbone resonance assignments of the F-actin binding domain of mouse αN-catenin.

Bacterial histidine kinase as signal sensor and transducer.

Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2

CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1

CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions.

Calcium Binding and Conformation of Regulatory Light Chains of Smooth Muscle Myosin of Scallop1

Calcium-induced conformational transition revealed by the solution structure of apo calmodulin

Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3

Calexcitin B is a new member of the sarcoplasmic calcium-binding protein family.

Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety

Calmodulin in action: diversity in target recognition and activation mechanisms.

Calmodulin target database

Characterization of a conserved "threonine clasp" in CAP-Gly domains: role of a functionally critical OH/pi interaction in protein recognition.

Characterization of novel calmodulin-binding peptides with distinct inhibitory effects on calmodulin-dependent enzymes

Characterization of the ATP-binding domain of the sarco(endo)plasmic reticulum Ca(2+)-ATPase: probing nucleotide binding by multidimensional NMR.

Characterization of the intrinsic and TSC2-GAP-regulated GTPase activity of Rheb by real-time NMR.

Cholesterol modulates Orai1 channel function

Complete structural analysis of globoseries glycolipids by two-dimensional nuclear magnetic resonance

Conformational coupling of Mg2+ and Ca2+ on the three-state folding of calexcitin B.

Conformational states of syntaxin-1 govern the necessity of N-peptide binding in exocytosis of PC12 cells and Caenorhabditis elegans

Crystal structure of the amino-terminal microtubule-binding domain of end-binding protein 1 (EB1)

Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor.

Crystal structure of type I ryanodine receptor amino-terminal -trefoil domain reveals a disease-associated mutation"hot spot"loop

Crystal structure of venus, a yellow fluorescent protein with improved maturation and reduced environmental sensitivity

Crystallographic evidence for water-assisted photo-induced peptide cleavage in the stony coral fluorescent protein Kaede

DREAM is a critical transcriptional repressor for pain modulation

Detecting protein kinase recognition modes of calmodulin by residual dipolar couplings in solution NMR.

Detection of nuclear Overhauser effects between degenerate amide proton resonances by heteronuclear three-dimensional NMR spectroscopy

Domain fusion analysis by applying relational algebra to protein sequence and domain databases

Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion

Equilibrium folding intermediates of a Greek key beta-barrel protein.

Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.

FRET evidence for a conformational change in TFIIB upon TBP-DNA binding.

Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin

Four-dimensional heteronuclear triple-resonance NMR of isotopically enriched proteins for sequential assignment of backbone atoms

Functional silencing of TATA-binding protein (TBP) by a covalent linkage of the N-terminal domain of TBP-associated factor 1.

High-resolution structure of TBP with TAF1 reveals anchoring patterns in transcriptional regulation

How calpain is activated by calcium

Human general transcription factor TFIIB: conformational variability and interaction with VP16 activation domain

Identification and characterization of subfamily-specific signatures in a large protein superfamily by a hidden Markov model approach

Improved three-dimensional1H−13C−1H correlation spectroscopy of a13C-labeled protein using constant-time evolution ⬇️

Inhibition of RAS function through targeting an allosteric regulatory site.

Inhibitory Mechanism of Escherichia coli RelE-RelB Toxin-Antitoxin Module Involves a Helix Displacement Near an mRNA Interferase Active Site

Initial activation of STIM1, the regulator of store-operated calcium entry

Insights into a Single Rod-like Helix in Activated Radixin Required for Membrane−Cytoskeletal Cross-Linking ⬇️

Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate

Largen: a molecular regulator of mammalian cell size control

Lateral self-assembly of E-cadherin directed by cooperative calcium binding

Ligand-induced conformational changes via flexible linkers in the amino-terminal region of the inositol 1,4,5-trisphosphate receptor.

Light-dependent regulation of structural flexibility in a photochromic fluorescent protein

MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.

Measurement of the exchange rates of rapidly exchanging amide protons: Application to the study of calmodulin and its complex with a myosin light chain kinase fragment ⬇️

Mechanistic Insight into the Microtubule and Actin Cytoskeleton Coupling through Dynein-Dependent RhoGEF Inhibition

Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc

Mg2+ and Ca2+ differentially regulate DNA binding and dimerization of DREAM

Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation

Molecular and structural basis of target recognition by calmodulin.

Molecular basis for E-cadherin recognition by killer cell lectin-like receptor G1 (KLRG1).

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors

Molecular mechanics of calcium-myristoyl switches

Molecular structure and target recognition of neuronal calcium sensor proteins.

Multiple Calmodulin-Binding Sites Positively and Negatively Regulate Arabidopsis CYCLIC NUCLEOTIDE-GATED CHANNEL12.

Multiplexed Real-Time NMR GTPase Assay for Simultaneous Monitoring of Multiple Guanine Nucleotide Exchange Factor Activities from Human Cancer Cells and Organoids

Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane

N-terminal region (domain 1) of calmodulin is the low affinity site for Ca2+. A 13C NMR study of S-cyanocalmodulin.