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Lista de obras de Jacek Jemielity

2'-O-Methylation of the second transcribed nucleotide within the mRNA 5' cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion

2’- O -methylation of the second transcribed nucleotide within mRNA 5’ cap impacts protein production level in a cell specific manner and contributes to RNA immune evasion

artículo científico publicado en 2022

5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes.

artículo científico publicado en 2018

5'-fluoro(di)phosphate-labeled oligonucleotides are versatile molecular probes for studying nucleic acid secondary structure and interactions by 19F NMR

artículo científico publicado en 2020

7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity

artículo científico publicado en 2012

A direct method for the synthesis of nucleoside 5′-methylenebis(phosphonate)s from nucleosides

A fluorescent HTS assay for phosphohydrolases based on nucleoside 5'-fluorophosphates: its application in screening for inhibitors of mRNA decapping scavenger and PDE-I.

artículo científico publicado en 2016

A novel approach to solid phase chemical synthesis of oligonucleotide mRNA cap analogs

artículo científico publicado en 2005

A novel route for preparing 5' cap mimics and capped RNAs: phosphate-modified cap analogues obtained via click chemistry

artículo científico publicado en 2016

A simple and rapid synthesis of nucleotide analogues containing a phosphorothioate moiety at the terminal position of the phosphate chain

artículo científico publicado en 2007

Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to decapping scavenger activity monitoring

artículo científico publicado en 2016

Adenosine 5'-tetraphosphate is a highly potent purinergic endothelium-derived vasoconstrictor.

artículo científico publicado en 2008

Affinity of dinucleotide cap analogues for human decapping scavenger (hDcpS).

artículo científico publicado en 2007

Affinity resins containing enzymatically resistant mRNA cap analogs--a new tool for the analysis of cap-binding proteins

artículo científico publicado en 2012

Amino-Functionalized 5' Cap Analogs as Tools for Site-Specific Sequence-Independent Labeling of mRNA.

artículo científico publicado en 2017

Analysis of decapping scavenger cap complex using modified cap analogs reveals molecular determinants for efficient cap binding.

artículo científico publicado en 2013

Analysis of mononucleotides by tandem mass spectrometry: investigation of fragmentation pathways for phosphate- and ribose-modified nucleotide analogues

artículo científico publicado en 2017

Applications of Phosphate Modification and Labeling to Study (m)RNA Caps

artículo científico publicado en 2017

Assignment of the absolute configuration of P-chiral 5' mRNA cap analogues containing phosphorothioate moiety

artículo científico publicado en 2007

Azido-Functionalized 5' Cap Analogues for the Preparation of Translationally Active mRNAs Suitable for Fluorescent Labeling in Living Cells

artículo científico publicado en 2017

Azido-Functionalized 5′ Cap Analogues for the Preparation of Translationally Active mRNAs Suitable for Fluorescent Labeling in Living Cells

artículo científico publicado en 2017

Binding studies of eukaryotic initiation factor eIF4E with novel mRNA dinucleotide cap analogues

artículo científico publicado en 2003

Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation

artículo científico publicado en 2021

Biomolecular condensates amplify mRNA decapping by coupling protein interactions with conformational changes in Dcp1/Dcp2

artículo científico publicado en 2020

Bisphosphonate mRNA cap analog attached to Sepharose for affinity chromatography of decapping enzymes

artículo científico publicado en 2008

Bisphosphonate modification in tetraphosphate 5'mRNA cap analogs – synthesis and biochemical properties

Cap analogs containing 6-thioguanosine--reagents for the synthesis of mRNAs selectively photo-crosslinkable with cap-binding biomolecules.

artículo científico publicado en 2014

Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential

artículo científico publicado en 2016

Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses

artículo científico publicado en 2017

ChemInform Abstract: Synthetic mRNA Cap Analogues with a Modified Triphosphate Bridge - Synthesis, Applications and Prospects

Chemical synthesis and binding activity of the trypanosomatid cap-4 structure

artículo científico publicado en 2004

Chemically Modified Poly(A) Analogs Targeting PABP: Structure Activity Relationship and Translation Inhibitory Properties

Clickable trimethylguanosine cap analogs modified within the triphosphate bridge: synthesis, conjugation to RNA and susceptibility to degradation

artículo científico publicado en 2016

Cover Feature: Fluorescent Turn‐On Probes for the Development of Binding and Hydrolytic Activity Assays for mRNA Cap‐Recognizing Proteins (Chem. Eur. J. 27/2019)

artículo científico publicado en 2019

Differential inhibition of mRNA degradation pathways by novel cap analogs

artículo científico publicado en 2005

Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase Activity

artículo científico publicado en 2020

Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression

artículo científico publicado en 2009

Dual activity of certain HIT-proteins: A. thaliana Hint4 and C. elegans DcpS act on adenosine 5'-phosphosulfate as hydrolases (forming AMP) and as phosphorylases (forming ADP).

artículo científico publicado en 2010

Efficient Synthesis of Trifluoromethylated Purine Ribonucleosides and Ribonucleotides

scientific article published on 01 December 2020

Efficient and Rapid Synthesis of Nucleoside Diphosphate Sugars from Nucleoside Phosphorimidazolides

Enzymatic Assays to Explore Viral mRNA Capping Machinery

artículo científico publicado en 2021

Enzymatically stable 5′ mRNA cap analogs: Synthesis and binding studies with human DcpS decapping enzyme

artículo científico publicado en 2006

Ethylenediamine derivatives efficiently react with oxidized RNA 3′ ends providing access to mono and dually labelled RNA probes for enzymatic assays and in vivo translation

artículo científico publicado en 2021

Ethynyl, 2-Propynyl, and 3-Butynyl C-Phosphonate Analogues of Nucleoside Di- and Triphosphates: Synthesis and Reactivity in CuAAC.

artículo científico publicado en 2015

Evaluation of carboxyfluorescein-labeled 7-methylguanine nucleotides as probes for studying cap-binding proteins by fluorescence anisotropy

artículo científico publicado en 2021

ExciTides: NTP-derived probes for monitoring pyrophosphatase activity based on excimer-to-monomer transitions

artículo científico publicado en 2018

Exploring the potential of phosphotriazole 5' mRNA cap analogues as efficient translation initiators

artículo científico publicado en 2018

Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation

artículo científico publicado en 2020

Five eIF4E isoforms from Arabidopsis thaliana are characterized by distinct features of cap analogs binding

artículo científico publicado en 2014

Fluorescence-Based Activity Screening Assay Reveals Small Molecule Inhibitors of Vaccinia Virus mRNA Decapping Enzyme D9

artículo científico publicado en 2022

Fluorescent Turn-On Probes for the Development of Binding and Hydrolytic Activity Assays for mRNA Cap-Recognizing Proteins

artículo científico publicado en 2019

Fluorinated Phosphoadenosine 5′-Phosphosulfate Analogues for Continuous Sulfotransferase Activity Monitoring and Inhibitor Screening by 19 F NMR Spectroscopy

Functional and LC-MS/MS analysis ofin vitrotranscribed mRNAs carrying phosphorothioate or boranophosphate moieties reveal polyA tail modifications that prevent deadenylation without compromising protein expression

artículo científico publicado en 2020

Gold-decorated polymer vessel structures as carriers of mRNA cap analogs

Hint2, the mitochondrial nucleoside 5'-phosphoramidate hydrolase; properties of the homogeneous protein from sheep (Ovis aries) liver

artículo científico publicado en 2013

Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase

artículo científico publicado en 2021

Identification of the HIT-45 protein from Trypanosoma brucei as an FHIT protein/dinucleoside triphosphatase: substrate specificity studies on the recombinant and endogenous proteins

artículo científico publicado en 2009

Influence of electric charge variation at residues 209 and 159 on the interaction of eIF4E with the mRNA 5' terminus

artículo científico publicado en 2004

Influence of the Length of the Phosphate Chain in mRNA 5′ Cap Analogues on Their Interaction with Eukaryotic Initiation Factor 4E

artículo científico publicado en 2003

Interaction between yeast eukaryotic initiation factor eIF4E and mRNA 5' cap analogues differs from that for murine eIF4E.

artículo científico publicado en 2003

Interaction of human decapping scavenger with 5′ mRNA cap analogues: structural requirements for catalytic activity

Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses

artículo científico publicado en 2015

Introducing SuFNucs: Sulfamoyl-Fluoride-Functionalized Nucleosides That Undergo Sulfur Fluoride Exchange Reaction

scientific article published in 2022

Kinetic analysis of IFIT1 and IFIT5 interactions with different native and engineered RNAs and its consequences for designing mRNA-based therapeutics

scientific article published on 28 October 2019

Kinetic and solvent isotope effects on biotransformation of aromatic amino acids and their derivatives

artículo científico publicado en 2016

Kinetics of C. elegans DcpS cap hydrolysis studied by fluorescence spectroscopy

artículo científico publicado en 2007

Magnetic-nanoparticle-decorated polypyrrole microvessels: toward encapsulation of mRNA cap analogues.

artículo científico publicado en 2013

Methylene analogues of adenosine 5'-tetraphosphate. Their chemical synthesis and recognition by human and plant mononucleoside tetraphosphatases and dinucleoside tetraphosphatases.

artículo científico publicado en 2006

N1-Propargylguanosine Modified mRNA Cap Analogs: Synthesis, Reactivity, and Applications to the Study of Cap-Binding Proteins.

artículo científico publicado en 2019

Nicotinamide-Containing Di- and Trinucleotides as Chemical Tools for Studies of NAD-Capped RNAs

scientific article published on 27 November 2018

Novel "anti-reverse" cap analogs with superior translational properties

artículo científico publicado en 2003

Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5' cap Analogs: Synthesis and Evaluation as Modulators of Translation

artículo científico

Novel dinucleoside 5',5'-triphosphate cap analogues. Synthesis and affinity for murine translation factor eIF4E.

artículo científico publicado en 2005

Phosphate-modified analogues of m(7)GTP and m(7)Gppppm(7)G-Synthesis and biochemical properties

artículo científico

Phosphodiester modifications in mRNA polyA tail prevent deadenylation without compromising protein expression

artículo científico publicado en 2020

Phosphoroselenoate dinucleotides for modification of mRNA 5' end

artículo científico publicado en 2009

Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation

artículo científico publicado en 2009

Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo

artículo científico publicado en 2010

Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells

artículo científico publicado en 2007

Plant nucleoside 5'-phosphoramidate hydrolase; simple purification from yellow lupin (Lupinus luteus) seeds and properties of homogeneous enzyme

artículo científico publicado en 2011

Potential therapeutic applications of RNA cap analogs.

artículo científico publicado en 2013

Preparation of synthetically challenging nucleotides using cyanoethyl P-imidazolides and microwaves

artículo científico publicado en 2012

Purine and pyrimidine dinucleoside polyphosphates differentially affect the phenylpropanoid pathway in Vitis vinifera L. cv. Monastrell suspension cultured cells

scientific article published on 13 December 2019

Quick Access to Nucleobase-Modified Phosphoramidites for the Synthesis of Oligoribonucleotides Containing Post-Transcriptional Modifications and Epitranscriptomic Marks

RNA Ligation for Mono and Dually Labeled RNAs

artículo científico publicado en 2021

Recognition of different nucleotidyl-derivatives as substrates of reactions catalyzed by various HIT-proteins

Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation

artículo científico publicado en 2018

SYNTHESIS AND BIOCHEMICAL PROPERTIES OF NOVEL mRNA 5′ CAP ANALOGS RESISTANT TO ENZYMATIC HYDROLYSIS

artículo científico publicado en 2005

Solid-Phase Synthesis of RNA 5'-Azides and Their Application for Labeling, Ligation, and Cyclization Via Click Chemistry

artículo científico publicado en 2020

Solid-supported synthesis of 5'-mRNA CAP-4 from Trypanosomatids

artículo científico publicado en 2007

Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect

artículo científico publicado en 2021

Structural analysis of 5′-mRNA–cap interactions with the human AGO2 MID domain

artículo científico publicado en 2011

Structural basis of mRNA-cap recognition by Dcp1-Dcp2

artículo científico publicado en 2016

Structural requirements for Caenorhabditis elegans DcpS substrates based on fluorescence and HPLC enzyme kinetic studies

artículo científico publicado en 2010

Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis

artículo científico publicado en 2018

Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis

artículo científico publicado en 2021

Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis

Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism

scientific article published on 29 April 2022

Synthesis and biochemical studies of tetraphosphate 5' mRNA cap analogs bearing bisphosphonate modification

artículo científico publicado en 2008

Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS

artículo científico publicado en 2008

Synthesis and enzymatic characterization of methylene analogs of adenosine 5'-tetraphosphate (P4A).

artículo científico publicado en 2005

Synthesis and evaluation of fluorescent cap analogues for mRNA labelling

artículo científico publicado en 2013

Synthesis and evaluation of stability of m3G-CAP analogues in serum-supplemented medium and cytosolic extract.

artículo científico publicado en 2013

Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety—fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis

artículo científico publicado en 2012

Synthesis and properties of mRNA cap analogs containing phosphorothioate moiety in 5',5'-triphosphate chain

artículo científico publicado en 2005

Synthesis of 3H and 13C labeled mRNA cap dinucleotides--useful tools for NMR, biochemical, and biological studies

artículo científico publicado en 2007

Synthesis of Leishmania cap-4 intermediates, cap-2 and cap-3.

artículo científico publicado en 2007

Synthesis of RNA 5'-Azides from 2'-O-Pivaloyloxymethyl-Protected RNAs and Their Reactivity in Azide-Alkyne Cycloaddition Reactions

artículo científico publicado en 2017

Synthesis of Trifluoromethylated Purine Ribonucleotides and Their Evaluation as 19F NMR Probes

scientific article published on 13 February 2020

Synthesis of anti-reverse cap analogs (ARCAs) and their applications in mRNA translation and stability

artículo científico publicado en 2007

Synthesis of biotin labelled cap analogue--incorporable into mRNA transcripts and promoting cap-dependent translation

scientific article published on 01 November 2012

Synthesis of fluorophosphate nucleotide analogues and their characterization as tools for ¹⁹F NMR studies.

artículo científico publicado en 2015

Synthesis of novel mRNA 5' cap-analogues: dinucleoside P1, P3-tri-, P1, P4-tetra-, and P1, P5-pentaphosphates

artículo científico publicado en 2003

Synthesis of nucleoside phosphosulfates

artículo científico publicado en 2012

Synthesis of nucleotide sugars and nucleoside 5'-phosphosulfates by MgCl2 mediated coupling

Synthesis of tritium labeled [3R-3H]-, and [3S-3H]-L-phenylalanine

artículo científico publicado en 2001

Synthesis of tritium labeled isotopomers ofL-tyrosine

artículo científico publicado en 2002

Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes

artículo científico publicado en 2014

Synthetic Capped mRNAs for Cap-Specific Photo-Cross-Linking Experiments

artículo científico publicado en 2016

Synthetic dinucleotide mRNA cap analogs with tetraphosphate 5',5' bridge containing methylenebis(phosphonate) modification

artículo científico publicado en 2009

Synthetic m3G-CAP attachment necessitates a minimum trinucleotide constituent to be recognised as a nuclear import signal

artículo científico publicado en 2016

Synthetic mRNA cap analogs with a modified triphosphate bridge – synthesis, applications and prospects

Synthetic mRNAs with superior translation and stability properties.

artículo científico

The Strategies to Support the COVID-19 Vaccination with Evidence-Based Communication and Tackling Misinformation

artículo científico publicado en 2021

The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro

artículo científico publicado en 2005

The first examples of mRNA cap analogs bearing boranophosphate modification.

artículo científico publicado en 2008

The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5' cap modulates protein expression in living cells

artículo científico publicado en 2020

The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5’ cap modulates protein expression in living cells

artículo científico publicado en 2019

The synthesis of isopropylidene mRNA cap analogs modified with phosphorothioate moiety and their evaluation as promoters of mRNA translation.

artículo científico publicado en 2013

Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications

artículo científico publicado en 2010

Towards novel efficient and stable nuclear import signals: synthesis and properties of trimethylguanosine cap analogs modified within the 5′,5′-triphosphate bridge

artículo científico publicado en 2014

Translation initiation factor 4E in complex with m2(7,2'O)GppCCl2ppG mRNA 5' cap analog

Translation initiation factor 4E in complex with m7GppppG mRNA 5' cap analog

Translation, stability, and resistance to decapping of mRNAs containing caps substituted in the triphosphate chain with BH3, Se, and NH

artículo científico publicado en 2011

Tritium Secondary Kinetic Isotope Effect on Phenylalanine Ammonia-Lyase-Catalyzed Reaction

artículo científico publicado en 1999

Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex.

artículo científico publicado en 2016

Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation

artículo científico publicado en 2021

Virus-like particle-mediated intracellular delivery of mRNA cap analog with in vivo activity against hepatocellular carcinoma

artículo científico publicado en 2014

Weak binding affinity of human 4EHP for mRNA cap analogs

artículo científico publicado en 2007

eIF4E phosphorylation by MST1 reduces translation of a subset of mRNAs, but increases lncRNA translation.

artículo científico publicado en 2017

m7GTP alphaS is a strong and stable inhibitor of cap-dependent translation

artículo científico publicado en 2008

mRNA Cap Modification through Carbamate Chemistry: Synthesis of Amino- and Carboxy-Functionalised Cap Analogues Suitable for Labelling and Bioconjugation

artículo científico publicado en 2015

mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation

artículo científico publicado en 2017

mRNA decapping is promoted by an RNA-binding channel in Dcp2

artículo científico publicado en 2008

mRNAs biotinylated within the 5' cap and protected against decapping: new tools to capture RNA-protein complexes

scientific article published on 05 November 2018

mRNAs containing the histone 3' stem-loop are degraded primarily by decapping mediated by oligouridylation of the 3' end.

artículo científico publicado en 2012