Lista de obras - Silvia Soddu - Dominio Público Uruguay

A mutated p53 status did not prevent the induction of apoptosis by sulforaphane, a promising anti-cancer drug

artículo científico publicado en 2005

ATM is activated by default in mitosis, localizes at centrosomes and monitors mitotic spindle integrity.

artículo científico publicado en 2006

ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition

artículo científico publicado en 2013

Abscopal effect of radiation therapy: Interplay between radiation dose and p53 status

artículo científico publicado en 2014

Abstract P3-06-01: ATM Heterozygosity as a Breast Cancer-Susceptibility Factor in the General Population

Activation of p53 function in carcinoma cells by the alpha6beta4 integrin

artículo científico publicado en 1999

Adenovirus infection induces reentry into the cell cycle of terminally differentiated skeletal muscle cells.

artículo científico publicado en 1995

An Alternative Splice Variant of HIPK2 with Intron Retention Contributes to Cytokinesis

scientific article published on 20 February 2020

Apoptosis induced by a HIPK2 full-length-specific siRNA is due to off-target effects rather than prevalence of HIPK2-Δe8 isoform.

artículo científico publicado en 2015

CDKL5 localizes at the centrosome and midbody and is required for faithful cell division

artículo científico publicado en 2017

Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb

artículo científico publicado en 2002

Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint

artículo científico publicado en 2006

Corrigendum

correction published 2015-02-04

Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer

artículo científico publicado en 2016

Dual targeting of HER3 and MEK may overcome HER3-dependent drug-resistance of colon cancers.

artículo científico publicado en 2016

Effects of Y361-auto-phosphorylation on structural plasticity of the HIPK2 kinase domain

artículo científico publicado en 2017

Epitelial-to-mesenchimal transition and invasion are upmodulated by tumor-expressed granzyme B and inhibited by docosahexaenoic acid in human colorectal cancer cells.

artículo científico publicado en 2016

Erratum to: Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer

artículo científico publicado en 2016

Evaluation of the molecular mechanisms involved in the gain of function of a Li-Fraumeni TP53 mutation

artículo científico publicado en 2005

Expression of exogenous wt-p53 does not affect normal hematopoiesis: implications for bone marrow purging.

artículo científico publicado en 1997

Extrachromosomal Histone H2B Contributes to the Formation of the Abscission Site for Cell Division

artículo científico publicado en 2019

From p63 to p53 across p73.

artículo científico publicado en 2001

Functional Classification of the ATM Variant c.7157C>A and <i>In Vitro</i> Effects of Dexamethasone

artículo científico publicado en 2021

Gal-3 is stimulated by gain-of-function p53 mutations and modulates chemoresistance in anaplastic thyroid carcinomas.

artículo científico publicado en 2009

Growth and differentiation signals by the insulin-like growth factor 1 receptor in hemopoietic cells are mediated through different pathways

artículo científico publicado en 1999

HIPK2 Phosphorylates the Microtubule-Severing Enzyme Spastin at S268 for Abscission

scientific article published on 05 July 2019

HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis.

artículo científico publicado en 2018

HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation.

artículo científico publicado en 2013

HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity

artículo científico publicado en 2015

HIPK2 is involved in cell proliferation and its suppression promotes growth arrest independently of DNA damage.

artículo científico publicado en 2009

HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function

artículo científico publicado en 2004

HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage.

artículo científico publicado en 2011

HIPK2 sustains apoptotic response by phosphorylating Che-1/AATF and promoting its degradation

artículo científico publicado en 2014

HIPK2-T566 autophosphorylation diversely contributes to UV- and doxorubicin-induced HIPK2 activation

artículo científico publicado en 2017

HIPK2: a multitalented partner for transcription factors in DNA damage response and development.

artículo científico publicado en 2007

HIPKs: Jack of all trades in basic nuclear activities.

artículo científico publicado en 2008

HOPS/TMUB1 retains p53 in the cytoplasm and sustains p53-dependent mitochondrial apoptosis

scientific article published on 23 December 2019

High Mobility Group A1 (HMGA1) proteins interact with p53 and inhibit its apoptotic activity.

artículo científico publicado en 2005

High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.

artículo científico publicado en 2007

Homeodomain interacting protein kinase 2 activation compromises endothelial cell response to laminar flow: protective role of p21(waf1,cip1,sdi1)

artículo científico publicado en 2009

Homeodomain-interacting Protein Kinase-2 Stabilizes p27kip1 by Its Phosphorylation at Serine 10 and Contributes to Cell Motility ⬇️

artículo científico publicado el 29 de junio de 2011

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

artículo científico publicado en 2002

Homeodomain-interacting protein kinase-2 stabilizes p27kip1 by its phosphorylation at serine 10 and contributes to cell motility.

artículo científico publicado en 2014

Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilization

artículo científico publicado en 2005

Immune response to cytomegalovirus in patients with acquired-immunodeficiency syndrome related complex (ARC) and AIDS.

artículo científico publicado en 1987

Increase of BCNU sensitivity by wt-p53 gene therapy in glioblastoma lines depends on the administration schedule

artículo científico publicado en 1999

Investigation into the reactivity of the coordinatively unsaturated phosphonodithioato [Ni(MeOpdt)2] towards 2,4,6-tris(2-pyridyl)-1,3,5-triazine: goals and achievements

scientific article published on 02 April 2007

Lonidamine induces apoptosis in drug-resistant cells independently of the p53 gene.

artículo científico publicado en 1996

MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis

artículo científico publicado en 2007

MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway

artículo científico publicado en 2009

MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response

artículo científico publicado en 2015

MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors

artículo científico publicado en 2018

MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response.

artículo científico publicado en 2010

Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis

artículo científico publicado en 2009

Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits

artículo científico publicado en 2018

Mutant cohesin drives chromosomal instability in early colorectal adenomas

artículo científico publicado en 2014

Mutant p53 gains new function in promoting inflammatory signals by repression of the secreted interleukin-1 receptor antagonist.

artículo científico publicado en 2014

NF-Y mediates the transcriptional inhibition of the cyclin B1, cyclin B2, and cdc25C promoters upon induced G2 arrest

artículo científico publicado en 2000

Oncogenes belonging to the CSF-1 transduction pathway direct p53 tumor suppressor effects to monocytic differentiation in 32D cells ⬇️

artículo científico publicado el 31 de julio de 1997

Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer development

artículo científico publicado en 2019

P53 detection by fluorescence lifetime on a hybrid fluorescein isothiocyanate gold nanosensor.

artículo científico publicado en 2009

PKC theta ablation improves healing in a mouse model of muscular dystrophy

artículo científico publicado en 2012

Pax8 has a critical role in epithelial cell survival and proliferation ⬇️

artículo científico publicado el 18 de julio de 2013

Prognostic role of serum p53 antibodies in lung cancer

artículo científico publicado en 2015

Repression of the antiapoptotic molecule galectin-3 by homeodomain-interacting protein kinase 2-activated p53 is required for p53-induced apoptosis.

artículo científico publicado en 2006

Retinoic acid and cAMP differentially regulate human chromogranin A promoter activity during differentiation of neuroblastoma cells.

artículo científico publicado en 1995

Ser58 of mouse p53 is the homologue of human Ser46 and is phosphorylated by HIPK2 in apoptosis

artículo científico publicado en 2006

Serum p53 antibody detection in patients with impaired lung function.

artículo científico publicado en 2013

Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation.

artículo científico publicado en 2009

TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.

artículo científico publicado en 2003

TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability

artículo científico publicado en 2020

The Cockayne syndrome group A and B proteins are part of a ubiquitin-proteasome degradation complex regulating cell division

artículo científico publicado en 2020

The Loss of the p53 Activator HIPK2 Is Responsible for Galectin-3 Overexpression in Well Differentiated Thyroid Carcinomas ⬇️

artículo científico publicado el 17 de junio de 2011

The beta 4 integrin subunit is expressed in mouse fibroblasts and modulated by transforming growth factor-beta 1.

artículo científico publicado en 1996

The effects of end point overdispersions on the validity of single-dose tumorigenicity assays.

artículo científico publicado en 1995

Updates on HIPK2: a resourceful oncosuppressor for clearing cancer ⬇️

artículo científico publicado el 13 de agosto de 2012

Wt-p53 action in human leukaemia cell lines corresponding to different stages of differentiation.

artículo científico publicado en 1998

hMENA(11a) contributes to HER3-mediated resistance to PI3K inhibitors in HER2-overexpressing breast cancer cells.

artículo científico publicado en 2015

p53 displacement from centrosomes and p53-mediated G1 arrest following transient inhibition of the mitotic spindle.

artículo científico publicado en 2001

p53 is involved in the differentiation but not in the differentiation-associated apoptosis of myoblasts

scientific article published on 01 May 2000

p53 localization at centrosomes during mitosis and postmitotic checkpoint are ATM-dependent and require serine 15 phosphorylation.

artículo científico publicado en 2004

p53 mitotic centrosome localization preserves centrosome integrity and works as sensor for the mitotic surveillance pathway

scientific article published on 07 November 2019

p53 re-expression inhibits proliferation and restores differentiation of human thyroid anaplastic carcinoma cells.

artículo científico publicado en 1997

Lista de obras de Silvia Soddu

A mutated p53 status did not prevent the induction of apoptosis by sulforaphane, a promising anti-cancer drug

ATM is activated by default in mitosis, localizes at centrosomes and monitors mitotic spindle integrity.

ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition

Abscopal effect of radiation therapy: Interplay between radiation dose and p53 status

Abstract P3-06-01: ATM Heterozygosity as a Breast Cancer-Susceptibility Factor in the General Population

Activation of p53 function in carcinoma cells by the alpha6beta4 integrin

Adenovirus infection induces reentry into the cell cycle of terminally differentiated skeletal muscle cells.

An Alternative Splice Variant of HIPK2 with Intron Retention Contributes to Cytokinesis

Apoptosis induced by a HIPK2 full-length-specific siRNA is due to off-target effects rather than prevalence of HIPK2-Δe8 isoform.

CDKL5 localizes at the centrosome and midbody and is required for faithful cell division

Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb

Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint

Corrigendum

Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer

Dual targeting of HER3 and MEK may overcome HER3-dependent drug-resistance of colon cancers.

Effects of Y361-auto-phosphorylation on structural plasticity of the HIPK2 kinase domain

Epitelial-to-mesenchimal transition and invasion are upmodulated by tumor-expressed granzyme B and inhibited by docosahexaenoic acid in human colorectal cancer cells.

Erratum to: Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer

Evaluation of the molecular mechanisms involved in the gain of function of a Li-Fraumeni TP53 mutation

Expression of exogenous wt-p53 does not affect normal hematopoiesis: implications for bone marrow purging.

Extrachromosomal Histone H2B Contributes to the Formation of the Abscission Site for Cell Division

From p63 to p53 across p73.

Functional Classification of the ATM Variant c.7157C>A and <i>In Vitro</i> Effects of Dexamethasone

Gal-3 is stimulated by gain-of-function p53 mutations and modulates chemoresistance in anaplastic thyroid carcinomas.

Growth and differentiation signals by the insulin-like growth factor 1 receptor in hemopoietic cells are mediated through different pathways

HIPK2 Phosphorylates the Microtubule-Severing Enzyme Spastin at S268 for Abscission

HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis.

HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation.

HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity

HIPK2 is involved in cell proliferation and its suppression promotes growth arrest independently of DNA damage.

HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function

HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage.

HIPK2 sustains apoptotic response by phosphorylating Che-1/AATF and promoting its degradation

HIPK2-T566 autophosphorylation diversely contributes to UV- and doxorubicin-induced HIPK2 activation

HIPK2: a multitalented partner for transcription factors in DNA damage response and development.

HIPKs: Jack of all trades in basic nuclear activities.

HOPS/TMUB1 retains p53 in the cytoplasm and sustains p53-dependent mitochondrial apoptosis

High Mobility Group A1 (HMGA1) proteins interact with p53 and inhibit its apoptotic activity.

High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.

Homeodomain interacting protein kinase 2 activation compromises endothelial cell response to laminar flow: protective role of p21(waf1,cip1,sdi1)

Homeodomain-interacting Protein Kinase-2 Stabilizes p27kip1 by Its Phosphorylation at Serine 10 and Contributes to Cell Motility ⬇️

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

Homeodomain-interacting protein kinase-2 stabilizes p27kip1 by its phosphorylation at serine 10 and contributes to cell motility.

Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilization

Immune response to cytomegalovirus in patients with acquired-immunodeficiency syndrome related complex (ARC) and AIDS.

Increase of BCNU sensitivity by wt-p53 gene therapy in glioblastoma lines depends on the administration schedule

Investigation into the reactivity of the coordinatively unsaturated phosphonodithioato [Ni(MeOpdt)2] towards 2,4,6-tris(2-pyridyl)-1,3,5-triazine: goals and achievements

Lonidamine induces apoptosis in drug-resistant cells independently of the p53 gene.

MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis

MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway

MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response

MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors

MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response.

Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis

Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits

Mutant cohesin drives chromosomal instability in early colorectal adenomas

Mutant p53 gains new function in promoting inflammatory signals by repression of the secreted interleukin-1 receptor antagonist.

NF-Y mediates the transcriptional inhibition of the cyclin B1, cyclin B2, and cdc25C promoters upon induced G2 arrest

Oncogenes belonging to the CSF-1 transduction pathway direct p53 tumor suppressor effects to monocytic differentiation in 32D cells ⬇️

Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer development

P53 detection by fluorescence lifetime on a hybrid fluorescein isothiocyanate gold nanosensor.

PKC theta ablation improves healing in a mouse model of muscular dystrophy

Pax8 has a critical role in epithelial cell survival and proliferation ⬇️

Prognostic role of serum p53 antibodies in lung cancer

Repression of the antiapoptotic molecule galectin-3 by homeodomain-interacting protein kinase 2-activated p53 is required for p53-induced apoptosis.

Retinoic acid and cAMP differentially regulate human chromogranin A promoter activity during differentiation of neuroblastoma cells.

Ser58 of mouse p53 is the homologue of human Ser46 and is phosphorylated by HIPK2 in apoptosis

Serum p53 antibody detection in patients with impaired lung function.

Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation.

TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.

TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability

The Cockayne syndrome group A and B proteins are part of a ubiquitin-proteasome degradation complex regulating cell division

The Loss of the p53 Activator HIPK2 Is Responsible for Galectin-3 Overexpression in Well Differentiated Thyroid Carcinomas ⬇️

The beta 4 integrin subunit is expressed in mouse fibroblasts and modulated by transforming growth factor-beta 1.

The effects of end point overdispersions on the validity of single-dose tumorigenicity assays.

Updates on HIPK2: a resourceful oncosuppressor for clearing cancer ⬇️

Wt-p53 action in human leukaemia cell lines corresponding to different stages of differentiation.

hMENA(11a) contributes to HER3-mediated resistance to PI3K inhibitors in HER2-overexpressing breast cancer cells.

p53 displacement from centrosomes and p53-mediated G1 arrest following transient inhibition of the mitotic spindle.