Lista de obras - Amy Keating - Dominio Público Uruguay

A Barcoding Strategy Enabling Higher-Throughput Library Screening by Microscopy

artículo científico publicado en 2015

A Synthetic Coiled-Coil Interactome Provides Heterospecific Modules for Molecular Engineering

artículo científico publicado en 2010

A computationally guided protein-interaction screen uncovers coiled-coil interactions involved in vesicular trafficking.

artículo científico publicado en 2009

A rational route to probing membrane proteins

artículo científico publicado en 2007

A set of computationally designed orthogonal antiparallel homodimers that expands the synthetic coiled-coil toolkit.

artículo científico publicado en 2014

AB-Bind: Antibody binding mutational database for computational affinity predictions.

artículo científico publicado en 2015

AVID: an integrative framework for discovering functional relationships among proteins

artículo científico publicado en 2005

Analysis of coiled-coil interactions between core proteins of the spindle pole body

artículo científico publicado en 2008

Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cells both in vitro and in vivo

artículo científico publicado en 2014

Cluster expansion models for flexible-backbone protein energetics.

artículo científico publicado en 2009

Combinatorial bZIP dimers display complex DNA-binding specificity landscapes.

scientific article published on 10 February 2017

Comparison of the peptide binding preferences of three closely related TRAF paralogs: TRAF2, TRAF3, and TRAF5

artículo científico publicado en 2016

Comprehensive identification of human bZIP interactions with coiled-coil arrays

artículo científico publicado en 2003

Computing van der Waals energies in the context of the rotamer approximation.

artículo científico publicado en 2007

Data-driven prediction and design of bZIP coiled-coil interactions

artículo científico publicado en 2015

Design of a heterospecific, tetrameric, 21-residue miniprotein with mixed alpha/beta structure.

artículo científico publicado en 2005

Design of peptide inhibitors that bind the bZIP domain of Epstein-Barr virus protein BZLF1

artículo científico publicado en 2011

Design of protein-interaction specificity gives selective bZIP-binding peptides.

artículo científico publicado en 2009

Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.

artículo científico publicado en 2014

Designing helical peptide inhibitors of protein-protein interactions

artículo científico publicado en 2016

Designing specific protein-protein interactions using computation, experimental library screening, or integrated methods

artículo científico publicado en 2012

Determinants of BH3 Binding Specificity for Mcl-1 versus Bcl-xL

artículo científico publicado en 2010

Determinants of homodimerization specificity in histidine kinases.

artículo científico publicado en 2011

Enriching Peptide Libraries for Binding Affinity and Specificity Through Computationally Directed Library Design.

artículo científico publicado en 2017

Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1

artículo científico publicado en 2017

Generating High-Accuracy Peptide-Binding Data in High Throughput with Yeast Surface Display and SORTCERY.

artículo científico publicado en 2016

Genome-wide prediction and validation of peptides that bind human prosurvival Bcl-2 proteins

artículo científico publicado en 2014

Helix bundle loops determine whether histidine kinases autophosphorylate in cis or in trans.

artículo científico publicado en 2013

Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays

artículo científico publicado en 2010

Increasing the affinity of selective bZIP-binding peptides through surface residue redesign.

artículo científico publicado en 2014

Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.

artículo científico publicado en 2018

Locating Herpesvirus Bcl-2 Homologs in the Specificity Landscape of Anti-Apoptotic Bcl-2 Proteins.

artículo científico publicado en 2015

Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes

artículo científico publicado en 2010

Modeling backbone flexibility to achieve sequence diversity: the design of novel alpha-helical ligands for Bcl-xL.

artículo científico publicado en 2007

Modular assembly of a protein nanotriangle using orthogonally interacting coiled coils

artículo científico publicado en 2017

Multicoil2: predicting coiled coils and their oligomerization states from sequence in the twilight zone.

artículo científico publicado en 2011

Multistate protein design using CLEVER and CLASSY.

artículo científico publicado en 2013

Paircoil2: improved prediction of coiled coils from sequence.

artículo científico publicado en 2005

Peptide design by optimization on a data-parameterized protein interaction landscape

article published in the Proceedings of the National Academy of Sciences of the United States of America

Personalized Prognostic Risk Score for Long-Term Survival for Children with Acute Leukemia after Allogeneic Transplantation

artículo científico publicado en 2017

PixelDB: Protein-peptide complexes annotated with structural conservation of the peptide binding mode

artículo científico publicado en 2017

PixelDB: Protein-peptide complexes annotated with structural conservation of the peptide binding mode

scientific article published on 01 August 2018

Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL.

artículo científico publicado en 2014

Predicting helix orientation for coiled-coil dimers

artículo científico publicado en 2008

Predicting specificity in bZIP coiled-coil protein interactions

artículo científico publicado en 2004

Protein binding specificity versus promiscuity.

artículo científico publicado en 2010

Rapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains.

artículo científico publicado en 2016

Reducing minimal residual disease with blinatumomab prior to HCT for pediatric patients with acute lymphoblastic leukemia

scientific article published on 01 July 2019

SORTCERY-A High-Throughput Method to Affinity Rank Peptide Ligands

artículo científico publicado en 2014

Selective peptide inhibitors of antiapoptotic cellular and viral Bcl-2 proteins lead to cytochrome c release during latent Kaposi's sarcoma-associated herpesvirus infection.

artículo científico publicado en 2015

Selectivity in subunit composition of Ena/VASP tetramers.

artículo científico publicado en 2015

Specific coiled-coil interactions contribute to a global model of the structure of the spindle pole body

artículo científico publicado en 2010

Structural specificity in coiled-coil interactions.

artículo científico publicado en 2008

Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1

scientific article published on 14 February 2019

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

artículo científico publicado en 2010

The Orientations of Large Aspect-Ratio Coiled-Coil Proteins Attached to Gold Nanostructures.

artículo científico publicado en 2016

The influence of stem cell source on transplant outcomes for pediatric patients with acute myeloid leukemia

artículo científico publicado en 2019

The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains

artículo científico publicado en 2002

X-ray vs. NMR structures as templates for computational protein design.

scientific article published on October 2009

Lista de obras de Amy Keating

A Barcoding Strategy Enabling Higher-Throughput Library Screening by Microscopy

A Synthetic Coiled-Coil Interactome Provides Heterospecific Modules for Molecular Engineering

A computationally guided protein-interaction screen uncovers coiled-coil interactions involved in vesicular trafficking.

A rational route to probing membrane proteins

A set of computationally designed orthogonal antiparallel homodimers that expands the synthetic coiled-coil toolkit.

AB-Bind: Antibody binding mutational database for computational affinity predictions.

AVID: an integrative framework for discovering functional relationships among proteins

Analysis of coiled-coil interactions between core proteins of the spindle pole body

Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cells both in vitro and in vivo

Cluster expansion models for flexible-backbone protein energetics.

Combinatorial bZIP dimers display complex DNA-binding specificity landscapes.

Comparison of the peptide binding preferences of three closely related TRAF paralogs: TRAF2, TRAF3, and TRAF5

Comprehensive identification of human bZIP interactions with coiled-coil arrays

Computing van der Waals energies in the context of the rotamer approximation.

Data-driven prediction and design of bZIP coiled-coil interactions

Design of a heterospecific, tetrameric, 21-residue miniprotein with mixed alpha/beta structure.

Design of peptide inhibitors that bind the bZIP domain of Epstein-Barr virus protein BZLF1

Design of protein-interaction specificity gives selective bZIP-binding peptides.

Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.

Designing helical peptide inhibitors of protein-protein interactions

Designing specific protein-protein interactions using computation, experimental library screening, or integrated methods

Determinants of BH3 Binding Specificity for Mcl-1 versus Bcl-xL

Determinants of homodimerization specificity in histidine kinases.

Enriching Peptide Libraries for Binding Affinity and Specificity Through Computationally Directed Library Design.

Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1

Generating High-Accuracy Peptide-Binding Data in High Throughput with Yeast Surface Display and SORTCERY.

Genome-wide prediction and validation of peptides that bind human prosurvival Bcl-2 proteins

Helix bundle loops determine whether histidine kinases autophosphorylate in cis or in trans.

Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays

Increasing the affinity of selective bZIP-binding peptides through surface residue redesign.

Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.

Locating Herpesvirus Bcl-2 Homologs in the Specificity Landscape of Anti-Apoptotic Bcl-2 Proteins.

Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes

Modeling backbone flexibility to achieve sequence diversity: the design of novel alpha-helical ligands for Bcl-xL.

Modular assembly of a protein nanotriangle using orthogonally interacting coiled coils

Multicoil2: predicting coiled coils and their oligomerization states from sequence in the twilight zone.

Multistate protein design using CLEVER and CLASSY.

Paircoil2: improved prediction of coiled coils from sequence.

Peptide design by optimization on a data-parameterized protein interaction landscape

Personalized Prognostic Risk Score for Long-Term Survival for Children with Acute Leukemia after Allogeneic Transplantation

PixelDB: Protein-peptide complexes annotated with structural conservation of the peptide binding mode

PixelDB: Protein-peptide complexes annotated with structural conservation of the peptide binding mode

Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL.

Predicting helix orientation for coiled-coil dimers

Predicting specificity in bZIP coiled-coil protein interactions

Protein binding specificity versus promiscuity.

Rapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains.

Reducing minimal residual disease with blinatumomab prior to HCT for pediatric patients with acute lymphoblastic leukemia

SORTCERY-A High-Throughput Method to Affinity Rank Peptide Ligands

Selective peptide inhibitors of antiapoptotic cellular and viral Bcl-2 proteins lead to cytochrome c release during latent Kaposi's sarcoma-associated herpesvirus infection.

Selectivity in subunit composition of Ena/VASP tetramers.

Specific coiled-coil interactions contribute to a global model of the structure of the spindle pole body

Structural specificity in coiled-coil interactions.

Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

The Orientations of Large Aspect-Ratio Coiled-Coil Proteins Attached to Gold Nanostructures.

The influence of stem cell source on transplant outcomes for pediatric patients with acute myeloid leukemia

The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains

X-ray vs. NMR structures as templates for computational protein design.