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Lista de obras de Jiří Neužil

A further characterization of alanine dehydrogenase from Streptomyces aureofaciens

artículo científico publicado en 1989

A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression

artículo científico publicado en 2007

A simple indirect colorimetric assay for measuring mitochondrial energy metabolism based on uncoupling sensitivity

scientific article published on 20 November 2020

A vitamin E analogue suppresses malignant mesothelioma in a preclinical model: a future drug against a fatal neoplastic disease?

artículo científico publicado en 2004

Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells

artículo científico publicado en 2011

Aging of cardiac myocytes in culture: oxidative stress, lipofuscin accumulation, and mitochondrial turnover

artículo científico publicado en 2004

Alpha-tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells

artículo científico publicado en 2004

Alpha-tocopheryl succinate inhibits autophagic survival of prostate cancer cells induced by vitamin K3 and ascorbate to trigger cell death

artículo científico publicado en 2012

Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stress.

artículo científico publicado en 2005

Alpha-tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system?

artículo científico publicado en 2005

Alpha-tocopheryl succinate sensitises a T lymphoma cell line to TRAIL-induced apoptosis by suppressing NF-kappaB activation.

artículo científico

Alpha-tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability

artículo científico publicado en 2002

Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints

artículo científico publicado en 2018

Anticancer drugs targeting the mitochondrial electron transport chain

artículo científico publicado en 2011

Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death

artículo científico publicado en 2017

Apoptosis and inhibition of gap-junctional intercellular communication induced by LA-12, a novel hydrophobic platinum(IV) complex

scientific journal article

Asbestos exposure affects poly(ADP-ribose) polymerase-1 activity: role in asbestos-induced carcinogenesis

artículo científico publicado en 2011

Association of MiR-126 with soluble mesothelin-related peptides, a marker for malignant mesothelioma

artículo científico publicado en 2011

Bid integrates intrinsic and extrinsic signaling in apoptosis induced by alpha-tocopheryl succinate in human gastric carcinoma cells.

artículo científico publicado en 2009

Bilirubin attenuates radical-mediated damage to serum albumin

artículo científico publicado en 1993

Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger

scientific article published on 21 December 2009

CD133-positive cells are resistant to TRAIL due to up-regulation of FLIP.

artículo científico publicado en 2008

Cancer cells with high expression of CD133 exert FLIP upregulation and resistance to TRAIL-induced apoptosis.

artículo científico publicado en 2008

Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents

artículo científico publicado en 2015

Circulating epigenetic biomarkers in lung malignancies: From early diagnosis to therapy.

artículo científico publicado en 2016

Classification of mitocans, anti-cancer drugs acting on mitochondria

artículo científico publicado en 2012

Clinical significance of circulating miR-126 quantification in malignant mesothelioma patients

artículo científico publicado en 2012

Clinical, Diagnostic, and Treatment Characteristics of -Related Metastatic Pheochromocytoma and Paraganglioma

Coenzyme Q blocks biochemical but not receptor-mediated apoptosis by increasing mitochondrial antioxidant protection

scientific article published in 2001

Combined circulating epigenetic markers to improve mesothelin performance in the diagnosis of malignant mesothelioma

artículo científico publicado en 2015

Cooperative effect of fructose bisphosphate and glyceraldehyde-3-phosphate dehydrogenase on aldolase action

artículo científico publicado en 1990

Correction: Characterisation of Mesothelioma-Initiating Cells and Their Susceptibility to Anti-Cancer Agents.

artículo científico publicado en 2016

Corrigendum to “Mitochondrially targeted anti-cancer agents” [Mitochondrion 10 (2010) 670–681]

scholarly article published in Mitochondrion

Corrigendum to: “Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy” [Free Radic Biol Med. 50 (2011) 1546–1555]

artículo científico publicado en 2013

Cyclopentenone prostaglandins induce endothelial cell apoptosis independent of the peroxisome proliferator-activated receptor-gamma

artículo científico publicado en 2004

Daxx inhibits stress-induced apoptosis in cardiac myocytes

artículo científico publicado en 2008

Decreased apoptotic response of inclusion-cell disease fibroblasts: a consequence of lysosomal enzyme missorting?

artículo científico publicado en 2002

Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer

artículo científico publicado en 2020

Dissociation of apoptosis induction and CD36 upregulation by enzymatically modified low-density lipoprotein in monocytic cells

artículo científico publicado en 2002

Editorial: The Bioenergetics of Cancer, the Warburg Hypothesis and the Mitochondrial Function

artículo científico publicado en 2013

Enzymatically modified low-density lipoprotein upregulates CD36 in low-differentiated monocytic cells in a peroxisome proliferator-activated receptor-gamma-dependent way.

artículo científico publicado en 2004

Enzymic degradation of bromoxynil by cell-free extracts ofStreptomyces felleus

scientific article published on 01 January 1988

Epigenetic Regulation of miRNA Expression in Malignant Mesothelioma: miRNAs as Biomarkers of Early Diagnosis and Therapy

scientific article published on 29 November 2019

Erratum to: Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death

scholarly article published in Pharmaceutical Research

Erratum to: α-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels

scholarly article published in Apoptosis

Evaluation of respiration of mitochondria in cancer cells exposed to mitochondria-targeted agents

artículo científico publicado en 2015

Exosomal miR-126 as a circulating biomarker in non-small-cell lung cancer regulating cancer progression

artículo científico publicado en 2017

Exosomal transfer of miR-126 promotes the anti-tumour response in malignant mesothelioma: Role of miR-126 in cancer-stroma communication

artículo científico publicado en 2019

Exosome-derived microRNAs in cancer metabolism: possible implications in cancer diagnostics and therapy.

artículo científico publicado en 2017

Expression of human myoglobin in H9c2 cells enhances toxicity to added hydrogen peroxide

article

Four-miRNA Signature to Identify Asbestos-Related Lung Malignancies

scientific article published on 26 September 2018

Future use of mitocans against tumour-initiating cells?

artículo científico publicado en 2009

Hepatic processing determines dual activity of alpha-tocopheryl succinate: a novel paradigm for a shift in biological activity due to pro-vitamin-to-vitamin conversion

artículo científico publicado en 2005

High molecular weight forms of mammalian respiratory chain complex II

artículo científico publicado en 2013

Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner

artículo científico publicado en 2011

Horizontal transfer of mitochondria between mammalian cells: beyond co-culture approaches.

artículo científico publicado en 2016

Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

artículo científico publicado en 2017

Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans

artículo científico publicado en 2013

Inhibition of inflammatory endothelial responses by a pathway involving caspase activation and p65 cleavage.

artículo científico publicado en 2001

Inhibitors of succinate: quinone reductase/Complex II regulate production of mitochondrial reactive oxygen species and protect normal cells from ischemic damage but induce specific cancer cell death.

artículo científico

Isolating dividing neural and brain tumour cells for gene expression profiling.

artículo científico publicado en 2015

K-Ras and mitochondria: dangerous liaisons

artículo científico publicado en 2011

Liposomal formulation of alpha-tocopheryl maleamide: in vitro and in vivo toxicological profile and anticancer effect against spontaneous breast carcinomas in mice.

artículo científico publicado en 2009

Lyophilised liposome-based formulations of alpha-tocopheryl succinate: preparation and physico-chemical characterisation

artículo científico publicado en 2010

MAC'09, Otto and us…

artículo científico publicado en 2010

Malignant mesothelioma: biology, diagnosis and therapeutic approaches

artículo científico publicado en 2009

Mechanism of miR-222 and miR-126 regulation and its role in asbestos-induced malignancy

artículo científico publicado en 2020

Metformin directly targets the H3K27me3 demethylase KDM6A/UTX

scientific article published on 08 May 2018

MiR-126 in intestinal-type sinonasal adenocarcinomas: exosomal transfer of MiR-126 promotes anti-tumour responses

article

MicroRNA in Metabolic Re-Programming and Their Role in Tumorigenesis

artículo científico publicado en 2016

MicroRNA regulation of cancer metabolism: role in tumour suppression

artículo científico publicado en 2014

MicroRNA-126 induces autophagy by altering cell metabolism in malignant mesothelioma

artículo científico publicado en 2016

MicroRNA-126 suppresses mesothelioma malignancy by targeting IRS1 and interfering with the mitochondrial function

artículo científico publicado en 2014

MicroRNAs as regulators of mitochondrial function: role in cancer suppression.

artículo científico

Mitocans Revisited: Mitochondrial Targeting as Efficient Anti-Cancer Therapy

artículo científico publicado en 2020

Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II.

artículo científico publicado en 2007

Mitocans, a class of emerging anti-cancer drugs

scientific article published on 01 January 2009

Mitocans: mitochondrial targeted anti-cancer drugs as improved therapies and related patent documents

artículo científico publicado en 2006

Mitochondria as targets for cancer therapy

artículo científico publicado en 2009

Mitochondria in cancer: why mitochondria are a good target for cancer therapy

artículo científico publicado en 2014

Mitochondria play a central role in apoptosis induced by alpha-tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor-mediated pro-apoptotic signaling

artículo científico publicado en 2003

Mitochondria transmit apoptosis signalling in cardiomyocyte-like cells and isolated hearts exposed to experimental ischemia-reperfusion injury

artículo científico publicado en 2007

Mitochondria-Driven Elimination of Cancer and Senescent Cells

artículo científico publicado en 2018

Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments

scientific article published on 19 June 2020

Mitochondria-driven elimination of cancer and senescent cells

scientific article published in 2019

Mitochondria: An intriguing target for killing tumour-initiating cells

artículo científico

Mitochondrial Complex II: At the Crossroads

artículo científico publicado en 2017

Mitochondrial DNA Affects the Expression of Nuclear Genes Involved in Immune and Stress Responses in a Breast Cancer Model

artículo científico publicado en 2020

Mitochondrial DNA in Tumor Initiation, Progression, and Metastasis: Role of Horizontal mtDNA Transfer

artículo científico publicado en 2015

Mitochondrial Genome Transfer to Tumor Cells Breaks The Rules and Establishes a New Precedent in Cancer Biology

artículo científico publicado en 2018

Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer

artículo científico publicado en 2016

Mitochondrial complex II and reactive oxygen species in disease and therapy

scientific article published on 01 December 2020

Mitochondrial complex II, a novel target for anti-cancer agents

artículo científico publicado el 6 de noviembre de 2012

Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA.

artículo científico publicado en 2015

Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis

artículo científico publicado en 2003

Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II

artículo científico publicado en 2010

Mitochondrial targeting of α-tocopheryl succinate enhances its anti-mesothelioma efficacy.

artículo científico publicado en 2013

Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy

artículo científico publicado en 2011

Mitochondrial targeting overcomes ABCA1-dependent resistance of lung carcinoma to α-tocopheryl succinate

artículo científico publicado en 2013

Mitochondrially targeted anti-cancer agents

artículo científico publicado en 2010

Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice

artículo científico publicado en 2022

Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner.

artículo científico publicado en 2015

Mitochondrially targeted vitamin E succinate modulates expression of mitochondrial DNA transcripts and mitochondrial biogenesis

artículo científico publicado en 2015

Mitochondrially targeted α-tocopheryl succinate is antiangiogenic: potential benefit against tumor angiogenesis but caution against wound healing

artículo científico publicado en 2011

Molecular mechanism for the selective impairment of cancer mitochondrial function by a mitochondrially targeted vitamin E analogue

artículo científico publicado en 2012

Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins.

artículo científico publicado en 2006

Oxidation of Free Fatty Acids in Low Density Lipoprotein by 15-Lipoxygenase Stimulates Nonenzymic, α-Tocopherol-mediated Peroxidation of Cholesteryl Esters

scientific article published in Journal of Biological Chemistry

Oxidation of parenteral lipid emulsion by ambient and phototherapy lights: Potential toxicity of routine parenteral feeding

article

Oxidative stress mediates toxicity of pyridoxal isonicotinoyl hydrazone analogs

artículo científico publicado en 2004

Partial purification and characterization of anhydrotetracycline oxygenase of Streptomyces aureofaciens

scientific article published on 01 January 1987

Platelets Facilitate the Wound-Healing Capability of Mesenchymal Stem Cells by Mitochondrial Transfer and Metabolic Reprogramming

artículo científico publicado en 2020

Powerhouse down: Complex II dissociation in the respiratory chain

artículo científico publicado en 2014

Profiling tumor-associated markers for early detection of malignant mesothelioma: an epidemiologic study

artículo científico publicado en 2008

Pyridoxal isonicotinoyl hydrazone analogs induce apoptosis in hematopoietic cells due to their iron-chelating properties

artículo científico publicado en 2003

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

artículo científico publicado en 2018

Reactive oxygen species are generated by the respiratory complex II--evidence for lack of contribution of the reverse electron flow in complex I.

artículo científico publicado en 2013

Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors

artículo científico publicado en 2020

Requirement for, Promotion, or Inhibition by α-Tocopherol of Radical-Induced Initiation of Plasma Lipoprotein Lipid Peroxidation

scientific article published on 01 January 1997

Role of thioredoxin-1 in apoptosis induction by alpha-tocopheryl succinate and TNF-related apoptosis-inducing ligand in mesothelioma cells

artículo científico publicado en 2006

Secretory phospholipase A2 and lipoprotein lipase enhance 15-lipoxygenase-induced enzymic and nonenzymic lipid peroxidation in low-density lipoproteins

artículo científico publicado en 1998

Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2high Breast Cancer

artículo científico publicado en 2016

Selective cancer cell killing by alpha-tocopheryl succinate

artículo científico publicado en 2001

Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

Selenium supplementation induces mitochondrial biogenesis in trophoblasts

artículo científico publicado en 2015

Structural re-arrangement and peroxidase activation of cytochrome c by anionic analogues of vitamin E, tocopherol succinate and tocopherol phosphate

artículo científico publicado en 2014

Succinate Mediates Tumorigenic Effects <i>via</i> Succinate Receptor 1: Potential for New Targeted Treatment Strategies in Succinate Dehydrogenase Deficient Paragangliomas

artículo científico publicado en 2021

Succinobucol induces apoptosis in vascular smooth muscle cells

artículo científico publicado en 2011

Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II.

artículo científico publicado en 2009

TRAIL induces apoptosis but not necroptosis in colorectal and pancreatic cancer cells preferentially via the TRAIL-R2/DR5 receptor.

artículo científico publicado en 2017

Targeting the Mitochondrial Electron Transport Chain Complexes for the Induction of Apoptosis and Cancer Treatment

artículo científico publicado el 1 de enero de 2013

The Assembly Factor SDHAF2 Is Dispensable for Flavination of the Catalytic Subunit of Mitochondrial Complex II in Breast Cancer Cells

artículo científico publicado en 2016

The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy

artículo científico publicado en 2010

The effect of mitochondrially targeted anticancer agents on mitochondrial (super)complexes.

artículo científico publicado en 2015

The mobility of mitochondria: intercellular trafficking in health and disease

artículo científico publicado en 2017

The potential role of CD133 in immune surveillance and apoptosis: a mitochondrial connection?

artículo científico publicado en 2011

The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria

artículo científico publicado en 2016

Therapeutic targeting of SDHB-mutated pheochromocytoma/paraganglioma with pharmacologic ascorbic acid

scientific article published on 09 March 2020

Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress.

artículo científico publicado en 2011

Thrombomodulin is silenced in malignant mesothelioma by a poly(ADP-ribose) polymerase-1-mediated epigenetic mechanism

artículo científico publicado en 2011

Tocopherol-associated protein-1 accelerates apoptosis induced by alpha-tocopheryl succinate in mesothelioma cells

artículo científico publicado en 2006

Transcriptional profiling of dividing tumor cells detects intratumor heterogeneity linked to cell proliferation in a brain tumor model.

artículo científico publicado en 2015

Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism.

artículo científico publicado en 2017

Tumour-initiating cells vs. cancer 'stem' cells and CD133: what's in the name?

artículo científico publicado en 2007

Vitamin E Analogues Inhibit Angiogenesis by Selective Induction of Apoptosis in Proliferating Endothelial Cells: The Role of Oxidative Stress

artículo científico publicado en 2007

Vitamin E amides, a new class of vitamin E analogues with enhanced proapoptotic activity

artículo científico publicado en 2005

Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway.

artículo científico publicado en 2005

Vitamin E analogs, a novel group of "mitocans," as anticancer agents: the importance of being redox-silent

artículo científico publicado en 2007

Vitamin E analogs: a new class of multiple action agents with anti-neoplastic and anti-atherogenic activity.

artículo científico publicado en 2002

Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria

artículo científico publicado en 2007

Vitamin E analogues as anticancer agents: lessons from studies with alpha-tocopheryl succinate

artículo científico publicado en 2006

Vitamin E analogues as inducers of apoptosis: structure-function relation

artículo científico publicado en 2003

Vitamin E analogues as mitochondria-targeting compounds: from the bench to the bedside?

artículo científico publicado en 2009

Vitamin E analogues: a new class of inducers of apoptosis with selective anti-cancer effects

artículo científico publicado en 2004

Vitamin E succinate and cancer treatment: a vitamin E prototype for selective antitumour activity

artículo científico publicado el 17 de noviembre de 2003

alpha-Lipoic acid modulates extracellular matrix and angiogenesis gene expression in non-healing wounds treated with hyperbaric oxygen therapy

artículo científico publicado en 2008

alpha-Lipoic acid supplementation inhibits oxidative damage, accelerating chronic wound healing in patients undergoing hyperbaric oxygen therapy

artículo científico publicado en 2005

alpha-Tocopherol in atherogenesis: do we know its real role?

artículo científico publicado en 1998

alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels

artículo científico publicado en 2010

alpha-Tocopheryl succinate inhibits angiogenesis by disrupting paracrine FGF2 signalling

artículo científico publicado en 2007

alpha-Tocopheryl succinate inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors

artículo científico publicado en 2004

alpha-Tocopheryl succinate promotes selective cell death induced by vitamin K3 in combination with ascorbate.

artículo científico publicado en 2010

alpha-Tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manner

artículo científico publicado en 2006

α-Tocopheryl hydroquinone is an efficient multifunctional inhibitor of radical-initiated oxidation of low density lipoprotein lipids

artículo científico publicado el 22 de julio de 1997

α-Tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: Implication for sensitisation of resistant cancer cells to TRAIL apoptosis

scientific article published on 28 February 2006

α-Tocopheryl succinate-induced apoptosis in Jurkat T cells involves caspase-3 activation, and both lysosomal and mitochondrial destabilisation

artículo científico publicado en 1999

α-Tocopheryloxyacetic acid is superior to α-tocopheryl succinate in suppressing HER2-high breast carcinomas due to its higher stability