Lista de obras - Maria Ruzzene - Dominio Público Uruguay

2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2.

artículo científico publicado en 2004

A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours

artículo científico publicado en 2015

A procedure allowing measurement of cytosolic CA2+ in rat platelets. Inhibition of a plasma lipoprotein on fura 2-AM loading

artículo científico publicado en 1991

Aberrant signalling by protein kinase CK2 in imatinib-resistant chronic myeloid leukaemia cells: biochemical evidence and therapeutic perspectives

artículo científico publicado en 2013

Addiction of Cancer Cells to CK2: Survival at All Costs or Achilles' Heel?

Addiction to protein kinase CK2: a common denominator of diverse cancer cells?

artículo científico publicado en 2009

Analysis of the interaction between piD261/Bud32, an evolutionarily conserved protein kinase of Saccharomyces cerevisiae, and the Grx4 glutaredoxin

artículo científico publicado en 2004

Assessment of CK2 constitutive activity in cancer cells

artículo científico publicado en 2010

Autocatalytic tyrosine-phosphorylation of protein kinase CK2 alpha and alpha' subunits: implication of Tyr182

artículo científico publicado en 2001

Biochemical analysis of the interactions between the proteins involved in the [FeFe]-hydrogenase maturation process

artículo científico publicado en 2012

Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA)

artículo científico publicado en 2003

Bovine prion protein as a modulator of protein kinase CK2

artículo científico publicado en 2000

CD45 regulates apoptosis induced by extracellular adenosine triphosphate and cytotoxic T lymphocytes.

artículo científico publicado en 1996

CK2 Function in the Regulation of Akt Pathway

Casein kinase: the triple meaning of a misnomer

artículo científico publicado en 2014

Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential

artículo científico publicado en 2014

Chimeric peptides as modulators of CK2-dependent signaling: Mechanism of action and off-target effects

artículo científico publicado en 2015

Comparative analysis of CK2 expression and function in tumor cell lines displaying sensitivity vs. resistance to chemical induced apoptosis

artículo científico publicado en 2008

Cross-talk between the CK2 and AKT signaling pathways in cancer

artículo científico publicado en 2017

Cyclic GMP and nitroprusside inhibit the activation of human platelets by fluoroaluminate

artículo científico publicado en 1989

Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells

artículo científico publicado en 2009

Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity.

artículo científico publicado en 2015

Development and exploitation of CK2 inhibitors

artículo científico publicado en 2005

Different Persistence of the Cellular Effects Promoted by Protein Kinase CK2 Inhibitors CX-4945 and TDB.

artículo científico publicado en 2015

Differential phosphorylation of Akt1 and Akt2 by protein kinase CK2 may account for isoform specific functions

artículo científico publicado en 2014

Effects of CK2 inhibition in cultured fibroblasts from Type 1 Diabetic patients with or without nephropathy

artículo científico publicado en 2015

Effects of calcium chelators, divalent cations and sulfhydryl reagents on calcium uptake and motility of bovine spermatozoa

artículo científico publicado en 1988

Effects of the CK2 inhibitors CX-4945 and CX-5011 on drug-resistant cells

artículo científico publicado en 2012

Enhancing chemosensitivity to gemcitabine via RNA interference targeting the catalytic subunits of protein kinase CK2 in human pancreatic cancer cells

artículo científico publicado en 2010

Exploiting the repertoire of CK2 inhibitors to target DYRK and PIM kinases.

artículo científico publicado en 2013

Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency

scientific journal article

Functional protein network activation mapping reveals new potential molecular drug targets for poor prognosis pediatric BCP-ALL

artículo científico publicado en 2010

Helicobacter pylori periplasmic receptor CeuE (HP1561) modulates its nickel affinity via organic metallophores

artículo científico publicado en 2014

Hematopoietic lineage cell specific protein 1 associates with and down-regulates protein kinase CK2.

artículo científico publicado en 1999

Heterogeneity of CK2 phosphorylation sites in the NS5A protein of different hepatitis C virus genotypes

artículo científico publicado en 2007

Hierarchical phosphorylation of a 50-kDa protein by protein tyrosine kinases TPK-IIB and C-Fgr, and its identification as HS1 hematopoietic-lineage cell-specific protein

scientific journal article

How do protein kinases recognize their substrates?

artículo científico publicado en 1996

Increased activity of c-Src and Csk in fibroblasts transformed by v-src oncogene

artículo científico publicado en 2002

Inhibition of protein kinase CK2 by condensed polyphenolic derivatives. An in vitro and in vivo study

artículo científico publicado en 2004

Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity

artículo científico publicado en 2013

Lamin A Ser404 is a nuclear target of Akt phosphorylation in C2C12 cells

artículo científico publicado en 2008

Multiple myeloma cell survival relies on high activity of protein kinase CK2.

artículo científico publicado en 2006

Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole

artículo científico publicado en 2004

Pharmacological inhibition of protein kinase CK2 reverts the multidrug resistance phenotype of a CEM cell line characterized by high CK2 level.

artículo científico publicado en 2007

Phosphatidylinositol 3-kinase is recruited to a specific site in the activated IL-1 receptor I

scholarly article by Sandra Marmiroli published in October 1998

Phosphoproteomic Profiling of NSCLC Cells Reveals That Ephrin B3 Regulates Pro-survival Signaling through Akt1- Mediated Phosphorylation of the EphA2 Receptor

Phosphoproteomic profiling of NSCLC cells reveals that ephrin B3 regulates pro-survival signaling through Akt1-mediated phosphorylation of the EphA2 receptor.

artículo científico publicado en 2011

Phosphorylation and activation of the atypical kinase p53-related protein kinase (PRPK) by Akt/PKB

artículo científico publicado en 2007

Phosphorylation of the Saccharomyces cerevisiae Grx4p glutaredoxin by the Bud32p kinase unveils a novel signaling pathway involving Sch9p, a yeast member of the Akt / PKB subfamily

artículo científico publicado en 2008

Phosphorylation, Signaling, and Cancer: Targets and Targeting

artículo científico publicado en 2015

Platelet activation by diacylglycerol or ionomycin is inhibited by nitroprusside

artículo científico publicado en 1991

Platelet responses promoted by the activation of protein kinase C or the increase of cytosolic Ca2+ are potentiated by adrenaline. Effects of cAMP and staurosporine

artículo científico publicado en 1991

Protein kinase CK2 accumulation in "oncophilic" cells: causes and effects.

artículo científico publicado en 2011

Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways

artículo científico publicado en 2012

Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells

artículo científico publicado en 2002

Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain

artículo científico publicado en 2016

Protein kinase CK2 phosphorylates and upregulates Akt/PKB.

artículo científico publicado en 2005

Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response

artículo científico publicado en 2012

Psoralen—fatty acid cycloadducts activate protein kinase C (PKC) in human platelets

artículo científico publicado en 1994

Pyrvinium pamoate does not activate protein kinase CK1, but promotes Akt/PKB down-regulation and GSK3 activation

artículo científico publicado en 2013

Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2

artículo científico publicado en 2009

Role of protein kinase CK2 in antitumor drug resistance

scientific article published on 05 July 2019

Salicylic acid activates nitric oxide synthesis in Arabidopsis

artículo científico publicado en 2007

Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2').

artículo científico publicado en 2001

Ser/Thr phosphorylation of hematopoietic specific protein 1 (HS1): implication of protein kinase CK2

artículo científico publicado en 2000

Site specificity of p72 syk protein tyrosine kinase: efficient phosphorylation of motifs recognized by Src homology 2 domains of the Src family

artículo científico publicado en 1995

Specificity of T-cell protein tyrosine phosphatase toward phosphorylated synthetic peptides

scientific article published on 01 January 1993

Spontaneous autophosphorylation of Lyn tyrosine kinase at both its activation segment and C-terminal tail confers altered substrate specificity.

artículo científico publicado en 1998

Src Homology-2 Domains Protect Phosphotyrosyl Residues against Enzymatic Dephosphorylation

artículo científico publicado en 1998

Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A

artículo científico publicado en 2012

Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2).

artículo científico publicado en 2014

Targeting Protein Kinase CK2: Evaluating CX-4945 Potential for GL261 Glioblastoma Therapy in Immunocompetent Mice

artículo científico publicado en 2017

Tetrabromocinnamic Acid (TBCA) and Related Compounds Represent a New Class of Specific Protein Kinase CK2 Inhibitors

scholarly article by Mario A Pagano published in January 2007

The antioxidant butylated hydroxytoluene (BHT) inhibits the dioctanoylglycerol-evoked platelet response but potentiates that elicited by ionomycin

artículo científico publicado en 1992

The antioxidant butylated hydroxytoluene stimulates platelet protein kinase C and inhibits subsequent protein phosphorylation induced by thrombin

artículo científico publicado en 1991

The ataxia related G1107D mutation of the plasma membrane Ca2+ ATPase isoform 3 affects its interplay with calmodulin and the autoinhibition process.

artículo científico publicado en 2016

The carboxy-terminal domain of Grp94 binds to protein kinase CK2 alpha but not to CK2 holoenzyme.

artículo científico publicado en 2001

The importance of negative determinants as modulators of CK2 targeting. The lesson of Akt2 S131.

artículo científico publicado en 2018

The p23 co-chaperone protein is a novel substrate of CK2 in Arabidopsis

artículo científico publicado en 2011

The selectivity of inhibitors of protein kinase CK2: an update

artículo científico publicado en 2008

The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain

artículo científico publicado en 2005

Tyrosine phosphorylation of protein kinase CK2 by Src-related tyrosine kinases correlates with increased catalytic activity

artículo científico publicado en 2003

pCMB Treatment Reveals the Essential Role of Cysteinyl Residues in Conferring Functional Competence to the Regulatory Subunit of Protein Kinase CK2

artículo científico publicado en 2000

pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase: effect on schizophrenia susceptibility

artículo científico publicado en 2008

Lista de obras de Maria Ruzzene

2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2.

A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours

A procedure allowing measurement of cytosolic CA2+ in rat platelets. Inhibition of a plasma lipoprotein on fura 2-AM loading

Aberrant signalling by protein kinase CK2 in imatinib-resistant chronic myeloid leukaemia cells: biochemical evidence and therapeutic perspectives

Addiction of Cancer Cells to CK2: Survival at All Costs or Achilles' Heel?

Addiction to protein kinase CK2: a common denominator of diverse cancer cells?

Analysis of the interaction between piD261/Bud32, an evolutionarily conserved protein kinase of Saccharomyces cerevisiae, and the Grx4 glutaredoxin

Assessment of CK2 constitutive activity in cancer cells

Autocatalytic tyrosine-phosphorylation of protein kinase CK2 alpha and alpha' subunits: implication of Tyr182

Biochemical analysis of the interactions between the proteins involved in the [FeFe]-hydrogenase maturation process

Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA)

Bovine prion protein as a modulator of protein kinase CK2

CD45 regulates apoptosis induced by extracellular adenosine triphosphate and cytotoxic T lymphocytes.

CK2 Function in the Regulation of Akt Pathway

Casein kinase: the triple meaning of a misnomer

Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential

Chimeric peptides as modulators of CK2-dependent signaling: Mechanism of action and off-target effects

Comparative analysis of CK2 expression and function in tumor cell lines displaying sensitivity vs. resistance to chemical induced apoptosis

Cross-talk between the CK2 and AKT signaling pathways in cancer

Cyclic GMP and nitroprusside inhibit the activation of human platelets by fluoroaluminate

Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells

Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity.

Development and exploitation of CK2 inhibitors

Different Persistence of the Cellular Effects Promoted by Protein Kinase CK2 Inhibitors CX-4945 and TDB.

Differential phosphorylation of Akt1 and Akt2 by protein kinase CK2 may account for isoform specific functions

Effects of CK2 inhibition in cultured fibroblasts from Type 1 Diabetic patients with or without nephropathy

Effects of calcium chelators, divalent cations and sulfhydryl reagents on calcium uptake and motility of bovine spermatozoa

Effects of the CK2 inhibitors CX-4945 and CX-5011 on drug-resistant cells

Enhancing chemosensitivity to gemcitabine via RNA interference targeting the catalytic subunits of protein kinase CK2 in human pancreatic cancer cells

Exploiting the repertoire of CK2 inhibitors to target DYRK and PIM kinases.

Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency

Functional protein network activation mapping reveals new potential molecular drug targets for poor prognosis pediatric BCP-ALL

Helicobacter pylori periplasmic receptor CeuE (HP1561) modulates its nickel affinity via organic metallophores

Hematopoietic lineage cell specific protein 1 associates with and down-regulates protein kinase CK2.

Heterogeneity of CK2 phosphorylation sites in the NS5A protein of different hepatitis C virus genotypes

Hierarchical phosphorylation of a 50-kDa protein by protein tyrosine kinases TPK-IIB and C-Fgr, and its identification as HS1 hematopoietic-lineage cell-specific protein

How do protein kinases recognize their substrates?

Increased activity of c-Src and Csk in fibroblasts transformed by v-src oncogene

Inhibition of protein kinase CK2 by condensed polyphenolic derivatives. An in vitro and in vivo study

Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity

Lamin A Ser404 is a nuclear target of Akt phosphorylation in C2C12 cells

Multiple myeloma cell survival relies on high activity of protein kinase CK2.

Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole

Pharmacological inhibition of protein kinase CK2 reverts the multidrug resistance phenotype of a CEM cell line characterized by high CK2 level.

Phosphatidylinositol 3-kinase is recruited to a specific site in the activated IL-1 receptor I

Phosphoproteomic Profiling of NSCLC Cells Reveals That Ephrin B3 Regulates Pro-survival Signaling through Akt1- Mediated Phosphorylation of the EphA2 Receptor

Phosphoproteomic profiling of NSCLC cells reveals that ephrin B3 regulates pro-survival signaling through Akt1-mediated phosphorylation of the EphA2 receptor.

Phosphorylation and activation of the atypical kinase p53-related protein kinase (PRPK) by Akt/PKB

Phosphorylation of the Saccharomyces cerevisiae Grx4p glutaredoxin by the Bud32p kinase unveils a novel signaling pathway involving Sch9p, a yeast member of the Akt / PKB subfamily

Phosphorylation, Signaling, and Cancer: Targets and Targeting

Platelet activation by diacylglycerol or ionomycin is inhibited by nitroprusside

Platelet responses promoted by the activation of protein kinase C or the increase of cytosolic Ca2+ are potentiated by adrenaline. Effects of cAMP and staurosporine

Protein kinase CK2 accumulation in "oncophilic" cells: causes and effects.

Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways

Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells

Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain

Protein kinase CK2 phosphorylates and upregulates Akt/PKB.

Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response

Psoralen—fatty acid cycloadducts activate protein kinase C (PKC) in human platelets

Pyrvinium pamoate does not activate protein kinase CK1, but promotes Akt/PKB down-regulation and GSK3 activation

Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2

Role of protein kinase CK2 in antitumor drug resistance

Salicylic acid activates nitric oxide synthesis in Arabidopsis

Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2').

Ser/Thr phosphorylation of hematopoietic specific protein 1 (HS1): implication of protein kinase CK2

Site specificity of p72 syk protein tyrosine kinase: efficient phosphorylation of motifs recognized by Src homology 2 domains of the Src family

Specificity of T-cell protein tyrosine phosphatase toward phosphorylated synthetic peptides

Spontaneous autophosphorylation of Lyn tyrosine kinase at both its activation segment and C-terminal tail confers altered substrate specificity.

Src Homology-2 Domains Protect Phosphotyrosyl Residues against Enzymatic Dephosphorylation

Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A

Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2).

Targeting Protein Kinase CK2: Evaluating CX-4945 Potential for GL261 Glioblastoma Therapy in Immunocompetent Mice

Tetrabromocinnamic Acid (TBCA) and Related Compounds Represent a New Class of Specific Protein Kinase CK2 Inhibitors

The antioxidant butylated hydroxytoluene (BHT) inhibits the dioctanoylglycerol-evoked platelet response but potentiates that elicited by ionomycin

The antioxidant butylated hydroxytoluene stimulates platelet protein kinase C and inhibits subsequent protein phosphorylation induced by thrombin

The ataxia related G1107D mutation of the plasma membrane Ca2+ ATPase isoform 3 affects its interplay with calmodulin and the autoinhibition process.

The carboxy-terminal domain of Grp94 binds to protein kinase CK2 alpha but not to CK2 holoenzyme.

The importance of negative determinants as modulators of CK2 targeting. The lesson of Akt2 S131.

The p23 co-chaperone protein is a novel substrate of CK2 in Arabidopsis